Transcription Factor Inhibitors

• 1-(4-Hexyphenyl)-2-propane-1-one
  A small, molecular irreversible covalent inhibitor of thyroid hormone receptor-β(TRβ) interaction with coactivator (SRC2).

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-251468	131906-57-5	C15H20O	5 mg

• BMS 961

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-362717	185629-22-5	C23H26FNO4	10 mg/50 mg

• Elbfluorene
  Selective inhibitor of CDK1/cyclin B with some P-glycoprotein-modulating properties. Weakly inhibits CDK5/p25 with no effect on CDK2/cyclin E and CDK4/cyclin D1.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-221585	n.n.	C19H13NO3	1 mg/5 mg

• ER 50891

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-362733	187400-85-7	C29H24N2O2	10 mg/50 mg

• ERB 041

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-362734	524684-52-4	C15H10FNO3	10 mg/50 mg

• NSC308848
  An inhibitor of small molecular transcription factors.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-215588	69408-82-8	C18H21N3O2	5 mg/25 mg

• Pifithrin-α, Cyclic-
  The cyclized form of Pifithrin-a, a specific inhibitor of p53. Suppression of p53 activity has shown protection of healthy cells towards chemotherapy and radiation, and neuroprotection against excitotoxicity.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-203194	60477-34-1	C16H16N2S•HBr	10 mg

• Pifithrin-α, p-Nitro
  A cell-permeable p53 inhibitor that serves as the prodrug form of Pifithrin-α, p-Nitro, Cyclic.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-222176	n.n.	C15H15N3O3S ·HBr	5 mg

• Pifithrin-α, p-Nitro, Cyclic
  A cell-permeable p53 inhibitor that exhibits 10-fold higher potency (ED₅₀ = 30 nM in protecting etoposide-induced cortical neuron death) and 50% longer half-life (t1/2 = 6h in neuron culture medium at 37°C) than Pifithrin-α.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-222177	n.n.	C15H13N3O2S	5 mg

• Pifithrin-μ
  Blocks p53 interaction with Bcl-xL and Bcl-2 and inhibits p53 mitochondrial translocation without affecting the transactivation function of p53.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-203195	64984-31-2	C8H7NO2S	10 mg/50 mg

• STA-21
  Blocks constitutive STAT3 signaling.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-200757	28882-53-3	C19H14O4	1 mg

• Stat3 Inhibitor V, Stattic
  A selective inhibitor of the STAT3 transcription factor, blocks phosphorylation and dimerization.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-202818	19983-44-9	C8H5NO4S	25 mg

• Stat3 Inhibitor VI, S3I-201
  An inhibitor of the Stat3 transcription factor.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-204304	501919-59-1	C16H15NO7S	10 mg

• STAT3 Inhibitor VII
  A cell permeable dihydroquinoline that specifically inhibits JAK1, JAK2, TYK2, and STAT3. This pathway is important in cell proliferation and so this inhibitor is ideal to inhibit cell proliferation in cancer cells.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-355978	n.n.	C19H7F7N2O3	5 mg

• Stat3 Inhibitor VIII, 5,15-DPP
  A cell-permeable porphyrin compound that binds STAT3 (KD = 880 nM by SPR) and prevents STAT3 SH2 domain-mediated ligand binding (IC50 = 280 nM) and dimerization (~60% inhibition at 50 µM in HEK293).

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-204305	22112-89-6	C32H22N4	25 mg

• STAT5 Inhibitor
  A cell permeable nonpetidic nicotinoyl hydrazone which suppresses STAT5 via binding to the SH2 domain.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-355979	n.n.	C16H11N3O3	10 mg

• Tanshinone IIA
  Promotes anti-inflammatory, anti-oxidative, and cytotoxic activity, and induces apoptosis. Can decrease levels of iNOS and inhibit synthesis of TNF-α, nitric oxide, and IL-1β.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-200932	568-72-9	C19H18O3	5 mg/25 mg