NALP5 Background Information
NACHT-, LRR- and PYD-containing protein (NALP) family function in the regulation of apoptosis and inflammatory signaling pathways. Members of the NALP family (also designated Pyrin-containing APAF1-like proteins) include NALP1 through NALP11. Several family members, such as NALP1, NALP2, NALP3 and NALP6 influence NFkB and caspase pathways as components of the inflammasome. NALP5 (also designated MATER) is a maternal effect protein required for early embryonic development. Most short NALPs, such as NALP5, have a C-terminal leucine-rich repeat (LRR) region, an N-terminal pyrin (MEFV) domain (PYD), followed by a NACHT domain, and a NACHT-associated domain (NAD). The predicted 1,200-amino acid human NALP5 protein shares 53% sequence identity with the mouse protein. The gene which encodes the human NALP5 protein maps to chromosome 19q13.4.
