Prostaglandins

• 1a,1b-dihomo Prostaglandin E1
  Prostaglandin E1 (PGE1) is not a major naturally occurring PG, but it is widely administered clinically for several indications including peripheral occlusive vascular disease, neonatal cardiology and erectile dysfunction. COX metabolism of the unusual fatty acid 10,13,16-docosatrienoic acid yields 1a,1b-dihomo PGE1. This rare metabolite has been recovered from incubations of whole sheep seminal vesicles, but has not been reported in humans. In ex vivo preparations of rat aorta and rat PRP, 1a,1b-dihomo PGE1 were found to be much less active than PGE1 itself.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-223191	n.n.	C22H38O5	1 mg/5 mg

• 1a,1b-dihomo Prostaglandin F2α
  The theoretical product of adrenic acid in the COX pathway. Primarily produced in renal medulla where adrenic acid is selectively distributed.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205071	57944-39-5	C22H38O5	1 mg/5 mg

• 2-(3-hydroxyoctyl)-5-oxo-1-pyrrolidineheptanoic acid
  Prostaglandin E2 (PGE2) activates four E prostanoid (EP) receptors, EP1-4. EP4 is a Gs protein-coupled receptor that plays important roles in bone formation and resorption, cancer and atherosclerosis by elevating the second messenger cAMP. This chemical is an 8-aza-9-oxo-15-hydroxy saturated analog of PGE2. It selectively binds the EP4 receptor (Ki = 35 nM) relative to the EP1, EP2, and EP3 receptors (Ki = 3,000, 2,000, and >3,000 nM, respectively). This chemical stimulates cAMP formation in excised murine ovaries .

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-223250	64054-40-6	C19H35NO4	500 µg/1 mg

• 2,3-dinor Fluprostenol
  Fluprostenol is a well-studied, potent analog of PGF2α acting primarily through the FP receptor. β-Oxidation of fluprostenol yields 2,3-dinor fluprostenol. It is anticipated that this analog will be a prominent metabolite of the parent compound when administered to animals or humans. It is likely that 2,3-dinor fluprostenol will retain some biological activity with respect to the eicosanoid receptors. However, no studies on the pharmacology of this compound have been published.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-223464	n.n.	C21H25F3O6	25 µg/50 µg

• 2,3-dinor Prostaglandin E1
  Prostaglandin E1 (PGE1) is not a major naturally occurring prostaglandin, but it is widely administered clinically for several indications including erectile dysfunction, peripheral occlusive vascular disease,and in neonatal cardiology(1,2) The metabolism of PGE1 is normally initiated by oxidation at C-15, resulting in 13,14-dihydro-15-keto PGE1 as the major metabolite. Inhibition of this pathway or saturation by excess substrate could, in theory, lead to enhanced production of 2,3-dinor metabolites, including 2,3-dinor PGE1. The biological activity of 2,3-dinor PGE1 has not been published.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-223465	7046-40-4	C18H30O5	25 µg/50 µg

• 2,3-dinor-11β-Prostaglandin F2α
  A major F2 isoprostane, has been shown to be produced in vivo by free radical-dependent peroxidation of arachidonic acid (sc-200770).

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205095	240405-20-3	C18H30O5	25 µg/50 µg

• 2,3-dinor-6-keto Prostaglandin F1α, sodium salt
  2,3-dinor-6-keto prostaglandin F1α (2,3-dinor-6-keto PGF1α) is the β-oxidation product of 6-keto PGF1α and major urinary metabolite of PGI2 in humans. 2,3-dinor-6-keto PGF1α makes up 23% of recovered radioactivity in urine after administration of labeled 6-keto PGF1α and 20.5% after administration of labeled PGI2. In healthy human subjects, the average excreted 2,3-dinor-6-keto PGF1α level is ~100 pg/mg creatinine.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-223467	n.n.	C18H29O6 ·Na	100 µg/500 µg

• 2,3-dinor-8-iso Prostaglandin F2α
  An F2 isoprostane metabolite, that has been shown to be produced in vivo by free radical-dependent peroxidation of arachidonic acid (sc-200770).

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205096	221664-05-7	C18H30O5	25 µg/50 µg

• 20-ethyl Prostaglandin E2
  An analog of PGE2 (sc-201225) in which the ω-chain has been extended by the addition of two methylene carbon atoms; ligand binding assay results have not been published.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205099	37492-24-3	C22H36O5	1 mg/5 mg

• 20-ethyl Prostaglandin F2α
  An analog of Prostaglandin GF2α in which the ω-chain has been extended by the addition of two more methylene carbon atoms; in vivo effects may be prolonged.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205100	36950-85-3	C22H38O5	1 mg/5 mg

• 20-hydroxy Prostaglandin E2
  The putative first intermediate in the metabolism by cytochrome P450 of PGE2 (sc-201225). Similar compounds have been shown to have interesting biological activity, however, binding assay results have not been published for this compound.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205103	57930-95-7	C20H32O6	50 µg/100 µg

• 20-hydroxy Prostaglandin F2α
  The ω-oxidation product of PGF2α. Cultured type II alveolar cells from pregnant rabbits metabolize exogenous PGF2α via microsomal cytochrome P450 ω-oxidation, producing 20-hydroxy PGF2α and its 15-hydroxy PGDH metabolites. Cells from male rabbits exhibit only the 15-hydroxy PGDH pathway.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205104	57930-92-4	C20H34O6	50 µg/100 µg

• 3-methoxy Limaprost
  Limaprost is an analog of prostaglandin E1 (PGE1) with structural modifications intended to give it greater potency and a prolonged half-life. Limaprost is an inhibitor of ADP and collagen-induced platelet aggregation as well as being 10-1,000 times more potent than PGE1 as an inhibitor of platelet adhesiveness measured in vitro. 3-methoxy Limaprost results from the Michael addition of methanol to the limaprost 2,3 double bond. The resulting novel compound is likely to retain FP receptor agonist activity; however there are no published studies of the pharmacological properties of 3-methoxy limaprost.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-223548	n.n.	C23H40O6	500 µg/1 mg

• 3-methoxy Prostaglandin F1α
  A novel analog of PGF1α with a methoxy group in the 3-position of the upper side chain. No published reports describing the pharmacology of this compound.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205111	54432-43-8	C21H38O6	1 mg/5 mg

• 5-[[4-(ethoxycarbonyl)phenyl]azo]-2-hydroxy-benzeneacetic acid
  A selective inhibitor of 15-hydroxy prostaglandin dehydrogenase (PDGH); acts to prolong the lifetime and activity of endogenously produced prostaglandins both in cell culture and in vivo.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205129	78028-01-0	C17H16N2O5	1 mg/5 mg

• 5-cis Carbaprostacyclin
  A stable analog of PGI2 and an isomer of carbaprostacyclin; a weak inhibitor of human platelet aggregation.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205134	69609-77-4	C21H34O4	1 mg/5 mg

• 5-cis Iloprost
  5-cis Iloprost is a C-5 cis-isomer of iloprost, a second generation structural analog of prostaglandin I2 (prostacyclin). Iloprost displays a ten-fold greater potency than the first generation stable prostacyclin analogs, typified by carbaprostacyclin. There are no published studies of the pharmacological properties of 5-cis iloprost.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-223694	n.n.	C22H32O4	500 µg/1 mg

• 5-cis-15(R)-Iloprost
  5-cis-15(R)-Iloprost is the C-5 cis-isomer and 15(R)-epimer of iloprost, which is a second generation structural analog of prostaglandin I2 (prostacyclin). Iloprost displays ten-fold greater potency than the first generation stable prostacyclin analogs, typified by carbaprostacyclin. There are no published studies of the pharmacological properties of 5-cis-15(R)-iloprost.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-223695	n.n.	C22H32O4	500 µg/1 mg

• (±)5-iPF2α-VI
  A minor isoprostane constituent; type VI isoprostanes form internal lactones, which facilitates their extraction and purification from biological samples.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205138	180469-63-0	C20H34O5	25 µg/100 µg

• (+)-5-trans Cloprostenol
  A derivative of prostaglandin F2α that has been used as a luteolytic agent, induces uterine contraction, and elicits arterial contractions.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205139	57968-81-7	C22H29ClO6	1 mg/5 mg

• 5-trans Fluprostenol
  An impurity that is routinely found in bulk preparations of fluprostenol in amounts ranging from 1-3%; this impurity occurs in the finished prodrug Travoprost in similar amounts.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205140	57968-83-9	C23H29F3O6	1 mg/5 mg

• 5-trans Fluprostenol isopropyl ester
  Travoprost is the Alcon trade name for fluprostenol isopropyl ester, which is an F-series prostaglandin analog that has been approved for use as an ocular hypotensive drug. Fluprostenol isopropyl ester is a prodrug that is converted by esterase enzymatic activity in the cornea to yield the corresponding free acid. 5-trans Fluprostenol isopropyl ester (5-trans Travoprost) is an impurity that is routinely found in bulk preparations of fluprostenol isopropyl ester in amounts ranging from 1-3%. The pharmacology of 5-trans fluprostenol isopropyl ester has not been studied extensively to date.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-223703	n.n.	C26H35F3O6	1 mg/5 mg

• 5-trans Latanoprost
  Latanoprost is an F-series prostaglandin analog that has been approved for use as an ocular hypotensive drug. 5-trans Latanoprost is an isomer of latanoprost wherein the double bond between carbons 5 and 6 has been changed from cis (Z) to trans (E). The trans isomer of latanoprost occurs as an impurity of 2-5% in most commercial preparations of bulk drug product. The present compound was prepared as an analytical standard for detection and quantitation of this impurity. From what can be inferred from the study of other trans isomers of F-type prostaglandins, 5-trans latanoprost’s biological activity is similar to that of the cis isomer. However, there are no specific published reports on the biological activity, and on the intraocular hypotensive activity in particular, of 5-trans latanoprost.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-223704	n.n.	C26H40O5	1 mg/5 mg

• 5-trans Latanoprost (free acid)
  An F-series prostaglandin (PG) analog that was approved for ocular hypotensive drug use. The trans isomer of latanoprost occurs as an impurity in commercial preparations of the bulk drug product. The present compound was prepared primarily as an analytical standard for detection and quantitation of this impurity.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205141	903549-49-5	C23H34O5	1 mg/5 mg

• 5-trans Prostaglandin D2
  The trans isomer of prostaglandin D2 (PGD2) occurs as an impurity between 2-5% in most commercial preparations of bulk drug product. This compound was prepared primarily as an analytical standard for detection and quantitation of impurity. From what can be inferred from the study of other trans isomers of F-type prostaglandins, the biological activity of 5-trans PGD2 is likely to be similar to cis isomers. However, there are no specific published reports on biological activity of 5-trans PGD2.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-223705	n.n.	C20H32O5	1 mg/5 mg

• 5-trans Prostaglandin E2
  A naturally occuring compound that shows a potency that is 18 times greater than PGE2 (sc-201225) in cases of activation of adenylate cyclase in NCB-20 cell homogenates.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205142	36150-00-2	C20H32O5	1 mg/5 mg

• 5-trans Prostaglandin F2α
  5-trans PGF2α, when administered intravenously to anesthetized rabbits, caused a ten-fold increase in respiratory rate, but this attribute was common to a number of F-series compounds and analogs.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205143	36150-01-3	C20H34O5	1 mg/5 mg

• 5-trans Prostaglandin F2α, tromethamine salt
  5-trans PGF2α tromethamine salt is a derivative of 5-trans PGF2α. It has increased water solubility and its solubility in PBS is 25 mg/ml compared to 10 mg/ml for 5-trans PGF2α.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-223706	n.n.	C20H33O5•C4H12NO3	1 mg/5 mg

• 5-trans Prostaglandin F2β
  5-trans PGF2α is the 9β-hydroxy isomer of 5-trans PGF2α with no published reports on the biological activity of this compound.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205144	36150-02-4	C20H34O5	1 mg/5 mg

• 5-trans U-44069
  5-trans U-44069 is the C-5 double bond isomer of U-44069. There are no published reports on biological activities.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-223707	n.n.	C21H34O4	1 mg/5 mg

• 5-trans U-46619
  U-46619 is a TP receptor agonist that exhibits properties similar to Thromboxane A2, inducing platelet aggregation and vascular smooth muscle contraction. This is a minor impurity (2-5%) that is variably present in most commercial preparations of U-46619. The biological activity of 5-trans U-46619 has rarely been tested separately from U-46619 itself. The only case published to date, 5-trans U-46619 was found to be half as potent of an inhibitor of Prostaglandin E synthase as the 5-cis version of U-46619.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-223708	n.n.	C21H34O4	1 mg/5 mg

• 6-keto Prostaglandin E1
  A metabolite isolated after the incubation of PGI2 with rabbit liver microsomes.1 Although, it is not produced in appreciable amounts following IV infusion of PGI2 in humans.2 It is equipotent with PGI2 as a vasodilator, while in most other aspects its activity resembles PGE1.3

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205157	67786-53-2	C20H32O6	1 mg/5 mg

• 6-keto Prostaglandin F1α-d4
  6-keto Prostaglandin F1α-d4 (6-keto PGF1α-d4) contains four deuterium atoms at positions 3, 3', 4, and 4’. It is used as an internal standard for the quantification of PGF1α by GC- or LC-mass spectrometry.6-keto prostaglandin F1α (6-keto PGF1α) is the inactive, non-enzymatic hydrolysis product of PGI2(1,2). 6-keto PGF1α is a useful marker of PGI2 biosynthesis in vivo(3). When [3H]-PGI2 is injected into healthy human males, 6.6% of the radioactivity is recovered from urine as [3H]-6-keto PGF1α(3).

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-221103	n.n.	C20H30D4O6	25 µg/50 µg

• 6,15-diketo-13,14-dihydro Prostaglandin F1α
  A metabolite of PGI2. Known to enhance cholesterol catabolism and the intracellular cAMP in bovine arterial smooth muscle cells.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205160	63983-53-9	C20H34O6	100 µg/500 µg

• 6α-Prostaglandin I1
  A stable Prostaglandin I2 (PGI2) analog resistant to hydrolysis in aqueous solutions; promotes cyclic AMP accumulation in human thyroid slices and cells in a concentration dependent manner.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205163	62777-90-6	C20H34O5	1 mg/5 mg

• 6β-Prostaglandin I1
  A stable PGI2 analog resistant to hydrolysis in aqueous solutions. Has a much longer half-life than PGI2, but a greatly reduced molar potency for receptor mediated function. 6β-PGI1 has a Kact for adenylate cyclase in NCB-20 cells of 4.2 µM compared with 18 nM for PGI2. The potency for vasodilation and inhibition of platelet aggregation is about 1% of PGI2.1,2

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205164	62770-50-7	C20H34O5	1 mg/5 mg

• 8-epi-Prostaglandin F_2α
  A biologically active isoprostane produced by the non-enzymatic free radical catalyzed peroxidation of arachidonic acid (sc-200770).

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-201261	27415-26-5	C20H34O5	1 mg

• 8-iso Misoprostol
  Misoprostol is a widely sold analog of prostaglandin E1 (PGE1) that has potent but relatively non-selective agonist activity with respect to the prostanoid EP receptor subgroup. Misoprostol has been used therapeutically for many years in humans for treatment of gastric ulcer disease under the Searle tradename Cytotec. 8-iso Misoprostol is one of several impurities which are possible in the production of bulk commercial preparations of misoprostol. It is also somewhat difficult to distinguish from other impurities such as 11β-misoprostol. The pharmacology and EP receptor binding affinity for 8-iso misoprostol has not been published.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-223751	1256643-55-6	C22H38O5	1 mg/5 mg

• 8-iso Prostaglandin A1
  8-iso Prostaglandin A1 (8-iso PGA1) is an isoprostane and a member of prostanoids of non-cyclooxygenase origin. It occurs as a common minor impurity in most commercial preparations of PGE1. The biological activity of 8-iso PGA1 has not been studied in depth or reported in the literature.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-221134	n.n.	C20H32O4	1 mg/5 mg

• 8-iso Prostaglandin A2
  Isoprostanes are prostaglandin (PG)-like compounds produced in vivo by free radical-catalyzed peroxidation of arachidonoyl-containing lipids. 8-iso PGA2 is produced from peroxidation of arachidonic acid esterified in phospholipids. 8-iso PGA2 is the dehydration product of 8-iso PGE2, which is a potent renal vasoconstrictor. Evidence for the in vivo production of 8-iso PGA2 has been shown in rat liver under conditions of oxidative stress. There are no published studies of the pharmacological properties of 8-iso PGA2.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-221135	n.n.	C20H30O4	1 mg/5 mg

• 8-iso Prostaglandin E1
  Isoprostanes are a family of prostanoid molecules of non-cyclooxygenase origin. 8-iso Prostaglandin E1 (8-iso PGE1) is an isoprostane that is found in human semen at levels of 7 µg/ml. It is a pulmonary vasoconstrictor in anesthetized dogs with a potency similar to PGF2α.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-223752	21003-46-3	C20H34O5	500 µg/1 mg

• 8-iso Prostaglandin E2
  Shown to be a potent renal vasoconstrictor in the rat, inhibit U-46619 or I-BOP-induced platelet aggregation, relax smooth muscle in porcine coronary artery, and cause bronchodilation in porcine tracheal smooth muscle.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205172	27415-25-4	C20H32O5	500 µg/5 mg

• 8-iso Prostaglandin E2 isopropyl ester
  A more lipophillic derivative of 8-iso PGE₂ (sc-205172) which is the epimer at C-8 of PGE₂ (sc-201225), which has shown both vasoconstriction and vasodilation activity.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-221136	n.n.	C23H38O5	1 mg/5 mg

• 8-iso Prostaglandin E2-d4
  A labeled version of 8-iso PGE2 which is shown to be a potent renal vasoconstrictor in the rat, inhibit U-46619 or I-BOP-induced platelet aggregation, relax smooth muscle in porcine coronary artery, and cause bronchodilation in porcine tracheal smooth muscle.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-221137	27415-25-4 (unlabeled)	C20H28D4O5	25 µg/50 µg

• 8-iso Prostaglandin F1α
  8-iso PGF1α is an isoprostane that was first identified in human semen. It is a member of the isoprostane family, which are eicosanoids of non-cyclooxygenase origin. 8-iso PGF1α is present along with its 19-hydroxy congener at 5-10 µg/ml of seminal plasma.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205173	26771-96-0	C20H36O5	1 mg/5 mg

• 8-iso Prostaglandin F1α-d9
  Intended for use as an internal standard for the quantification of 8-iso PGF1α by GC- or LC-mass spectrometry.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-221139	26771-96-0 (unlabeled)	C20H27D9O5	25 µg/50 µg

• 8-iso Prostaglandin F1β
  This is a potential autoxidation product of DGLA. There are no published reports on its on its biological activity or isolation from any biological source.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-221138	n.n.	C20H36O5	1 mg/5 mg

• 8-iso Prostaglandin F2α-d4
  Intended for use as an internal standard for the quantification of 8-iso PGF2α by GC- or LC-mass spectrometry.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205174	211105-40-7	C20H30D4O5	25 µg/50 µg

• 8-iso Prostaglandin F2β
  8-iso PGF2β does not promote aggregation of human whole blood and exhibits very weak contraction of human umbilical vein artery. However, 8-iso PGF2β moderately contracts both the canine and porcine pulmonary vein, although the effect is much weaker than that exhibited by other isoprostanes such as 8-iso PGE1, 8-iso PGE2, or 8-iso PGF2α.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205175	177020-26-7	C20H34O5	1 mg/5 mg

• 8-iso Prostaglandin F3α
  8-iso PGF3α is an isoprostane produced from the free-radical peroxidation of EPA. There is not much known about the biological activity of 8-iso PGF3α. There is one report that it is inactive in a TP receptor mediated assay of human platelet shape change, where 8-iso PGF2α has an ED50 value of 1 µM.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-221141	7045-31-0	C20H32O5	50 µg/100 µg

• 8-iso-13,14-dihydro-15-keto Prostaglandin F2α
  A PG-like product of non-specific lipid peroxidation; weakly inhibits the U-46619 or collagen-induced aggregation of human platelets.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205176	191919-02-5	C20H34O5	50 µg/100 µg

• 8-iso-15-keto Prostaglandin E2
  An isoprostane produced by the free radical peroxidative degradation of membrane lipids the putative first metabolite of the biologically active compound, 8-iso PGE2 (sc-205172) via the 15-hydroxy PGDH pathway.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-223753	n.n.	C20H30O5	100 µg/500 µg

• 8-iso-15-keto Prostaglandin F2α
  A prostaglandin-like product of non-specific lipid peroxidation; a vasoconstrictor when tested on the rat isolated thoracic aorta, acting via the TP (thromboxane) receptor.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-221143	n.n.	C20H32O5	100 µg/500 µg

• 8-iso-15-keto Prostaglandin F2β
  8-iso Prostaglandin F2β (8-iso PGF2β) is an isomer of PGF2α which is of non-enzymatic origin. It is one of 64 possible isomers of PGF2α which can be produced by free radical peroxidation of arachidonic acid. 8-iso PGF2β has very weak contraction of human umbilical vein artery and does not promote aggregation of human whole blood. However, 8-iso PGF2β moderately contracts both the canine and porcine pulmonary vein, but the effect is much weaker than that exhibited by other isoprostanes such as 8-iso PGE1, 8-iso PGE2, or 8-iso PGF2α. 8-iso-15-keto PGF2β is a potential metabolite of 8-iso PGF2β via the 15-hydroxy PG dehydrogenase pathway. There are no published reports on the formation or biological activity of 8-iso-15-keto PGF2β.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-221142	n.n.	C20H32O5	1 mg/5 mg

• 8-iso-15(R)-Prostaglandin F2α
  8-iso-15(R) PGF2α is one member of a large family of prostaglandin-like eicosanoids formed by the free radical peroxidation of arachidonic acid in membrane phospholipids.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205177	214748-65-9	C20H34O5	100 µg/500 µg

• 8-iso-16-cyclohexyl-tetranor Prostaglandin E2
  A synthetic analog of 8-iso PGE2 (sc-205172), an epimer of PGE2 (sc-201225), that has not been researched, however, E-type prostaglandins have been widely reported to have inflammatory, cytoprotective, and a variety of other effects.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205178	53319-30-5	C22H34O5	1 mg/5 mg

• 8-iso-17-phenyl trinor Prostaglandin F2α
  8-iso-17-phenyl trinor Prostaglandin F2α (8-iso-17-phenyl trinor PGF2α) is the C-8 epimer of bimatoprost (free acid), a metabolically stable analog of PGF2α. Bimatoprost (free acid) binds to the FP receptor on ovine luteal cells with a relative potency of 756% compared to that of PGF2α. At the rat recombinant FP receptor expressed in CHO cells bimatoprost inhibits PGF2α binding with a K_i of 1.1 nM. There are no published studies of the pharmacological properties of 8-iso-17-phenyl trinor PGF2α.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-221144	n.n.	C23H32O5	1 mg/5 mg

• 8-iso-17-phenyl trinor Prostaglandin F2β
  An isomer of bimatoprost that is epimerized at the 8 and 9 positions. There are no published reports on the biological activity of compound.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-221145	n.n.	C23H32O5	1 mg/5 mg

• 8,12-iso-iPF2α-VI-d11
  This compound contains 11 deuterium atoms at the 16, 16', 17, 17', 18, 18', 19, 19', 20, 20, and 20 positions. It is intended for use as an internal standard for the quantification of 8,12-iso-iPF2α-VI by GC- or LC-mass spectrometry. The relative abundance of deuterium atoms incorporated into each molecule has not been determined. Cayman certifies that less that 1% of the product has no deuterium incorporation (<1% d0). Isoprostanes are non-enzymatic, non-cyclooxygenase prostanoid products of peroxidative damage to membrane lipids. Among the many isoprostane isomers, 8,12-iso-iPF2α-VI has been demonstrated to be one of the predominant isomers formed and is also present in urine as one of the major isoprostane products. 8,12-iso-iPF2α-VI-d11 is a deuterated internal standard for use in isoprostane quantitation by mass spec modalities. The substance is diastereomeric at C-5, but is otherwise an optically active, single enantiomer.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-221154	n.n.	C20H23D11O5	10 µg/25 µg

• 9-deoxy-9-methylene Prostaglandin E2
  A stable, isosteric analog of PGE2 that retains the biological profile of PGE2 with few side effects.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205182	61263-32-9	C21H34O4	1 mg/5 mg

• 9-deoxy-9-methylene-16,16-dimethyl Prostaglandin E2
  A potent metabolism resistant analog of prostaglandin E2 (PGE2; sc-201225) with an extended half-life under physiological conditions.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-223758	61263-35-2	C23H38O4	500 µg/1 mg

• 9-deoxy-9-methylene-16,16-dimethyl Prostaglandin E2 (potassium salt)
  A potent analog of 16,16-Dimethyl-prostaglandin E2 which is an antisecretory, antiulcer Prostaglandin E2 (PGE2; sc-201225) analog with potent cytoprotective activity that binds to PGDH.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205183	122576-55-0	C23H37O4 ·K	1 mg/10 mg

• 9-keto Fluprostenol
  An analog of prostaglandin E2 with structural modifications intended to give greater potency and a prolonged half-life.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205186	156406-33-6	C23H27F3O6	1 mg/5 mg

• 9-keto Fluprostenol isopropyl ester
  Has the potential to act as an EP agonist in prodrug form. No studies on the pharmacology of this compound have been published to date. A potential metabolite of Travoprost.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-221167	1219032-18-4	C26H33F3O6	1 mg/5 mg

• 9-oxo-11α,16R-dihydroxy-17-cyclobutyl-5Z,13E-dien-1-oic acid
  Butaprost is a structural analog of prostaglandin E2 (PGE2) with good selectivity for the EP2 receptor subtype. Butaprost binds with about 1/10 the affinity of PGE2 to the recombinant murine EP2 receptor, and does not bind appreciably to any of the other murine EP receptors or TP, DP, IP, or FP receptors. This chemical is a free acid, 2-series analog of butaprost. It is the less active C-16 epimer compared to the 16(S) isomer, which has the same stereochemistry as butaprost. Butaprost has frequently been used to pharmacologically define the EP receptor expression profile of various animal and human cells and tissues. Since the majority of reports related to butaprost utilize the methyl ester derivative, it may be some time before the precise pharmacology of the free acid compounds, like this chemical, is reported.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-223759	212310-16-2	C23H36O5	1 mg/5 mg

• 9,10-dihydro-15-deoxy-Δ12,14-Prostaglandin J2
  Designed as an analog of the PPARγ-binding prostaglandins which could not undergo this conjugation reaction. In human neuroblastoma SH-SY5Y cells, compound was not cytotoxic at up to 25 µM. Failed to covalently modify thioredoxin or induce oxidative stress at 50 µM.3

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-223760	n.n.	C20H30O3	500 µg/1 mg

• 9,11-methane-epoxy Prostaglandin 1α
  A stable epoxymethano analog of PGH1 that produces a strong and dose-related aggregation of washed rabbit platelets and contraction of rabbit aortic strips.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205190	72517-81-8	C21H36O4	100 µg/500 µg

• 9α,11β-PGF2 (9α,11β-Prostaglandin F2)
  Has been reported to cause bronchoconstriction and inhibit platelet aggregation. Also shown to inhibit adipose differentiation.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-201246	38432-87-0	C20H34O5	1 mg/10 mg

• 9β,11α-Prostaglandin F2
  The C-9 epimer of PGF2α (sc-201227), shown to exhibit negative chronotropic activity, and to act as a bronchodilator.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-201244	4510-16-1	C20H34O5	1 mg/10 mg

• ACS 67
  Latanoprost is an F-series prostaglandin (PG) analog which has been approved for use as an ocular hypotensive drug for the treatment of glaucoma. Latanoprost is an isopropyl ester, a prodrug form which is converted to latanoprost (free acid) by endogenous esterase enzymes. The free acid form is 200 times more potent than latanoprost as an FP receptor ligand for the human recombinant FP receptor. ACS 67 is an analog of latanoprost (free acid) that contains a hydrogen sulfide releasing component conjugated to the latanoprost carboxyl group. In glaucomatous pigmented rabbits, ACS 67 reduced intra-ocular pressure (IOP) more rapidly and to a greater extent than latanoprost (15 versus 25. mm Hg at four hours) at a dose of 0.005% for each compound. ACS 67 also increased the levels of reduced glutathione and cGMP in the aqueous humor of glaucomatous pigmented rabbits better than latanoprost.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-291832	1088434-86-9	C32H38O5S3	1 mg/5 mg

• 11-deoxy Prostaglandin E1
  11-deoxy Prostaglandin E1 (11-deoxy PGE1) is a synthetic analog of PGE1. Early reports show that it is a selective agonist for the EP2 receptor but effective at much higher concentrations than PGE2. However, later studies show that it is a non-selective agonist of EP receptors and stimulates cAMP release in Jurkat cells with an EC₅₀ of 0.25 µM. 11-deoxy PGE1 also exhibits bronchodilator and vasodepressor responses in guinea pigs. It also exhibits selectively for the murine EP3 receptor and is essentially equipotent to PGE1 at this receptor subtype. The Ki values for binding to the murine EP1, EP2, EP3, and EP4 receptors are 600, 45, 1.1, and 23 nM, respectively.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-223150	37786-00-8	C20H34O4	500 µg/1 mg

• 11-deoxy Prostaglandin E2
  A stable, synthetic analog of PGE2 (sc-201225) that has been shown to have powerful bronchoconstrictor effects, in contrast to PGE2, which has been shown to have bronchodilation effects

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-204962	35536-53-9	C20H32O4	1 mg/5 mg

• 11-deoxy Prostaglandin F1α
  A synthetic analog of PGF1α. Exhibits vasopressor and bronchoconstrictor activities at about half the strength of PGF2α in guinea pigs.3

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-204964	37785-98-1	C20H36O4	1 mg/5 mg

• 11-deoxy Prostaglandin F1β
  A synthetic analog of PGF1β. Exhibits bronchodilator and vasodepressor activities in guinea pigs at a dose of 500 µg/kg.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-204965	37785-99-2	C20H36O4	1 mg/5 mg

• 11-deoxy Prostaglandin F2β
  An related compound of PGF2β. There are no published reports on the biological activity of this compound.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-204966	37786-07-5	C20H34O4	1 mg/5 mg

• 1-deoxy Prostaglandin F_2α
  A synthetic analog of PGF2α. It is a more potent agonist than PGF2α at inducing smooth muscle contractions of rabbit aorta, guinea pig trachea, and dog saphenous vein.1 It is approximately 20% less potent than U-46619.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-204963	37786-06-4	C20H34O4	1 mg/5 mg

• 11-deoxy-11-methylene Prostaglandin D2
  One of the five primary enzymatic prostaglandins derived directly from PGH2; a novel, chemically stable, isosteric analog of PGD2 wherein the 11-keto group is replaced by an exocyclic methylene.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-204967	100648-29-1	C21H34O4	1 mg/5 mg

• 11-deoxy-11-methylene-15-keto Prostaglandin D2
  One of the five primary enzymatic prostaglandins derived directly from PGH2. Many of the biological effects of PGD2 are transduced in vivo by a classical 7-transmembrane GPCR, the DP1 receptor. However, a second receptor, the chemokine-related CRTH2 receptor, also binds PGD2. This new receptor was recently identified on human eosinophils, where it binds selectively the PGD2 metabolite 13,14-dihydro-15-keto PGD2.4 Was prepared as a more chemically stable ligand for this receptor. There are no published studies of the pharmacological properties of 11-deoxy-11-methylene-15-keto PGD2.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-220575	n.n.	C21H32O4	100 µg/500 µg

• 11-deoxy-16,16-dimethyl Prostaglandin E2
  A stable synthetic analog of PGE2 (sc-201225), shown to act as a selective agonist for EP2 and EP3 receptors, and has shown effective inhibition of gastric acid secretion and ulcer formation in the rat.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-204968	53658-98-3	C22H36O4	1 mg/5 mg

• 11-keto Fluprostenol
  An analog of prostaglandin D2 (PGD2) with structural modifications intended to give it a prolonged half-life and greater potency. A well-studied, potent analog of PGF2α which acts primarily through the FP receptor. Oxidation at C-11 of fluprostenol yields 11-keto fluprostenol. 11-keto Fluprostenol exhibits moderate binding to the CRTH2/DP2 receptor compared to PGD2 and essentially no activity at the DP1 receptor.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-220576	n.n.	C23H27F3O6	1 mg/5 mg

• 11β-13,14-dihydro-15-keto Prostaglandin F2α
  A metabolite of Prostaglandin D2 (PGD2) in the 15-hydroxy PGDH pathway.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-204976	107615-77-0	C20H34O5	50 µg/100 µg

• 11β-Misoprostol
  A widely sold analog of prostaglandin E1 (PGE1) that has potent but relatively non-selective agonist activity with respect to the prostanoid EP receptor subgroup.1 Has been used therapeutically for many years in humans in the treatment of gastric ulcer disease under the Searle tradename Cytotec. 11β-Misoprostol is one of several impurities which are possible in the production of commercial lots of bulk misoprostol, and is somewhat difficult to distinguish from other impurities such as 8-iso misoprostol. The pharmacology and EP receptor binding affinity for 11β-misoprostol have not been published.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-220585	58717-36-5	C22H38O5	500 µg/1 mg

• 11β-Prostaglandin E1
  11β-Prostaglandin E1 (11β-PGE1) is an epimerized form of PGE1 at the C-11 position. 11β-PGE1 is a less potent isomer of PGE1. It is 13% and 3.6% as potent as PGE1 in contracting the rat uterus and guinea pig ileum, respectively.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-204977	24570-01-2	C20H34O5	1 mg/5 mg

• 11β-Prostaglandin E2
  An epimer of PGE2 (sc-201225) shown to moderately inhibit PGE2 binding to rat hypothalamic membranes, stimulate bone resorption and to inhibit PGE2 binding to the prostaglandin transporter protein.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-223155	38310-90-6	C20H32O5	500 µg/1 mg

• 11β-Prostaglandin F1β
  The stereoisomer of PGF1α with both C-9 and C-11 hydroxyls inverted (β), yet there are no published reports on the biological activity.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-204978	37785-86-7	C20H36O5	1 mg/5 mg

• 11β-Prostaglandin F2α Ethanolamide
  The theoretical hepatic metabolite of PGD2-EA, is produced during COX-2 metabolism of the endogenous cannabinoid AEA which is found in brain, liver, and other mammalian tissues. PGD2-EA is formed in activated RAW 264.7 cells treated with AEA.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-204979	714966-38-8	C22H39NO5	1 mg/5 mg

• 13,14-dehydro-15-cyclohexyl Carbaprostacyclin
  Inhibits the ADP-induced aggregation of human platelets with potency that is comparable to that of carbaprostacyclin.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-204994	145375-81-1	C21H30O4	50 µg/500 µg

• 13,14-dihydro Prostaglandin F1α
  13,14-dihydro PGF1α is a potential metabolite of PGF1α.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-204995	20592-20-5	C20H38O5	1 mg/5 mg

• 13,14-dihydro Prostaglandin F2α
  13,14-dihydro PGF2α is the counterpart of PGF2α which is saturated on the lower side chain. It causes luteolysis in hamsters with a potency five times greater than PGF2α. The ED50 for 13,14-dihydro PGF2α as a luteolytic agent in hamsters is 1.5 µg/100 g.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-204996	27376-74-5	C20H36O5	1 mg/5 mg

• 13,14-dihydro-15-keto Prostaglandin A2
  Rapidly metabolized to 13,14-dihydro-15-keto PGE2, which is present in the plasma of humans and other mammals.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-204997	74872-89-2	C20H30O4	1 mg/5 mg

• 13,14-dihydro-15-keto Prostaglandin D1
  The theoretical D-series metabolite of dihomo-γ-linolenic acid (DGLA), but to date it has not been isolated as a natural product. An inhibitor of ADP-induced platelet aggregation in humans with an IC₅₀ value of 320 ng/ml, about 1/10 as potent as PGD2. 13,14-dihydro-15-keto PGD1 is the theoretical metabolite of PGD1 via the 15-hydroxy PG.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-220594	n.n.	C20H34O5	1 mg/5 mg

• 13,14-dihydro-15-keto Prostaglandin D2
  A metabolite of PGD2 which is formed through the 15-hydroxy PGDH pathway; a selective agonist for the CRTH2/DP2 receptor; inhibits ion flux in canine colonic mucosa preparation.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-204998	59894-07-4	C20H32O5	1 mg/5 mg

• 13,14-dihydro-15-keto Prostaglandin E1
  A metabolite of PGE1 with much reduced biological activity. Steady state plasma concentrations are roughly 10 pg/ml. This compound is a weak inhibitor of ADP-induced platelet aggregation in human PRP and washed platelets with IC₅₀ values of 54 and 200 µM, respectively, compared to PGE1 which has an IC₅₀ of 40 nM.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-204999	5094-14-4	C20H34O5	1 mg/5 mg

• 13,14-dihydro-15-keto Prostaglandin E2
  A metabolite of PGE2 (sc-201225) biosynthesized by the enzymes 15-hydroxy PGDH and 15-oxo-PG δ13-reductase.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205000	363-23-5	C20H32O5	1 mg/5 mg

• 13,14-dihydro-15-keto Prostaglandin F1α
  13,14-dihydro-15-keto Prostaglandin F1α (13,14-dihydro-15-keto PGF1α) is a metabolite of PGF1α that has been found in the rat stomach. The measurement of 13,14-dihydro-15-keto PGF1α can be used as a marker of the in vivo production of PGF1α.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-223166	29044-75-5	C20H36O5	500 µg/1 mg

• 13,14-dihydro-15-keto Prostaglandin F2α isopropyl ester
  13,14-dihydro-15-keto PGF2α isopropyl ester is a more lipid soluble derivative of 13,14-dihydro-15-keto PGF2α. There are no published reports on the biological activity of this compound.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205001	199920-18-8	C23H40O5	1 mg/5 mg

• 13,14-dihydro-15-keto Prostaglandin J2
  Various biological properties exist for both PGJ2 and its metabolites such as inhibition of platelet aggregation, antitumor, and antiviral activity. It isthe dehydration product of 13,14-dihydro-15-keto PGD2 and is a presumed metabolite of PGJ2 via the 15-hydroxy PG dehydrogenase pathway. There are no published studies of the pharmacological properties or the formation of 13,14-dihydro-15-keto PGJ2 in vivo.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-220599	n.n.	C20H30O4	500 µg/1 mg

• 13,14-dihydro-15-keto-tetranor Prostaglandin F1β
  13,14-dihydro-15-keto tetranor-Prostaglandin F1β is an important urinary metabolite of PGE2 that is excreted in guinea pig urine at a concentration range of 1.34-2.74 µg/kg.1

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205002	23015-45-4	C16H28O5	25 µg /50 µg

• 13,14-dihydro-15(R,S)-hydroxy-16,16-difluoro Prostaglandin E1-d4
  Intended for use as an internal standard for the quantification of 13,14-dihydro-15(R,S)-hydroxy-16,16-difluoro Prostaglandin E1 by GC- or LC-mass spectrometry (MS).

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-287299	n.n.	C20H30D4F2O5	25 µg/50 µg

• 13,14-dihydro-15(R)-Prostaglandin E1
  13,14-dihydro-15(R)-PGE1 is an analog of 13,14-dihydro-PGE1, which has the hydroxyl group at C-15 in the unnatural R configuration.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205003	201848-10-4	C20H36O5	1 mg/5 mg

• 13,14-dihydro-16,16-difluoro Prostaglandin D2
  An analog of PGD2; has activity that is comparable to that of PGE1, suggesting that this analog of PGD2 could be biologically active.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-287300	n.n.	C20H32F2O5	100 µg/500 µg

• 13,14-dihydro-16,16-difluoro Prostaglandin J2
  An analog of PGD2 that can inhibit both platelet aggregation and cell growth.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-287302	n.n.	C20H30F2O4	100 µg/500 µg

• 13,14-dihydro-19(R)-hydroxy Prostaglandin E1
  The theoretical metabolite of 13,14-dihydro PGE1 by ω-1 hydroxylase. There are no known reports on its biosynthesis or biological activity.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-220600	n.n.	C20H36O6	50 µg/100 µg

• 15-cyclohexyl pentanor Prostaglandin F2α
  An analog of PGF2α with resistance to 15-hydroxy PGDH metabolism. Binds to the FP receptor on ovine luteal cells with a relative affinity of 46% in comparison to PGF2α.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205016	58611-97-5	C21H34O5	1 mg/5 mg

• 15-deoxy-Δ^12,14-Prostaglandin A₁
  A synthetic PGA1 analog that shares common structural features with 15-deoxy-Δ12,14-PGJ2, which is a ligand for PPARγ. Antimitotic and antitumor activity have been reported for a similar analog, but there are no published reports on the biological activity of 15-deoxy-Δ12,14-PGA1 at this time.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-220615	573951-20-9	C20H30O3	1 mg/5 mg

• 15-deoxy-Δ12,14-Prostaglandin A2
  15-deoxy-Δ12,14-PGA2 is a synthetic analog of PGA2. It shares common structural features with 15-deoxy-Δ12,14-PGJ2, which is a ligand for PPARγ (1,2). Antitumor and antimitotic activity have been reported for a similar analog,(3) but there are no published reports on the biological activity of 15-deoxy-Δ12,14-PGA2 at this time.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-223167	112839-31-3	C20H28O3	500 µg/1 mg

• 15-deoxy-Δ12,14-Prostaglandin D2
  A synthetic analog of PGD2 and a potential precursor to the PPARγ ligand 15-deoxy-Δ12,14-PGJ2.1 Exhibits cytotoxic effects on L1210 murine leukemia cells in vitro. 15-deoxy-Δ12,14-PGD2 is 10-fold more potent than PGD2 in this activity.2 However, it is a less effective inhibitor of ADP-induced platelet aggregation compared to PGD2.3

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205017	85235-11-6	C20H30O4	500 µg/1 mg

• 15-deoxy-Δ12,14-Prostaglandin J2
  A cyclopentanone prostaglandin and endogenous PPARγ ligand, formed via the the dehydration of PGD2 (sc-201221), that binds to DP1 and DP2 receptors.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205018	89886-60-2	C20H28O3	1 mg/5 mg

• 15-deoxy-Δ12,14-Prostaglandin J2-2-glycerol ester
  Formed from PGD2 by the elimination of two molecules of water. Binds selectively to PPARγ with an EC₅₀ value of 2 µM in a murine chimera system. More potent than PGD2, Δ12-PGJ2, and PGJ2 in stimulating lipogenesis in C3H10T1/2 cells. The EC₅₀ value for induction of adipocyte differentiation in cultured fibroblasts is 7 µM. PG glycerol esters are generated by the action of cyclooxygenase-2 on the endocannabinoid 2-arachidonyl glycerol. The biosynthesis of PGH, PGD, PGE, PGF, and TXA-2-glyceryl ester compounds have all been documented and though the stability and metabolism of these PG products has been investigated, little is known about their intrinsic biological activity.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-220616	n.n.	C23H34O5	100 µg/500 µg

• 15-deoxy-Δ^12,14-Prostaglandin J₂-biotinamide
  One of the cyclopentenone PGs, which have documented metabolic (peroxisome proliferator-activated receptor γ-activating), antimitotic, and antiproliferative effects.1,2,3 The activity of the compounds in this class, which includes PGs in both the A- and J-series, may result from changes in gene expression and the interaction with non-classical pathways. An affinity probe that allows 15-deoxy-Δ^12,14-PGJ₂ to be detected through an interaction with the biotin ligand. 15-deoxy-Δ^12,14-PGJ₂-biotinamide was designed to allow 15-deoxy-Δ^12,14-PGJ₂ to be detected in complexes with nuclear receptors and/or nucleic acid or protein binding partners. It is thus a tool to be used in the general elucidation of the mechanism of action of the cyclopentenone PGs.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-220617	n.n.	C35H54N4O4S	50 µg/100 µg

• 15-epi Prostaglandin A1
  15-epi PGA1 is the 15(R) stereoisomer of PGA1. Prostaglandins of the A-series, including some with 15(R) stereochemistry, are natural products of gorgonian soft corals. PGA1 causes renal vasodilation, increased urine sodium excretion, and decreased arterial pressure in hypertensive patients. There are no published reports on the biological activity of 15-epi PGA1 at this time.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205020	20897-92-1	C20H32O4	1 mg/5 mg

• 15-keto Bimatoprost
  The Allergan trade name for 17-phenyl trinor prostaglandin F2α (17-phenyl trinor PGF2α) ethyl amide, an F-series PG analog that has been approved for use as an ocular hypotensive drug.1 Oxidation of the C-15 hydroxyl group produces 15-keto bimatoprost which is a potential metabolite of bimatoprost when bimatoprost is administered to intact animals.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-220619	n.n.	C25H35NO4	1 mg/5 mg

• 15-keto Fluprostenol
  An F-series prostaglandin analog which has been approved for many years as a luteolytic in veterinary animals. The isopropyl ester of fluprostenol (travoprost) was recently introduced as an ocular hypotensive drug. Oxidation of the C-15 hydroxyl group of fluprostenol produces 15-keto fluprostenol. 15-keto Fluprostenol is a potential metabolite of fluprostenol when administered to intact animals and is also one of the common minor impurities found in commercial preparations of the bulk drug compound. Products of β-oxidation account for most of the metabolites of fluprostenol recovered in plasma and urine. However, 15-keto fluprostenol is a minor metabolite, and one which could be enhanced in situations where β-oxidation is reduced.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-220620	n.n.	C23H27F3O6	1 mg/5 mg

• 15-keto Fluprostenol isopropyl ester
  An F-series prostaglandin analog which has been approved for use as an ocular hypotensive drug. Oxidation of the C-15 hydroxyl group without isopropyl ester hydrolysis produces 15-keto fluprostenol isopropyl ester (15-keto travoprost). 15-keto Travoprost is a potential metabolite of travoprost when administered to intact animals and is also one of the common minor impurities found in commercial preparations of the bulk drug compound. In general, F-series prostaglandin analogs with a 15-keto functional group lose a great deal of their FP receptor binding affinity, but retain enough to show a continued weak IOP hypotensive response. The efficacy of 15-keto travoprost as an ocular hypotensive has not been established.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-220621	404830-45-1	C26H33F3O6	1 mg/5 mg

• 15-keto Iloprost
  The C-15 oxidized derivative of iloprost, which is a second generation structural analog of prostaglandin I2 (prostacyclin). Iloprost displays ten-fold greater potency than the first generation stable analogs, typified by carbaprostacyclin. There are no published studies of the pharmacological properties of 15-keto iloprost.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-220622	n.n.	C22H30O4	500 µg/1 mg

• 15-keto Latanoprost
  Latanoprost is an F-series prostaglandin (PG) analog that has been approved for use as an ocular hypotensive drug. Oxidation of the C-15 hydroxyl group without isopropyl ester hydrolysis produces 15-keto latanoprost. 15-keto Latanoprost is a potential metabolite of latanoprost when administered to intact animals. 15-keto Latanoprost is one of the common minor impurities found in commercial preparations of bulk drug compounds. Although much less potent that the parent compound latanoprost, 15-keto latanoprost still retains the ability to produce a small but measurable decrease (1 mm Hg) in the intraocular pressure of normal cynomolgus monkeys when administered at a dose of 1 µg/eye. 15-keto Latanoprost is also miotic in the normal cat eye, causing an 8 mm reduction in pupillary diameter at 5 µg/eye. Again, this is not as potent as many other F-type PGs; for example, PGF2α will produce this degree of miosis at a dose of less than 1 µg/eye. Products of β-oxidation account for most of the metabolites from latanoprost recovered in plasma and urine. However, 15-keto latanoprost is a minor metabolite, which could be enhanced in situations where β-oxidation is reduced.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-223168	n.n.	C26H38O5	1 mg/5 mg

• 15-keto Latanoprost (free acid)
  A potential metabolite of Latanoprost when administered to intact animals. Also one of the common minor impurities found in commercial preparations of the bulk drug compound. Although much less potent than the parent compound Latanoprost, 15-keto Latanoprost still retains the ability to produce a small but measurable decrease (1 mm Hg) in the intraocular pressure of normal cynomolgus monkeys when administered at a dose of 1 µg/eye. 15-keto Latanoprost is also a miotic in the normal cat eye, causing an 8 mm Hg reduction in pupillary diameter at 5 µg/eye. Again, this is not as potent as many other F-type prostaglandins.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-220623	n.n.	C23H32O5	1 mg/5 mg

• 15-keto Prostaglandin E1
  15-keto PGE1 is the inactive metabolite of PGE1 produced by 15-hydroxy PGDH. It has greatly reduced biological activity compared to PGE1.1,2

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205024	22973-19-9	C20H32O5	500 µg/1 mg

• 15-keto Prostaglandin F1α
  15-keto PGF1α is the initial metabolite of PGF1α via 15-hydroxy PGDH. In mammals, oxidation of C-15 markedly attenuates receptor binding and activity. In fish, the 15-keto compounds serve as post-ovulatory pheromones and are more active than the parent prostaglandins.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205025	21562-58-3	C20H34O5	1 mg/5 mg

• 15(R)-15-methyl Prostaglandin A2
  A synthetic prostaglandin E2 (PGE2) analog developed for its cytoprotective activity. It is one of several impurities which are possible in the production of commercial lots of bulk arbaprostil. The pharmacology and EP receptor binding affinity for 15(R)-15-methyl PGA2 has not been published.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-220626	n.n.	C21H32O4	1 mg/5 mg

• 15(R)-15-methyl Prostaglandin D2
  The physiological actions of PGD2 include inhibition of platelet aggregation, lowering of body temperature, regulation of sleep and relaxation of vascular smooth muscle. PGD2 mediates its effects by two distinct G-protein-coupled receptors, CRTH2/DP2 and DP14. 15(R)-15-methyl PGD2 is a selective, potent agonist for the CRTH2/DP2 receptor. The EC₅₀ values for eosinophil CD11b expression, actin polymerization, and chemotaxis are 1.4, 3.8, and 1.7 nM, respectively, each of which is approximately 3-5 fold lower than those for PGD2. In contrast the EC₅₀ for the DP1-mediated increase in platelet cAMP by 15(R)-15-methyl PGD2 is >10 µM.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-223169	210978-26-0	C21H34O5	1 mg/5 mg

• 15(R)-15-methyl Prostaglandin E2
  An analog of PGE2 (sc-201225) that undergoes acid catalyzed epimerization into 15(S)-15-methyl PGE2 (sc-223170), shown to inhibit gastric acid secretion and increase the total ouput and rate of output of duodenal bicarbonate secretion.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205027	55028-70-1	C21H34O5	1 mg/5 mg

• 15(R)-15-methyl Prostaglandin F2α
  A metabolically stable analog of PGF_2α. An inactive, prodrug PGF agonist intended for activation by gastric acid after oral administration.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205028	35864-81-4	C21H36O5	1 mg/5 mg

• 15(R)-15-methyl Prostaglandin F2α methyl ester
  A lipid soluble prodrug form of 15(R)-15-methyl PGF2α with increased membrane permeability. Acid-catalyzed epimerization of 15(R)-15-methyl PGF2α methyl ester and hydrolysis of the ester converts it into the active 15(S)-15-methyl PGF2α.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205029	35700-22-2	C22H38O5	1 mg/5 mg

• 15-keto-17-phenyl trinor Prostaglandin F2α
  An F-series prostaglandin (PG) analog that has been approved for use as an ocular hypotensive drug. Oxidation of the C-15 hydroxyl group and amide hydrolysis of Bimatoprost produces 15-keto-17-phenyl trinor PGF2α. A potential metabolite of Bimatoprost when administered to intact animals and its analogs are potential minor impurities in commercial preparations of their corresponding bulk drug compounds. Although much less potent that the parent compound, 15-keto PGs still retain the ability to produce a small but measurable decrease (1 mm Hg) in the intraocular pressure of normal cynomolgus monkeys when administered at a dose of 1 µg/eye.2 15-keto Latanoprost (15-keto-17-phenyl-13,14-dihydro trinor PGF2α isopropyl ester) is a miotic in the normal cat eye, causing an 8 mm reduction in pupillary diameter at 5 µg/eye. Again, this is not as potent as many other F-type PGs.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-220624	n.n.	C23H30O5	1 mg/5 mg

• 15(R)-17-phenyl trinor Prostaglandin F2α
  An F-series prostaglandin analog which has been approved for use as an ocular hypotensive drug, sold under the Allergan trade name Bimatoprost.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205030	41639-71-8	C23H32O5	1 mg/5 mg

• 15(R)-Bimatoprost isopropyl ester
  A latanoprost-related isomer.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205031	130273-87-9	C26H38O5	1 mg/10 mg

• 15(R)-Iloprost
  A second generation structural analog of prostacyclin (PGI2) that has roughly a ten-fold greater potency than the first generation stable analogs.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205033	85026-51-3	C22H32O4	500 µg/1 mg

• 15(R)-Prostaglandin D2
  Many of the effects of prostaglandin D2 (PGD2) are transduced via a traditional 7-transmembrane GPCR, the DP1 receptor. However, in certain leukocytes and other immune cells, a second PGD2 receptor referred to as the CRTH2 or DP2 receptor has been cloned and characterized. It is a surprisingly potent agonist at the DP2 receptor, being about 5 times more potent than PGD2 itself. 15(R)-PGD2 has the potential to be produced endogenously as a natural ligand for DP2, unlike the synthetic 15-methyl analogs. In preliminary reports, 15(R)-PGD2 has also been reported to be a potent and selective DP2 receptor agonist.5,6

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-220629	n.n.	C20H32O5	1 mg/5 mg

• 15(R)-Prostaglandin E1
  15(R)-PGE1 is the “unnatural” C-15 stereoisomer of PGE1. It is basically inactive biologically when compared to PGE1. It is a non-competitive inhibitor of 15-hydroxy PGDH with an IC₅₀ of 189 µM.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205034	20897-91-0	C20H34O5	1 mg/5 mg

• 15(R)-Prostaglandin E2
  The C-15 epimer of the naturally occurring 15(S)-PGE2 (sc-201225) isomer, displaying lower potency, but may undergo acid catalyzed epimerization yielding the active isomer.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205035	38873-82-4	C20H32O5	1 mg /5 mg

• 15(R)-Prostaglandin F2α
  The C-15 epimer of the naturally occurring mammalian autacoid PGF2α. It only has 25% of the potency of PGF2α in hamster antifertility studies,1 which might be due to reduced affinity for FP receptors.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205036	37658-84-7	C20H34O5	1 mg/5 mg

• 15(R),19(R)-hydroxy Prostaglandin E1
  19(R)-Hydroxylated prostaglandins occur in µg/ml concentrations in the semen of some mammalian species, especially primates. In the case of humans, the compounds are primarily of the PGE series, and the hydroxyl stereochemistry is 15(S),19(R).1 19(R)-Hydroxylated prostaglandins are also found in the seminal plasma of marsupials, where F-type compounds of the 1 and 2-series predominate.2 The 15(R)-hydroxy epimer of these 19-hydroxylated prostaglandins is the inverse or “unnatural” isomer at C-15.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-220630	n.n.	C20H34O6	50 µg/100 µg

• 15(S)-15-methyl Prostaglandin E1
  A metabolically stable synthetic analog of PGE1, where in sharp contrast to the bronchodilatory effects of PGE1, this compound is a weak constrictor of human respiratory tract smooth muscle.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205038	35700-26-6	C21H36O5	1 mg/5 mg

• 15(S)-15-methyl Prostaglandin E2
  A metabolically stable, potent analog of PGE2 (sc-210225), that has demonstrated potent gastric antisecretory activities.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-223170	35700-27-7	C21H34O5	500 µg/1 mg

• 15(S)-15-methyl Prostaglandin F2α
  A metabolically stable analog of PGF2α. It is a potent uterine stimulant and abortifacient which can be given intramuscularly to induce labor. Induces luteolysis and reduces serum progesterone concentrations when given as an intramuscular injection in non-pregnant rhesus monkeys.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205039	35700-23-3	C21H36O5	1 mg/5 mg

• 15(S)-15-methyl Prostaglandin F2α methyl ester
  A derivative of 15(S)-15-methyl PGF2α with increased membrane permeability.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205040	35700-21-1	C22H38O5	1 mg/5 mg

• 15(S)-Fluprostenol
  A prodrug (Travoprost) which is converted by esterase enzymatic activity in the cornea to yield the corresponding free acid. The free acid, (+)-15(R)-fluprostenol, is a potent FP receptor agonist. The 15(R)-epimers of most prostaglandins are about 100 times less potent than the natural, 15(S)-isomers. However, the neighboring phenoxy group at C-16 reverses the absolute configuration at C-15 in the fluprostenol series. Therefore, 15(S)-fluprostenol is less active as an FP agonist than 15(R)-fluprostenol.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-220633	40666-16-8	C23H29F3O6	1 mg/5 mg

• 15(S)-Fluprostenol isopropyl ester
  The unnatural C-15 epimer of Travoprost. Travoprost is the Alcon trade name for fluprostenol isopropyl ester, (Flu-Ipr) an F-series prostaglandin analog that has been approved for use as an ocular hypotensive drug. Flu-Ipr is a prodrug which is converted by esterase enzymatic activity in the cornea to yield the corresponding free acid. The free acid, fluprostenol, is a potent FP receptor agonist. In human and animal models of glaucoma, FP receptor agonist activity corresponds very closely with intraocular hypotensive activity. Inversion of the stereochemistry at the 15 position of ocular hypotensive prostaglandins generally lowers the potency approximately 100 fold.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-220634	157283-68-6	C26H35F3O6	1 mg/5 mg

• 15(S)-Latanoprost
  A 3 µg dose of 15(S)-Latanoprost caused a 1 mmHg reduction of IOP in normotensive cynomolgus monkeys.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205045	145773-22-4	C26H40O5	1 mg/5 mg

• 16-(trifluoromethyl)-phenoxy Prostaglandin Lactol
  An F-series prostaglandin analog with potent FP agonist activity. Fluprostenol is used in animal reproduction as a luteolytic, while the isopropyl ester has been approved for use as an ocular hypotensive drug. An intermediate in the synthesis of fluprostenol. 16CF3 Lactol can be converted to the free acid of fluprostenol by Wittig reaction with commercially available reagents.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-220637	n.n.	C17H19F3O4	5 mg/10 mg

• 16-phenoxy tetranor Prostaglandin A2
  A minor metabolite found in human plasma after intravenous administration of sulprostone.1 Its biological activity has not been studied or reported.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205047	51639-10-2	C22H26O5	1 mg/5 mg

• 16-phenoxy tetranor Prostaglandin E2
  The free acid form of sulprostone (sc-201348) formed by the hydrolysis of the methylsulfonamide bond - shown to be a minor metabolite of sulprostone found in human plasma after parenteral administration of the drug.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-220640	n.n.	C22H28O6	1 mg/5 mg

• 16-phenoxy tetranor Prostaglandin F2α
  A metabolically stable analog of PGF2α where it binds to the FP receptor on ovine luteal cells with much greater affinity (440%) than PGF2α.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205571	51705-19-2	C22H30O6	1 mg

• 16-phenoxy tetranor Prostaglandin F2α
  A metabolically stable analog of PGF2α where it binds to the FP receptor on ovine luteal cells with much greater affinity (440%) than PGF2α.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205572	51705-19-2	C22H30O6	5 mg

• 16-phenyl tetranor Prostaglandin E1
  A metabolically stable synthetic PGE1 analog. There are no reports on the biological activity of this compound.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-220641	n.n.	C22H30O5	1 mg/5 mg

• 16-phenyl tetranor Prostaglandin E2
  A metabolically stable synthetic analog of PGE2, believed to be five times more potent than PGE2 in causing hypotension in dogs, and comparable to PGE2 in inhibiting histamine-induced bronchoconstriction in conscious guinea pigs.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205048	38315-44-5	C22H28O5	1 mg/10 mg

• 16-phenyl tetranor Prostaglandin F2α
  A metabolically stable analog of PGF2α. The affinity of 16-phenyl tetranor PGF2α at the FP receptor of ovine luteal cells is substandard (8.7%) compared to PGF2α.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205049	38315-48-9	C22H30O5	1 mg/5 mg

• 16,16-dimethyl Prostaglandin A1
  A metabolism resistant analog of PGA1 that inhibits the viral replication in both HSV and HIV-1 infection systems in vitro at concentrations that do not adversely alter cellular DNA synthesis. The ID50 for HSV-1 strains in Vero cells and human foreskin fibroblasts are 3.8-5.6 µg/ml and 4.6-7.3 µg/ml, respectively. The ID₅₀ for T cells acutely infected with HIV-1 is 2.5 µg/ml.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205050	41692-24-4	C22H36O4	1 mg/5 mg

• 16,16-dimethyl Prostaglandin A2
  A metabolism resistant analog of PGA2 with a prolonged half-life in vivo; inhibits the proliferation of Sendai virus in cultured African green monkey kidney cells.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205051	41691-92-3	C22H34O4	1 mg/5 mg

• 16,16-dimethyl Prostaglandin D2
  16,16-dimethyl PGD2 is a metabolically stable synthetic analog of PGD2. It increases systemic blood pressure in rats and enhances ADP-induced human platelet aggregation.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-223172	64072-59-9	C22H36O5	500 µg/1 mg

• 16,16-dimethyl Prostaglandin E1
  A metabolically stable synthetic analog of PGE1 that in vitro, induces human vascular smooth muscle contractions. It is 2, 3, and 6 times more potent than PGF2α in contracting tracheal, bronchial, and bronchiolar smooth muscle, respectively.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205052	41692-15-3	C22H38O5	1 mg/5 mg

• 16,16-dimethyl Prostaglandin E2 p-(p-acetamidobenzamido) phenyl ester
  A crystalline prostaglandin derivative believed to act as a prodrug for the antisecretory, antiulcer Prostaglandin E2 (PGE2; sc-201225) analog, 16,16-dimethyl PGE2 (sc-201240).

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205053	62873-55-6	C37H48N2O7	500 µg/1 mg

• 16,16-dimethyl Prostaglandin F2α
  A metabolically stable analog of PGF2α that binds to the FP receptor on ovine luteal cells with slightly better affinity (159%) than PGF2α.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205054	39746-23-1	C22H38O5	1 mg/5 mg

• 16,16-dimethyl Prostaglandin F2β
  A metabolically stable analog of PGF2β. Prevents bronchospasm in asthmatics but is less potent than PGE2.1

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205055	59769-89-0	C22H38O5	1 mg/5 mg

• 16(S)-Iloprost
  A second generation structural analog of prostacyclin (PGI2) with roughly ten-fold greater potency than the first generation stable analogs, typified by carbaprostacyclin. Binds with equal affinity to the recombinant human EP1 and IP receptors with a Ki value of 11 nM.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205058	74843-14-4	C22H32O4	500 µg/1 mg

• 17-phenoxy Prostaglandin F2α isopropyl ester
  An analog of PGF2α containing a 17-phenoxy group on the lower side chain and an isopropyl ester at the C-1 position.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-220648	n.n.	C26H38O6	1 mg/5 mg

• 17-phenoxy trinor Prostaglandin F2α
  A novel analog of PGF2α. A similar analog, 16-phenoxy tetranor PGF2α, binds to the FP receptor on luteal cells with much greater affinity (440%) than PGF2α.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-220649	n.n.	C23H32O6	1 mg/5 mg

• 17-phenyl trinor 8-iso Prostaglandin E2
  The C-8 epimer of the selective EP3 receptor agonist, 17-phenyl trinor PGE2 9 (sc-201255), which is a synthetic analog of PGE2 (sc-201225).

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-220650	n.n.	C23H28O5	1 mg/5 mg

• 17-phenyl trinor Prostaglandin A2
  A synthetic prostaglandin analog designed for greater potency and increased half-life. There are no published reports of the biological activity of 17-phenyl trinor PGA2 in the literature at this time.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205060	38315-51-4	C23H28O4	1 mg/5 mg

• 17-phenyl trinor Prostaglandin D2
  17-phenyl trinor Prostaglandin D2 (17-phenyl trinor PGD2) is a chemically stable analog of PGD2, the lower side chain is modified by the addition of a phenyl group at C-17 in place of the last 3 ω-chain carbon atoms. This modification has not been reported in a D-type prostaglandin. However, in the PGE and PGF series, the analogous modification leads to a stable, more potent agonist which embodies the same biological activities as the parent prostaglandins.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-223178	n.n.	C23H30O5	1 mg/5 mg

• 17-phenyl trinor Prostaglandin E2 serinol amide
  A stable analog of the selective EP1 and EP3 receptor agonist, 17-Phenyl-trinor-prostaglandin E2 (sc-201255). Also analogous to PGE2 glyceryl ester, but has been modified to increase receptor binding affinity.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-220651	n.n.	C26H37NO6	1 mg/5 mg

• 17-phenyl trinor-13,14-dihydro Prostaglandin A2
  A synthetic PG analog with biological activity not widely reported. The PGF2α analog latanoprost, bearing the same features as the lower side chain, has recently been approved as a pharmaceutical for the treatment of glaucoma.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205061	130209-80-2	C23H30O4	1 mg/10 mg

• 17-trans Prostaglandin E3
  17-trans PGE3 is an isomer of PGE3 which could result from COX metabolism of dietary trans-fatty acids. There are no published reports on the biological activity of this compound.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-223179	n.n.	C20H30O5	100 µg/500 µg

• 17-trans Prostaglandin F3α
  17-trans PGF3α is a double bond isomer of PGF3α. It is a potential metabolite of trans dietary fatty acids. There are no published reports on the biological activity.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-223180	211100-24-2	C20H32O5	50 µg/100 µg

• 17-trifluoromethylphenyl trinor Prostaglandin F2α
  Apart of the 17-phenyl trinor prostaglandin F2α group; a number of these derivatives have been approved for the treatment of glaucoma.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205062	221246-34-0	C24H31O5F3	1 mg/5 mg

• 17-trifluoromethylphenyl-13,14-dihydro trinor Prostaglandin F1α
  A lot of 17-aryl trinor and 16-aryloxy tetranor prostaglandin F2α derivatives have been approved for treatment of glaucoma. These “ring” prostaglandin (PG) analogs have improved efficacy over the PGs with an n-alkyl lower side chain. Of these, the ones where the 13,14-double bond has been hydrogenated retain relatively good potency, but show a significantly reduced incidence of local irritant side effects. 17-trifluoromethylphenyl-13,14-dihydro trinor PGF1α (17-TFM-PGF1α) is a typical “ring” analog reminiscent of trifluoromethyl-phenoxy ring of Travoprost. The a chain of 17-TFM-PGF1α is saturated, making this compound a formal member of the one-series PGs. Recent work has shown that in the “ring” series of analogs, this modification has little impact on FP receptor binding. As an ocular hypotensive agent, it is expected that 17-TFM-PGF1α would act like the free acid of latanoprost.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-223181	n.n.	C24H33F3O5	1 mg/5 mg

• 17-trifluoromethylphenyl-13,14-dihydro trinor Prostaglandin F2α
  A lot of 17-phenyl trinor prostaglandin F2α (17-phenyl trinor PGF2α) derivatives have been approved for treatment of glaucoma.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-223182	n.n.	C24H33O5F3	1 mg/5 mg

• 17,20-dimethyl Prostaglandin F1α
  17,20-dimethyl PGF1α is an analog of the limaprost family with structural modifications that give it a prolonged half-life and greater potency. Limaprost is an analog of PGE1 which is orally active in both rats and guinea pigs. The additional methyl groups in the lower side chain confer a 10-1,000 fold increase in potency over the parent compound. 17,20-dimethyl PGF1α has lower side chain modifications that are identical to limaprost. There are no published reports describing the pharmacology of 17,20-dimethyl PGF1α.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-223183	n.n.	C22H40O5	1 mg/5 mg

• 19(R)-hydroxy Prostaglandin A2
  Presumed to be a non-enzymatic dehydration metabolite of 19(R)-hydroxy PGE2, which is also found in semen.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205068	52087-58-8	C20H30O5	50 µg/100 µg

• 19(R)-hydroxy Prostaglandin B2
  Base treatment of human seminal plasma extracts converts 19-hydroxy PGE compounds present in sample into corresponding PGB compounds, generating strong conjugated dienone chromophores. This method has been used to provide a rapid, UV-based analytical method for PGE quantitation. Due to its chemical stability and strong UV absorbance at 278 nm, 19(R)-hydroxy PGB2 is also used as an internal standard in extractions and HPLC to determine recovery of arachidonic acid metabolites.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-223190	n.n.	C20H30O5	50 µg/100 µg

• 19(R)-hydroxy Prostaglandin E1
  Derived from PGE1 (sc-201223), has been shown to be an agonist for the EP1 (320 nM) and EP3 (80 nM) receptor subtypes, which leads to contraction of smooth muscle.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205069	64625-55-4	C20H34O6	50 µg/100 µg

• 19(R)-hydroxy Prostaglandin F1α
  An ω-1 hydroxylase metabolite of PGF1α that has been identified in the semen of humans and marsupials, 1,2 yet there are no published reports on its biological activity.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205070	81371-59-7	C20H36O6	50 µg/100 µg

• 15(R),19(R)-hydroxy Prostaglandin E2
  The inverse or “unnatural” isomer at C-15 of 19(R)-Hydroxy-prostaglandin E2 (sc-201252), associated with selectively agonizing EP2 receptors - useful in the deconvolution of EP-receptor function.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205037	54142-29-9	C20H32O6	50 µg/100 µg

• 15(R),19(R)-hydroxy Prostaglandin F1α
  19(R)-Hydroxylated prostaglandins occur in µg/ml concentrations in the semen of some mammalian species, especially primates. In the case of humans, the compounds are primarily of the PGE series, and the hydroxyl stereochemistry is 15(S),19(R). 19(R)-Hydroxylated prostaglandins are also found in the seminal plasma of marsupials, where F-type compounds of the 1 and 2-series predominate. The 15(R)-hydroxy epimer of these 19-hydroxylated prostaglandins is the inverse or “unnatural” isomer at C-15. The biological role of 19(R)-hydroxylated prostaglandins is not well established. In the F-series, 19(R)-hydroxylation is associated with a significant loss of receptor-mediated biological activity in some assays.3

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-220631	n.n.	C20H36O6	50 µg/100 µg

• 15(R),19(R)-hydroxy Prostaglandin F2α
  19(R)-Hydroxylated prostaglandins (PGs) occur in µg/ml concentrations in the semen of certain mammalian species, especially primates. In the case of humans, the compounds are primarily of the PGE series, and the hydroxyl stereochemistry is 15(S),19(R).1 19(R)-Hydroxylated PGs are also found in the seminal plasma of marsupials, where F-type compounds of the 1 and 2-series predominate.2 The 15(R)-hydroxy epimer of these 19-hydroxylated PGs is the inverse or “unnatural” isomer at C-15. In the F-series, 19(R)-hydroxylation is associated with a significant loss of receptor-mediated biological activity in some assays.3

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-220632	n.n.	C20H34O6	50 µg/100 µg

• 15(S)-15-methyl Prostaglandin 2
  A metabolically stable synthetic analog of PGD2, but unlik PGD2, 15(S)-15-methyl PGD2 induces vasoconstriction and increases systemic blood pressure with much reduced inhibitory activity on ADP-induced platelet aggregation. It also exhibits strong antifertility activity in hamsters.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205569	85280-90-6	C21H34O5	1 mg

• 15(S)-15-methyl Prostaglandin 2
  A metabolically stable synthetic analog of PGD2, but unlik PGD2, 15(S)-15-methyl PGD2 induces vasoconstriction and increases systemic blood pressure with much reduced inhibitory activity on ADP-induced platelet aggregation. It also exhibits strong antifertility activity in hamsters.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205570	85280-90-6	C21H34O5	5 mg

• AH 23848, calcium salt hydrate
  Thromboxane (TXA2) activates the T prostanoid (TP) receptor. Prostaglandin E2 (PGE2) activates four E prostanoid (EP) receptors, EP1-4. AH-23848 is a dual antagonist of TP1 and EP4 receptors. It originally was found to inhibit TXA2-induced platelet aggregation (IC₅₀ = 0.26 μM) and the contraction of human bronchial smooth muscle induced by the TP agonist U-46619. AH-23848 was subsequently demonstrated to impair PGE2-mediated relaxation of piglet saphenous vein by antagonizing the PGE2 receptor EP4. Through inhibiting EP4, it likewise suppresses serum-induced cAMP generation, cyclin A synthesis, as well as the proliferation of fibroblasts4, as well as reduces metastasis in a murine model of metastatic breast cancer.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-221224	n.n.	[C29H34NO5]2 ·Ca ·+ ·xH2O	1 mg/5 mg

• AL 8810
  An 11β-fluoro analog of PGF2α which acts as a potent and selective antagonist at the FP receptor.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205204	246246-19-5	C24H31O4F	1 mg/5 mg

• AL 8810 ethyl amide
  An analog of AL 8810 in which the C-1 carboxyl group has been modified to an N-ethyl amide. This modification is analogous to the PG N-ethyl amides, as typified by Bimatoprost, that have been introduced as alternative PG ocular hypotensive prodrugs.2 In contrast to AL 8810 which contracted the cat iris, AL 8810 ethyl amide showed no contraction activity at concentrations up to 10-4 M and did not antagonize the activity of PGF2α-ethanolamide in this system.3

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-221232	n.n.	C26H36FNO3	1 mg/5 mg

• AL 8810 isopropyl ester
  AL 8810 is an 11β-fluoro analog of prostaglandin F2α (PGF2α) which acts as a potent and selective antagonist at the FP receptor.1 AL 8810 isopropyl ester is a lipid soluble, esterified prodrug form of AL 8810 comparable to the commonly used therapeutic intraocular prostaglandin compounds such as Latanoprost2 and Travoprost.3 The pharmacology of AL 8810 isopropyl ester has not been published

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205205	208114-93-6	C27H37FO4	1 mg/5 mg

• AL 8810 methyl ester
  An 11β-fluoro analog of prostaglandin F2α (PGF2α) which acts as a potent and selective antagonist at the FP receptor. AL 8810 methyl ester is a lipid soluble, esterified prodrug form of AL 8810 analogous to the commonly used therapeutic intraocular PG compounds such as latanoprost2 and travoprost.3 The pharmacology of AL 8810 methyl ester has not been published.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-221233	n.n.	C25H33FO4	1 mg/5 mg

• Azelaoyl-PAF
  Potent PPARγ agonist which competes for the thiazoladinedione binding site. More potent compared to 15-deoxy-Δ12,14-prostaglandin J2 and equipotent with rosiglitazone as a ligand for this receptor.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-221278	n.n.	C33H66NO9P	1 mg/5 mg

• Beraprost (sodium salt)
  An analog of prostacyclin. Oral beraprost therapy improved the survival and pulmonary hemodynamics of patients with primary pulmonary hypertension.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-204644	88475-69-8	C24H29O5 ·Na	1 mg/5 mg

• Bicyclo Prostaglandin E2
  A stable breakdown product of the PGE2 (sc-201225) metabolite 13,14-dihydro-15-keto Prostaglandin E2 (sc-205000) - typically used to measure the biosynthesis and disposition of PGE2 due to its superior stability.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205222	74158-09-1	C20H30O4	1 mg/5 mg

• Bicyclo Prostaglandin E2 Lipid Maps MS Standard
  A stable breakdown product of the PGE2 (sc-201225) metabolite 13,14-dihydro-15-keto Prostaglandin E2 (sc-205000) - typically used to measure the biosynthesis and disposition of PGE2 due to its superior stability.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205223	74158-09-1	C20H30O4	1 mg/5 mg

• Bicyclo Prostaglandin E1
  Bicyclo Prostaglandin E1 (bicyclo PGE1) is a stable, base-catalyzed transformation product of the PGE1 metabolite 13,14-dihydro-15-keto PGE1. A stable, base-catalyzed transformation product of the PGE1 metabolite 13,14-dihydro-15-keto PGE1. 1

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-221356	n.n.	C20H32O4	1 mg/5 mg

• Bimatoprost
  Converted by an amidase enzymatic activity in the bovine and human cornea to yield the corresponding free acid. The free acid, 17-phenyl trinor PGF2α, is a potent FP receptor agonist. In human and animal models of glaucoma, FP receptor agonist activity corresponds very closely with intraocular hypotensive activity.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205224	155206-00-1	C25H37NO4	1 mg/5 mg

• Bimatoprost amide
  An F-series prostaglandin analog in which the C-1 carboxyl group has been modified to an unsubstituted amide; a potential hypotensive prodrug.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205225	155205-89-3	C23H33NO4	1 mg/5 mg

• Bimatoprost cyclopropyl amide
  17-phenyl trinor Prostaglandin F2α ethyl amide (17-phenyl trinor PGF2α ethyl amide) is sold under the Allergan trade name Bimatoprost and is an F-series prostaglandin analog which has been approved for use as an ocular hypotensive drug. The free acid, 17-phenyl trinor PGF2α, is a potent FP receptor agonist. Bimatoprost cyclopropyl amide is a novel analog of Bimatoprost. Currently, there are no published reports on the biological activity of Bimatoprost cyclopropyl amide.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-221358	n.n.	C26H37NO4	1 mg/5 mg

• Bimatoprost diethyl amide
  Bimatoprost diethyl amide is an analog of PGF2α wherein the C-1 carboxyl group has been modified to an N-diethyl amide. Prostaglandin esters have been shown to have ocular hypotensive activity. Prostaglandin N-ethyl amides were recently introduced as alternative prostaglandin hypotensive prodrugs. Studies have shown that bovine and human corneal tissue converts the N-ethyl amides of various prostaglandins to the free acids with a conversion efficiency of about 2.5 µg/g corneal tissue/hr. However, dialkyl amides such as bimatoprost diethyl amide are inert to corneal amidase activity, and are not converted in any detectable amount to the corresponding free acids. These compounds may therefore be useful tools in elucidating the claim that prostaglandin amides have intrinsic intraocular hypotensive activity.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-221359	n.n.	C27H41NO4	1 mg/5 mg

• 17-phenyl trinor PGF2α isopropyl ester
  An F-series prostaglandin analog which has been approved for use as an ocular hypotensive drug.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205226	130209-76-6	C26H38O5	1 mg/10 mg

• Bimatoprost serinol amide
  2-Arachidonyl glycerol (2-AG) exhibits cannabinoid agonist activity at the CB1 receptor,1 is an important endogenous monoglyceride species,2 and is thus considered to be the natural ligand for the CB1 receptor. 2-AG can also be metabolized by COX-2 to form prostaglandin 2-glyceryl esters.3 These 2-glyceryl esters rapidly equilibrate to form 90:10 mixtures favoring the more stable 1-glyceryl ester. Bimatoprost serinol amide is a stable analog of PGF2α 2-glyceryl ester incorporating an activity-enhancing 17-phenyl substitution. The biological activity of bimatoprost serinol amide has not yet been determined.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-221360	n.n.	C26H39NO6	1 mg/5 mg

• Bimatoprost-d4
  17-phenyl trinor Prostaglandin F2α ethyl amide-d4 (17-phenyl trinor PGF2α ethyl amide-d4) contains four deuterium atoms at the 3, 3, 4, and 4 positions. It is intended for use as an internal standard for the quantification of 17-phenyl trinor PGF2α ethyl amide by GC- or LC-mass spectrometry. 17-phenyl trinor PGF2α ethyl amide is an F-series prostaglandin analog which has been approved for use as an ocular hypotensive drug. There is some controversy as to whether 17-phenyl trinor PGF2α N-ethyl amide is a prodrug analogous to prostaglandin ester prodrugs such as latanoprost. There is some evidence that unmetabolized Bimatoprost is a weak FP receptor agonist. Investigations have shown that Bimatoprost is converted by an amidase enzymatic activity in the bovine and human cornea to yield the corresponding free acid, with a conversion rate of about 40 µg/g corneal tissue/24 hours. The free acid, 17-phenyl trinor PGF2α, is a potent FP receptor agonist.In human and animal models of glaucoma, FP receptor agonist activity corresponds very closely with intraocular hypotensive activity.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-221361	n.n.	C25H32D4NO4	25 µg/50 µg

• Bimatoprost, free acid
  Bimatoprost (free acid) is a metabolically stable analog of PGF2α and is a potent agonist for the FP receptor. It binds to the FP receptor on ovine luteal cells with a relative potency of 756% compared to that of PGF2α. Bimatoprost inhibits PGF2α binding with a Ki of 1.1 nM at the rat recombinant FP receptor expressed in CHO cells. The isopropyl ester of bimatoprost is slightly better than PGF2α isopropyl ester in reducing the intraocular pressure in the cat eye with no irritation.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-223818	38344-08-0	C23H32O5	1 mg/5 mg

• Bimatoprost, free acid-d4
  This compound contains four deuterium atoms at the 3, 3', 4, and 4' positions. It is intended for use as an internal standard for the quantification of bimatoprost (free acid) by GC- or LC-mass spectrometry. Bimatoprost (free acid) is a metabolically stable analog of prostaglandin F2α (PGF2α) and is a potent agonist for the FP receptor. It binds to the FP receptor on ovine luteal cells with a relative potency of 756% compared to that of PGF2α. At the rat recombinant FP receptor expressed in CHO cells bimatoprost (free acid) inhibits PGF2α binding with a K_i of 1.1 nM. The isopropyl ester of bimatoprost (free acid)-d4 is slightly better than PGF2α isopropyl ester in reducing the intraocular pressure in the cat eye without any irritation.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-221362	n.n.	C23H28D4O5	25 µg/50 µg

• Butaprost, free acid
  Butaprost is an EP2 selective agonist that has frequently been used to pharmacologically define the EP receptor expression profile of various human and animal tissues and cells. Prostaglandin free acids generally bind to their cognate receptors with 10 to 100 times the affinity of the corresponding ester derivative. Consistent with this trend, butaprost binds to membranes from EP2 receptor-transfected CHO cells with a Ki value of 2,400, whereas butaprost, free acid exhibits a significantly lower Ki value of 73 nM. Butaprost (free acid) is therefore another useful tool for characterizing EP receptor-mediated signalling events.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-223847	433219-55-7	C23H38O5	500 µg/1 mg

• BW 245C
  A selective agonist for the DP1 receptor, where the K_i for the inhibition of [3H]-PGD2 binding to isolated human platelet membranes is 0.9 nM. This compound has a reported IC₅₀ of 2.5 nM for the inhibition of ADP-induced human platelet aggregation and an IC₅₀of 250 nM for the inhibition of rat platelet aggregation.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205230	72814-32-5	C19H32N2O5	1 mg/5 mg

• BW 246C
  The less active C-8 diastereomer of the DP receptor agonist BW 245C. The activity of BW 245C is 70-fold greater than that of BW 246C.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205231	65705-83-1	C19H32N2O5	1 mg/5 mg

• BW A868C
  Hydantoin compound structurally related to the DP agonist BW245C. BW A868C antagonizes prosaglandin D2 and BW245C-induced activation of human platelet adenylate cyclase. Has been shown to antagonize accumulation of cAMP in rabbit non-pigmented ciliary epithelial cells. Shows virtually no effect on human TP, IP, EP1, EP2, and FP receptors. K_i is approximately 1.7 nM.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-204660	118675-50-6	C25H37N3O5	1 mg/10 mg

• Carbaprostacyclin-biotin
  A structural analog of prostacyclin (PGI2) with about 1/10 the receptor binding affinity of prostacyclin. It is a relatively indiscriminant ligand for prostaglandin receptors, binding to all the recombinant human PG receptors, except the TP receptor, with an affinity which is a significant fraction of the natural ligand. Carbaprostacyclin-biotinamide is therefore a useful affinity ligand for the binding and purification of a number of different receptors subtypes.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-221394	n.n.	C36H60N4O5S	100 µg/500 µg

• CAY10404
  One of the most selective inhibitors of COX-2 which has been reported to date, with a selectivity index (SI; SI = IC₅₀ COX-1/IC₅₀ COX-2) of >500,000. (The COX-1 IC₅₀ is >500 mM, and COX-2 IC₅₀ is <1 nM.) As a reference point, the SI of celecoxib is about 400. Thus, compound has an SI which is several logs greater than the first generation of selective COX-2 inhibitors, and is comparable to the SI of second generation selective COX-2 inhibitors, such as valdecoxib and etoricoxib.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-223860	n.n.	C17H12F3NO3S	1 mg/5 mg

• CAY10449
  Potent compounds with high-affinity ligands and functional antagonists for the human IP (prostacyclin) receptor. Antagonizes the carbaprostacyclin-induced activation of human neuroblastoma adenylate cyclase, blocking cyclic AMP accumulation in a dose-dependent manner. Likewise, it inhibits the binding of tritiated iloprost to rodent neuroblastoma cells with a Ki of about 3 nM.1

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-223863	n.n.	C19H21N3O2	1 mg/5 mg

• CAY10471
  The biological effects of prostaglandin D2 are transduced by at least two 7-transmembrane G-protein coupled receptors, designated DP1 and CRTH2/DP2. BAY-u3405 (Ramatroban) is approved to be used as human medication for the treatment of allergic rhinitis that has recorded activity as an antagonist of both the TP and CRTH2/DP2 receptors (1,2). CAY10471 is an analog of BAY-u3405 which contains modifications that increase both its selectivity and potency for the human CRTH2/DP2 receptor (3). CAY10471 binds to the human CRTH2/DP2, DP1, and TP receptors with Ki values of 0.6, 1200, and >10,000 nM, respectively (3).

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-221402	627865-18-3	C21H21FN2O4S	1 mg/5 mg

• CAY10526
  Inhibits prostaglandin E2 (PGE2) production through the selective modulation of mPGES-1 expression. It dose-dependently inhibits PGE2 production in lipopolysaccharide-stimulated RAW 264.7 cells without any effect on COX-2 expression.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-223868	938069-71-7	C12H7BrO3S	1 mg/5 mg

• CAY10595
  The biological effects of prostaglandin D2 (PGD2) are transduced by at least two 7-transmembrane G protein-coupled receptors, designated CRTH2/DP2 and DP1. In humans, CRTH2/DP2 is expressed on Th2 cells, basophils and eosinophils where it mediates the chemotactic activity of PGD2. CAY10595, as a racemic mixture, is a potent CRTH2/DP2 receptor antagonist that binds the human receptor with a K_ι value of 10 nM . The R-enantiomer of CAY10595 is significantly more potent exhibiting K_ι values of 5 and 5.3 nM at the murine and human CRTH2/DP2 receptor, respectively. The R- enantiomer of CAY10595 inhibits eosinophil chemotaxis induced by 13,14-dihydro-15-keto-PGD2 with an IC₅₀ value of 7.3 nM.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-223875	916047-16-0	C20H13Cl2FN2O5	1 mg /5 mg

• Ciprostene (calcium salt)
  This product has been shown to exhibit biological activity similar to PGI2, and to induce hypotension and causes tachycardia.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205247	81703-55-1	C44H72Ca2O8	1 mg/5 mg

• (+)-Cloprostenol
  The optically active, 15(R) enantiomer of cloprostenol responsible for the majority of its biological activity; a synthetic analog of prostaglandin F2α (PGF2α).

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205259	54276-21-0	C22H29ClO6	1 mg/5 mg

• (+)-Cloprostenol (sodium salt)
  A more water soluble, crystalline form of (+)-cloprostenol; an FP receptor agonist and a potent luteolytic agent in rats and hamsters.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205260	62561-03-9	C22H28ClO6 ·Na	1 mg/5 mg

• Corey Lactone Aldehyde Benzoate
  Corey lactone aldehyde benzoate is a versatile, chiral intermediate used in the preparation of prostaglandins and prostaglandin analogs.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205265	39746-01-5	C15H14O5	500 mg/1 g

• (−)-Corey Lactone Diol
  The reduced version of Corey aldehyde, with alcohol groups at both C-11 and C-13. This allows the introduction of ω chain constituents via alternate chemistries, such as nucleophilic displacements.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205266	32233-40-2	C8H12O4	1 g/5 g

• Corey PG-Lactone Diol
  Versatile, chiral intermediate used to prepare prostaglandins and prostaglandin analogs.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-223900	n.n.	C15H24O4	1 g/5 g

• Δ17-U-46619
  The first direct, stable analog of TXA3 ever synthesized. There are no published reports on its activity to date.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-221739	n.n.	C21H32O4	50 µg/100 µg

• Δ12-Prostaglandin D2
  Prostaglandin D2 is one of the five primary enzymatic prostaglandins derived directly from PGH2. PGD2 is produced abundantly in the CSF by the lipocalin-type PGD synthase, and in the periphery by myeloid cells including mast cells and basophils by a second, hematopoietic-type PGD synthase. PGD2 is chemically unstable, and its use and analysis is complicated by its short in vivo half-life. Δ12-PGD2 is one of the initial chemical decomposition products of PGD2. Δ12-PGD2 is an intermediate in the pathway leading to Δ12-PGJ2, which is a cyclopentenone prostaglandin with antimitotic and carcinogenic activities. The metabolism of Δ12-PGD2 involves the addition of thiol nucleophiles.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-224019	64072-89-5	C20H32O5	500 µg/1 mg

• Δ17-6-keto Prostaglandin F1α
  The non-enzymatic hydrolysis product of PGI3. PGI3 is a COX pathway metabolite of EPA in various tissues such as seminal vesicles, PMNL, lung and ocular tissues.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205548	68324-95-8	C20H32O6	100 µg/500 µg

• Δ17-Prostaglandin E1
  A naturally occurring E-series prostaglandin produced by the COX metabolism of ω-3 arachidonic acid; about half as potent as PGE1 as an inhibitor of ADP-induced aggregation of rabbit PRP.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205549	7046-45-9	C20H32O5	1 mg/5 mg

• ent-8-iso Prostaglandin F2α
  A prostaglandin F2α (sc-201227) analog formed non-enzymatically via free radical peroxidation of Arachidonic Acid (sc-200770).

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-221587	n.n.	C20H34O5	25 µg/50 µg

• ent-8-iso Prostaglandin F2α-d9
  A labeled prostaglandin F2α (sc-201227) analog which is formed non-enzymatically via free radical peroxidation of Arachidonic Acid (sc-200770).

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-221588	n.n.	C20H25D9O5	10 µg/25 µg

• ent-8-iso-15(S)-Prostaglandin F2α
  A biologically active isoprostane produced by the non-enzymatic free radical catalyzed peroxidation of arachidonic acid (sc-200770), showing vasoconstrictive activity.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-221589	n.n.	C20H34O5	25 µg/50 µg

• ent-Prostaglandin E2
  The enantiomer of PGE2 (sc-201225), formed in vitro in oxidative stress conditions, and useful in the deconvolution of prostaglandin biochemistry.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205311	65085-69-0	C20H32O5	1 mg/5 mg

• ent-Prostaglandin F2α
  The opposite enantiomer of PGF2α. Generated via the isoprostane pathway of free radical-catalyzed lipid peroxidation and has been implicated as a marker of oxidative stress. Levels are elevated in human urine from heavy cigarette smokers and patients with hypercholesterolemia.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205312	54483-31-7	C20H34O5	1 mg/5 mg

• (+)-Fluprostenol
  Is the metabolically stable analog of PGF2α. Is a potent FP prostanoid receptor agonist. The optically active enantiomer of fluprostenol. Expected potency is 2x that of (+/−)-fluprostenol. PGF2α binding to human and rat FP receptors is. An effective inhibitor of rat adipose precursor differentiation in primary cultures.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205326	54276-17-4	C23H29F3O6	1 mg/10 mg

• (+)-Fluprostenol Lactone Diol
  An intermediate used in the preparation of (+)-fluprostenol.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-221618	n.n.	C18H19F3O5	100 mg/500 mg

• (+)-Fluprostenol methyl amide
  The optically active enantiomer of fluprostenol and would be expected to have twice the potency as the racemic mixture. (+)-Fluprostenol methyl amide is a methyl amide analog of (+)-fluprostenol. There are no published reports on the biological activity of (+)-fluprostenol methyl amide.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-221619	n.n.	C24H32F3NO5	1 mg/5 mg

• (+)-Fluprostenol methyl ester
  An F-series prostaglandin analog which, for many years, has been approved for as a luteolytic in veterinary animals. The isopropyl ester of fluprostenol (travoprost) is an effective ocular hypotensive drug. This compound is a methyl ester analog of fluprostenol.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205328	73275-76-0	C24H31F3O6	1 mg/5 mg

• (+)-Fluprostenol-d4
  Fluprostenol-d4 contains four deuterium atoms at the 3, 3', 4, and 4' positions. It is intended for use as an internal standard for the quantification of fluprostenol by GC- or LC-mass spectrometry. Fluprostenol is a metabolically stable analog of prostaglandin F2α (PGF2αα) with potent FP receptor agonist activity.It inhibits PGF2α binding to human and rat FP receptors with IC₅₀ values of 3.5 and 7.5 nM, respectively. Fluprostenol is a much more potent luteolytic agent than PGF2α in rats with a minimum fully effective dose of 270 · g/kg to terminate pregnancy. It is also an effective inhibitor of rat adipose precursor differentiation in primary cultures with an IC₅₀ value of 3-10 x 10-11 M.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-221621	n.n.	C23H25D4F3O6	50 µg/100 µg

• HQL-79
  A selective inhibitor of hematopoietic prostaglandin D (PGD) synthase.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205344	162641-16-9	C22H27N5O	1 mg/5 mg

• Iloprost
  A second generation structural analog of prostacyclin (PGI) with about ten-fold greater potency than the first generation stable analogs; binds with equal affinity to the human recombinant EP1 and IP receptors.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205349	78919-13-8	C22H32O4	500 µg/1 mg

• iPF2α-IV
  One of dozens of possible stereo- and regioisomeric isoprostanes which can be created from arachidonic acid. iPF2α-IV is an isoprostane from the relatively unexplored Type IV isoprostanes.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205352	331962-00-6	C20H34O5	25 µg/50 µg

• iPF2α-VI-d4
  Intended for use as an internal standard for the quantification of iPF2α-VI by GC- or LC-mass spectrometry.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205353	214977-79-4	C20H30D4O5	10 µg/25 µg

• Latanoprost (free acid)
  An F-series prostaglandin (PG) analog which has been approved for use as an ocular hypotensive drug.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205364	41639-83-2	C23H34O5	1 mg/5 mg

• Latanoprost (free acid)-d4
  Contains four deuterium atoms at the 3, 3, 4, and 4 positions. It is intended for use as an internal standard for the quantification of Lat-FA by GC- or LC-mass spectrometry.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-221832	n.n.	C23H30D4O5	50 µg/100 µg

• Latanoprost ethyl amide
  An F-series prostaglandin analog in which the C-1 carboxyl group has been modified to an N-ethyl amide.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-221833	n.n.	C25H39NO4	1 mg/5 mg

• Latanoprost ethyl amide-d4
  Contains four deuterium atoms at the 3, 3', 4, and 4' positions. It is intended for use as an internal standard for the quantification of Lat-NEt by GC- or LC-mass spectrometry.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-221834	n.n.	C25H34D4NO4	25 µg/50 µg

• Latanoprost Lactol
  An F-series prostaglandin analog which has been approved for use as an ocular hypotensive drug. Latanoprost lactol is an intermediate in the synthesis of latanoprost. Latanoprost lactol can be converted to the free acid of latanoprost by Wittig reaction with commercially available reagents.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205365	352276-28-9	C18H26O4	5 mg/10 mg

• Latanoprost Lactone Diol
  An F-series prostaglandin analog, approved for use as an ocular hypotensive drug. It is an intermediate in the synthesis of latanoprost. Latanoprost lactone diol can be converted to the free acid of latanoprost by reduction with DIBAL followed by Wittig reaction with commercially available reagents.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205366	145667-75-0	C18H24O4	10 mg/50 mg

• Latanoprost-d4
  Contains four deuterium atoms at the 3, 3', 4, and 4' positions. It is intended for use as an internal standard for the quantification of latanoprost by GC- or LC-mass spectrometry.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-221835	n.n.	C26H36D4O5	50 µg/100 µg

• Limaprost
  An analog of PGE1 with structural modifications intended to give a prolonged half-life and greater potency; 10-1,000 times more potent than PGE1 as a platelet adhesive inhibitor.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205374	74397-12-9	C22H36O5	1 mg/5 mg

• Lumula
  A hybrid eicosanoid analog which incorporates the “docosanoid” features of unoprostone as well as the “prostamide” features of bimatoprost.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-221863	n.n.	C24H43NO4	1 mg/5 mg

• Misoprostol (free acid)
  A synthetic E prostaglandin that has been shown to prevent tissue corrosion induced by certain anti-inflammatory compounds. Shown to have negative effects on the murine nervous system.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205390	112137-89-0	C21H36O5	1 mg/5 mg

• Misoprostol (free acid)-d5
  A deuterium labeled version of Misoprostol (SC-29333), a synthetic E prostaglandin shown to prevent tissue corrosion induced by certain anti-inflammatory compounds. Shown to have negative effects on the murine nervous system.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-221944	n.n.	C21H31D5O5	50 µg/250 µg

• NS-304
  A prodrug of the active form of MRE-269, which is a potent and selective agonist for the human IP receptor.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205416	475086-01-2	C26H32N4O4S	1 mg/5 mg

• PGA1 (Prostaglandin A1)
  An anti-inflammatory cyclopentenone prostaglandin, biosynthesized from dihomo-γ-linolenic acid, shown to stimulate renin release, inhibit NFκB activation, activate PPARs, and much more.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-201213	14152-28-4	C20H32O4	1 mg/10 mg

• PGA2 (Prostaglandin A2)
  Shown to possess antitumor activity, induce γ-glutamylcysteine synthetase and apoptosis in L-1210 cells, and to activate intrinsic apoptotic pathways by directly stimulating mitochondrial outer membrane permeabilization.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-201215	13345-50-1	C20H30O4	1 mg/10 mg

• PGB1 (Prostaglandin B1)
  A nonenzymatic dehydration product of PGE1(sc-201223) and a metabolite of PGA1(sc-201213) that has been shown to modify the pressor responses to sympathetic nerve stimulation.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-201217	13345-51-2	C20H32O4	1 mg/10 mg

• PGB2 (Prostaglandin B2)
  Most abundant prostaglandin released from osteoblasts. Inhibits glucagon-stimulated hepatocyte cAMP accumulation.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-201219	13367-85-6	C20H30O4	1 mg/10 mg

• PGD2 (Prostaglandin D2)
  A major cellular regulator shown to bind to the DP and CRTH2 receptors, that inhibits platelet aggregation, proliferation of cells, activation of neutrophils, and is thought to be involved in sleep regulation.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-201221	41598-07-6	C20H32O5	1 mg/10 mg

• PGE1 (Prostaglandin E1)
  A potent vasodilator, inhibitor of human platelet aggregation, and has been shown to affect PKC and adenylate cyclase - yielding a multitude of physiological implications.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-201223	745-65-3	C20H34O5	1 mg/10 mg

• PGE2 (Prostaglandin E2)
  The most physiologically abundant eicosanoid, nearly ubiquitous through all cell types, demonstrating an astounding number of biological functions, including neuronal, metabolic, and immune system activities.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-201225	363-24-6	C20H32O5	1 mg/10 mg

• PGF1α (Prostaglandin F1α)
  A biosynthesis product from dihomo-γ-linolenic acid (DGLA) via the cyclooxygenaze (COX) pathway, a stable metabolite of prostacyclin (sc--201231), and a smooth muscle relaxant.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-201229	745-62-0	C20H36O5	1 mg/10 mg

• PGF2α (Prostaglandin F2α)
  A major uterine luteolytic prostaglandin, an endogenous agonist of PGF2Rα shown to: promote neutrophil chemotaxis, stimulate COX2 expression, and regulate adrenal endocrine function.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-201227	38562-01-5	C24H45NO8	1 mg/10 mg

• PGH2 (Prostaglandin H2)
  A thromboxane A2 precursor that is a potent platelet aggregator of vascular smooth muscle contraction.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-201266	42935-17-1	C20H32O5	50 µg/1 mg

• PGI2·Na (Prostaglandin I2·Na, Prostacyclin)
  An unstable eicosanoid (t_1/2 ~ 2 minutes under physiological conditions) shown to induce vasodilation, inhibit platelet aggregation, as well as demonstrate fibrinolytic and cytoprotective activity.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-201231	61849-14-7	C20H31O5 ·Na	1 mg/10 mg

• PGJ2 (Prostaglandin J2)
  A metabolite of PGD2 (sc-201221) that has been shown to inhibit platelet aggregation, smooth muscle proliferation, and phosphoinositide turnover. Demonstrates anti-neoplastic and antiviral activity.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-201248	60203-57-8	C20H30O4	1 mg/10 mg

• Prostaglandin A1 ethyl ester
  Prostaglandins of the A-series are natural products of gorgonian soft coral. It is a prodrug form of PGA1 with enhanced lipid solubility where PGA1 has been shown to cause increased urine sodium excretion, lowered arterial pressure in hypertensive patients and renal vasodilation. There are no published reports on the biological activity of this chemical at this time.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205443	93464-24-5	C22H36O4	1 mg/5 mg

• Prostaglandin A3
  The presence of PGE3 has been reported in biosynthetic preparations of ovine seminal vesicles1 and in the ocular tissues of primates.2 PGA3 exhibits good affinity for the canine EP2 and EP4 receptors in a radioligand binding assay3,4 and has a weak affinity for human PPARγ.5

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205444	36614-31-0	C20H28O4	100 µg/1 mg

• Prostaglandin A1-biotinamide
  One of the cyclopentenone prostaglandins, that have well documented antimitotic and antiproliferative effects. The activity of the compounds in this class, which include prostaglandins in both the A- and J-series, may result from changes in gene expression and the interaction with non-classical pathways. An affinity probe which allows PGA1 to be detected through an interaction with the biotin ligand and was designed to allow PGA1 to be detected in complexes with DNA and/or other nucleic acid or protein binding partners. A tool to be used in the general elucidation of the mechanism of action of the cyclopentenone prostaglandins.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-224212	n.n.	C36H60N4O5S	100 µg/500 µg

• Prostaglandin A2-d4
  Contains four deuterium atoms at the 3, 3', 4, and 4' positions and is intended for use as an internal standard for the quantification of PGA2 by GC- or LC- mass spectrometry. A naturally occurring prostaglandin in gorgonian corals where it may function in self defense. It is generally not present in mammalsand has low biological potency in most bioassays, but does show some antiviral/antitumor activity.1 At a 25 µM concentration, PGA2 blocks the cell cycle progression of NIH 3T3 cells at the G1 and G2/M phase.2 It has also been shown to act as a vasodilator with natriuretic properties.3

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-224213	n.n.	C20H26D4O4	50 µg/100 µg

• Prostaglandin B3
  A non-enzymatic dehydration product resulting from the treatment of Prostaglandin E3 (PGE3) with strong base.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205445	36614-32-1	C20H28O4	100 µg/500 µg

• Prostaglandin B2-d4
  Contains four deuterium atoms at the 3, 3', 4, and 4' positions and is intended for use as an internal standard for the quantification of PGB2 by GC- or LC-mass spectrometry. A non-enzymatic dehydration product resulting from the treatment of PGE2 or PGA2 with strong base. It has weak agonist activity on TP receptors and can increase pulmonary blood pressure in the rabbit at relatively high doses (5 mg/kg).

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-224214	n.n.	C20H26D4O4	100 µg/50 µg

• Prostaglandin Bx
  A mixture of oligomers of PGB1 (sc-201217) with a molecular weight of 1,000-1,500, that has demonstrated anti-inflammatory and cytoprotective activity.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-222193	39306-29-1	(PGB)n ·n=3-5	500 µg/1 mg

• Prostaglandin D1
  PGD1 an inhibitor of ADP-induced platelet aggregation in humans with a potency about 1/10 of PGD2.1

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205446	17968-82-0	C20H34O5	1 mg/5 mg

• Prostaglandin D2 Ethanolamide
  A PGD2 (sc-201221) analog formed via Anandamide (Arachinodoyl Ethanolamine; AEA; sc-200790), which acts as a substrate for cyclooxygenase.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205447	398138-28-8	C22H37NO5	1 mg/5 mg

• Prostaglandin D2-1-glyceryl ester
  The glycero-ester of PGD2 (sc-201221) that is structurally similar to the endocannabinoid 2-AG; little is know about the biological activity of this prostaglandin derivative.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205448	309260-52-4	C23H38O7	1 mg/5 mg

• Prostaglandin D3
  Produced via the metabolism of EPA in the COX pathway. Compound is equipotent to PGD2 in decreasing systemic blood pressure in rats and in decreasing intraocular pressure in rabbits. It is 3-5 times more potent than PGD2 in the inhibition of ADP-induced human platelet aggregation.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205449	71902-47-1	C20H30O5	50 µg/100 µg

• Prostaglandin D1 Alcohol
  The synthetic analog of PGD1 with a primary alcohol in place of the C-1 carboxyl. PGD1 is the theoretical D-series metabolite of dihomo-γ-linolenic acid (DGLA), but to date it has not been isolated as a natural product. An inhibitor of ADP-induced platelet aggregation in humans with an IC₅₀ value of 320 ng/ml, about 1/10 as potent as PGD2.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-224215	1176470-37-3	C20H36O4	1 mg/5 mg

• Prostaglandin D1-d4
  Contains four deuterium atoms at the 3, 3', 4, and 4' positions and is intended for use as an internal standard for the quantification of PGD1 by GC- or LC-mass spectrometry. The theoretical D-series metabolite of dihomo-γ-linolenic acid (DGLA), but to date it has not been isolated as a natural product. It is an inhibitor of ADP-induced platelet aggregation in humans with an IC₅₀value of 320 ng/ml, about 1/10 as potent as PGD2.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-224216	n.n.	C20H30D4O5	25 µg/50 µg

• Prostaglandin D2 methyl ester
  The major eicosanoid product of mast cells and is produced in large quantities by hematopoietic PGD synthase during allergic and asthmatic anaphylaxis. It causes vasodilation, flushing, hypotension, and is an inhibitor of platelet aggregation. PGD2 is also produced in the brain via a soluble, secreted PGD-synthase also known as β-trace. In the brain, PGD2 produces normal physiological sleep and lowering of body temperature. PGD2 methyl ester is a more lipid-soluble, cell-permeable prodrug form of PGD2.5 It binds to the human and murine PGD2 receptors (DP1 and CRTH2/DP2) with 5-10 fold lower affinity than PGD2.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-222194	49852-81-5	C21H34O5	500 µg/1 mg

• Prostaglandin D2 serinol amide
  Exhibits cannabinoid (CB) agonist activity at the CB1 receptor,1 and is an important endogenous monoglyceride species,2 which is considered to be the natural ligand for the CB1 receptor. Can also be sequentially metabolized by COX-2 and specific PG synthases to form PG 2-glyceryl esters.3 In activated RAW 264.7 cells, PGD2 2-glyceryl ester is the primary product of 2-AG metabolism in the COX pathway.3 PGD2 serinol amide (PGD2-SA) is a stable analog of PGD2 2-glyceryl ester. Unlike PGD2 2-glyceryl ester and other fatty acyl 2-glyceryl esters, PGD2-SA will not isomerize to the less active primary (1-glyceryl) ester.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-224217	63928-03-0	C23H39NO6	1 mg/5 mg

• Prostaglandin D2-d9
  Contains nine deuterium atoms at the 17, 17', 18, 18', 19, 19', 20, 20, and 20 positions and is intended for use as an internal standard for the quantification of PGD2 by GC- or LC-mass spectrometry. PGD2 is the major eicosanoid product of mast cells and is released in large quantities during allergic and asthmatic anaphylaxis.Mastocytosis patients produce excessive amounts of PGD2, which causes vasodilation, flushing, hypotension, and syncopal episodes. PGD2 is produced in the brain via an alternative pathway involving a soluble, secreted PGD-synthase and known as β-trace. In the brain, Produces normal physiological sleep and lowering of body temperature. Further pharmacological actions include inhibition of platelet aggregation and relaxation of vascular smooth muscle. PGD2 inhibits human ovarian tumor cell proliferation with an IC₅₀ value of 6.8 µM.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-224218	n.n.	C20H23D9O5	25 µg/50 µg

• Prostaglandin E1 Ethanolamide
  Prostaglandin E1 ethanolamide (PGE1-EA) is the ethanolamine-amide analog of PGE1. Conversion of AEA, the ethanolamide of arachidonic acid, to PGE2-EA has been determined in vitro. It is not established whether this conversion occurs in whole animals, nor has the pharmacology of the resultant prostaglandin ethanolamides been rigorously studied.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205450	210976-81-1	C22H39NO5	1 mg/5 mg

• Prostaglandin E2 p-acetamidophenyl ester
  A crystalline derivative of PGE2 (sc-201225) that is esterified at the carboxylic acid moiety - potentially useful in structure-activity studies designed to probe prostaglandin receptor binding.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205451	57790-52-0	C28H39NO6	1 mg/5 mg

• Prostaglandin E2 p-benzamidophenyl ester
  A crystalline derivative of PGE2 (sc-201225) that is esterified at the carboxylic acid moiety. Potentially useful for structure-activity studies aimed to understand binding interactions between prostaglandins and their receptors.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205452	57790-53-1	C33H41NO6	1 mg/5 mg

• Prostaglandin E2-1-glyceryl ester
  The glycero-ester of PGE2 (sc-201225) that is structurally similar to the endocannabinoid 2-AG; little is know about the biological activity of this prostaglandin derivative.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205453	37497-47-5	C23H38O7	1 mg/5 mg

• Prostaglandin E3
  Formed via the COX metabolism of eicosapentaenoic acid,1 where in human ocular tissue, it comprises 2.4% of the COX products formed.1 When applied to the eyes of a rabbit, a 1 µg dose of PGE3 decreases intraocular pressure from 21 mmHg to about 17 mmHg.2

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205454	802-31-3	C20H30O5	50 µg/100 µg

• Prostaglandin E1 Alcohol
  PGE1 alcohol is a non-irritant bronchodilator, with relaxant activity on the human bronchial muscle in vitro, comparable to PGE1 at concentrations of 0.01 to 10.0 µg/ml. PGE1 alcohol binds to the mouse recombinant EP3 and EP4 receptors with K_i values of 330 and 190 nM, respectively. Asthmatics receiving single dose inhalation treatments reported significant but short-acting bronchodilation at doses of 10 and 30 µg.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-224219	21562-57-2	C20H36O4	500 µg/1 mg

• Prostaglandin E2 Ethanolamide
  An analog of PGE2 (sc-201225) with improved water solubility and stability, shown to act as an agonist with all four known EP receptor subtypes EP1 - EP4, and induce apoptosis in CRC cells.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-222196	194935-38-1	C22H37NO5	500 µg/1 mg

• Prostaglandin E2 methyl ester
  An analog of PGE2 (sc-201225) with enhanced lipid solubility, that is believed to be involved with rapid-eye-movement sleep regulation.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-224220	31753-17-0	C21H34O5	500 µg/1 mg

• Prostaglandin E2 serinol amide
  A stable analog of the PGE2 2-glyceryl ester, which equilibrates rapidly to the more stable 1-glyceryl ester (sc-205453) - potentially useful to probe the action of this elusive 2-glycero species.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-224221	n.n.	C23H39NO6	1 mg/500 µg

• Prostaglandin E2-PEG11-biotinamide
  A functionalized derivative of PGE2 (sc-201225) designed to allow PGE2 to be detected or immobilized using the biotin ligand without interference due to the lengthy and hydrophillic PEG11 linker.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-224222	n.n.	C54H96N4O17S	50 µg/100 µg

• Prostaglandin F1α Alcohol
  An analog of PGF1α with a primary alcohol replacing the C-1 carboxyl group. No biological activity has been published on this compund, but its corresponding analog, PGE1, is a relatively selective EP3 and EP4 receptor ligand.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205455	13487-47-3	C20H38O4	1 mg/10 mg

• Prostaglandin F1β
  PGF1β is the C-9 epimer of PGF1α. It was shown to improve respiratory rate in experimental animals when administered intravenously.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205458	10164-73-5	C20H36O5	1 mg/5 mg

• Prostaglandin F2α 1,11-lactone
  A lipid-soluble internal ester of PGF2α. Hydrolysis of the lactone by plasma esterases readily produces free PGF2α in rats and monkeys, but not in humans. PGF2α 1,11-lactone is active as an antifertility agent with greatly reduced vasoactivity compared to PGF2α.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205459	62410-84-8	C20H32O4	1 mg/5 mg

• Prostaglandin F2α 1,15-lactone
  A lipid-soluble internal ester of PGF2α. Hydrolysis of the lactone readily produces free PGF2α in plasma. In rhesus monkeys, a total dose of 15 mg of PGF2α 1,15-lactone terminates early pregnancy, whereas PGF2α is ineffectiv

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205460	55314-49-3	C20H32O4	1 mg/5 mg

• Prostaglandin F2α 1,9-lactone
  A lipid-soluble internal ester of PGF2α. Resistant to hydrolysis by human plasma esterases even after incubation for 20 hours under physiological conditions. PGF2α 1,9-lactone exhibits little antifertility and vasoactivity compared to PGF2α.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205461	55314-48-2	C20H32O4	1 mg/5 mg

• Prostaglandin F2α Alcohol
  An analog of PGF2α where the C-1 carboxyl group has been reduced to a primary alcohol. Studies on rat uteri display it as a weak agonist. Compounded is reported to retain ocular hypotensive properties, but the nature of these receptors which mediate said effects are disputed.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205456	13261-27-3	C20H36O4	1 mg/10 mg

• Prostaglandin F2α Alcohol methyl ether
  An analog of PGF2α in which the C-1 carboxyl group has been replaced an O-methyl ether. Reported to retain ocular hypotensive properties,1 but the receptors which mediate this activity have not been clearly documented.2

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205457	143656-18-2	C21H38O4	1 mg/10 mg

• Prostaglandin F2α dimethyl amide
  A weak FP receptor antagonist. In gerbil colon, PGF2α dimethyl amide at a dose of 3.2 µg/ml inhibits the contractile effects of PGF2α (at 6 ng/ml) by 50%.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205462	68192-15-4	C22H39NO4	1 mg/5 mg

• Prostaglandin F2α Ethanolamide
  Produced by COX-2 metabolism of the endogenous cannabinoid, arachidonoyl ethanolamide; a potent dilator of the cat iris sphincter, which is a model system for testing potential intraocular hypotensive agents.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205463	353787-70-9	C22H39NO5	1 mg/5 mg

• Prostaglandin F2α ethyl amide
  An analog of PGF2α where PG esters have displayed to have ocular hypotensive activity.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205464	54130-36-8	C22H39NO4	1 mg/5 mg

• Prostaglandin F2α isopropyl ester
  An ester prodrug of PGF2α with enhanced lipid solubility; the ester functionality is readily hydrolyzed in vivo to release the active compound PGF2α.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205465	53764-90-2	C23H40O5	1 mg/5 mg

• Prostaglandin F2α methyl ester
  One of the first prostaglandin esters shown to have ocular hypotensive activity; the methyl ester is about 4-5 times more potent than the free acid, PGF2α.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205466	33854-16-9	C22H38O5	500 µg/1 mg

• Prostaglandin F2α-1-glyceryl ester
  Equilibrates rapidly (within minutes) with the more stable 1-glyceryl ester, producing a 10:90 2:1-glyceryl ester mixture in typical aqueous media; little is known about its intrinsic biological activity.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205467	43042-79-1	C23H40O7	1 mg/5 mg

• Prostaglandin F2α-d4
  A widely distributed prostaglandin occurring in many species. Causes contraction of vascular, intestinal,bronchial, and myometrial smooth muscle, and also exerts potent luteolytic activity.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205468	34210-11-2	C20H30D4O5	50 µg/100 µg

• Prostaglandin F2β (tromethamine salt)
  A derivative of PGF2β with increased water solubility, and in PBS is 25 mg/ml compared to 10 mg/ml for PGF2β.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205469	89847-02-9	C24H45NO8	1 mg/5 mg

• Prostaglandin F3α
  A COX product of EPA, where the biosynthesis of this compound from EPA was demonstrated in vitro, in human and rabbit ocular tissues. It has only 25% affinity at the ovine luteal FP receptor compared to PGF2α.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205470	745-64-2	C20H32O5	100 µg/500 µg

• Prostaglandin F1α-d9
  Contains nine deuterium atoms at the 17, 17', 18, 18', 19, 19', 20, 20, and 20 positions and is intended for use as an internal standard for the quantification of PGF1α by GC- or LC-mass spectrometry. PGF1α is the putative metabolite of dihomo-γ-linolenic acid (DGLA) via the cyclooxygenase (COX) pathway. Both PGF1α and PGF2α have been shown to act as priming pheromones for male Atlantic salmon with a threshold concentration of 10-11 M. PGF1α binds to the ovine corpus luteum FP receptor at only 8% of the relative potency of PGF2α. But it is only half as active as PGF2α in inducing human respiratory smooth muscle contractions in vitro.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-224223	n.n.	C20H27D9O5	25 µg/50 µg

• Prostaglandin F2α diethyl amide
  An analog of PGF2α in which the C-1 carboxyl group has been modified to an N-diethyl amide. PG esters have ocular hypotensive activity.1 PG N-ethyl amides were recently introduced as alternative PG hypotensive prodrugs.2 Studies in our laboratories have shown that bovine and human corneal tissue convert the N-ethyl amides of various PGs to the free acids with a conversion efficiency of about 4 µg/g corneal tissue/hr.3 However, we find that dialkyl amides such as PGF2α-NEt2 are inert to corneal amidase activity, and not converted in any detectable amount to the corresponding free acids. These compounds may therefore be useful tools in elucidating the claim that PG amides have intrinsic intraocular hypotensive activity.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-224224	n.n.	C24H43NO4	1 mg/5 mg

• Prostaglandin F2α dimethyl amine
  A derivative of PGF2α that was designed as a PG antagonist for in vitro and in vivo studies. A weak FP receptor antagonist.1 In gerbil colon, PGF2α dimethyl amine at a dose of 3.2 µg/ml inhibits the contractile effects of PGF2α (at 6 ng/ml) by 60%.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-224225	n.n.	C22H41NO3	1 mg/5 mg

• Prostaglandin F2α serinol amide
  Exhibits cannabinoid agonist activity at the CB1 receptor, is an important endogenous monoglyceride species, and is therefore considered to be the natural ligand for the CB1 receptor. 2-AG can also be metabolized by COX-2 and prostaglandin D, E, F, and I synthases to form prostaglandin 2-glyceryl (PG 2-glyceryl) esters. PGF2α-SA is a stable analog of PGF2α 2-glyceryl ester.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-224227	n.n.	C23H41NO6	1 mg/5 mg

• Prostaglandin F2α-d9
  Contains nine deuterium atoms at the 17, 17', 18, 18', 19, 19', 20, 20, and 20 positions and is intended for use as an internal standard for the quantification of PGF2α by GC- or LC-mass spectrometry. PGF2α is a widely distributed PG occurring in many species. Which causes contraction of vascular, bronchial, intestinal, and myometrial smooth muscle, and also exhibits potent luteolytic activity.1 PGF2α exerts its receptor mediated physiological activity at 50-100 nM. Maximal ovine myometrial contraction can be achieved at 125 nM PGF2α in vitro.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-224228	n.n.	C20H25D9O5	25 µg/50 µg

• Prostaglandin F2a
  A major uterine prostaglandin that has been shown to cause contraction of vascular, bronchial, intestinal, myometrial smooth muscle, and to inhibit adipocyte differentiation.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-203219	551-11-1	C20H34O5	1 mg

• Prostaglandin F2α Ethanolamide-d4
  Contains four deuterium atoms at the 3, 3', 4, and 4' positions and is intended for use as an internal standard for the quantification of PGF2α-EA by GC- or LC-mass spectrometry. Produced by cyclooxygenase 2 (COX-2) metabolism of the endogenous cannabinoid arachidonoyl ethanolamide (AEA) found in brain, liver, and other mammalian tissues. AEA can be metabolized by fatty acid amide hydrolase (FAAH) to give free arachidonic acid, which is the well known and conventional substrate for COX enzymes. It has also been reported that AEA can be used directly by COX-2 to produce ethanolamide congeners of the classical prostaglandins, including PGE2. PGF2α-EA has been reported to be biosynthesized by this mechanism when AEA was infused into the lung and liver of living mice. It is a potent dilator (EC₅₀ = 58 nM) of the cat iris sphincter, which is a model system for testing potential intraocular hypotensive agents.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-224226	n.n.	C22H35D4NO5	25 µg/50 µg

• Prostaglandin G2
  The first intermediary in the COX pathway which is stable enough to be isolated and characterized - the C15 hydroperoxide of PGH2 (sc-201266).

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205471	51982-36-6	C20H32O6	25 µg/50 µg

• Prostaglandin H1
  A COX metabolite of DGLA and the precursor to all 1-series prostaglandins and thromboxanes that has been shown to be a suicide inhibitor of platelet thromboxane synthase (K_i = 28 μM).

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205472	52589-22-7	C20H34O5	25 µg/50 µg

• Prostaglandin I3 (sodium salt)
  Synthesized from EPA by COX and PGI synthase. PGI3 has a short in vivo half-life and is hydrolyzed to Δ17-6-keto PGF1α. The platelet and vascular activity of PGI3 is equivalent to that of PGI2.1,2

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205473	68324-96-9	C20H29NaO5	500 µg/1 mg

• Prostaglandin K1
  PGK1 is the 9,11-diketone formed by the oxidation of PGE1 or PGD1. Whether this compound exists biologically is uncertain. it is known to be resistant to metabolism by 15-hydroxy PGDH in vitro. In an intact porcine model of balloon angioplasty restenosis, PGK1 was equivalent in activity and potency to PGE1.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205474	69413-73-6	C20H32O5	100 µg/500 µg

• Prostaglandin K2
  The 9,11-diketone formed by the oxidation of PGE2 or PGD2. Whether this compound exists biologically is uncertain, but it is known to be resistant to metabolism by 15-hydroxy PGDH in vitro.1

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-224229	n.n.	C20H30O5	100 µg/500 µg

• RHC-80267
  A selective inhibitor of DAG lipase activity in canine platelets and in a variety of mammalian cells. Also inhibits glucose- and carbachol-induced insulin release from intact islets. An inhibitor of Angiotensin II and ATP-induced synthesis of 6-keto-prostaglandin F1α.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-222251	83654-05-1	C20H34N4O4	10 mg

• RO1138452
  RO1138452 is one of the more potent high-affinity ligands and functional antagonists for the human IP (prostacyclin) receptor. It antagonizes the carbaprostacyclin-induced activation of human neuroblastoma adenylate cyclase, blocking the accumulation of cyclic AMP in a dose-dependent manner. It also inhibits the binding of tritiated iloprost to rodent neuroblastoma cells with a Ki of approximately 1.5 nM. At levels between 2-20 mg/kg in rats, RO1138452 shows significant analgesic activity in standard antinociceptive assays.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-222261	221529-58-4	C19H23N3O	1 mg/5 mg

• (S)-(-)-1,1'-Bi-2-naphthol
  S-BINOL is a chiral auxiliary for the asymmetric reduction of 15-keto prostaglandin intermediates to 15(S)-alcohols.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205499	18531-99-2	C20H14O2	250 mg/1 g

• (S)-AL 8810
  An 11β-fluoro analog of PGF2α that acts as a potent and selective antagonist at the FP receptor. The C-15 epimer of AL 8810, having the inverse, (S), or “natural” configuration at C-15 relative to AL 8810, which is 15-(R).

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-224272	n.n.	C24H31O4F	1 mg/5 mg

• (+)-Travoprost
  A prodrug which is converted by esterase enzymatic activity in the cornea to yield the corresponding free acid.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205327	157283-68-6	C26H35F3O6	1 mg/5 mg

• Tafluprost
  A number of 17-phenyl trinor PGF2α derivatives have been approved for the treatment of glaucoma. Of these, the ones wherein the 13,14-double bond has been hydrogenated retain relatively good potency, but show a significantly reduced incidence of local irritant side effects. Alternatively, it was recently reported that analogs incorporating a 15-deoxy-15,15-difluoro modification also had a favorable ophthalmic activity profile. Tafluprost is a 2-series, 16-phenoxy analog of PGF2α with the 15,15-difluoro substitution. Tafluprost free acid is a very potent FP receptor agonist. The ester prodrug forms of tafluprost are also potent ocular hypotensives in monkeys.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-222336	209860-87-7	C25H34F2O5	500 µg/1 mg

• Tafluprost (free acid)
  A very strong FP receptor agonist.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205516	209860-88-8	C22H28F2O5	1 mg/5 mg

• TBS-Corey Lactone Aldehyde
  A versatile, hydroxyl-protected intermediate for the synthesis of prostaglandins and prostaglandin analogs. Prostaglandin derivatives with modifications in the alpha chain, the omega chain, or both, are readily accessible from TBS-Corey aldehyde.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205517	64091-14-1	C14H24O4Si	100 mg/1 g

• tetranor-PGDM
  Major metabolite of PGD2 that is detectable in human and murine urine.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205522	133161-96-3	C16H24O7	25 µg/100 µg

• tetranor-PGDM-d6
  Contains six deuterium atoms at the 17, 17', 18, 18', 19 and 19' positions and is intended for use as an internal standard for the quantification of tetranor-PGDM by GC- or LC-mass spectrometry (MS). Prostaglandin D2 (PGD2) is synthesized by hematopoietic-type PGD-synthase (H-PGDS) in mast cells and is released in large quantities during allergic and asthmatic anaphylaxis. Produced in the brain by lipocalin PGD-synthase also known as β-trace. In the brain, PGD2 produces normal physiological sleep and lowering of body temperature. Additional pharmacological actions include inhibition of platelet aggregation and relaxation of vascular smooth muscle.4 tetranor-PGDM is a major metabolite of PGD2 that is detectable in human and murine urine.5 The levels of tetranor-PGDM and 2,3-dinor-11b-PGF2α, which is a related PGD2 metabolite, in human urine were found to be 1.5 ± 0.3 and 0.6 ± ng/mg creatinine, respectively.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-224305	n.n.	C16H18O7D6	25 µg/500 µg

• tetranor-PGEM
  The major urinary metabolite of PGE1 and PGE2, and is used as a urinary marker of PGE2 biosynthesis. Approximately 15% of an infused dose of PGE2 appears as this metabolite in the urine of humans. Normal healthy males excrete 7-40 µg of tetranor-PGEM over a 24-hour period.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-222350	24769-56-0	C16H24O7	25 µg/50 µg

• tetranor-PGEM-d6
  Intended for use as an internal standard for the quantification of tetranor PGEM by GC- or LC-mass spectrometry.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-224306	n.n.	C16H18O7D6	25 µg/50 µg

• tetranor-PGFM
  The major urinary metabolite of PGF2α. Normal healthy females excrete 7-13 µg of tetranor-PGFM per day compared to 11-59 µg per day for healthy males. In pregnant females, tetranor-PGFM levels in the urine are 2 to 5-fold higher and diminish to pre-pregnancy levels soon after labor.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205523	23109-94-6	C16H26O7	25 µg/50 µg

• Thromboxane B2-d4
  Contains four deuterium atoms at the 3, 3', 4, and 4' positions and is intended for use as an internal standard for the quantification of TXB2 by GC- or LC-mass spectrometry. A stable, biologically inert metabolite formed from the non-enzymatic hydrolysis of TXA2, which has a half-life of about 30 seconds.1 Urinary analysis of TXB2 accurately reflects intrarenal TXA2 synthesis, and measurement of 11-dehydro and 2,3-dinor thromboxane metabolites gives the best estimate of systemic TXA2 secretion.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-224310	n.n.	C20H30D4O6	25 µg/50 µg

• trans-Resveratrol-d4
  Internal standard for the quantification of trans-resveratrol by GC- or LC-mass spectrometry.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-224316	n.n.	C14H8D4O3	100 µg/500 µg

• Treprostinil
  A stable analog of prostacyclin that is used clinically for the treatment of primary pulmonary hypertension; prevents NF-κB translocation to the nucleus.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205533	81846-19-7	C23H34O5	1 mg/5 mg

• U-44069
  Prostaglandin endoperoxide receptor agonist/antagonist.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-202848	56985-32-1	C21H34O4	1 mg/5 mg

• U-51605
  An inhibitor of both PGI and thromboxane synthases with more selectivity towards PGI synthase.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205535	64192-56-9	C20H32N2O2	500 µg/1 mg

• Unoprostone
  Analog checmical of PGF2a incorporating a 13,14-dihydro-15-keto modificiation and a two-carbon extension of the aliphatic lower side chain.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205536	120373-36-6	C22H38O5	1 mg/10 mg

• Unoprostone isopropyl ester
  Free acid analog of prostoglandin F2a, the prodrug form of unoprostone (clinically known as Rescula).

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205537	120373-24-2	C25H44O5	1 mg/10 mg

• ZK118182 isopropyl ester

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-358886	154927-31-8	C23H37ClO5	100 µg/500 µg