epitope mapping within an internal region of WDTC1 of human origin
recommended for detection of WDTC1 of mouse, rat and human origin by WB, IF and ELISA; also reactive with additional species, including equine, canine, bovine, porcine and avian
WDTC1 Background Information WDTC1 (WD and tetratricopeptide repeats 1), also known as ADP or DCAF9, is a 677 amino acid protein that contains seven WD repeats, two TPR repeats and exists as six alternatively spliced isoforms. WDTC1 is the human ortholog of Drosophila adp (adipose), an obesity gene involved in fat storage. WDTC1 is encoded by a gene located on human chromosome 1, which spans 260 million base pairs, contains over 3,000 genes and comprises nearly 8% of the human genome. Chromosome 1 houses a large number of disease-associated genes, including those involved in familial adenomatous polyposis, Stickler syndrome, Parkinson’s disease, Gaucher disease, schizophrenia and Usher syndrome. Aberrations in chromosome 1 are found in a variety of cancers, including head and neck cancer, malignant melanoma and multiple myeloma.
