Phosphodiesterase Inhibitors

1,3-Dipropylxanthine
A caffeine analog and phosphodiesterase inhibitor that has some selectivity for A2 adenosine receptors. UV lmax = 273 nm, log e=3.98.
Katalog # CAS Nummer Summenformel Menge
sc-213513 31542-62-8 C₁₁H₁₆N₄O₂ 50 mg
4-{[3',4'-(Methylenedioxy)benzyl]amino}-6-methoxyquinazoline
This substance has been demonstrated to be a specific and potent inhibitor of cGMP-specific phosphodiesterase. It is not shown to have an effect on other PDE isozymes.
Katalog # CAS Nummer Summenformel Menge
sc-352371 150450-42-3 C₁₇H₁₅N₃O₃ 1 mg
7-(β-Hydroxyethyl)-theophylline
Weak phosphodiesterase inhibitor resembling theophylline in its pharmacological profile. Used as an intermediate in the preparation of 7-substituted xanthines.
Katalog # CAS Nummer Summenformel Menge
sc-202836 519-37-9 C₉H₁₂N₄O₃ 5 g
8-Methoxymethyl-IBMX
Shown to inhibit Cam-PDE which results in an increase in cGMP but not cAMP levels in rabbit aortic slices. Also reported to potentially cause vasodilation and relieve pulmonary artery pressure in rabbits.
Katalog # CAS Nummer Summenformel Menge
sc-201192 78033-08-6 C₁₂H₁₈N₄O₃ 10 mg/50 mg
Amrinone
This compound is a selective cAMP phosphodiesterase (PDE-3) inhibitor with positive inotropic and vasodilatory activity. It is also cardiotonic.
Katalog # CAS Nummer Summenformel Menge
sc-207288 60719-84-8 C₁₀H₉N₃O 1 g
Anagrelide hydrochloride
Potent type III phosphodiesterase (PDE3) inhibitor (IC₅₀ = 36 nM). Produces potent thrombocytopenic effects via inhibition of megakaryocyte maturation and inhibits platelet aggregation .
Katalog # CAS Nummer Summenformel Menge
sc-203513 58579-51-4 C₁₀H₇Cl₂N₃O.HCl 10 mg/50 mg
BRL-50481
The first selective PDE7 inhibitor (K_i=180 nM).
Katalog # CAS Nummer Summenformel Menge
sc-201178 433695-36-4 C₉H₁₂N₂O₄S 10 mg/50 mg
Caffeine
CNS stimulant. Blocks adenosine A1 and A2A receptors. cAMP phosphodiesterase inhibitor. Interferes with the uptake and storage of Ca²⁺ by the sarcoplasmic reticulum in skeletal muscle.
Katalog # CAS Nummer Summenformel Menge
sc-202514 58-08-2 C₈H₁₀N₄O₂ 5 g
CDP 840 hydrochloride
Katalog # CAS Nummer Summenformel Menge
sc-362723 162542-90-7 C₂₅H₂₇NO₂.HCl 10 mg/50 mg
Chlorpromazine, Hydrochloride
Calmodulin-dependent stimulation of cyclic nucleotide phosphodiesterase inhibitor. A peripheral vasodilator. Inhibitor of lysosomal sphingomyelinase and of TNF-α production.
Katalog # CAS Nummer Summenformel Menge
sc-202537 69-09-0 C₁₇H₁₉ClN₂S•HCl 500 mg
Cilostamide (OPC 3689)
A specific phosphodiesterase 3 (PDE3) inhibitor. The compound has been shown to block DNA binding of p-Stat3, increase cAMP levels, and block the effects of insulin and IGF-1 on meiosis
Katalog # CAS Nummer Summenformel Menge
sc-201180 68550-75-4 C₂₀H₂₆N₂O₃ 5 mg/25 mg
Cilostazol
Contains vasodilator, antimitogenic, andtithrombotic, and cardiotonic properties. Also been observed to inhibit mitogenesis, migration of vascular smooth muscle cells, and platelet aggregation.
Katalog # CAS Nummer Summenformel Menge
sc-201182 73963-72-1 C₂₀H₂₇N₅O₂ 10 mg/50 mg
CP 80633
Selective inhibitor of phosphodiesterase type 4 which does not display significant isozyme selectivity of PDE4. Inhibits hydrolysis of cAMP in isolated monocytes, eosinophils, human peripheral blood and T cells. Exhibits anti-inflammatory and bronchodilatory activity in vivo.
Katalog # CAS Nummer Summenformel Menge
sc-205276 135637-46-6 C₁₈H₂₄N₂O₃ 10 mg/50 mg
Denbufylline
Selective xanthine derivative that inhibits PDE IV. Has bronchodilatory properties. Exhibits negative inotropic effects by acting on verapamil-sensitive sites of Ca²⁺ channels in guinea pig ventricle papillary muscle independently of its PDE inhibitory activity.
Katalog # CAS Nummer Summenformel Menge
sc-203915 57076-71-8 C₁₆H₂₄N₄O₃ 5 mg
Dipyridamole
A phosphodiester, cGMP, and non-specific nucleoside transport inhibitor with antioxidant properties.
Katalog # CAS Nummer Summenformel Menge
sc-200717 58-32-2 C₂₄H₄₀N₈O₄ 1 g/5 g
EHNA
An inhibitor of adenosine deaminase (ADA) and a selective inhibitor of cyclic nucleotide phosphodiesterase- 2 (PDE2).
Katalog # CAS Nummer Summenformel Menge
sc-201184 51350-19-7 C₁₄H₂₃N₅O•HCl 10 mg/50 mg
Etazolate Hydrochloride
Selective inhibitor of cAMP-specific phosphodiesterase (PDE IV, IC₅₀=2 µM).
Katalog # CAS Nummer Summenformel Menge
sc-201186 51022-77-6 C₁₄H₁₉N₅O₂ ·HCl 5 mg/25 mg
Gisadenafil besylate
Katalog # CAS Nummer Summenformel Menge
sc-361185 334827-98-4 C₂₃H₃₃N₇O₅S.C₆H₆O₃S 10 mg/50 mg
IBMX
A nonspecific inhibitor of cyclic nucleotide phosphodiesterases. Raises intracellular cyclic AMP levels.
Katalog # CAS Nummer Summenformel Menge
sc-201188 28822-58-4 C₁₀H₁₄N₄O₂ 200 mg/1 g
Ibudilast
Katalog # CAS Nummer Summenformel Menge
sc-203080 50847-11-5 C₁₄H₁₈N₂O 10 mg
ICI 63197
Potent phosphodiesterase (PDE) 4 inhibitor (IC₅₀ = 35 nM for inhibition of [3H]-rolipram binding to rat brain). Antidepressant following systemic administration in vivo.
Katalog # CAS Nummer Summenformel Menge
sc-203600 27277-00-5 C₉H₁₃N₅O 10 mg/50 mg
Mesopram
Orally active phosphodiesterase (PDE) 4 inhibitor. Inhibits Th1 cell proliferation and decreases production of IFN-γ, TNF-α, IL-10 and iNOS in vitro. Triggers ovulation and exhibits efficacy against experimental autoimmune encephalomyelitis and murine colitis in vivo.
Katalog # CAS Nummer Summenformel Menge
sc-204077 189940-24-7 C₁₄H₁₉NO₄ 10 mg/50 mg
Milrinone
A PDE3 inhibitor that exhibits vasodilator and positive inotropic effects. Can be inhibited by carbachol (sc-202092).
Katalog # CAS Nummer Summenformel Menge
sc-201193 78415-72-2 C₁₂H₉N₃O 10 mg/50 mg
MY-5445
An inhibitor of platelet aggregation via an increase in cyclic GMP. Shown to affect cyclic GMP phosphodiesterase and cause relaxation of rat aorta.
Katalog # CAS Nummer Summenformel Menge
sc-201195 78351-75-4 C₂₀H₁₄ClN₃ 10 mg
Obscurolide A1
Weak phosphodiesterase inhibitor.
Katalog # CAS Nummer Summenformel Menge
sc-203167 144397-99-9 C₁₅H₁₇NO₅ 1 mg/5 mg
Pentoxifylline
Non-selective phosphodiesterase inhibitor. Inhibits endotoxin-induced synthesis of TNF-α.
Katalog # CAS Nummer Summenformel Menge
sc-203184 6493-05-6 C₁₃H₁₈N₄O₃ 1 g
Phosphodiesterase 4 Inhibitor
Pyrazole compound with a high-affinity active site binding inhibitor of phosphodiesterases IVB and IVD (IC₅₀ = 33 nM and 21 nM). More potent than Rolipram (IC₅₀ = 570 nM and 1.1 µM for PDEIVB and PDEIVD), respectively and greater selectivity over PDEIB, PDEIIA, PDEIIIB, PDEVA, PDEVIIB, PDEVIIIA, PDEIXA and PDEXIA (IC₅₀ > 30 µM) and minimally inhibit PDEXA with an IC50 of 6.9 µM.
Katalog # CAS Nummer Summenformel Menge
sc-204190 346440-86-6 C₁₄H₁₅N₃O₄ 10 mg/50 mg
Phosphodiesterase V Inhibitor II
A cell-permeable tetrahydro-β-carboline-hydantoin compound. Acts as a potent and highly selective phosphodiesterase V inhibitor.
Katalog # CAS Nummer Summenformel Menge
sc-222167 n.n. C₂₄H₂₅N₃O₃ 5 mg
Quazinone (Ro 13-6438)
Selective inhibitor of cGMP-inhibited phosphodiesterase (PDE III, IC₅₀=0.6 µM).
Katalog # CAS Nummer Summenformel Menge
sc-201196 70018-51-8 C₁₁H₁₀ClN₃O 10 mg/50 mg
R-(-)-Rolipram
Shown to specifically inhibit PDE IV and affect cellular functions. Also reported to demonstrate anti-inflammatory characteristics via reduction of antigen-induced prostaglandin D2 release.
Katalog # CAS Nummer Summenformel Menge
sc-201199 85416-75-7 C₁₆H₂₁NO₃ 5 mg
Ro 20-1724
A selective inhibitor of cGMP-insensitive PDE4 (type IV phosphodiesterase, PDE IV) found in immune cells which increase endothelial cAMP levels and stabilize the endothelial barrier.
Katalog # CAS Nummer Summenformel Menge
sc-200709 29925-17-5 C₁₅H₂₂N₂O₃ 100 mg/1 g
Rolipram
Selective inhibitor of cAMP-specific phosphodiesterase (PDE4); promotes apoptosis in HL60 cells through a cAMP-independent mechanism.
Katalog # CAS Nummer Summenformel Menge
sc-3563 61413-54-5 C₁₆H₂₁NO₃ 5 mg/50 mg
RS 25344 hydrochloride
A potent and selective phosphodiesterase (PDE) 4 inhibitor (IC50 values are 0.28, > 100, 160 and 330 nM at PDE4, PDE1, PDE2 and PDE3 respectively). Has been shown to inhibit eosinophil chemotaxis and increase progressive motility of spermatozoa in vitro.
Katalog # CAS Nummer Summenformel Menge
sc-296280 152814-89-6 C₁₉H₁₃N₅O₄•HCl•xH₂O 10 mg/50 mg
S-(+)-Rolipram
An inhibitor of cyclic AMP-specific phosphodiesterase. Ten times less potent than the (R)-(-)-Rolipram isomer. Presents neuroprotection against excitotoxic insult.
Katalog # CAS Nummer Summenformel Menge
sc-201200 85416-73-5 C₁₆H₂₁NO₃ 5 mg
Siguazodan
PDE III inhibitor, inotropic, vasodilator and antiplatelet agent with sustained activity. Synergizes with PDE IV inhibitors (Roliprams) in blocking antigen-induced bronchospasm in the guinea pig.
Katalog # CAS Nummer Summenformel Menge
sc-201201 115344-47-3 C₁₄H₁₆N₆O 5 mg/25 mg
Theobromine
Weak phosphodiesterase inhibitor and adenosine receptor blocker. Diuretic and smooth-muscle relaxant.
Katalog # CAS Nummer Summenformel Menge
sc-203296 83-67-0 C₇H₈N₄O₂ 5 g/25 g
Theophylline
Cyclic phosphodiesterase inhibitor. Weakly inhibits alkaline phosphodiesterases and 5’-nucleotidase. Muscle relaxant, cardiac stimulant and diuretic. Used for the treatment of asthma.
Katalog # CAS Nummer Summenformel Menge
sc-202835 58-55-9 C₇H₈N₄O₂ 5 g/25 g
Trequinsin hydrochloride
Ultrapotent, highly selective inhibitor of cGMP-inhibited phosphodiesterase (PDE lll) in vitro. Potentiates adenosine-stimulated cAMP accumulation.
Katalog # CAS Nummer Summenformel Menge
sc-358713 78416-81-6 C₂₄H₂₇N₃O₃ ·HCl 10 mg
Vinpocetine
Selective inhibitor of Ca²⁺/CaM-PDE with potential neuroprotective and vasodialative properties.
Katalog # CAS Nummer Summenformel Menge
sc-201204 42971-09-5 C₂₂H₂₆N₂O₂ 20 mg/100 mg
YM 976
Orally active inhibits PDE4 (IC₅₀ = 2.2 nM). Low emetogenic activity, suggested to be due to poor brain penetration.
Katalog # CAS Nummer Summenformel Menge
sc-204411 191219-80-4 C₁₇H₁₆ClN₃O 10 mg/50 mg
Zaprinast (M&B 22948)
Katalog # CAS Nummer Summenformel Menge
sc-201206 37762-06-4 C₁₃H₁₃N₅O₂ 20 mg/100 mg