santa cruz biotechnology, inc.
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| | Sodium Channel Modulators
- 5-(N-Ethyl-N-isopropyl)-Amiloride
A selective inhibitor of Na+/H+ exchange through inhibitor of the Na+/H+ antiporter protein.| Katalog # | CAS Nummer | Summenformel | Menge |
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| sc-202458 | 1154-25-2 | C11H18ClN7O | 5 mg |
- 5-(N-Methyl-N-isobutyl)-Amiloride
Potent inhibitor of the Na+/H+ antiporter. Possible antitumor agent.| Katalog # | CAS Nummer | Summenformel | Menge |
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| sc-202929 | 96861-65-3 | C11H18ClN7O | 5 mg |
- 5-(N,N-Hexamethylene)amiloride
An inhibitor of Na+/H+ antiport.| Katalog # | CAS Nummer | Summenformel | Menge |
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| sc-239021 | 1428-95-1 | C12H18ClN7O | 25 mg |
- A 887826
| Katalog # | CAS Nummer | Summenformel | Menge |
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| sc-362708 | 1266212-81-0 | C26H29ClN4O3 | 10 mg/50 mg |
- Allethrin
Type I pyrethroid, a very weakly active "negative" control for inhibition of calcineurin (PP2B) by type II pyrethroids.| Katalog # | CAS Nummer | Summenformel | Menge |
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| sc-202921 | 584-79-2 | C19H26O3 | 10 mg/25 mg |
- Amiloride, 5-(N,N-Dimethyl)-, hydrochloride
An inhibitor of the Na+-H+ exchanger with stronger potency over Amiloride. Protects against cardiac contractile dysfunction during reperfusion by normalizing tissue Na+ levels.| Katalog # | CAS Nummer | Summenformel | Menge |
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| sc-202459 | 1214-79-5 | C8H12ClN7O ·HCl | 5 mg |
- Batrachotoxin
A toxic steroidal alkaloid, which is found in neotropical poison dart frogs from the genus, Phyllobates.| Katalog # | CAS Nummer | Summenformel | Menge |
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| sc-201086 | 23509-16-2 | C31H42N2O6 | 10 µg |
- Benzamil hydrochloride hydrate
| Katalog # | CAS Nummer | Summenformel | Menge |
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| sc-252410 | 161804-20-2 (anhydrous) | C13H14ClN7O ·HCl ·xH2O | 10 mg |
- Benzamil•HCl
This product is a potent sodium channel blocker. It has been shown to be capable of blocking Ca2+ transients in cardiomyocytes.| Katalog # | CAS Nummer | Summenformel | Menge |
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| sc-201070 | 2898-76-2 | C13H14ClN7O··HCl | 50 mg |
- BIA 2-093
Voltage-gated sodium channel blocker; significantly blocks excitatory amino acid (glutamate and aspartate) release.| Katalog # | CAS Nummer | Summenformel | Menge |
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| sc-252432 | 236395-14-5 | C17H16N2O3 | 10 mg |
- Brevetoxin PbTx-2, Ptychodiscus brevis
Lipid-soluble polyether neurotoxin that binds to nerve and muscle Na+ channels causing an excessive influx of Na+ across membranes. Binds at site 5 on the voltage-sensitive Na+ channel.| Katalog # | CAS Nummer | Summenformel | Menge |
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| sc-203853 | 79580-28-2 | C50H70O14 | 100 µg |
- Bupivacaine Free Base
Local anesthetic which binds to the intracellular portion of sodium channels and blocks sodium influx into the nerve cells| Katalog # | CAS Nummer | Summenformel | Menge |
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| sc-204657 | 38396-39-3 | C18H28N2O | 1 g/5 g |
- Butacaine Sulphate
| Katalog # | CAS Nummer | Summenformel | Menge |
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| sc-210971 | 149-15-5 | C18H30N2O2•1/2 ·H2SO4 | 1 g |
- Co 102862
State-dependent inhibitor of voltage-gated Na+ channels; anticonvulsant.| Katalog # | CAS Nummer | Summenformel | Menge |
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| sc-203900 | 181144-66-1 | C14H12FN3O2 | 10 mg/50 mg |
- Dihydroouabain
A cardiac glycoside and an inhibitor of the sodium-potassium pump.| Katalog # | CAS Nummer | Summenformel | Menge |
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| sc-252720 | 1183-35-3 | C29H46O12 | 50 mg |
- Disopyramide
An antiarrhythmic (class IA) and a sodium channel blocker.| Katalog # | CAS Nummer | Summenformel | Menge |
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| sc-207585 | 3737-09-5 | C21H29N3O | 100 mg |
- Disopyramide phosphate salt
A class IA antiarrhythmic and a sodium channel blocker.| Katalog # | CAS Nummer | Summenformel | Menge |
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| sc-252757 | 22059-60-5 | C21H29N3O•H3PO4 | 1 g |
- Encainide hydrochloride
This is a sodium channel blocker and class Ic antiarrhythmic. Encainide is a non-chiral antiarrhythmic and benzanilide derivative.| Katalog # | CAS Nummer | Summenformel | Menge |
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| sc-252774 | 66794-74-9 | C22H28N2O2•HCl | 10 mg |
- Flecainide acetate
Cardiac Na+ channel blocker. Open Na+ channel blocker which inhibits fast cardiac muscle Na+ current in a use- and concentration-dependent manner. Orally-active class Ic antiarrhythmic agent.| Katalog # | CAS Nummer | Summenformel | Menge |
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| sc-203581 | 54143-56-5 | C17H20F6N2O3 ·C2H4O2 | 10 mg/50 mg |
- Grayanotoxin III Hemi(ethyl acetate)
A member of the Grayanotoxin family. Modulates Na+ channels and disturbs potentials, leading to Ca2+ channel flux and release of GABA and glutamates. | Katalog # | CAS Nummer | Summenformel | Menge |
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| sc-201076 | 4678-45-9 | C20H34O6•0.5C4H8O2 | 1 mg |
- Halofantrine hydrochloride
A blocker of delayed rectifier potassium current via the inhibition of hERG channel.| Katalog # | CAS Nummer | Summenformel | Menge |
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| sc-255195 | 36167-63-2 | C26H30Cl2F3NO ·. ·HCl | 10 mg |
- Kavain (+/-)
A lipophilic kavapyrone shown to significantly antagonize dopamine depletion in murine striatal neurons. Also reported to block various cationic v-gated channels.| Katalog # | CAS Nummer | Summenformel | Menge |
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| sc-201077 | 500-64-1 | C14H14O3 | 50 mg/250 mg |
- KB-R7943 MESYLATE
Cell-permeable isothiourea derivative. Inhibits the influx/reverse mode of NCX and directly modulates Na+/Mg2+ exchange in a Ca2+-dependent manner. Inhibits nicotinic ACh receptors and NMDA receptor channels.| Katalog # | CAS Nummer | Summenformel | Menge |
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| sc-202681 | 182004-65-5 | C16H17N3O3S ·MeSO3H | 10 mg |
- KC 12291 hydrochloride
Orally active atypical voltage-gated sodium channel blocker. Inhibits sustained sodium currents (INaL) and prevents diastolic contracture in isolated atria in vitro (IC50 values are 9.6 and 0.55 - 0.79 μM respectively). Displays anti-ischemic, bradycardic and cardioprotective activity in vivo.
| Katalog # | CAS Nummer | Summenformel | Menge |
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| sc-204028 | 181936-98-1 | C22H27N3O3S•HCl | 10 mg/50 mg |
- KR-32568
Sodium/H2 exchanger-1 (NHE-1) inhibitor; inhibited NHE-1-mediated rabbit platelet swelling; in anesthetized rats, reduced infarct size from 67% (control) to 43% (at 0.1 mg/kg) and 24% (at 1.0 mg/kg); reduced number of ventricular premature beats from 530 to 266 (at 0.1 mg/kg) and 115 (at 1.0 mg/kg); reduced ventricular fibrillation incidence from 17 to 8 (0.1 mg/kg) and 0 (1.0 mg/kg); implications for research and treatment of myocardial ischemic diseases.| Katalog # | CAS Nummer | Summenformel | Menge |
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| sc-252934 | 852146-73-7 | C13H12FN3O2 | 5 mg |
- Lamotrigine
A phenyltriazine inhibitor of voltage gated sodium channels of presynaptic neurons. Known to suppress the release of glutamate and aspartate.| Katalog # | CAS Nummer | Summenformel | Menge |
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| sc-201079 | 84057-84-1 | C9H7Cl2N5 | 10 mg/50 mg |
- Lappaconitine hydrobromide
This product is a selective blocker of the TTX-sensitive Na+ channels, and does not influence on the activation threshold of Na+ channels.
| Katalog # | CAS Nummer | Summenformel | Menge |
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| sc-300905 | 97792-45-5 | C32H44N2O8•HBr | 10 mg |
- Lidocaine
Anasthetic and class Ib antiarrhythmic agent. Blocks voltage-gated sodium channels in the inactivated state.
| Katalog # | CAS Nummer | Summenformel | Menge |
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| sc-204056 | 137-58-6 | C14H22N2O | 50 mg/1 g |
- Lidocaine hydrochloride hydrate
Na+ channel blocker| Katalog # | CAS Nummer | Summenformel | Menge |
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| sc-202211 | 6108-05-0 | C14H22N2O•HCl•xH2O | 5 g |
- Mepivacaine hydrochloride
Local anesthetic. Reversibly blocks inward current of transient Na+, as well as the steady-state K+ outward current. Blocks tandem pore (TASK) and Kv1.5, potassium channels in model systems. | Katalog # | CAS Nummer | Summenformel | Menge |
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| sc-252996 | 1722-62-9 | C15H22N2O•HCl | 1 g |
- Mexiletine hydrochloride
This chemical is a Class IB antiarrhythmic, as well as a sodium channel blocker.| Katalog # | CAS Nummer | Summenformel | Menge |
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| sc-253048 | 5370-01-4 | C11H17NO ·HCl | 25 g |
- Monensin Na
A monovalent cation ionophore with specificity for Na+. Forms a lipophilic complex which freely crosses cell membranes.| Katalog # | CAS Nummer | Summenformel | Menge |
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| sc-200109 | 22373-78-0 | C36H61O11 ·Na | 1 g |
- PD-85639
A potent and selective sodium channel blocker. It binds specifically to a local anesthetic receptor site on the Na+ channel α-subunit that is allosterically linked to neurotoxin receptor site 21. | Katalog # | CAS Nummer | Summenformel | Menge |
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| sc-201084 | 150034-24-5 | C24H32N2O | 5 mg/25 mg |
- Phenamil methanesulfonate (free base)
Amiloride analog. Irreversibly blocks amiloride-sensitive Na+ channels.| Katalog # | CAS Nummer | Summenformel | Menge |
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| sc-202280 | 2038-35-9 | C12H12ClN7O ·CH3SO3H | 5 mg/25 mg |
- Procainamide hydrochloride
A blocker of Na+ channels that demonstrates antiarrhythmic effects.| Katalog # | CAS Nummer | Summenformel | Menge |
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| sc-202297 | 614-39-1 | C13H21N3O ·HCl | 10 g |
- Quinidine sulfate dihydrate
A diastereomer of quinine and a Na+ channel blocker. Also a class I antiarrhythmic drug.| Katalog # | CAS Nummer | Summenformel | Menge |
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| sc-205967 | 6591-63-5 | C40H54N4O10S | 5 g |
- QX 222
Na+ channel blocker| Katalog # | CAS Nummer | Summenformel | Menge |
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| sc-203673 | 21236-55-5 | C13H21N2O•Cl | 10 mg/50 mg |
- QX 314 chloride
Membrane impermeable quaternary derivative of lidocaine, a voltage-activated Na+ channel blocker.| Katalog # | CAS Nummer | Summenformel | Menge |
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| sc-203674 | 5369-03-9 | C16H27N2OCl | 50 mg |
- QX-314
A strong inhibitor of intracellular voltage-sensitive sodium ion conductance. Effectively blocks cardiac Na+ channels when applied from either side of the membrane, but blocks neuronal Na+channels only from the intracellular side.| Katalog # | CAS Nummer | Summenformel | Menge |
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| sc-3579 | 21306-56-9 | C16H27BrN2O | 100 mg |
- QX-314 (bromide)
A membrane-impermeant lidocaine derivative that selectively blocks sodium channels on nociceptive neurons.| Katalog # | CAS Nummer | Summenformel | Menge |
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| sc-205480 | 24003-58-5 | C16H27N2O ·Br | 1 mg/5 mg |
- R(-)-Me5 hydriodide
A demonstrated potent sodium channel antagonist, that may be used as a sodium channel blocker in sketetal muscle.
| Katalog # | CAS Nummer | Summenformel | Menge |
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| sc-301654 | n.n. | C13H21NO•HI | 5 mg |
- Ralfinamide mesylate
| Katalog # | CAS Nummer | Summenformel | Menge |
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| sc-362788 | 202825-45-4 | C18H23FN2O5S.CH3SO3H | 10 mg/50 mg |
- Riluzole
A sodium channel blocker and potent neuroprotective agent shown to block tetrodotoxin-sensitive and -resistant sodium channels.| Katalog # | CAS Nummer | Summenformel | Menge |
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| sc-201081 | 1744-22-5 | C8H5F3N2OS | 20 mg/100 mg |
- SDZ-201106 (-)
(-)-Enantiomer of sodium channel opener SDZ-201106.| Katalog # | CAS Nummer | Summenformel | Menge |
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| sc-222301 | 97730-95-5 (racemic) | C29H30N4O2 | 5 mg |
- SDZ-201106 (+)
(+)-Enantiomer of sodium channel opener SDZ-201106.| Katalog # | CAS Nummer | Summenformel | Menge |
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| sc-222302 | 97730-95-5 (racemic) | C29H30N4O2 | 5 mg |
- SDZ-201106 (±), (DPI-201106)
Sodium channel opener. Positive inotropic agent. | Katalog # | CAS Nummer | Summenformel | Menge |
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| sc-201072 | 97730-95-5 | C29H30N4O2 | 20 mg/100 mg |
- Sipatrigine
| Katalog # | CAS Nummer | Summenformel | Menge |
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| sc-362796 | 130800-90-7 | C15H16Cl3N5 | 10 mg/50 mg |
- Tocainide hydrochloride
This is a sodium channel blocker; Class IB antiarrhythmic.| Katalog # | CAS Nummer | Summenformel | Menge |
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| sc-253706 | 71395-14-7 | C11H16N2O•HCl | 10 mg |
- Triamterene
Diuretic, Na+ channel blocker.| Katalog # | CAS Nummer | Summenformel | Menge |
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| sc-213103 | 396-01-0 | C12H11N7 | 5 g |
- Veratridine
An agent that opens voltage dependent Na+ channels, blocks Na+ channel activation, and induces Ca2+ influx.| Katalog # | CAS Nummer | Summenformel | Menge |
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| sc-201075 | 71-62-5 | C36H51NO11 | 10 mg/50 mg |
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