PKG Activators and Inhibitors

8-(4-Chlorophenylthio)guanosine 3',5'-cyclic Monophosphate sodium salt
Katalog # CAS Nummer Summenformel Menge
sc-202029 51239-26-0 C₁₆H₁₄ClN₅O₇PS ·Na 1 mg/5 mg
8-(4-Chlorophenylthio)guanosine 3',5'-cyclic Monophosphate triethylammonium salt
Selective activator of cGMP-dependent protein kinase Iα, Iβ and type II as well as of cGMP-gated ion channels.
Katalog # CAS Nummer Summenformel Menge
sc-202432 54364-02-2 C₁₆H₁₄ClN₅O₇PS ·C₆H₁₅N 1 mg/5 mg
8-pCPT-cGMP, TEA
Selective membrane-permeable activator of protein kinase G that has a higher activation potential than cGMP. Does not significantly affect cGMP-regulated phosphodiesterases. Inhibits the thrombin-induced phosphorylation of human platelets mediated by myosin light chain kinase (MLCK) and protein kinase C (PKC). Note: 25 µmol = 14.73 mg.
Katalog # CAS Nummer Summenformel Menge
sc-221150 n.n. C₁₆H₁₄ClN₅O₇PS ·(CH₃CH₂)₃NH 25 µmol
(D) DT-2
A potent, cell permeable and highly selective polypeptide inhibitor of cGMP dependent protein kinase 1α.
Katalog # CAS Nummer Summenformel Menge
sc-361974 n.n. C₁₂₂H₂₂₃N₅₃O₂₃ ·(free ·peptide) 500 µg
Guanosine 3′,5′-cyclic Monophosphate, b-Phenyl-1,N2-etheno-8-bromo-, Sodium Salt
A potent cell-permeable activator of protein kinase G type 1a and 1b. Reported to be one of the best known activators of PKG isozyme 1b. Also acts as an excellent muscle relaxant.
Katalog # CAS Nummer Summenformel Menge
sc-203434 144510-04-3 C₁₈H₁₄BrN₅O₇P ·Na 10 µmol
Guanosine-3',5'-cyclic Monophosphothioate, Sp-Isomer sodium salt
Metabolically resistant activator of cGMP-dependent protein kinases (PKGs). Low membrane permeability.
Katalog # CAS Nummer Summenformel Menge
sc-203065 86562-10-9 (non-salt) C₁₀H₁₁N₅O₆SP ·Na 500 µg/1 mg
H-8 • 2HCL
A cAMP-dependent, cGMP-dependent, and Ca²⁺-phospholipid-dependent protein kinase inhibitor that potently blocks signaling pathways.
Katalog # CAS Nummer Summenformel Menge
sc-200526 84478-11-5 C₁₂H₁₅N₃O₂S ·2HCl 10 mg/50 mg
HA-1004
A potent inhibitor of cyclic AMP-dependent protein kinase and cyclic GMP-dependent protein kinase.
Katalog # CAS Nummer Summenformel Menge
sc-200537 91742-10-8 C₁₂H₁₅N₅O₂S ·2HCl 10 mg/50 mg
HA-1077 dihydrochloride
Shown to be an antiproliferative agent via inhibition of Rho kinase signaling pathways. Also has been reported to be a vasodilator by inhibition of Ca²⁺ channels.
Katalog # CAS Nummer Summenformel Menge
sc-200583 103745-39-7 C₁₄H₁₇N₃O₂S•2HCl 10 mg/50 mg
KT5823
A derivative of K-252a, a selective inhibitor of PKG, and has been shown to dose dependently inhibits spontaneous apoptosis of neutrophils.
Katalog # CAS Nummer Summenformel Menge
sc-3534 126643-37-6 C₂₉H₂₅N₃O₅ 100 µg
PKG Inhibitor
A specific cyclic GMP-dependent protein kinase inhibitor reported to block NMDA potentiation and GABA nitric oxide depression.
Katalog # CAS Nummer Summenformel Menge
sc-201161 82801-73-8 C₃₈H₇₄N₁₈O₁₀ 1 mg
Rp-8-Br-PET-cyclic GMPS, Sodium Salt
A metabolically-stable, competitive inhibitor of protein kinase G types 1a and 1b (K_i = 30 nM). Blocks cGMP-gated retinal type ion channels (IC₅₀ = 25 µM) and the activation of purified PKA type II (K_i = 10 µM). More lipophilic and cell-permeable than Rp-8-pCPT-cGMPS . Note: 1 µmol = 0.56 mg.
Katalog # CAS Nummer Summenformel Menge
sc-203989 172806-20-1 C₁₈H₁₄BrN₅O₆PS•Na 1 µmol
Rp-8-pCPT-cyclic GMPS Sodium
Potent selective inhibitor of cGK (also known as PKG) 1α, 1β and type II. Resistant to mammalian cyclic nucleotide-dependent phosphodiesterases. No metabolic side effects.
Katalog # CAS Nummer Summenformel Menge
sc-202030 153660-04-9 C₁₆H₁₄ClN₅O₆PS₂ ·Na 100 µg/1 mg
Sp-8-pCPT-cyclic GMPS Sodium
Potent activator of both cGMP-dependent protein kinase 1α, 1β and type II and cAMP-dependent protein kinase II. Excellent cell membrane permeability and phosphodiesterase stability.
Katalog # CAS Nummer Summenformel Menge
sc-202433 160385-87-5 C₁₆H₁₄N₅ClO₆S₂P ·Na 1 mg