epitope mapping near the N-terminus of Pdcd-5 of human origin
recommended for detection of Pdcd-5 of mouse, rat and human origin by WB, IF and ELISA; non cross-reactive with other Pdcd family members; also reactive with additional species, including bovine and porcine
TransCruz reagent for Gel Supershift and ChIP applications, sc-162004 X, 200 µg/0.1 ml
Pdcd-5 Background Information Pdcd-5 (Programmed cell death protein 5), also known as TFAR19, is a 125 amino acid protein that is widely expressed with highest expression in heart, testis, kidney, pituitary gland, adrenal gland and placenta. Belonging to the Pdcd family, Pdcd-5 is activated in cells undergoing apoptosis. Pdcd-5 may be an important regulator of TIP60 by inhibiting its proteasome-dependent degradation. TIP60, also known as K(lysine) acetyltransferase 5, is a protein involved in transcription, DNA damage response and cell cycle control. Pdcd-5 is encoded by a gene located on human chromosome 19q13.11. Chromosome 19 consists of approximately 63 million bases and makes up over 2% of human genomic DNA. Chromosome 19 is recognized for having the greatest gene density of the human chromosomes. It is the genetic home for a number of immunoglobulin superfamily members including the killer cell and leukocyte Ig-like receptors, a number of ICAMs, the CEACAM and PSG family and Fcå receptors.
