5'-Guanidinonaltrindole di(trifluoroacetate) salt hydrate A selective opioid receptor antagonist. GNTI is five-fold more potent and 500-fold more selective than norbinaltorphimine (nor-BNI) for the opioid receptor in smooth muscle preparations.
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sc-252280
219655-57-9 (anhydrous)
C27H29N5O3··2C2HF3O2··xH2O
5 mg
6'-Guanidinonaltrindole ditrifluoroacetate dihydrate 6'-GNTI is a selective agonist of /∂ opioid receptor heterodimers in the spinal cord and has the unique property of selectively activating only opioid receptor heterodimers, but not homomers. 6'-GNT functions as an analgesic demonstrating that opioid receptor heterodimers are functionally relevant in vivo.
BNTX maleate salt hydrate BNTX is a selective d1 non peptide opioid receptor antagonist that has been used as a tool to study various functions of opioid receptors.
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sc-300255
n.n.
C31H31NO8•xH2O
5 mg
BRL 52537 hydrochloride Potent and highly κ/μ selective κ-opioid receptor agonist (25 times more potent than morphine).
GR 89696 fumarate Highly potent subtype-selective kappa-opioid receptor agonist.
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sc-203982
126766-32-3
C19H25Cl2N3O3 ·C4H4O4
10 mg/50 mg
HZ2 A compound that displays a high and selective affinity towards κ opioid receptors (KORs). Mechanistic studies show that the keto carbonyl group of HZ2 binds to a lysine residue of KOR.
(±)-J 113397 Potent and selective NOP antagonist receptor (IC50 values are 2.3, 1400, 2200 and > 10000 nM for NOP, κ, μ and δ-opioid receptors respectively). Nociceptin/orphanin FQ-induced hyperalgesia inhibitor in the mouse tail-flick test.
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sc-204020
n.n.
C24H37N3O2
10 mg/50 mg
JTC 801 High affinity, selective NOP receptor antagonist (Ki = 8.2 nM). Displays approximately 12.5-, 129- and 1055-fold selectivity over human μ-, κ- and δ-opioid receptors respectively. In vivo shows anti-nociceptive effects in acute pain models. Orally active.
LPK-26 LPK-26 is an analog of ICI-199441 and (-)U50,488H (classic kappa agonists). It has extremely high kappa affinity (0.64 nM) and low mu and delta receptor affnities (1170 and 10,000nM). LPK-26 produces an antinocicpetive effect with much higher potency in vivo than morphine or U50488. LPK-26 does not produce physical dependence in mice, but it does suppress naloxone-induced behavioral effects in mice treated with morphine.
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sc-252971
492451-07-7
C18H24Cl2N2O•HCl
5 mg
Metaphit methanesulfonate salt An irreversible, non-competitive antagonist at the phencyclidine site on the NMDA receptor.
Naloxone methiodide Quaternary salt of naloxone that is a nonselective antagonist at opioid receptors. It does not cross the blood-brain barrier.
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sc-255387
93302-47-7
C20H24INO4
25 mg/100 mg
Naltriben methanesulfonate hydrate Naltriben methanesulfonate is a highly selective ∂2 opioid receptor antagonist. Ligand binding assays show biphasic binding of the antagonist to the single receptor type.
NNC 63-0532 Potent non-peptide agonist for the NOP receptor (EC50 = 305 nM, KI = 7.3 nM); ~ 12-fold selective over other receptors. Centrally active following systemic administration in vivo.
Opipramol dihydrochloride 1/ 2 opioid receptor agonist; an antagonist at D2, 5HT2 and H1 receptors; atypical antidepressant, anxiolytic and antipsychotic.
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sc-255404
909-39-7
C23H29N3O ·2HCl
25 mg
Org 27569 CB1 receptor allosteric modulator. Exhibits increased binding of the CB1 agonist. Inhibits CB1 receptor antagonist effectiveness in vitro.
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sc-204151
868273-06-7
C24H28ClNO3
10 mg/50 mg
Salvinorin A Highly potent and selective non-nitrogenous k-opioid agonist. Exhibits allosteric modulation of µ-opioid receptor binding. Reported brain-penetrand and exhibiting psychoactive properties.
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sc-204260
83729-01-5
C23H28O8
1 mg
SCH 221510 A selective and potent nociceptin opioid receptor (NOP) agonist.
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sc-358790
322473-89-2
C28H31NO
10 mg/50 mg
SDM25N hydrochloride Potent and selective non-peptide d antagonist. Higher selectivity than naltrindole.
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sc-203694
342884-62-2
C26H26N2O3•HCl
10 mg/50 mg
Sialorphin An analgesic and an exocrine and endocrine signaling mediator, predominantly synthesized in the submandibular gland and prostate of adult rats. Sialorphin prevents spinal and renal NEP from breaking down substance P and Met-enkephalin in vitro. It inhibits the breakdown of substance P with an IC50 of 0.4-1 µM and behaves as a competitive inhibitor. Elicits potent antinociceptive responses in two behavioral rat models of injury-induced acute and tonic pain. Has a role in erectile function most likely through a mechanism that involves relaxation of corporal smooth muscle tissue.
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sc-253554
131748-26-0
C26H42N12O8
1 mg
SNC 121 Saturated analog of potent and selective δ opioid receptor agonist SNC 80, with similar binding profile to the parent compound.
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sc-204291
159860-31-8
C28H41N3O2
10 mg
SNC 162 Potent and selective non-peptide δ-opioid receptor agonist (Ki = 0.63 nM). Shows > 8000-fold selectivity over μ-opioid receptors and is centrally active following systemic administration in vivo.
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sc-204292
178803-51-5
C27H37N3O
10 mg/50 mg
SNC 80 Highly selective and potent non-peptide δ−opioid receptor agonist.
