 |
- goat polyclonal IgG, 200 µg/ml
- epitope mapping near the N-terminus of Pdcd-1 of mouse origin
- recommended for detection of Pdcd-1 of mouse and rat origin by WB, IP, IF and ELISA
- blocking peptide, sc-10299 P
|
|
| |
Bestellinformationen
Empfohlene Supportprodukte:
(Klicken Sie auf die gewünschte Anwendung um passenden Supportprodukte anzuzeigen.)
| |
| Spezies |
Gen |
Gen ID |
Chromosomaler Locus |
mRNA (Isoform) Accession # |
Protein Accession # |
OMIM™ Nummer |
| Maus |
Pdcd1 |
18566 |
1 D |
|
Q02242
|
n.n. |
| |
Pdcd-1 Background Information
Pdcd-1 (Programmed Cell Death-1 protein), also designated CD279, is a type I transmembrane receptor and a member of the immunoglobin gene superfamily. Pdcd-1 contains an immunoreceptor tyrosine-based inhibitory motif (ITIM) within the cytoplasmic domain, which is conserved between the mouse and human homologs. Expression of Pdcd-1 is detected in mouse thymus, and it is induced in stimulated B and T cell lines, where it may play a role in the negative regulation of various immune responses. Receptors such as Pdcd-1 function by recruiting tyrosine phosphatases, including SHP-1 and SHIP, which are responsible for altering various B cell responses. Additionally, in activated lymphocytes, Pdcd-1 mediates the activation of the classical type of programmed cell death. |
|
|
Pdcd-1 (E-18)
Klicken Sie auf das Bild um es zu vergrößern.
|
|
Pdcd-1 (E-18): sc-10299. Western blot analysis of Pdcd-1 expression in NFS-5 C-1 whole cell lysate.
|
|
Download
|
|
