PDCD7 Background Information
PD-1 (programmed cell death-1 protein) is a type I transmembrane receptor and a member of the immunoglobin gene superfamily. Expression of PD-1 is detected in mouse thymus, and it is induced in stimulated B and T cell lines, where it may play a role in the negative regulation of various immune responses. PD-2 (also known as PDCD2, PDL2 or B7DC) is highly expressed in placenta, heart, pancreas, lung and liver. PD-2 is also expressed in spleen, lymph nodes and thymus. Pdcd-4 is a nuclear protein localized to the nucleus of proliferating cells. ALG-2 (apoptosis-linked gene 2), also designated programmed cell death protein 6, is a Ca2+-binding protein that participates in regulatory events occurring late in the apoptotic program and where several death signals converge. Pdcd-7, also designated programmed cell death protein 7, is a 485 amino acid protein that promotes apoptosis when overexpressed. Human Pdcd-7 and the mouse Pdcd-7 protein, designated as Es18, share 95% homology in the overlapping region.
