PARP Inhibitors

1,5-Isoquinolinediol
An inhibitor of PARP, NOS-2, and PARS. Presents cellular protective and neuroprotective properties.
Katalog # CAS Nummer Summenformel Menge
sc-200127 5154-02-9 C₉H₇NO₂ 20 mg/100 mg
3-(4-Chlorophenyl)quinoxaline-5-carboxamide
Strong quinoxaline-based PARP inhibitor with a 5-fold selectivity towards PARP-2 ) over PARP-1. Exhibits good pharmacokinetics. Brain-permeant.
Katalog # CAS Nummer Summenformel Menge
sc-220851 n.n. C₁₅H₁₀ClN₃O 5 mg
3-Aminobenzamide
Shown to inhibit PARP, nitric oxide-induced apoptosis, endogenous poly-ADP-ribosyltransferases, and UV/stress induced apoptosis.
Katalog # CAS Nummer Summenformel Menge
sc-3501 3544-24-9 C₇H₈N₂O 100 mg/5 g
3-Methyl-5-AIQ hydrochloride
Strong inhibitor of poly(ADP-ribose) polymerase-1 in vitro. Exhibits outstanding therapeutic benefits in models of myocardial infarction, ischaemia-reperfusion of the liver and kidney, heart transplantation and acute lung inflammation.
Katalog # CAS Nummer Summenformel Menge
sc-220870 n.n. C₁₀H₁₀N₂O•HCl 1 mg
4-Amino-1,8-naphthalimide
A PARP inhibitor. Sensitizes cells to DNA damaging agents and impedes PARP response to oxygen radicals.
Katalog # CAS Nummer Summenformel Menge
sc-200125 1742-95-6 C₁₂H₈N₂O₂ 20 mg/100 mg
4-HQN
Shown to be a potent PARP inhibitor which decreases activation of transcription factor NFκB and AP-1 in lipopolysaccharide-induced endotoxic shock.
Katalog # CAS Nummer Summenformel Menge
sc-200129 491-36-1 C₈H₆N₂O 50 mg/1 g
5-AIQ hydrochloride
A poly (ADP-ribose) polymerase-1 (PARP-1) inhibitor.
Katalog # CAS Nummer Summenformel Menge
sc-214307 93117-07-8 C₉H₉ClN₂O 1 mg/5 mg
6(5H)-Phenanthridinone
A potent PARP inhibitor and immunosuppressant. Inhibits concanavalin A-induced lymphocyte proliferation. Potentiates radiation effects on cell proliferation. Blocks PARP activity in the apoptotic response to DNA damage.
Katalog # CAS Nummer Summenformel Menge
sc-200124 1015-89-0 C₁₃H₉NO 200 mg
ABT-888
Shown to be a potent inhibitor of PARP-1 and PARP-2, which can result in apoptosis and suppression of cell growth.
Katalog # CAS Nummer Summenformel Menge
sc-202901 912445-05-7 C₁₃H₁₆N₄O ·2HCl 1 mg/5 mg
Benzamide
An inhibitor of PARP. Shows neuroprotective blockade of NAD⁺ and ATP depletion by excessive PARP activation in neurons.
Katalog # CAS Nummer Summenformel Menge
sc-202494 55-21-0 C₇H₇NO 5 g
BMS 493
Katalog # CAS Nummer Summenformel Menge
sc-361124 215030-90-3 C₂₉H₂₄O₂ 10 mg/50 mg
EB-47 dihydrochloride dihydrate
Very potent and water soluble PARP-1 inhibitor. Shows cytoprotective effects against oxidative damage in cells and in in vivo models of reperfusion injury and inflammation.
Katalog # CAS Nummer Summenformel Menge
sc-221574 n.n. C₂₄H₂₇N₉O₆•2HCl•2H₂O 1 mg/5 mg
Minocycline, Hydrochloride
A tetracycline compound with anticollagenase, antimicrobial, and anti-inflammatory properties. Reported to inhibit the enzymatic activity of PARP-1 and angiogenesis.
Katalog # CAS Nummer Summenformel Menge
sc-203339 13614-98-7 C₂₃H₂₇N₃O₇•HCl 50 mg
NU 1025
A potent PARP-1 inhibitor that enhances the cytotoxicity of the DNA methylating compound MTIC (sc-211930), bleomycin, and γ-irradiaton.
Katalog # CAS Nummer Summenformel Menge
sc-203166 90417-38-2 C₉H₈N₂O₂ 5 mg
PARP Inhibitor II, INH2BP
Cell-permeable poly(ADP-ribose) polymerase (PARP) inhibitor. Offers protection against peroxynitrite and hydroxyl radicals.
Katalog # CAS Nummer Summenformel Menge
sc-203344 137881-27-7 C₉H₆INO₂ 5 mg
PARP Inhibitor III, DPQ
PARP Inhibitor III is a highly potent, selective inhibitor of PARP. PARP enzymes are involved in a myriad of cellular functions, such as apoptosis, DNA repair, telomeric maintenance and post-translational modification.
Katalog # CAS Nummer Summenformel Menge
sc-202755 129075-73-6 C₁₈H₂₆N₂O₂ 1 mg/5 mg
PARP Inhibitor IX, EB-47
A cell-permeable, adenosine-substituted, isoindolinone compound that acts as a strong inhibitor of PARP-1. Has been shown to offer cytoprotective effects against oxidative damage in cells and in in vivo models of reperfusion injury and inflammation.
Katalog # CAS Nummer Summenformel Menge
sc-222125 n.n. C₂₄H₂₇N₉O₆ ·2HCl ·2H₂O 1 mg
PARP Inhibitor VIII, PJ34
A cell permeable inhibitor of poly(ADP-ribose) polymerase with an EC50=20nM.
Katalog # CAS Nummer Summenformel Menge
sc-204161 344458-15-7 C₁₇H₁₇N₃O₂•HCl 1 mg/5 mg
PARP Inhibitor XI, DR2313
A water soluble and brain-permeable pyrimidinone compound that functions as a Poly(ADP-ribose) polymerase inhibitor.
Katalog # CAS Nummer Summenformel Menge
sc-202756 284028-90-6 C₈H₁₀N₂OS 5 mg
PARP Inhibitor XII
A potent quinoxaline-based PARP inhibitor with selectivity towards PARP-2 over PARP-1. Has shown to be brain-permeant and exhibit good pharmacokinetics.
Katalog # CAS Nummer Summenformel Menge
sc-222126 n.n. C₁₅H₁₀ClN₃O 5 mg
PARP Inhibitor XIV
A cell-permeable isoquinolinedione compound that potently inhibits PARP-1 activity in a NAD+-competitive and reversible manner. Affects PPAR-2 activity with lower potency. Selectively inhibits PARP-1-mediated cellular PAR formation and is of little effect against PAR formation in fibroblasts derived from parp-1(-/-) mice. Its in vivo application is limited.
Katalog # CAS Nummer Summenformel Menge
sc-222127 1104546-89-5 C₁₅H₁₂N₂O₂ 10 mg
PJ-34
This is a potent, water soluble poly(ADP-ribose) polymerase (PARP) inhibitor (EC₅₀=20nM compared to EC₅₀=200µM of the prototypical PARP inhibitor 3-aminobenzamide. Inhibits peroxynitrite-induced cell necrosis (EC₅₀=20nM). This has significant, dose-dependent, anti-inflammatory effects in a variety of local inflammation models and provides cardioprotection by decreasing myocardial infarct size.
Katalog # CAS Nummer Summenformel Menge
sc-222179 344458-15-7 C₁₇H₁₇N₃O₂•HCl 1 mg/5 mg
TIQ-A
Potent poly(ADP-ribose) polymerase-1 (PARP-1) inhibitor (IC₅₀=450nM). Neuroprotective against oxygen-glucose deprivation injury in vitro in cultured murine cortical cells.
Katalog # CAS Nummer Summenformel Menge
sc-204916 420849-22-5 C₁₁H₇NOS 1 mg/5 mg