CAMTA2 Background Information
CAMTA2 (calmodulin binding transcription activator 2), also known as KIAA0909, is a 1,202 amino acid protein that localizes to the nucleus and contains one IPT/TIG domain, one CG-1 domain, two IQ domains and three ANK repeats. Expressed in brain tissue, CAMTA2 is thought to interact with calmodulin (CaM) and may function as a transcriptional activator, possibly playing a role in tumor suppression. Multiple isoforms of CAMTA2 exist due to alternative splicing events. The gene encoding CAMTA2 maps to human chromosome 17, which comprises over 2.5% of the human genome and encodes over 1,200 genes. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Tumor suppressor p53 is necessary for maintenance of cellular genetic integrity by moderating cell fate through DNA repair versus cell death. Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome. Like p53, BRCA1 is directly involved in DNA repair, though specifically it is recognized as a genetic determinant of early onset breast cancer and predisposition to cancers of the ovary, colon, prostate gland and fallopian tubes.
