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- goat polyclonal IgG, 200 µg/ml
- epitope mapping near the C-terminus of β3Gn-T4 of human origin
- recommended for detection of β3Gn-T4 of human origin by WB, IP, IF and ELISA; non cross-reactive with other β3Gn family members; also reactive with additional species, including porcine, equine and bovine
- blocking peptide, sc-137258 P
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Bestellinformationen
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| Spezies |
Gen |
Gen ID |
Chromosomaler Locus |
mRNA (Isoform) Accession # |
Protein Accession # |
OMIM™ Nummer |
| Human |
B3GNT4 |
79369 |
12q24.31 |
|
Q9C0J1
|
605864 |
| Human |
B3GNT4 |
79369 |
12q24.31 |
|
Q9C0J1
|
605864 |
| |
β3Gn-T4 Background Information
A family of human beta 1,3-galactosyltransferases (∫3Gn-Ts) consists of nine members (∫3Gn-T1, -T2, -T3, -T4, -T5, -T6, -T7, -T8 and -T9). ∫3Gn-T1 catalyzes the formation of type 1 oligosaccharides. ∫3GnT-2 converts lacto-N-triose II into lacto-N-tetraose and lacto-N-neotetraose and can form a heterodimer with ∫3Gn-T8, which, as a complex, exhibits higher enzymatic activity. Unlike the ubiquitously expressed ∫3Gn-T2, ∫3Gn-T3 is specifically expressed in colon, jejunum, stomach, esophagus, placenta and trachea, and ∫3Gn-T4 is mainly expressed in brain. ∫3Gn-T5 is essential for the biosynthesis of Lewis antigens and may play a role in gastric cancer as a result of its participation in chronic H. pylori infection. ∫3Gn-T6 may be a useful marker for distinguishing between benign adenomas and premalignant lesions. ∫3Gn-T7 acts as an anti-migration factor for a lung cancer cell line. |
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β3Gn-T4 (C-14)
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β3Gn-T4 (C-14): sc-137258. Western blot analysis of β3Gn-T4 expression in HeLa (A) and SK-BR-3 (B) whole cell lysates.
β3Gn-T4 (C-14): sc-137258. Western blot analysis of β3Gn-T4 expression in H4 (A), T98G (B) and BE(2)-M17 (C) whole cell lysates.
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