Peptide Receptor Ligands

(1R,1'S,3'R/1R,1'R,3'S)-L-054,264
Potent and selective somatostatin sst2 receptor agonist (Ki values are 4, 537, 2480, 3614 and 5017 nM for cloned human sst2, sst1, sst4, sst3 and sst5 receptors respectively).
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sc-203766 208706-12-1 C₃₃H₄₁N₅O₂•xH₂O 1 mg/10 mg
2-Furoyl-LIGRLO-amide trifluoroacetate salt
A potent, selective protease-activated receptor 2 (PAR2) agonist where PAR-2 activation is associated with increases in cAMP and intracellular Ca(2+).
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sc-213814 729589-58-6 (non-salt) C₃₆H₆₃N₁₁O₈ ·xC₂HF₃O₂ 1 mg
A-71623
A robust and selective CCL28 (cholecystokinin 1; CCK1) receptor agonist. In comparison to other CCL28 agonists the compound does not have a tyrosine residue in which sulfation is necessary for strong CCL28 agonist activity in larger peptides.
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sc-203487 130408-77-4 C₄₄H₅₆N₈O₉ 1 mg
AC 55541
Potent and selective protease-activated receptor 2 (PAR2) agonist (pEC50 = 6.7) that displays no activity at other PAR subtypes or at over 30 other receptors involved in inflammation and nociception. Stimulates cell proliferation, PI hydrolysis andCa²⁺ mobilization in vitro (pEC50 values are 6.7, 5.9 and 6.6 respectively) and exhibits pronociceptive activity in vivo.
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sc-203799 916170-19-9 C₂₅H₂₀BrN₅O₃ 5 mg/25 mg
(±)-AC 7954 hydrochloride
Highly selective, non-peptide urotensin II (UT) receptor agonist that displays potent activity at human and rat UT receptors (pEC50 values are 6.5 and 6.7 respectively).
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sc-203491 477313-09-0 C₁₉H₂₀ClNO₂ ·HCl 10 mg/50 mg
AG 045572
Selective gonadotropin-releasing hormone (GnRH) receptor antagonist (Ki values are 2.2, 3.8 and 6.0 nM for mouse, rat and human receptors respectively). Suppresses testosterone and luteinising hormone (LH) levels in vivo.
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sc-203499 263847-55-8 C₃₀H₃₇NO₅ 1 mg/10 mg
Antalarmin hydrochloride
A non-peptide CRF-RI receptor antagonist. Blocks ACTH release stimulated by CRH, and inflammation induced by carageenin in studies.
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sc-203820 220953-69-5 C₂₄H₃₄N₄.HCl 10 mg/50 mg
APC 366
Selective inhibitor of the mast cell tryptase (K_i= 7.1 μM).
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sc-203516 178925-65-0 C₂₂H₂₈N₆O₄ 5 mg
BIBO 3304 trifluoroacetate
High affinity NPY Y1 receptor antagonist (IC₅₀ values are 0.38 and 0.72 nM at human and rat receptors respectively) that displays > 2600-fold selectivity over Y2, Y4 and Y5 receptors. Inhibits NPY- and fasting-induced feeding in vivo following central administration. Also antagonizes anxiolytic-like effects of NPY.
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sc-203841 191868-14-1 C₂₉H₃₅N₇O₃ ·2CF₃CO₂H 10 mg/50 mg
BIBP 3226 trifluoroacetate
Mixed non-peptide neuropeptide Y Y₁ (NPY Y₁) and neuropeptide FF (NPFF) receptor antagonist (K_i values are 1.1, 79, 108, > 1000, > 1000 and >1000 for rNPY Y₁, hNPFF₂, rNPFF, rNPY Y₂, rNPY Y₄ and rNPY Y₅respectively) Produces an anxiogenic-like effect in rats following i.c.v. administration.
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sc-203842 159013-54-4 (non-salt) C₂₇H₃₁N₅O₃ ·CF₃CO₂H 1 mg/10 mg
BIIE 0246
A selective non-peptide antagonist which binds to the neuropeptide NPY Y₂RY₂ receptor in a competitive manner. In addition, BIIE 0246 suppresses another neuropeptide, [ahx^5-24]NPY.
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sc-203530 246146-55-4 C₄₉H₅₇N₁₁O₆•xH₂O 1 mg/10 mg
BMS 182874 hydrochloride
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sc-361123 153042-42-3 C₁₇H₁₉N₃O₃S.HCl 10 mg/50 mg
BMS 193885
Potent, competitive neuropeptide (NPY) Y1 antagonist (K_i = 3.3 nM, IC₅₀ = 5.9 nM) that displays > 47, > 100, > 160, > 160 and > 160-fold selectivity over σ1, α1, Y2, Y4 and Y5 receptors respectively. Reduces food intake and body weight via central Y1 inhibition and is brain penetrant.
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sc-203848 186185-03-5 C₃₃H₄₂N₄O₆ ·C₃H₆O₃ 10 mg/50 mg
Boc-MLF
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sc-361128 n.n. C₂₅H₃₉N₃O₆S 1 mg
BQ 788 sodium salt
Selective ETB antagonist
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sc-203534 156161-89-6 C₃₄H₅₀N₅O₇•Na 1 mg
BQ-610
A highly selective ET_A receptor antagonist (IC₅₀= 20 nM) which attenuates ET-induced reduction in cardiac output. It also inhibits ET-1- and ET-3-induced activation of adenylate cyclase (IC₅₀= 28.2 nM). BQ-610 is 30-fold more potent than BQ-123, in porcine aortic smooth muscle membrane assay.
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sc-221380 141595-53-1 C₃₆H₄₄N₆O₆ 500 µg
CGP 71683 hydrochloride hydrate
Selective and potent non-peptide NPY Y5 receptor antagonist.
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sc-203881 192322-50-2 C₂₆H₂₉N₅O₂S ·HCl ·1/4 ·H₂O 10 mg/50 mg
CI 988
A selective and effective antagonist of CCKBR (CCK2, CCK-B) receptors. Described to block the elevated levels of cytosolic Ca2⁺ induced by CCK-8.
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sc-205244 130332-27-3 C₃₅H₄₂N₄O₆ 10 mg/50 mg
CP 96345
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sc-361160 132746-60-2 C₂₈H₃₂N₂O 5 mg/25 mg
CP 154526
A compound described to act as a selective and potent non-peptide CRF-RI and ACTH antagonist.
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sc-205268 157286-86-7 C₂₃H₃₂N₄ ·HCl 10 mg/50 mg
CP 376395 hydrochloride
CRF1 receptor antagonist which is potent and selective. CRF-induced activation of the HPA axis is weakened in in vivo studies following oral activation.
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sc-205271 175140-00-8 C₂₁H₃₀N₂ ·HCl 10 mg/50 mg
Cyclosomatostatin
Non-selective somatostatin (sst) receptor antagonist. Effects of sst are blocked on release of growth hormone, insulin and glucagon, airway β-adrenergic function, modulation of ACh release and CRF-induced suppression of gastric empyting. Potentially acts as an sst receptor agonist in SH-SY5Y, the human neuroblastoma cell line.
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sc-205280 84211-54-1 C₄₄H₅₇N₇O₆ 1 mg
[D-Arg¹,D-Phe⁵,D-Trp^7,9,Leu¹¹]-Substance P
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sc-361166 96736-12-8 C₇₉H₁₀₉N₁₉O₁₂ 1 mg
Devazepide
A non-peptide CCL28 (cholecystokinin 1; CCK1) receptor antagonist. Shown to induce apoptosis and inhibit cell proliferation.
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sc-203562 103420-77-5 C₂₅H₂₀N₄O₂ 10 mg/50 mg
EMD 66684
Potent, selective non-peptide AT1 receptor antagonist.
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sc-203941 187683-79-0 C₂₈H₃₀N₈O₂ ·HCl 10 mg/50 mg
FK 888
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sc-361178 138449-07-7 C₃₆H₃₆N₄O₄ 10 mg
FPR A14
Formyl peptide receptor (FPR) agonist that potently activates neutrophils in vitro (EC50 values are 42 and 630 nM for neutrophil chemotaxis and Ca2+ mobilization respectively).
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sc-294992 n.n. C₂₃H₂₀N₂O₅ 10 mg/50 mg
GR 159897
A compound that acts as an effective and selective NK2 receptor antagonist.
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sc-361193 158848-32-9 C₂₃H₂₇FN₂O₂S 5 mg/25 mg
GR 231118
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sc-361194 158859-98-4 C₁₁₀H₁₇₀N₃₄O₂₄ 500 µg
GW 803430
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sc-363281 515141-51-2 C₂₅H₂₄ClN₃O₃S 10 mg/50 mg
ICI 216,140
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sc-361211 124001-41-8 C₄₅H₆₅N₁₃O₈ 1 mg
IRL-2500
Potent, selective ET(B) antagonist.
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sc-204018 169545-27-1 C₃₆H₃₅N₃O₄ 10 mg
JNJ 5207787
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sc-361218 683746-68-1 C₃₂H₃₈N₄O₂ 10 mg/50 mg
L 760735
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sc-362760 171242-11-8 C₂₆H₂₈F₇N₅O₂.HCl 10 mg/50 mg
L-152,804
Potent, selective non-peptide neuropeptide Y Y5 receptor antagonist (Ki = 26 nM for hY5). Displays > 300-fold selectivity over hY1, hY2, and hY4 receptors. Causes weight loss in diet-induced obese mice by modulating food intake and energy expenditure. Centrally active upon oral administration in vivo.
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sc-203618 6508-43-6 C₂₃H₂₆O₄ 10 mg/50 mg
L-168,049
Potent, orally active non-peptidyl human glucagon receptor antagonist.
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sc-204034 191034-25-0 C₂₄H₂₀BrClN₂O 10 mg/50 mg
L-368,899 hydrochloride
Potent, non-peptide spiroindenylpiperidine camphor-sulfonamide oxytocin receptor antagonist.
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sc-204037 148927-60-0 C₂₆H₄₂N₄O₅S₂•HCl 1 mg/10 mg
L-371,257
Orally active potent and selective oxytocin (OT) receptor antagonist.
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sc-204038 162042-44-6 C₂₈H₃₃N₃O₆ 10 mg
L-692,585
Potent, non-peptidyl growth hormone (GH) secretagogue. Will increase growth hormone levels in vivo.
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sc-204043 145455-35-2 C₃₂H₃₇N₇O₃•xH₂O 10 mg
L-732,138
A selective nonpepetide tachykinin NK-1R antagonist with 1000 fold more potency towards the NK-1R receptor over NK-2R and NK-3R receptors with an IC₅₀ = 2.3 nM.
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sc-203437 148451-96-1 C₂₂H₁₈F₆N₂O₃ 10 mg/50 mg
L-803,087 trifluoroacetate
Potent and selective sst4 agonist Potent and selective somatostatin sst4 receptor agonist. Ki values are 0.7, 199, 4720, 1280 and 3880 nM for cloned human sst4, sst1, sst2, sst3 and sst5 receptors respectively. Facilitates AMPA-mediated hippocampal synaptic responses in vitro and increases kainate-induced seizures in mice in vivo.
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sc-203619 217480-26-7 C₂₅H₂₉F₂N₅O₃ ·CF₃CO₂H 10 mg
LRGILS-NH2
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sc-361979 245329-01-5 C₂₉H₅₆N₁₀O₇ 1 mg
L-817,818
Potent and selective non-peptide somatostatin subtype-5 receptor agonist. Inhibits growth hormone release from rat pituitary cells and insulin release from mouse pancreatic islets in vitro.
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sc-204048 217480-27-8 C₃₃H₃₆N₄O₃ 10 mg
LU AA33810
A potent neuropeptide Y (NPY) Y5 receptor antagonist. Displays ≥ 3300-fold affinity for Y5 over Y1, Y2 and Y4 receptors. Also binds human 5-HT2B and 5-HT1A receptors (Ki values are 247 and 478 nM respectively). Exerts anxiolytic- and antidepressant-like effects in rat models of stress sensitivity.
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sc-295367 304008-29-5 C₁₉H₂₅N₃O₂S₃ 10 mg/50 mg
LY 225910
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sc-361237 133040-77-4 C₂₇H₂₄BrN₃O₂ 5 mg/25 mg
LY 288513
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sc-361242 147523-65-7 C₂₂H₁₈BrN₃O₂ 10 mg/50 mg
NBI 27914 hydrochloride
A selective corticotropin-releasing factor 1 inhibitor.
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sc-204119 184241-44-9 C₁₈H₂₀Cl₄N₄•HCl 10 mg/50 mg
NBI-31772
A non-peptide ligand. Exhibits high-affinity towards all six human insulin-like growth factor-I binding proteins (IGFBPs). Displaces insulin-like growth factor-I (IGF-I) from the IGF-I:IGFBP complex in 3T3 fibroblasts, but does not interact with the IGF receptors.
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sc-222047 n.n. C₁₇H₁₁NO₇ 5 mg
NNC 26-9100
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sc-361276 199522-35-5 C₂₂H₂₅N₆Cl₂SBr 10 mg
NTNCB hydrochloride
Potent, selective, competitive non-peptidic Y5 antagonist. Ki values are 8.0 and 16032 nM at human recombinant Y5 and Y1 receptors respectively. Potently antagonizes NPY inhibition of forskolin-stimulated cAMP. Some affinity for cloned human D2 and α2C receptors (Ki values are 63 and 100 nM respectively).
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sc-203655 486453-65-0 C₂₅H₃₃N₃O₄S.HCl 10 mg/50 mg
Oxytocin acetate salt hydrate
Involved in uterine contraction and lactation. Cys-Tyr-Ile-Gln-Asn-Cys-Pro-Leu-Gly-NH2 [Disulfide Bridge: 1-6]
Katalog # CAS Nummer Summenformel Menge
sc-279938 50-56-6 C₄₃H₆₆N₁₂O₁₂S₂ 1 mg/5 mg
PD 135158
A specific and effective CCK-BR antagonist. Reported to show limited affinity for substance P, benzodiazepine, GABAA, neurotensin, bradykinin, and 5-HT3 binding sites.
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sc-204163 130325-35-8 C₃₅H₄₄N₄O₆•1/2H₂₀ 10 mg/50 mg
PD 160170
Potent, selective non-peptide NPY Y1 antagonist; ; selective over Y2 and Y5 receptors. Antagonizes NPY-mediated inhibition of cAMP accumulation in SK-N-MC cells.
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sc-204836 181468-88-2 C₁₈H₁₇N₃O₄S 10 mg/50 mg
PD 168368
Neuromedin B antagonist displaying ~40-fold selectivity over GRP-R, BB2 and >300-fold selectivity over BRS-R. Antagonizes neuromedin B-stimulated Ca²⁺ release and inhibits proliferation of rat glioma cells.
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sc-204166 204066-82-0 C₃₁H₃₄N₆O₄ 1 mg/10 mg
PD 176252
Gastrin-releasing peptide and Neuromedin B antagonist. Inhibits proliferation of C6 glioma cells as well as NCI-H1299 xenograft proliferation in nude mice.
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sc-204171 204067-01-6 C₃₂H₃₆N₆O₅ 10 mg
[PYR1]-APELIN-13
The pyro-glutamine form of Apelin-13 (sc-351718) that has shown high activity.
Katalog # CAS Nummer Summenformel Menge
sc-359030 217082-60-5 C₆₉H₁₀₈N₂₂O₁₆S 1 mg
RO 90-7501
Inhibitor of amyloid β42 (Aβ42) fibril assembly; reduces Aβ42-induced toxicity (EC₅₀ = 2 μM).
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sc-204891 293762-45-5 C₂₀H₁₆N₆ 10 mg/50 mg
RP 67580
Potent and selective tachykinin NK1 receptor antagonist. Displays higher affinity at rat and mouse than human receptors. Antinociceptive in vivo, possibly partly via inhibition of calcium channels.
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sc-204894 135911-02-3 C₂₉H₃₀N₂O₂•xH₂O 10 mg/50 mg
S 25585
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sc-361325 263-849-50-9 C₂₂H₂₃F₃N₄O₆S 10 mg/50 mg
SB 218795
Potent, selective non-peptide NK3 antagonist
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sc-224280 174635-53-1 C₂₅H₂₀N₂O₃ 10 mg/50 mg
SB 222200
Potent, selective non-peptide NK3 antagonist. Brain penetrant
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sc-224282 174635-69-9 C₂₆H₂₄N₂O 10 mg/50 mg
SB 268262
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sc-362793 217438-17-0 C₁₈H₁₅N₃O₄S₂ 10 mg/50 mg
SB 334867
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sc-361344 249889-64-3 C₁₇H₁₃N₅O₂ 1 mg/10 mg
SB 408124
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sc-361345 288150-92-5 C₁₉H₁₈F₂N₄O 10 mg
SB-366791
A new, potent and selective vanilloid receptor (TRPV1) antagonist. An effective antagonist of hTRPV1 when stimulated by capsaicin, acid, or noxious heat.
Katalog # CAS Nummer Summenformel Menge
sc-222293 n.n. C₁₆H₁₄NO₂Cl 5 mg/25 mg
SCH 79797
A selective PAR₁ antagonist that has been shown to inhibit binding of a high-affinity thrombin receptor-activating peptide.
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sc-203693 245520-69-8 C₂₃H₂₅N₅ ·2HCl 10 mg/50 mg
SDZ NKT 343
Highly selective human tachykinin NK1 antagonist receptor(IC₅₀ values are 0.62 and 451 nM for human and rat receptors respectively) that displays > 130-fold selectivity over human NK2 and NK3 receptors. Potently antagonizes SP-induced Ca²⁺ efflux in vitro and inhibits mechanical hyperalgesia in vivo.
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sc-204274 180046-99-5 C₃₃H₃₃N₅O₅ 10 mg
SLIGRL-NH2
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sc-359903 171436-38-7 C₂₉H₅₆N₁₀O₇ 1 mg
SN 003
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sc-361361 197801-88-0 C₁₉H₂₅N₅O₂ 10 mg
SR 142948
Highly potent non-peptide neurotensin (NT) receptor antagonist that binds with high affinity (IC₅₀ = 0.32 - 3.96 nM). Attenuates amphetamine-induced hyperactivity and is orally active in vivo.
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sc-204297 184162-64-9 C₃₉H₅₁N₅O₆ 1 mg/10 mg
SR 27897
An effective non-peptide antagonist of CCL28 (cholecystokinin 1; CCK1) receptors. Described to act as selective and robust ligand for CCL28 binding sites.
Katalog # CAS Nummer Summenformel Menge
sc-204298 136381-85-6 C₂₀H₁₄ClN₃O₃S 10 mg/50 mg
SR 49059
Potent, selective, non-peptide, orally active vasopressin V1a receptor antagonist; devoid of agonist activity. Shows high affinity and efficacy at both rat (K_i = 1.6 nM) and human (K_i = 1.1-6.3 nM) V1a receptors. Potently antagonizes arginine vasopressin-induced effects in vitro (IC₅₀ = 3.7 nM for inhibition of human platelet aggregation) and is orally active in vivo.
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sc-204300 150375-75-0 C₂₈H₂₇Cl₂N₃O₇S 10 mg
SSR 146977 hydrochloride
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sc-361366 264618-44-2 C₃₅H₄₂Cl₂N₄O₂.HCl 10 mg/50 mg
Sulfisoxazole
Selective ETA endothelin antagonist receptor (IC₅₀ values are 600 and 2200 nM for ETA and ETB receptors respectively).
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sc-204313 127-69-5 C₁₁H₁₃N₃O₃S 50 mg
SUN-B 8155
In CHO/hCTR cells, non-peptide calcitonin (CT) receptor agonist fully stimulates cAMP production. Following i.p. administration, it also causes a significant reduction in serum calcium concentrations in vivo.
Katalog # CAS Nummer Summenformel Menge
sc-203704 345893-91-6 C₁₄H₁₅N₃O₃ 10 mg/50 mg
T 98475
Potent, non-peptide, and orally active gonadotropin-releasing hormone (GnRH, LHRH) receptor antagonist (IC₅₀ values are 0.2, 4.0 and 60 nM for human, monkey, and rat GnRH receptors respectively). Inhibits LH release in vitro (IC₅₀ = 100 nM) and reduces plasma LH concentration in castrated male cynomolgus monkeys.
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sc-204318 192887-28-8 C₃₇H₃₇F₂N₃O₄S 1 mg
Taltirelin
Synthetic thyrotropin-releasing hormone (TRH) analog. Displays ~ 30-100-fold more potent CNS activity and ~ 50-fold weaker endocrine activity than TRH. Both antinociceptive and neuroprotective.
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sc-204319 103300-74-9 C₁₇H₂₃N₇O₅ 1 mg/10 mg
TCS 1102
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sc-361375 916141-36-1 C₂₇H₂₆N₄O₂S 10 mg/50 mg
TCS OX2 29
Potent orexin 2 receptor (OX2) antagonist (IC₅₀ = 40 nM) that displays > 250 fold selectivity over OX1 and over 50 other ion channels, receptors and transporters.
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sc-204329 372523-75-6 C₂₃H₃₁N₃O₃•HCl•xH₂O 10 mg/50 mg
THIQ
Selective and potent melanocortin 4 (MC4) receptor agonist (IC₅₀ values are 1.2, 761 and 2067 nM for human MC4, MC3 and MC1 receptors respectively). Following systemic administration, enhances intracavernosal pressure and stimulates erectile activity in rats ex copula.
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sc-204343 312637-48-2 C₃₃H₄₁ClN₆O₂ 1 mg
TNF-α Antagonist
Also designated WP9QY, an cyclic peptide which mimics the most critical recognition loop on TNF receptor I.
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sc-358755 199999-60-5 C₅₈H₇₁N₁₁O₁₅S₂ 1 mg
Tramiprosate
Sulfated glycosaminoglycan (sGAG) mimetic that targets soluble amyloid β (Aβ) and maintains Aβ in a non-fibrillar form. Decreases brain amyloid plaque load by 30%, increases tau polymerization and is brain penetrant. Decreases Aβ42-induced neuronal death and inhibits amyloid deposition in vitro. Also a GABA analog that protects against the convulsant and cytotoxic activity of kainic acid in vivo.
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sc-204353 3687-18-1 C₃H₉NO₃S 50 mg
Wang resin
Useful resin in the synthesis of peptide acids using Fmoc synthesis strategy. Cleavage can be affected by 95% TFA.
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sc-286858 201058-08-4 n.n. 5 g/25 g
WIN 64338 hydrochloride
The first potent, non-peptide, competitive bradykinin B2 receptor antagonist. In organ bath studies, WIN 64338 inhibits [3H]-bradykinin binding on guinea pig trachea with nanomolar affinity but not active in the rabbit aorta (the classical bradykinin B1 preparation).
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sc-204398 151039-63-3 C₄₅H₆₈ClN₄OP.HCl 10 mg/50 mg
YIL 781
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sc-361410 875258-85-8 C₂₄H₂₈FN₃O₂.HCl 10 mg/50 mg
YM 022
Highly potent and selective non-peptide CCK2 silent antagonist (Ki values are 68 pM and 63 nM at CCK2 and CCK1 receptors respectively). Acts in vivo to potently inhibit gastrin-induced gastric acid secretion and histidine decarboxylase activation with a long duration of action.
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sc-204409 145084-28-2 C₃₂H₂₈N₄O₃ 10 mg/50 mg
ZD 7155 hydrochloride
Katalog # CAS Nummer Summenformel Menge
sc-361418 146709-78-6 C₂₆H₂₆N₆O.HCl 10 mg/50 mg