Sphingolipid Biosynthesis and Metabolism

• 3-O-Methylsphingomyelin
  A novel selective inhibitor of neutral sphingomyelinase, (Ki=37 µM) that is cell-permeable and does not inhibit acid sphingomyelinase1.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205580	n.n.	C32H65N2O6P	1 mg/5 mg

• Ceramide phosphorylethanolamine
  Sphingolipid with ethanolamine base, found in insect membranes.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-300332	n.n.	C38H77N2O6P	5 mg

• D-erythro-Ceramide C8 1-phosphate
  Cell permeable stimulator of DNA synthesis in cultured fibroblasts; antagonizes mitogenic activity.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-300407	n.n.	C26H52NO6P	1 mg

• D-erythro-Ceramine C8
  Inert to ceramidases; induces peak DNA fragmentation in 6 hrs; induces apoptosis in U937 cells.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-300408	n.n.	C26H53NO2	1 mg

• D-erythro-Dihydrosphingosine 1-phosphate
  Negative control for sphingosine-1-phosphate.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-300409	n.n.	C18H40NO5P	1 mg

• DL-PDMP
  PDMP is a ceramide analog first prepared in a search for inhibitors of glucosylceramide synthase.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-201391	73257-80-4	C23H38N2O3 ·HCl	10 mg/50 mg

• DL-PPMP
  This compound inhibits glucosylceramide synthetase and is more effective than PDMP in intact cells.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205655	149022-18-4	C29H50N2O3 ·HCl	5 mg/25 mg

• DL-threo-Dihydrosphingosine
  An inhibitor of sphingosine kinase activity, suppressing the generation of sphingosine-1-phosphate. Used as a tool to identify sphingosine kinase activity in various processes.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-201389	73938-69-9	C18H39NO2	10 mg/50 mg

• Fumonisin B1
  A fungal metabolite that inhibits serine/threonine phosphatases. Ceramide inhibition and induces apoptosis. Also increases immunotoxic effects by increasing expression of IL-1β, TNFα, IFN-©, IL-1α, IL-6, IL-10, IL-18 and IL- and CXCL9.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-201395	116355-83-0	C34H59NO15	1 mg/5 mg

• Fumonisin B2
  A structural analog of fumonisin B1 noted to inhibit sphingosine acyltransferase.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-201393	116355-84-1	C34H59NO14	1 mg/5 mg

• L-Cycloserine
  An irreversible inhibitor of 3-ketodihydrosphingosine synthetase, which is the first enzyme of the sphingolipid pathway, and causes the synthesis of sphingolipids to decrease.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-201387	339-72-0	C3H6N2O2	100 mg/500 mg

• L-erythro MAPP
  Useful as a negative control for D-erythro-MAPP where it does not raise endogenous ceramide levels or inhibit the growth of HL-60 cells1.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205740	143492-38-0	C23H39NO2	5 mg/25 µg

• Myriocin (ISP-1)
  A small molecule inhibitor of serine palmitoyltransferase, necessary for sphingolipid biosynthesis. A tool for depleting cells of sphingolipids.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-201397	35891-70-4	C21H39NO6	5 mg

• N-Butyldeoxynojirimycin·HCl
  Inhibits glucosylceramide synthase as well as α-glucosidase I and II without ceramide accumulation or cell death.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-201398	72599-27-0	C10H21NO4··HCl	5 mg/25 mg

• Oleylethanolamide
  A naturally occurring lipid analogue of the endogenous cannabinoid anandamide (sc-200790). Has been noted to cause activation of Neu/ErbB2 receptors.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-201400	111-58-0	C20H39NO2	10 mg/50 mg