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- goat polyclonal IgG, 200 µg/ml
- epitope mapping within an internal region of FBP3 of human origin
- recommended for detection of FBP3 of human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine, bovine, porcine and avian
- blocking peptide, sc-11104 P
- TransCruz reagent for Gel Supershift and ChIP applications, sc-11104 X, 200 µg/0.1ml
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| Spezies |
Gen |
Gen ID |
Chromosomaler Locus |
mRNA (Isoform) Accession # |
Protein Accession # |
OMIM™ Nummer |
| Human |
FUBP3 |
8939 |
9q34.11 |
XM_001125825 |
Q96I24
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FBP3 Background Information
Activation of FUSE, the far-upstream element, is required for the proper ex-pression of the mammalian gene c-Myc in undifferentiated cells. The binding of FBP (FUSE-binding protein or Far upstream element binding protein) to FUSE is necessary for c-Myc expression, indicating that FBP functions as a growth-dependent regulator of c-Myc expression. Isolated from proliferating HL60 cells, FBP, FBP2, and FBP3 comprise a family of single-stranded DNA-binding proteins that specifically bind to FUSE elements. The FBP transcription factors share a conserved central DNA-binding domain and show significant homology in their carboxyl-terminal activation domains. Expression of FBP is detected in undifferentiated cells and is substantially decreased following cellular differentiation.
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FBP3 (E-15)
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Western blot analysis of FBP3 expression in MCF7 (A,D), SK-BR-3 (B,E) and U-87 MG whole cell lysates. Antibodies tested include FBP3 (I-20): sc-11103 (A,B,C) and FBP3 (E-15): sc-11104 (D,E). |
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