epitope mapping within an internal region of TAF II p43 of human origin
recommended for detection of TAF II p43 of mouse, rat and human origin by WB, IF and ELISA; also reactive with additional species, including equine, canine and bovine
TAF II p43 Background Information TFIID is a general transcription factor that initiates preinitiation complex assembly through direct interaction with the TATA promoter element. Functioning as a multisubunit complex consisting of a small TATA-binding polypeptide and other TBP-associated factors (TAFs), TFIID mediates promoter responses to various transcriptional activators and repressors. TAF II p43, also known as TAF8, TAFII43 or TBN, is a 310 amino acid subunit of the TFIID complex that contains one histone-fold domain. Localized to either the nucleus or the cytoplasm depending on the developmental stage of the cell, TAF II p43 plays a role in fibroblast differentiation and is thought to be required for survival of the early embryo. Ectopic expression of the histone-fold domain results in a dominant-negative mutation that prevents TAF II p43 from regulating differentiation, an event that may be detrimental to developing cells. Four isoforms of TAF II p43 exist due to alternative splicing events.
