Vgl-1 Background Information The transcriptional enhancer factor-1 (TEF-1) family of transcription factors regulate tissue-specific gene expression in muscle and placenta. The mechanism whereby TEF-1 confers tissue specificity depends largely on the interaction of TEF-1 with tissue-specific cofactors. Transcription cofactor vestigial-like protein 1 (Vgl-1), also known as TONDU or TDU, is a TEF-1 cofactor that is critical for controlling tissue-specific gene activation of TEF-1. Vgl-1 interacts with TEF-1 through a conserved sequence known as the TONDU (TDU) motif. While Vgl-1 is expressed almost exclusively in placenta of adult human tissues, it is expressed more widely in human embryo tissues including kidney, lung, skeletal muscle, heart and placenta. Vgl-1 is 258 amino acids in length and localizes to the nucleus.
Vgl-1 (NQ-A1)
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Vgl-1 (NQ-A1): sc-135601. Western blot analysis of Vgl-1 expression in human Vgl-1 transfected (A) and non-transfected (B) 293T whole cell lysates.
