Thromboxane Synthase Inhibitors

• 2,3-dinor Thromboxane B1
  Thromboxane B2 (TXB2) is released in substantial quantities from aggregating platelets and metabolized during circulation to 11-dehydro TXB2 and 2,3-dinor TXB2. In rabbits and rats, 2,3-dinor TXB1 has been identified as another urinary metabolite of TXB2. However in human urine, only trace amounts of 2,3-dinor TXB1 have been identified. In rats, 2,3-dinor TXB1 is excreted at a much higher rate than 2,3-dinor TXB2 (19.2 ± 4.9 ng/24 hr and 1.6 ± 0.3 ng/24 hr, respectively). Therefore, urinary 2,3-dinor TXB1 is a suitable marker of thromboxane biosynthesis in rats.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-223466	n.n.	C18H32O6	25 µg/50 µg

• 11-dehydro Thromboxane B3
  A urinary metabolite of TXA3 in humans with enhanced dietary intake of EPA.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-204961	129228-55-3	C20H30O6	50 µg/500 µg

• Carbethoxyhexyl Imidazole
  A Thromboxane synthase inhibitor1.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205619	n.n.	C12H20N2O2	10 mg/50 mg

• Furegrelate Sodium (U-63557A)
  This product is a selective and potent thromboxane A2 synthase inhibitor in platelets. It has been shown to inhibit platelet aggregation.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-200705	85666-17-7	C15H10NO3··Na	10 mg/50 mg

• Ozagrel
  Potent and selective thromboxane A2 synthase inhibitor. Prevents cardiopulmonary dysfunction and displays protective effects on ischemia-reperfusion injury in various disease models.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-200760	82571-53-7	C13H12N2O2	10 mg/50 mg

• Thromboxane B3
  The stable hydrolysis product of TXA3 synthesized from EPA via COX and thromboxane synthase. Compound is biosynthesized in various tissues such as lung, seminal vesicles, PMNL, and ocular tissues.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205526	71953-80-5	C20H32O6	50 µg/100 µg

• U-46619 Glycine methyl ester
  A stable analog of the endoperoxide PGH2, and a TP receptor agonist; exhibits properties similar to TXA2, causing platelet shape change, aggregation, and contraction of vascular smooth muscle.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-224337	n.n.	C24H39NO5	50 µg/100 µg