| | Sphingolipids
- 2-Azido-1,3-di-o-pivaloyl-D-erythro-sphingosine
A derivative of Sphingosine, which is a selective inhibitor of protein kinase C activity and phorbol dibutyrate binding in vitro in human platelets. it does not inhibit protein kinase A or myosin light chain kinase.| Katalog # | CAS Nummer | Summenformel | Menge |
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| sc-213763 | n.n. | C28H51N3O4 | 20 mg |
- 3-Ketosphingosine HCl
A useful precursor for the preparation radiolabeled sphingosine1. A saturated form of 3-Ketosphingosine, or 3-ketosphinganine is the first intermediate in the biosynthesis of sphingosine2.| Katalog # | CAS Nummer | Summenformel | Menge |
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| sc-223547 | 19767-16-9 | C18H35NO2··HCl | 1 mg |
- 7(S)-Maresin 1
| Katalog # | CAS Nummer | Summenformel | Menge |
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| sc-358748 | 1268720-66-6 | C22H32O4 | 10 µg/25 µg |
- C-12 NBD Ceramide
A long-chain fluorescent ceramide analog that can be used for the measurement of alkaline and neutral ceramidase activity.| Katalog # | CAS Nummer | Summenformel | Menge |
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| sc-205232 | 202850-01-9 | C36H61N5O6 | 1 mg/5 mg |
- C-8 Ceramide
This product is metabolized within cells to generate natural ceramides, often causing a dramatic increase in cellular ceramide levels.| Katalog # | CAS Nummer | Summenformel | Menge |
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| sc-205233 | 74713-59-0 | C26H51NO3 | 1 mg/5 mg/25 mg |
- C-8 Ceramide-1-phosphate
C-8 ceramide-1-phosphate is a short-chain analog of naturally occurring ceramide-1-phosphate. The effects of C-8 ceramide-1-phosphate are essentially the opposite of C-8 ceramide: it induces cell division and DNA synthesis. The effects of C-8 ceramide-1-phosphate can be attenuated by simultaneous treatment with C-8 or C-2 ceramide.| Katalog # | CAS Nummer | Summenformel | Menge |
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| sc-223851 | 158983-53-0 | C26H52NO6P | 1 mg/5 mg |
- C16 Ceramide (N-Palmitoylsphingosine, D-erythro)
C16 ceramide is an abundant, hydrophobic molecular species of endogenous ceramide. It has been found to stimulate ceramide-activated protein kinase.| Katalog # | CAS Nummer | Summenformel | Menge |
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| sc-201379 | 24696-26-2 | C34H67NO3 | 5 mg/25 mg |
- C17 Sphingosine
The unnatural chain-shortened analog of sphingosine ideally suited for use as an internal standard for mass spectrometry1,2.| Katalog # | CAS Nummer | Summenformel | Menge |
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| sc-223852 | 6918-48-5 | C17H35NO2 | 5 mg/25 mg |
- C2 Phytoceramide
This product has been shown to inhibit yeast growth, and to act as a ceramide-activated protein phosphatase (CAPP) activator.| Katalog # | CAS Nummer | Summenformel | Menge |
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| sc-223853 | 475995-69-8 | C20H41N1O4 | 1 mg/5 mg |
- C8 Ceramine, D-erythro
C8 ceramine is an analog of ceramide in which the amide is substituted with an amine. This substitution renders it inert to ceramidases. It is highly effective at induction of apoptosis in U937 cells. Ceramine induces peak DNA fragmentation in 6 hrs compared to 18 hrs for C8 ceramide1.| Katalog # | CAS Nummer | Summenformel | Menge |
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| sc-223854 | 170926-06-4 | C26H53NO2 | 1 mg/5 mg |
- C8 Dihydroceramide
C8 Dihydroceramide is inactive and may be used as a negative control for C8 ceramide. | Katalog # | CAS Nummer | Summenformel | Menge |
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| sc-205611 | 145774-33-0 | C26H53NO3 | 5 mg/25 mg |
- D-erythro-MAPP
Synthetic analog of ceramide. Shown to selectively inhibit alkaline ceramidase.| Katalog # | CAS Nummer | Summenformel | Menge |
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| sc-203328 | 143492-38-0 | C23H39NO2 | 1 mg |
- D-erythro-Sphingosine (sulfate)
| Katalog # | CAS Nummer | Summenformel | Menge |
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| sc-203017 | 56607-20-6 | C18H37NO2 ·(free ·base) | 50 mg |
- D-erythro-Sphingosine C-15
| Katalog # | CAS Nummer | Summenformel | Menge |
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| sc-358749 | 86555-28-4 | C15H31NO2 | 1 mg/50 mg |
- D-erythro-Sphingosine C-20
Only central nervous system (CNS) gangliosides contain significant amounts of D-erythro-sphingosine C-20. The ratio of C-18 to C-20 sphingosine in the brain is thought to be related to some nervous system degeneration processes.| Katalog # | CAS Nummer | Summenformel | Menge |
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| sc-205282 | 6918-49-6 | C20H41NO2 | 500 µg/1 mg |
- Dihydro-D-erythro-Sphingosine
Biosynthetic precursor of sphingosine that inhibits protein kinase C (PKC) in Chinese hamster ovary cells (IC50 = 2.8 µM). Also directly inhibits phospholipase A2 (PLA2) and phospholipase D (PLD).| Katalog # | CAS Nummer | Summenformel | Menge |
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| sc-203911 | 764-22-7 | C18H39NO2 | 10 mg |
- D-erythro-Sphingosine, N-Oleoyl-
N-Oleoyl-D-erythro-sphingosine is a member of the ceramide family, acting as a signaling molecule with its function as a proapoptotic molecule among the most studied.| Katalog # | CAS Nummer | Summenformel | Menge |
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| sc-205936 | 5966-28-9 | C36H69NO3 | 1 mg/5 mg |
- N-Stearoyldihydro-D-erythro-Sphingosine
A member of the ceramide family, sphingosines were found to be potent inhibitors of gamma-thrombin-induced aggregation and secretion of washed human platelets. They are also used as a pharmacological inhibitor of PKC in human platelets.| Katalog # | CAS Nummer | Summenformel | Menge |
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| sc-205937 | 2304-80-5 | C36H73NO3 | 5 mg |
- Dihydrosphingosine-1-phosphate, D-erythro
A saturated analog of sphingosine-1-phosphate. Induces chemotaxis in HUVECs1. May be used as a negative control for intracellular effects of S1P2. Rapidly dephosphorylated by a sphingosine phosphatase in cultured human fibroblasts3. Ligand for S1P (EDG) receptors4| Katalog # | CAS Nummer | Summenformel | Menge |
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| sc-223941 | 28508-07-8 | C18H40NO5P | 1 mg |
- Epoxyquinone G109 (racemic)
A potent inhibitor of neutral sphingomyelinase (N-SMase), that is both selective and irreversible.| Katalog # | CAS Nummer | Summenformel | Menge |
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| sc-202602 | 163972-12-1 | C18H27NO4 | 2 mg |
- KRP 203-phosphate
A selective S1P1 receptor agonist, demonstrating a high affinity for S1P1 but not S1P3.1 | Katalog # | CAS Nummer | Summenformel | Menge |
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| sc-221790 | n.n. | C24H26ClNO6PS | 500 µg/1 mg |
- L-erythro-Sphingosine (synthetic)
| Katalog # | CAS Nummer | Summenformel | Menge |
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| sc-202687 | 6036-75-5 | C18H37NO2 | 5 mg |
- L-threo-Sphingosine C-18
This product has been shown to inhibits protein kinase C, and does not inhibit SPT activity, unlike its D-isomer.| Katalog # | CAS Nummer | Summenformel | Menge |
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| sc-205363 | 25695-95-8 | C18H37NO2 | 5 mg/10 mg |
- Lactosyl Ceramide, Bovine
Stimulates Ras-GTP loading, Raf and MEK kinases, p44 MAP kinase in human aortic smooth muscle cells.| Katalog # | CAS Nummer | Summenformel | Menge |
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| sc-204051 | 4682-48-8 | C53H101NO13 | 1 mg |
- Lignoceric ceramide
Naturally occurring ceramide and integral part of the sphingomyelin cycle. Lignoceric ceramide stimulates the proliferation of basophilic erythroblasts, suggesting a possible role in erythrocyte maturation.| Katalog # | CAS Nummer | Summenformel | Menge |
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| sc-202694 | 34435-05-7 | C42H83NO3 | 5 mg |
- MSDH-C
Potent inhibitor of the glycosphingolipid biosynthesis. At 10µM decreases de novo ceramide biosynthesis by about 90%. | Katalog # | CAS Nummer | Summenformel | Menge |
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| sc-203145 | 144474-37-3 | C22H45NO2S | 1 mg |
- N-Lignoceroyl-DL-dihydrosphingosine
| Katalog # | CAS Nummer | Summenformel | Menge |
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| sc-215462 | 75196-33-7 | C42H85NO3 | 1 mg/5 mg |
- N-SMase Spiroepoxide Inhibitor
Potent and selective irreversible inhibitor of neutral sphingomyelinase (N-SMase).| Katalog # | CAS Nummer | Summenformel | Menge |
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| sc-202721 | 282108-77-4 | C20H30N2O5 | 1 mg |
- N-Stearoyl-D-Sphingosine
| Katalog # | CAS Nummer | Summenformel | Menge |
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| sc-211176 | 2304-81-6 | C36H71NO3 | 1 mg/5 mg |
- Nervonic ceramide
Naturally occurring ceramide and integral part of the sphingomyelin cycle. Nervonic ceramide stimulates the proliferation of basophilic erythroblasts, suggesting a possible role in erythrocyte maturation.| Katalog # | CAS Nummer | Summenformel | Menge |
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| sc-202729 | 54164-50-0 | C42H81NO3 | 5 mg |
- Phytosphingosine
An endogenous sphingolipid signaling molecule. Induces caspase-8-mediated and mitochondrial activation-mediated apoptosis. | Katalog # | CAS Nummer | Summenformel | Menge |
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| sc-201385 | 554-62-1 | C18H39NO3 | 5 mg/25 mg |
- Psychosine
Glycolipid precursor of cerebrosides.| Katalog # | CAS Nummer | Summenformel | Menge |
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| sc-202781 | 2238-90-6 | C24H47NO7 | 5 mg |
- Sphingolactone-24
Selective and irreversible inhibitor of neutral sphingomyelinase (N-SMase).| Katalog # | CAS Nummer | Summenformel | Menge |
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| sc-203280 | 881177-99-7 | C18H29NO4 | 1 mg |
- Sphingomyelin (from bovine brain)
A sphingosine bonded to a fatty acid via an amide linkage. A precursor to ceramide second messengers via the action of sphingomyelinase and a a key molecule for ganglioside-bound amyloid β-protein generation.| Katalog # | CAS Nummer | Summenformel | Menge |
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| sc-201381 | 85187-10-6 | C41H83N2O6P | 100 mg/500 mg |
- D-erythro-Sphingosine-1-phosphate
A polar sphingolipid metabolite reported to stimulate DNA synthesis and cell division. Triggers both signal transduction pathways of calcium mobilization and phospholipase D activation. An EDG-1 GPCR family ligand.| Katalog # | CAS Nummer | Summenformel | Menge |
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| sc-201383 | 26993-30-6 | C18H38NO5P | 1 mg |
- Sphingosylphosphorylcholine, D-erythro
Shown to rapidly increase Ca2+ and free arachidonate levels in permeabilized cells. Also reported to reduce filaggrin and increase intracellular level of reactive oxygen species.| Katalog # | CAS Nummer | Summenformel | Menge |
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| sc-201384 | 1670-26-4 | C23H49N2O5P | 10 mg |
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