Prostaglandin Receptor Ligands

AH-6809
A prostaglandin DP-receptor inhibitor. The compound has been reported to antagonize the anti-aggregatory activity of BW245C, 9 α, 11 β-PGF₂, and PGD₂.
Katalog # CAS Nummer Summenformel Menge
sc-201342 33458-93-4 C₁₇H₁₄O₅ 5 mg/25 mg
AL 6598
Katalog # CAS Nummer Summenformel Menge
sc-358796 170291-06-2 C₂₃H₃₉ClO₅ 500 µg/1mg
AA 2414
Thromboxane A2 (TP) receptor antagonist. Antiasthmatic agent; inhibits platelet aggregation and bronchoconstriction induced by a TXA2 mimetic in guinea pigs.
Katalog # CAS Nummer Summenformel Menge
sc-203796 112665-43-7 C₂₂H₂₆O₄ 10 mg/50 mg
BAY-u 3405
Suppresses PGD2-induced migration of human eosinophils (IC₅₀ = 170 nM). Potent dual antagonist of TP/DP2 (CRTH2) prostanoid receptors (Ki values are 4.3, 4.5 and > 10000 nM for hDP2, hTP and hDP1 receptors respectively).
Katalog # CAS Nummer Summenformel Menge
sc-203834 116649-85-5 C₂₁H₂₁FN₂O₄S 10 mg/50 mg
Carbacyclin (Carbocyclic PGI2)
Carbacyclin is a stable analog of prostacyclin shown to inhibit platelet aggregation.
Katalog # CAS Nummer Summenformel Menge
sc-201250 69552-46-1 C₂₁H₃₄O₄ 1 mg/10 mg
1-(7-Carboxyheptyl)imidazole
Selective inhibitor of thromboxane synthetase.
Katalog # CAS Nummer Summenformel Menge
sc-205915 68887-68-3 C₁₁H₁₈N₂O₂ 10 mg/25 mg
cis-5,8,11,14,17-Eicosapentaenoic acid sodium salt
This compound reduces thromboxane A2 production.
Katalog # CAS Nummer Summenformel Menge
sc-214735 73167-03-0 C₂₀H₂₉NaO₂ 5 mg/10 mg
Cloprostenol Sodium
A synthetic F series prostaglandin that functions as a potent agonist towards the FP receptor.
Katalog # CAS Nummer Summenformel Menge
sc-201338 55028-72-3 C₂₂H₂₈O₆Cl ·Na 1 mg/10 mg
16,16-Dimethyl-prostaglandin E2
Prostaglandin E2 analog with potent cytoprotective activity and enhanced metabolic resistance yielding a longer half-life in vivo. Acts on all 4 EP receptors (EP1,2,3, and 4).
Katalog # CAS Nummer Summenformel Menge
sc-201240 39746-25-3 C₂₂H₃₆O₅ 1 mg
13,14-epoxy Travoprost
An impurity generated in the production of fluprostenol isopropyl ester.
Katalog # CAS Nummer Summenformel Menge
sc-287303 n.n. C₂₆H₃₅F₃O₇ 1 mg/5 mg
Fluprostenol
Fluprostenol is a prostaglandin F (FP) receptor agonist that is more selective than PGF2α (sc-201227).
Katalog # CAS Nummer Summenformel Menge
sc-201336 40666-16-8 C₂₃H₂₉F₃O₆ 1 mg/10 mg
GW 627368X
A selective and potent competitive antagonist of the EP4 receptor with additional human TP receptor affinity.
Katalog # CAS Nummer Summenformel Menge
sc-221702 439288-66-1 C₃₀H₂₈N₂O₆S 1 mg/5 mg
Latanoprost
Latanoprost is a prodrug (isopropyl ester) of 17-phenyl-13,14-dihydro prostaglandin F2α. The free acid form is a potent agonist at FP receptors. It is in clinical use as a topical antiglaucoma agent and has been shown to reduce IOP (intraoccular pressure).
Katalog # CAS Nummer Summenformel Menge
sc-201354 130209-82-4 C₂₆H₄₀O₅ 1 mg/5 mg
L-798,106
Potent and highly selective prostanoid EP3 receptor antagonist (Ki values are 0.3, 916, > 5000 and > 5000 nM at EP3, EP4, EP1 and EP2 respectively). Attenuates sulprostone-induced inhibition of EFS-evoked twitch and contractile responses in vivo.
Katalog # CAS Nummer Summenformel Menge
sc-204047 244101-02-8 C₂₇H₂₂BrNO₄S 10 mg/50 mg
L-655,240
A potent inhibitor of contractions induced by prostaglandin endoperoxide analogs. Also reported to be an inhibitor of thromboxane receptors.
Katalog # CAS Nummer Summenformel Menge
sc-201350 103253-15-2 C₂₁H₂₁ClFNO₂ 1 mg/5 mg
L-670,596
An orally active potent and selective thromboxane A2/prostaglandin endoperoxide receptor antagonist. Inhibits human platelet aggregation in vitro and the U-44069-induced contractions of guinea-pig trachea. Also prevents thromboxane-mediated endothelial cell death.
Katalog # CAS Nummer Summenformel Menge
sc-204041 121083-05-4 C₂₂H₂₁F₂NO₄S 10 mg
Misoprostol (SC-29333)
A synthetic E prostaglandin that has been shown to prevent tissue corrosion induced by certain anti-inflammatory compounds. Shown to have negative effects on the murine nervous system.
Katalog # CAS Nummer Summenformel Menge
sc-201264 59122-46-2 C₂₂H₃₈O₅ 10 mg/100 mg
Ozagrel hydrochloride
Potent and selective inhibitor of thromboxane (TXA2) synthetase (IC₅₀ = 4 nM). Does not inhibit prostacyclin (PGI2) synthetase, cyclooxygenase or PGE2 isomerase (IC₅₀ > 1 mM). Inhibits platelet aggregation in vitro and arachidonate-induced arterial contraction in vivo.
Katalog # CAS Nummer Summenformel Menge
sc-204153 74003-18-2 C₁₃H₁₄N₂O₂.HCl 10 mg/50 mg
Picotamide
Picotamide is a dually active thromboxane A2 and thromboxane A2 synthase inhibitor. It has been shown to exhibit platelet inhibitory effects ex vivo and in vitro.
Katalog # CAS Nummer Summenformel Menge
sc-201334 32828-81-2 C₂₁H₁₀N₄O₃ 10 mg/50 mg
17-Phenyl-trinor-prostaglandin E2
A synthetic analog of PGE2 (sc-201225), found to be a selective EP1 and EP3 receptor agonist, unlike PGE2 which antagonizes a variety of EP receptors.
Katalog # CAS Nummer Summenformel Menge
sc-201255 38315-43-4 C₂₃H₃₀O₅ 1 mg/10 mg
PTA2 (Pinane thromboxane A2)
A chemically stable, carbocyclic analog of thromboxane A2, that has been shown to act as a TP receptor antagonist which leads to coronary artery contraction and platelet aggregation induced by prostaglandin endoperoxide analogs and arachidonic acid.
Katalog # CAS Nummer Summenformel Menge
sc-201177 71111-01-8 C₂₄H₄₀O₃ 1 mg
SC-51089
A selective antagonist of prostaglandin E2, which displays specificity towards the EP1 receptor subtype. This compound contains a diacylhydrazine moiety, which has often been observed to release hydrazine.
Katalog # CAS Nummer Summenformel Menge
sc-201344 146033-02-5 C₂₂H₁₉ClN₄O₃ ·HCl 5 mg/25 mg
SC-51322
A potent and selective prostaglandin E2 antagonist (pA2=8.1). Displays in vivo analgesic activity in the mouse (ED50=0.9 mg/kg)1.
Katalog # CAS Nummer Summenformel Menge
sc-205848 n.n. C₂₂H₂₀ClN₃O₄S 5 mg/25 mg
SQ-29548
A compound that reversibly and competitively acts as a thromboxane A₂/prostraglandin endoperoxide receptor antagonist.
Katalog # CAS Nummer Summenformel Menge
sc-201332 98672-91-4 C₂₁H₂₉N₃O₄ 1 mg/10 mg
Seratrodast
A potent and selective thromboxane A₂ receptor antagonist with antioxidant effects. Inhibits peroxide-induced vasoconstriction in human placenta and bronchoconstriction in guinea pigs.
Katalog # CAS Nummer Summenformel Menge
sc-201352 112665-43-7 C₂₂H₂₆O₄ 10 mg/50 mg
Sulprostone
A metabolism-resistant synthetic analog of PGE2, that is a selective EP3 prostanoid receptor agonist. Shown to be a potent stiumulator of uterine smooth muscle contractions.
Katalog # CAS Nummer Summenformel Menge
sc-201348 60325-46-4 C₂₃H₃₁NO₇S 1 mg/5 mg
U-46619
Shown to be a potent agonist of thromboxane A2 receptor and also reported to cause constriction of coronary arteries. When bound to TXA2 receptors, this compound inhibits the release of hippocampal noradrenaline.
Katalog # CAS Nummer Summenformel Menge
sc-201242 56985-40-1 C₂₁H₃₄O₄ 1 mg/10 mg