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Home » Chemikalien » TRP Ligands
 

TRP Ligands

  • 1-Oleoyl-2-acetyl-sn-glycerol (OAG)
    A membrane-permeable, synthetic diacylglycerol analog, activator of Ca2+-dependent protein kinase C.
    Katalog #CAS NummerSummenformelMenge
    sc-20041786390-77-4C23H42O510 mg/50 mg
  • 2-APB
    A TRP inhibitor that also directly blocks the mitochondrial permeability transition pore, sarco/endoplasmic reticulum Ca2-ATPase pumps, and native store operated channels, as well as other ion channels.
    Katalog #CAS NummerSummenformelMenge
    sc-201487524-95-8C14H16BNO20 mg/100 mg
  • 3-Indoleacrylic acid
    Induces transcription of genes under the control of the trpE promoter. IAA also transcriptionally activates gene expression in plants. Some of the genes that are induced by IAA encode a family of proteins that contain nuclear localization signals that direct a β-glucuronidase reported protein into the nucleus.
    Katalog #CAS NummerSummenformelMenge
    sc-2565191204-06-4C11H9NO21 g/5 g
  • 4α-Phorbol 12-myristate 13-acetate
    A non-tumor promoting phorbol ester derivative used as a negative control for PKC activation by PMA (sc-3576). Also shown to bind to TRPV4 and to increase COX-2 mRNA in murine keratinocytes.
    Katalog #CAS NummerSummenformelMenge
    sc-20202163597-44-4C36H56O81 mg/5 mg
  • 4α-Phorbol 12,13-didecanoate
    A negative control for phorbol 12,13-didecanoate that has been shown to activate the TRPV4 receptor.
    Katalog #CAS NummerSummenformelMenge
    sc-20121027536-56-7C40H64O81 mg/5 mg
  • 6-Iodonordihydrocapsaicin
    A potent transient receptor potential vanilloid-1 (TRPV1) channel antagonist. Used in place of Capsazepine to investigate vanilloid receptor agonists.
    Katalog #CAS NummerSummenformelMenge
    sc-203785859171-97-4C17H26INO310 mg/50 mg
  • 6'-Iodononivamide
    Strong competitive TRPV1 antagonist. Convenient replacement for capsazepine in most of the in vitro preparations currently used to assess the activity of putative vanilloid receptor agonists.
    Katalog #CAS NummerSummenformelMenge
    sc-221109n.n.C17H26INO35 mg
  • 6’-Iodoresiniferatoxin
    High affinity TRPV1 (VR1) vanilloid receptor partial agonist (Ki = 0.71 nM; EC50 = 130 nM at human VR1). Displays partial agonism at human VR1 and full agonism at rat VR1.
    Katalog #CAS NummerSummenformelMenge
    sc-202025n.n.C37H39IO91 mg
  • AMG-9810
    A vanilloid receptor 1 antagonist which blocks a variety of known modes of VR1 activation. Also has been shown to block capsaicin-evoked depolarization and calcitonin gene-related peptide release.
    Katalog #CAS NummerSummenformelMenge
    sc-201477545395-94-6C21H23NO310 mg/50 mg
  • Anandamide
    An endogenous cannabinoid ligand that binds to brain and peripheral cannabinoid receptors CB1/CB2 and inhibits the binding of [3H]HU-243 to synaptosomal membranes.
    Katalog #CAS NummerSummenformelMenge
    sc-20079094421-68-8C22H37NO25 mg/25 mg
  • AP-18
    AP-18 is a novel TRPA1 channel blocker (CHO cells, IC50= 3.1 μM; human and mouse cell lines, IC50= 4.5 μM). It reduces cinnamaldehyde-induced nociception in vivo and blocks cold- and mustard oil-induced activation of mouse TRPA1 but not capsaicin-induced activation demonstrating selectivity vs. TRPV11.
    Katalog #CAS NummerSummenformelMenge
    sc-20382255224-94-7C11H12CINO5 mg/25 mg
  • Arachidonic Acid (20:4, n-6)
    A precursor to numerous eicosanoids as well as other bioactive molecules that can cause activation of protein kinase C.
    Katalog #CAS NummerSummenformelMenge
    sc-200770506-32-1C20H32O2100 mg/1 g
  • Arvanil
    A vanilloid analog which is 100-fold more potent than anandamide in producing hypothermia, analgesia and catalepsy.
    Katalog #CAS NummerSummenformelMenge
    sc-202065128007-31-8C28H41NO35 mg
  • BCTC
    An effective and potent transient receptor potential vanilloid-1 (TRPV1) channel antagonist.
    Katalog #CAS NummerSummenformelMenge
    sc-205599393514-24-4C20H25ClN4O10 mg/50 mg
  • Capsaicin
    An agonist at the TRPV1 capsaicin receptor, a ligand-gated non-selective cation channel. Exhibits neuroprotective effects in a model of transient global cerebral ischemia; reversibly inhibits platelet aggregation.
    Katalog #CAS NummerSummenformelMenge
    sc-3577404-86-4C18H27NO350 mg/1 g
  • Capsazepine
    A competitive agonist of the TRPV1 (VR-1) receptor and antagonist of Capsaicin action at this receptor. Prevents the development of Capsaicin-induced mechanical hyperalgesia. Blocks Resiniferatoxin- and Capsaicin-induced contractions of guinea pig treacheal smooth muscle
    Katalog #CAS NummerSummenformelMenge
    sc-201098138977-28-3C19H21ClN2O2S5 mg/25 mg
  • Eugenol
    An agonist of the TRPV1 receptor. Structural analogy to Capsaicin. Local anesthetic effect is correlated with TRPV1 agonism. Demonstrates antifungal and antimicrobial effects.
    Katalog #CAS NummerSummenformelMenge
    sc-20304397-53-0C10H12O21 g
  • Evodiamine
    An agonist of TRPV1 with comparable activity to Capsaicin. Inhibits prostaglandin E2 synthesis, cyclooxygenase-2 induction and NF-κB activation. Inhibits iNOS protein synthesis. Demonstrates antiangiogenesis. Promotes apoptosis in U937 cells.
    Katalog #CAS NummerSummenformelMenge
    sc-201479518-17-2C19H17N3O20 mg/100 mg
  • Farnesylthioacetic Acid (FTA)
    FTA has shown potent and specifc inhibition of methyl esterification of farnesylated proteins, inhibtion of Ca2+ channels and an agonist for TRPA1,
    Katalog #CAS NummerSummenformelMenge
    sc-200845135784-48-4C17H28O2S5 mg/25 mg
  • GSK1016790A
    GSK1016790A is a novel and potent TRPV4 channel agonist. The TRPV4 (transient receptor potential vanilloid 4) member of the TRP superfamily has been implicated in numerous physiological processes. GSK1016790A elicited Ca2+ influx in mouse and human TRPV4 expressing HEK cells (EC50 values of 18 and 2.1 nM, respectively), and evoked a dose-dependent activation of TRPV4 whole-cell currents at concentrations above 1 nM.
    Katalog #CAS NummerSummenformelMenge
    sc-255193942206-85-1C28H32Cl2N4O6S210 mg
  • HC-030031
    Potent and selective TRPA1 inhibitor that antagonizes allyl isothiocyanate (AITC)- and formalin-evoked calcium influx.
    Katalog #CAS NummerSummenformelMenge
    sc-203994349085-38-7C18H21N5O310 mg/50 mg
  • IBTU
    Potent vanilloid receptor 1 [TRPV1] antagonist with marked selectivity for the Ca+ entry-linked receptor subpopulation of TRPV1.
    Katalog #CAS NummerSummenformelMenge
    sc-221737n.n.C16H16ClIN2O2S1 mg/5 mg
  • Icilin
    A small molecule agonist of the TRPM8 receptor, producing cold sensation. Activates TRPM8 ~200-fold more potently than Menthol.
    Katalog #CAS NummerSummenformelMenge
    sc-20155736945-98-9C16H13N3O410 mg/50 mg
  • JYL-79
    Potent TRPV1 agonist. More potent than capsaicin with RTX binding affinity, agonism.
    Katalog #CAS NummerSummenformelMenge
    sc-221785n.n.C26H36N2O4S1 mg/5 mg
  • JYL-273
    Potent TRPV1 agonist (Ki=11nM). About 500-fold more potent than capsaicin . RTX binding affinity (Ki=6.35nM), agonism (calcium influx; EC50=2.83nM).
    Katalog #CAS NummerSummenformelMenge
    sc-202678289902-71-2C28H40N2O4S1 mg/5 mg
  • JYL-827
    Potent TRPV1 agonist. RTX binding affinity (Ki=29.3nM), antagonism (IC50=67nM).
    Katalog #CAS NummerSummenformelMenge
    sc-202193401572-96-1C26H37N3O4S21 mg/5 mg
  • JYL-1413
    A TRPV1 channel antagonist that has been shown to bind to RTX.
    Katalog #CAS NummerSummenformelMenge
    sc-202192735331-54-1C26H37N3O4S21 mg/5 mg
  • JYL-1433
    A selective ransient receptor potential vanilloid-1 (TRPV1) antagonist. Shown to inhibit calcium flux and capsaicin toxicity in epitheliall cell studies.
    Katalog #CAS NummerSummenformelMenge
    sc-202676565448-40-0C26H36N3FO4S21 mg/5 mg
  • JYL-1511
    A partial agonist for the TRPV1 channel. Research indicates that the presence of Cyclosporin A increases the efficiency of JYL-1511.
    Katalog #CAS NummerSummenformelMenge
    sc-202677623166-14-3C21H29N3O3S21 mg/5 mg
  • JNJ 17203212
    A high affinity TRPV1 receptor antagonist. Shown to elevates the micturition reflex threshold for activation in rodent bladder studies, and in rats weakens colonic hypersensitivity.
    Katalog #CAS NummerSummenformelMenge
    sc-204024821768-06-3C17H15F6N5O10 mg/50 mg
  • Linvanil
    TRPV1 ligand with low affinity to CB1 receptor (Kι=3.4µM). Inhibits anandamide uptake (IC50=8.0µM).
    Katalog #CAS NummerSummenformelMenge
    sc-205951n.n.C26H39NO35 mg
  • (-)-Menthol
    Cooling agent. Strongly activates TRPM8 (cold menthol receptor 1; CMR1) and TRPA1.
    Katalog #CAS NummerSummenformelMenge
    sc-2027052216-51-5C10H20O25 mg/100 mg
  • MSK-195
    Potent analgesic with EC50=0.96µg/kg in the acetic acid-induced writhing test. RTX binding affinity (Ki=603nM), agonism (calcium influx; EC50=240nM).
    Katalog #CAS NummerSummenformelMenge
    sc-202712289902-82-5C28H40N2O51 mg/5 mg
  • N-(p-Amylcinnamoyl) anthranilic Acid (ACA)
    Reported to be an inhibitor of PLA2 and glucose-induced arachidonic acid formation. Also shown to modulate the activity of different transient receptor potential channels.
    Katalog #CAS NummerSummenformelMenge
    sc-200734110683-10-8C21H23NO350 mg/250 mg
  • N-Arachidonoyl-serotonin
    A selective fatty acid amid hydrolase and TRPV1 channel inhibitor. Shown to be inactive against cPLA2 and CB1.
    Katalog #CAS NummerSummenformelMenge
    sc-201460187947-37-1C30H42N2O210 mg/50 mg
  • N-Oleoyldopamine (OLDA)
    Katalog #CAS NummerSummenformelMenge
    sc-201456105955-11-1C26H43NO35 mg/25 mg
  • Olvanil
    A potent agonist of the TRPV1 receptor, 10-fold more potent than Capsaicin. Interacts with Anandamide transporter and blocks intracellular Anandamide accumulation.
    Katalog #CAS NummerSummenformelMenge
    sc-20145458493-49-5C26H43NO35 mg/25 mg
  • PDNHV
    Resiniferatoxin-type phorboid vanilloid with capsaicin-like selectivity for TRPV1.
    Katalog #CAS NummerSummenformelMenge
    sc-202760251362-87-5C47H68O111 mg/5 mg
  • Polygodial
    Naturally occurring sesquiterpene that displays antinociceptive and antifungal properties. Found to down-regulate TRPA1 in spinal chord.
    Katalog #CAS NummerSummenformelMenge
    sc-2014896754-20-7C15H22O25 mg/25 mg
  • PSY-279
    TRPV1 agonist. Amide based RTX analog. RTX binding affinity (Ki=15nM), high agonism (calcium influx: EC50=0.29nM).
    Katalog #CAS NummerSummenformelMenge
    sc-202780289903-41-9C28H39NO51 mg/5 mg
  • RN 1734
    A selective TRPV4 antagonist (IC50 values are 2.3, 5.9 and 3.2 μM for hTRPV4, mTRPV4 and rTRPV4 receptors respectively). Has been shown to display selectivity for over other TRP channels (IC50 values are 2.3, >30, >30 and >100 μM for TRPV4, TRPV3, TRPM8 and TRPV1 respectively).
    Katalog #CAS NummerSummenformelMenge
    sc-296273946387-07-1n.n.10 mg/50 mg
  • RN 1747
    A selective TRPV4 agonist (EC50 values are 0.77, 4.0 and 4.1 μM for hTRPV4, mTRPV4 and rTRPV4 respectively). Shown to display selectivity over other TRP channels (EC50 values are 0.77, >30, >30 and >100 μM for TRPV4, TRPM8, TRPV3 and TRPV1 receptors respectively). Also has been shown to antagonize TRPM8 at relevant concentrations (IC50 = 4 μM).
    Katalog #CAS NummerSummenformelMenge
    sc-2962741024448-59-6n.n.10 mg/50 mg
  • Resiniferatoxin
    An irritant diterpenoid experimentally shown to release substance P from afferent nociceptive specific neurons and stimulate protein kinase C.
    Katalog #CAS NummerSummenformelMenge
    sc-2401557444-62-9C37H40O91 mg/5 mg
  • STEARDA
    Endogenous lipid, active in vivo. Enhances effects of endovanilloids at TRPV1 receptors
    Katalog #CAS NummerSummenformelMenge
    sc-204903105955-10-0C26H45NO310 mg
  • SU-154
    A TRPV1 antagonist.
    Katalog #CAS NummerSummenformelMenge
    sc-203285681810-30-0C26H36N3FO5S21 mg/5 mg
  • Tinyatoxin (TYX)
    Analog of resiniferatoxin (RTX). Less potent as an irritant than RTX. But more stable against air oxidation than RTX.
    Katalog #CAS NummerSummenformelMenge
    sc-20586358821-95-7C36H38O81 mg/5 mg
  • WS 3
    TRPM8 receptors agonist (EC50 = 3.7 μM) and cooling agent.
    Katalog #CAS NummerSummenformelMenge
    sc-20440139711-79-0C13H25NO10 mg/50 mg
  • WS 12
    Cooling agent and potent TRPM8 agonist (EC50 = 193 nM).
    Katalog #CAS NummerSummenformelMenge
    sc-20440068489-09-8C18H27NO210 mg/50 mg