epitope mapping near the C-terminus of SAPS1 of human origin
recommended for detection of SAPS1 of mouse, rat and human origin by WB, IF and ELISA; non cross-reactive with SAPS2; also reactive with additional species, including equine, canine and porcine
SAPS1 Background Information SAPS1 (SAPS domain family, member 1), also known as PP6R1 or SAP190, is a 943 amino acid protein that localizes to the cytoplasm and exists as multiple alternatively spliced isoforms. Expressed ubiquitously with notably higher expression in testis, SAPS1 functions as a regulatory subunit of the heterotrimeric protein phosphatase 6 (PP6) complex and is thought to play a role in protein scaffolding related to the PP6 complex. The gene encoding SAPS1 maps to human chromosome 19, which consists of over 63 million bases, houses approximately 1,400 genes and is recognized for having the greatest gene density of the human chromosomes. It is the genetic home for a number of immunoglobulin (Ig) superfamily members, including the killer cell and leukocyte Ig-like receptors, a number of ICAMs, the CEACAM and PSG family and Fc receptors (FcRs). Key genes for eye color and hair color also map to chromosome 19.
