PLA2 Inhibitors and Controls

• 7,7-Dimethyleicosadienoic Acid (DEDA)
  DEDA is an arachidonic acid analog that inhibits phospholipase A2 (PLA₂). It is reported to inhibit SRS-A biosynthesis occurring in peritoneal cells of rats.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-200707	89560-01-0	C22H40O2	10 mg/50 mg

• AACOCF3
  Shown to be a trifluoromethylketone derivative of arachidonic acid. Reported to directly binding and inhibiting cytosolic human phospholipase A2.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-201412	149301-79-1	C21H31F3O	10 mg/50 mg

• AACOCH3
  Negative control for AACOCF31,2 but stimulates AA release by way of possible inhibitor of metabolizing or uptake enzymes, or via direct stimulation of PLA21

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205590	n.n.	C21H34O	10 mg/50 mg

• Aristolochic Acid
  Shown to be an inhibitor of PLA2 and also suppress edema-inducing activity. Also reported as an anti-inflammatory agent.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-200731	313-67-7	C17H11NO7	50 mg/250 mg

• Aristolochic Acid B

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-358881	475-80-9	C16H9NO6	5 mg

• Cytidine 5'-diphosphocholine, Sodium Salt (CDP-choline)
  A potent inhibitor of PLA₂ with various hormone inducing as well as potential neural and non-neural cholinergic increasing properties.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-200713	33818-15-4	C14H25N4O11P2 ·Na	100 mg/1 g

• HELSS (Haloenol lactone suicide substrate, BEL, Bromoenol lactone)
  A potent and irreversible inhibitor of calcium-independent phospholipase and cellular cytosolic magnesium-dependent PAP.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-201418	88070-98-8	C16H13BrO2	5 mg/25 mg

• OBAA
  Potent inhibitor of phospholipase A2.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-202748	134531-42-3	C28H44O3	5 mg

• Manoalide
  Manoalide is a potent irreversible inhibitor of phospholipase C and A2. Its mechanism of action involves covalent modification of lysine residues. Also inhibits PLC and calcium channels.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-200733	75088-80-1	C25H36O5	1 mg

• Oleyoxyethyl Phosphorylcholine
  Oleyoxyethyl Phosphorylcholine is used as a potent inhibitor in order to investigate the various biological roles of phospholipase A2 (PLA₂).

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-200711	96720-06-8	C25H52NO5P	10 mg/50 mg

• ONO-RS-082
  Shown to be a potent phospholipase A2 inhibitor and block thromboxane production in human platelets stimulated by epinephrine.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-201410	99754-06-0	C21H22ClNO3	20 mg/100 mg

• PACOCF3
  Selective cPLA₂ (IC₅₀=45 µM) and iPLA₂ inhibitor (IC₅₀=3.8 µM).

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-201414	141022-99-3	C17H31F3O	10 mg/50 mg

• PACOCH3
  The compound is derived from β-ketostearic acid and is an analog of AACOCF₃ and PACOCF₃. The compound does not block the effects of PLA₂ and can be used as a control.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-201416	2922-51-2	C17H34O	10 mg/50 mg

• Quinacrine, Dihydrochloride
  A non-specific phospholipase A² (PLA²) inhibitor. Acts as an acetylcholine receptor antagonist. Suppresses glibenclamide-sensitive K⁺-currents (IC₅₀ = 4.4 µM). Also inhibits monoamine oxidase (MAO).

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-204222	69-05-6	C23H30CIN3O•2HCL	100 mg

• sPLA2 (Type III)
  Isolated from bee venom where one unit of enzyme hydrolyzes one µmol of Diheptanoyl Thio-PC per minute at 25° C.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205512	9001-84-7	n.n.	1 mg/5 mg

• Thioetheramide PC
  Thioetheramide-PC is a reversible inhibitor of secretory phospholipase A2 (sPLA₂) that binds to both the catalytic site and activator site of sPLA₂.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-202840	116457-99-9	C40H83N2O5PS	5 mg/25 mg

• sPLA2 inhibitor
  Orally active, potent secretory Phospholipase A2 (sPLA2; Group IIa) inhibitor.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-215901	393569-31-8	C31H37NO4	5 mg/25 mg

• YM 26734
  A competitive inhibitor of several isoforms of secretory PLA2 (sPLA2) that has been shown to negligibly effect sPLA2-IIF and cytosolic PLA2.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-204410	144337-18-8	C45H62O8	10 mg