LZP Background Information The epidermal growth factor (EGF) repeat-containing proteins constitute an expanding family of proteins that are involved in several cellular activities, such as blood coagulation, fibrinolysis, cell adhesion and neural and vertebrate development. LZP (liver-specific zona pellucida domain-containing protein), also known as OIT3 (Oncoprotein-induced transcript 3 protein), is a 545 amino acid protein that localizes to the nuclear envelope and contains one ZP domain and one EGF-like domain. Expressed specifically in liver tissue, LZP is thought to be involved in hepatocellular function and development and is down-regulated in hepatocellular carcinoma, suggesting an additional role in tumor suppression. Multiple isoforms of LZP exist due to alternative splicing events.
LZP (66CT25.7.1)
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LZP (66CT25.7.1): sc-130807. Western blot analysis of LZP expression in non-transfected (A) and human LZP transfected (B) 293 whole cell lysates.
LZP (66CT25.7.1): sc-130807. Western blot analysis of LZP expression in non-transfected: sc-117752 (A) and human LZP transfected: sc-373074 (B) 293T whole cell lysates.
