NALP2 (H-4) Antikörper: sc-166584

NALP2 Background Information
NALP2 (PAN1, PYPAF2) is a 1,062 amino acid protein that catalyzes the suppression of TNF- and CD40-induced NFKB1 activity at the level of the IKK complex by inhibiting NFKBIA degradation induced by TNF. When associated with PYCARD, NALP2 activates CASP1, which leads to the secretion of mature proinflammatory cytokine IL1B. As a putative member of the inflammasome, a protein complex which also includes PYCARD, CARD8 and CASP1, NALP2 may be involved in the activation of proinflammatory caspases. NAPL2 shows predominant expression in lung, placenta and thymus tissues, and demonstrates lower levels of expression in ovary, intestine and brain tissues. NAPL2 contains 1 DAPIN domain, 9 LRR (leucine-rich) repeats and 1 NACHT domain. The DAPIN domain is crucial for the suppression of NFKB1 activation and for inducing IL1B secretion in collaboration with caspase-1.