mt-TyrRS Background Information The fidelity of protein synthesis requires efficient discrimination of amino acid substrates by aminoacyl-tRNA synthetases. Aminoacyl-tRNA synthetases function to catalyze the aminoacylation of tRNAs by their corresponding amino acids, thus linking amino acids with tRNA-contained nucleotide triplets. Mt-TyrRS (Tyrosyl-tRNA synthetase, mitochondrial), also known as Tyrosine-tRNA ligase and Tyrosal-tRNA synthetase 2, is a 477 amino acid protein that belongs to the class-I aminoacyl-tRNA synthetase family. Containing a 16-amino acid mitchondrial targeting signal, mt-TyrRS is localized to the mitochondrial matrix where it exists as a homodimer and functions primarily to catalyze the attachment of tyrosine to tRNA(Tyr) in a two-step reaction. First, tyrosine is activated by ATP to form Tyr-AMP, then it is transferred to the acceptor end of tRNA(Tyr).
mt-TyrRS (C-24)
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mt-TyrRS (C-24): sc-130587. Western blot analysis of mt-TyrRS expression in CEM whole cell lysate.
