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- goat polyclonal IgG, 200 µg/ml
- epitope mapping near the N-terminus of GALE of human origin
- recommended for detection of GALE of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine, bovine and porcine
- blocking peptide, sc-160060 P
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GALE Background Information
GALE, also known as galactowaldenase, UDP-galactose-4-epimerase or SDR1E1, is a 348 amino acid protein that functions as the third enzyme in the Leloir pathway of galactose metabolism. A member of the sugar epimerase family, GALE exists as a homodimer, binds FAD as a cofactor and catalyzes the epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine and UDP-glucose to UDP-galactose. The gene encoding GALE maps to human chromosome 1p36.11 and mutations in this gene lead to the development of complex disorder known as epimerase-deficiency galactosemia (EDG) or galactosemia type 3, which is characterized by mental retardation, liver damage, cataracts and deafness. |
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GALE (N-13)
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GALE (N-13): sc-160060. Western blot analysis of GALE expression in non-transfected: sc-117752 (A) and human GALE transfected: sc-110864 (B) 293T whole cell lysates. GALE (N-13): sc-160060. Western blot analysis of GALE expression in non-transfected: sc-117752 (A) and human GALE transfected: sc-170673 (B) 293T whole cell lysates. |
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