DCL-1 Background Information
DCL-1, also known as CD302, CLEC13A (C-type lectin domain family 13 member A) or C-type lectin BIMLEC, is a 232 amino acid single-pass type I membrane protein involved in endocytosis, phagocytosis and cell adhesion and migration. A C-type lectin receptor, DCL-1 is widely expressed with highest levels found in peripheral blood, myeloid and B lymphoid cell lines, liver, ovary and lung. DCL-1 undergoes alternative splicing to produce three isoforms designated DCL-1 isoform 1, isoform 2 (also known as fusion protein variant V34-2) and isoform 3 (also designated fusion protein variant V33-2). DCL-1 isoforms 2 and 3 are produced in malignant lympoma cells, known as Hodgkin and Reed-Sternberg (HRS) cells. DCL-1 contains one C-type lectin domain and is encoded by a gene that maps to human chromosome 2q24.2. A number of genetic diseases are linked to genes on chromosome 2 including Harlequin icthyosis, sitosterolemia and Alström syndrome.
