Ser/Thr Kinase Inhibitors

• 1-Norokadaone
  Shown to exhibit inhibitory effects on Serine/Threonine Phosphatases and potential use as an okadaic acid negative control.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-287172	131204-29-0	C43H66O11	50 µg/100 µg

• 8-MA-cAMP
  A selective cAMP-dependent protein kinase (PKA) activator and a site selective cyclic AMP analog with a similar affinity to site B of both protein kinase A type I and II. A priming analog which acts synergistically together with analogs showing site A preference. Together with e.g. 8-piperidino cAMP, selective stimulation of type I can be achieved

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-257017	33823-18-6	C11H14N6O6PNa	1 vial

• 8-PIP-cAMP
  A selective cAMP-dependent protein kinase (PKA) activator which is a site selective cyclic AMP analog with high selectivity for the site A of protein kinase A type I and site B of type II. Acts synergistically together with analog having opposite site-selectivity.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-257021	31357-06-9	C15H20N6O6PNa	1 vial

• AD 198
  A PKC-delta activator. Phospholipid scramblase 3 (PLS3) is an enzyme which plays a crucial role in mitochondrial morphology, functions, and apoptotic response. During apoptosis, activated protein kinase C-delta (PKC-delta) translocates to mitochondria and phosphorylates PLS3. Used to show that PLS3 is a critical downstream effector of PKC-delta in AD 198-induced apoptosis.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-252351	98983-21-2	C39H43NO12	1 mg

• Akt1/2 kinase inhibitor
  An Isozyme selective Akt1/2 kinase inhibitor.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-300173	n.n.	C36H32F3N7O4	5 mg

• CGP-74514A hydrochloride
  CGP-74514A is a Cdk inhibitor selective for Cyclin-dependent kinase-1 (Cdk1).

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-300344	1173021-98-1	C19H24ClN7•HCl	5 mg/25 mg

• CKI-7 dihydrochloride
  A CK1 inhibitor which also inhibits SGK, S6K1 and MSK1. Inhibits SGK as potently as CK1.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-252621	1177141-67-1	C11H12ClN3O2S•2HCl	5 mg

• DCP-LA
  A selective PKC-epsilon (PKC- ) activator. In the in situ PKC assay with a reversed phase high-performance liquid chromatography, DCP-LA significantly activates PKC in PC-12 cells in a concentration (10 nM-100 µM)-dependent manner, with the maximal effect at 100 nM. Maintains a 7-fold greater potency for activation of PKC- over other PKC isozymes.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-255068	28399-31-7	C20H36O2	1 mg

• Guanosine 3',5'-cyclic monophosphorothioate, Rp Isomer triethylammonium salt
  cGMPS-dependent protein kinase Iå inhibitor.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-252867	86562-09-6	C16H27N6O6PS	1 mg

• H-9 dihydrochloride
  H-9 is a potent and competitive inhibitor of protein kinase C, cAMP-dependent protein kinase, cGRP cGMP and has been used in ligand affinity protein kinase purification.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-200553	116970-50-4	C11H13N3O2S ·2HCl	10 mg/50 mg

• K-252a
  At high concentrations it is an ATP-competitive inhibitor of cyclic nucleotide-dependent protien kinases. At very low concentrations, has been found to prolong the survival of septal, hippocampal, and cortical neurons

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-200517	99533-80-9	C27H21N3O5	100 µg/250 µg/1 mg

• K-252b
  A metabolite of Nocardiopsis sp. that acts as an antibiotic and a strong inhibitor of protein kinase C (PKC).

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-200585	99570-78-2	C26H19N3O5	100 µg/1 mg

• KRIBB3
  An inhibitior of PKC-dependent phosphorylation of Hsp27 through its direct binding to Hsp27. Has antimigratory and anti-invasive activities in MDA-MB-231 cells. KRIBB3 blocked phorbol 12-myristate 13-acetate-induced phosphorylation of Hsp27 and tumor cell migration.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-252935	129414-88-6	C19H19NO4	5 mg

• Methyl Okadaate
  Serine/Threonine protein phosphatase inhibitor

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-295454	78111-14-5	C45H70O13	100 µg

• Okadaic Acid, Potassium Salt
  An inhibitor of PP1, PP2A, PP2B, PP2C and endogenous phosphatase smooth muscle myosin. Additionally used to study tumor promotion, nitric oxide metabolism, apoptosis, cell cycling and calcium signaling.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-202261	155751-72-7	C44H67KO13	50 µg

• PS-1145 dihydrochloride
  PS-1145 has been shown to be an IKB kinase (IKK) inhibitor.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-301621	431898-65-6	C17H11ClN4O•2HCl	5 mg

• SB 220025 trihydrochloride
  A potent, specific inhibitor of human p38 mitogen-activated protein (MAP) kinase.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-253537	197446-75-6	C18H19FN6··3HCl	500 µg

• SB 431542 hydrate
  A potent and selective inhibitor of transforming growth factor-β superfamily type I activin receptor-like kinase (ALK) receptors.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-255604	301836-41-9 (anhydrous)	C22H16N4O3•xH2O	5 mg

• SB-505124

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-362794	694433-59-5	C20H21N3O2	10 mg/50 mg

• SB-505124 hydrochloride hydrate
  An inhibitor of ALK-5, demonstrated to suppress the action of TGF-β.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-253542	694433-59-5 (non-salt)	C20H21N3O2 ·xHCl ·yH2O	5 mg

• SIS3 hydrochloride
  A specific inhibitor of Smad3 phosphorylation via inhibiting the effects of TGF-β1. Reestablishes myofibroblast differentiation of scleroderma fibroblasts via reducing expression of α-SMA.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-253565	521984-48-5	C28H27N3O3 ·HCl	5 mg

• SMER28
  A cell-permeable quinazoline compound which augments the cytostatic effects of Rapamycin in Saccharomyces cerevisiae and acts as an autophagy stimulator both in mammalian cultures in vitro and in a Drosophila melanogaster HD model in vivo. Although SMER28 and Rapamycin do exhibit additive effects on the clearance of cellular autophagy substrates, SMER28 functions independently of Rapamycin by presumably acting on celluar target(s) downstream of the Rapamycin/FKBP12 target, mTOR.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-222320	307538-42-7	C11H10BrN3	10 mg

• Sp-8-pCPT-cAMPS

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-253602	129693-13-6 (non-salt)	C16H14ClNaN5O5PS2	2.5 mg

• Sp-Adenosine 3',5'-cyclic monophosphorothioate triethylammonium salt hydrate
  Sp-Diastereomer of adenosine 3',5'-cyclic monophosphorothioate is a potent, membrane-permeable activator of cAMP dependent protein kinase I and II that mimics the effects of cAMP as a second messenger in numerous systems while being resistant to cyclic nucleotide phosphodiesterases; exhibits greater specificity and affinity than forskolin and cAMP analogs such as dibutyryl-cAMP.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-258176	93602-66-5 (anhydrous)	C10H11N5O5PS•C6H16N•xH2O	1 mg

• Staurosporine
  Inhibits PKC and most other kinases, including tyrosine kinases; binds to ATP binding domain; inhibits topoisomerase II.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-3510	62996-74-1	C28H26N4O3	100 µg/1 mg