Bride of Sevenless Background Information
Drosophila melanogaster is a proven and effective model for studying developmental and cellular processes common to higher eukaryotes. Approximately 13,600 genes have been elucidated from more than 120 megabases of euchromatin, and they are organized among the chromosomes 2, 3, 4, X and Y, with the Y chromosome being predominately heterochromatic (1). Drosophila genes can be categorized based on the type of protein they encode and are represented by six major classifications, which include intracellular signaling proteins, transmembrane proteins, RNA binding proteins, secreted factors, transcription regulators (basic helix-
loop-helix, homeodomain containing, zinc finger containing, and chromatin associated) or other functional proteins (2). Among these proteins, BOSS (Bride of sevenless) is a seven transmembrane-containing ligand for the sevenless receptor tyrosine kinase (3). BOSS mediated activation of sevenless initiates intracellular cascades, which ensure proper compound eye development in Drosophila (3-7).
