Aldolase B Background Information
Fructose 1,6-bisphosphate aldolase catalyses the reversible condensation of glycerone-P and glyceraldehyde 3-phosphate into fructose 1,6-bisphosphate (1). Fructose 1,6-bisphosphate aldolase exists as three forms, the muscle-specific Aldolase A, the liver-specific aldolase B, and the brain-specific aldolase C (2). Aldolase A, B, and C arose from a common ancestral gene, from which aldolase B first diverged (3). Aldolase A is one of the most highly conserved enzymes known, with only about 2% of the residues changing per 100 million years (4). Aldolase B is regulated by the hormones insulin and glucagon and has been implicated in hereditary fructose intolerance disease (3,5). Aldolase C is a polypeptide that is exclusively expressed in Purkinje cells (6,8-10). Aldolase C-positive Purkinje cells are organized in the cerebellum as stripes or bands that run from anterior to posterior across the cerebellum and alternate with bands of Aldolase C-negative Purkinje cells (7,10).
