Posttranslational Modification Reagents

α-Hydroxyfarnesyl-phosphonic acid
α-Hydroxyfarnesylphosphonic acid potently inhibits farnesyltransferase in isolated enzyme assays and in whole cells.
Katalog # CAS Nummer Summenformel Menge
sc-200852 140633-12-1 C₁₅H₂₇O₄P 1 mg
Chaetomellic acid A
This is a potent inhibitor of farnesyltransferase in isolated enzyme assays (IC₅₀=55nM) but it is inactive in whole cells. Inhibition of farnesyltransferase is selective over geranylgeranyltransferase I and II (IC₅₀=92µM and 34µM respectively).
Katalog # CAS Nummer Summenformel Menge
sc-221420 148796-51-4 C₁₉H₃₂O₄ ·2Na 5 mg/25 mg
Farnesyl Thiosalicylic Acid
A farnesylcysteine mimic, blocks anchorage of Ras proteins to the membrane and to protein escorts. Decreases cellular Ras levels. Inhibits PPMTase methylation of Ras.
Katalog # CAS Nummer Summenformel Menge
sc-205322 162520-00-5 C₂₂H₃₀O₂S 1 mg/5 mg
Farnesylpyrophosphate
Farnesylpyrophosphate is an isoprenoid farnesyl-donor which is utilized by farnesyltransferase.
Katalog # CAS Nummer Summenformel Menge
sc-200847 13058-04-3 C₁₅H₂₅O₇P₂ ·3NH₄ 200 µg/5 mg
FPT Inhibitor I
A highly selective and potent inhibitor of farnesyltransferase. Exhibits inhibition of GGTase I and II at much higher concentrations.
Katalog # CAS Nummer Summenformel Menge
sc-221625 n.n. C₁₉H₂₉NO₆P•3Na 1 mg
FPT Inhibitor II
A cell permeable potent and selective inhibitor of farnesyltransferase. Is resistant to cleavage by phosphorylation. And inhibits Ras farnesylation in whole cells.
Katalog # CAS Nummer Summenformel Menge
sc-221626 n.n. C₁₇H₃₄NNa₂O₆P 1 mg
FPT Inhibitor III
A cell-permeable prodrug ester form of farnesyltransferase (FTase) inhibitor II. Preventing Ras-mediated transformation by inhibiting Ras processing in cells. Also inhibits C15 and C20 protein prenylation in NIH-3T3 cells.
Katalog # CAS Nummer Summenformel Menge
sc-221627 n.n. C₂₃H₃₉NO₇P•Na 1 mg
FTase Inhibitor I
A potent, cell-permeable, selective, peptidomimetic inhibitor of FTase. It is ~37-fold more active against FTase than against geranylgeranyltransferase. Is also very resistant to proteolysis.
Katalog # CAS Nummer Summenformel Menge
sc-221632 149759-96-6 C₂₂H₃₈N₄O₃S₂ 1 mg
FTase Inhibitor II
A potent FTase inhibitor. Prevents the farnesylation of Ras, which then results in its inability to associate with other cell signaling components in the cell.
Katalog # CAS Nummer Summenformel Menge
sc-221633 n.n. C₁₅H₂₁N₃O₄S₂ 1 mg
FTI-2148
An imidazolo-containing peptidomimetic that preferentially inhibits protein farnesyltransferase activity compared to protein geranylgeranyltransferase-I. Has been shown to disrupt Ras farnesylation in H-Ras-transformed NIH3T3 cells and prevent the growth of T. brucei rhodesiense and T. brucei brucei.
Katalog # CAS Nummer Summenformel Menge
sc-221634 n.n. C₂₄H₂₈N₄O₃S ·2CF₃CO₂H 500 µg
FTI-2628
A cell-permeable benzyl ester prodrug form of FTI-2148 that preferentially inhibits protein farnesyltransferase activity over protein geranylgeranyltransferase-I. Displays anti-malarial properties. Also suppresses parasitemia in P. berghei-infected mice by 46.1% with no apparent toxicity. Potently disrupts Ras farnesylation in H-Ras-transformed NIH 3T3 cells and inhibits the growth of P. falciparum in red blood cells.
Katalog # CAS Nummer Summenformel Menge
sc-221635 n.n. C₃₁H₃₄N₄O₃S 500 µg
FTI-276
A highly potent and selective CAAX peptidomimetic of the carboxyl terminal of Ras proteins that inhibits FTase in vitro. Inhibits GGTase I at a much higher concentration. Has been shown to selectively block the growth of a human lung carcinoma expressing oncogenic K-Ras in nude mice. Also inhibits oncogenic signaling and tumor growth of NIH 3T3 cells transformed with the Ras oncogene at 20 µM.
Katalog # CAS Nummer Summenformel Menge
sc-221636 n.n. C₂₁H₂₇N₃O₃S₂ 250 µg
FTI-276 trifluoroacetate salt
A highly potent RasCAAX peptidomimetic which antagonizes both H and K-Ras oncogenic signaling. This compound inhibits farnesyltransferase (Ftase) in vitro with an IC₅₀ of 500 pM. Used as an anti-cancer agent.
Katalog # CAS Nummer Summenformel Menge
sc-215057 170006-72-1 (non-salt) C₂₃H₂₈F₃N₃O₅S₂ 1 mg/5 mg
FTI-277 trifluoroacetate salt
Inhibitor of farnesyltransferase (Ftase). Highly potent (pM/nM) Ras CAAX peptidomimetic which antagonizes both H and K-Ras oncogenic signaling.
Katalog # CAS Nummer Summenformel Menge
sc-215058 170006-73-2 (free base) C₂₂H₂₉N₃O₃S₂ ·xC₂HF₃O₂ 1 mg/5 mg
Geranylgeranylpyrophosphate triammonium salt
Geranylgeranylpyrophosphate is a geranylgeranyl-donor molecule which is utilized by geranylgeranyltransferase for isoprenylation of target proteins.
Katalog # CAS Nummer Summenformel Menge
sc-200849 6699-20-3 (non-salt) C₂₀H₃₆O₇P₂•3NH₃ 200 µg
GGTI-2133
A cell-permeable non-thiol peptidomimetic that acts as a potent and selective inhibitor of GGTase I with a 140-fold selectivity relative to FTase.
Katalog # CAS Nummer Summenformel Menge
sc-221668 n.n. C₂₇H₂₈N₄O₃ 250 µg
GGTI-2147
A cell-permeable non-thiol peptidomimetic that acts as a strong and selective inhibitor of GGTase I. Blocks the geranyl-geranylation of Rap1A with an IC₅₀ value that is over 60-fold lower than that required to disrupt the farnesylation of H-Ras.
Katalog # CAS Nummer Summenformel Menge
sc-221669 n.n. C₂₈H₃₀N₄O₃ 250 g
GGTI-286
A potent, cell-permeable, and selective inhibitor of GGTase I. This methyl ester derivative of GGTI-287 is about 25-fold more potent than FTI-277 in inhibiting the processing of the geranylgeranylated protein Rap1A. GGTI-286 has also been shown to have a significant antiproliferative effect in human malignant glioma cells. It also selectively antagonizes oncogenic K-Ras4B.
Katalog # CAS Nummer Summenformel Menge
sc-221670 171744-11-9 C₂₃H₃₁N₃O₃S 250 µg
GGTI-287
A highly potent and selective peptidomimetic inhibitor of GGTase I than FTase in vitro.
Katalog # CAS Nummer Summenformel Menge
sc-221671 n.n. C₂₂H₂₉N₃O₃S 250 µg
GGTI-297
A potent, cell-permeable, and selective peptidomimetic inhibitor of GGTase I compared to FTase
Katalog # CAS Nummer Summenformel Menge
sc-221672 n.n. C₂₆H₃₁N₃O₃S 250 µg/1 mg
L-744,832 Dihydrochloride
Ras farnesyltransferase inhibitor. Induces tumor regression in transgenic mice with multiple oncogenic mutations by mediating alterations in both cell cycle control and apoptosis1. Induces p21 expression and arrests cells at G12. Causes enhanced mitotic sensitivity to taxol3.
Katalog # CAS Nummer Summenformel Menge
sc-221800 1177806-11-9 (free acid) C₂₆H₄₅N₃O₆S₂•2HCl 5 mg/25 mg
Manumycin A
An antibiotic generated by Streptomyces parvulus that acts as a selective and vigorous inhibitor of Ras farnesyltransferase.
Katalog # CAS Nummer Summenformel Menge
sc-200857 52665-74-4 C₃₁H₃₈N₂O₇ 1 mg
N-Acetyl-S-farnesyl-L-cysteine (AFC)
AFC specifically inhibits the S-farnesylcysteine methyl transferase in cell free extracts and in whole cells.
Katalog # CAS Nummer Summenformel Menge
sc-200839 135304-07-3 C₂₀H₃₃NO₃S 5 mg/25 mg
N-Acetyl-S-geranyl-L-cysteine (AGC)
AGC is a close structural analog of AFC and AGGC but is biologically inactive. It may be used as a negative control for either AFC1 or AGGC2.
Katalog # CAS Nummer Summenformel Menge
sc-221983 n.n. C₁₅H₂₅NO₃S 5 mg/25 mg
N-Acetyl-S-geranylgeranyl-L-cysteine (AGGC)
Shown to inhibit Ras carboxyl methylation which causes a decrease in cell proliferation. Also noted to be a competitive inhibitor for prenylcysteine methyl transferase.
Katalog # CAS Nummer Summenformel Menge
sc-200843 139332-94-8 C₂₅H₄₁NO₃S 5 mg/25 mg
Perillic Acid
Shown to elicit cytotoxicity, induce cell cycle arrest, and apoptosis via an increase in expression of p21, Bax, and caspase-3 in cells. Also has been reported to be a major metabolite of d-limonene.
Katalog # CAS Nummer Summenformel Menge
sc-200841 23635-14-5 C₁₀H₁₄O₂ 100 mg/500 mg
2-PCPA (hydrochloride)
Histones contain unstructured N-terminal residues that are the site of numerous post-translational modifications, involving acetylation, ubiquitination, methylation, and sumoylation to produce a specific gene regulatory outcome.
Katalog # CAS Nummer Summenformel Menge
sc-220762 n.n. C₉H₁₂ClN 10 mg/5 mg
S-Farnesyl-L-cysteine Methyl Ester
Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
Katalog # CAS Nummer Summenformel Menge
sc-222275 n.n. C₁₉H₃₃NO₂S 5 mg/25 mg