| | NOS Activators and Inhibitors
- 1-Amino-2-hydroxyguanidine, p-Toluenesulfonate
A potent cell-permeable inhibitor of NOS2 (inducible nitric oxide synthase; iNOS), in mouse macrophages and in vitro rat aortic smooth muscle cells (RASM).| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-3565 | n.n. | C8H15N4O4S | 10 mg |
- 1,3-PB-ITU dihydrobromide
Potent and selective inhibitor of inducible nitric oxide synthase (iNOS; NOS II).| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-220549 | n.n. | C12H18N4S2•2HBr | 10 mg |
- 1,3-PBITU, Dihydrobromide
Competitive and highly potent inhibitor of nitric oxide synthase (NOS) with a stronger selectivity for NOS2 than NOS3.| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-3568 | n.n. | C12H18N4S2··2HBr | 50 mg |
- 1,4-PB-ITU dihydrobromide
Potent inhibitor of inducible nitric oxide synthase (iNOS; NOS II).| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-202003 | 157254-60-9 | C12H18N4S2 ·2HBr | 10 mg/50 mg |
- 1400 W
A highly potent and selective inhibitor of inducible nitric-oxide synthase (iNOS).| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-3564 | 214358-33-5 | C10H15N3 ·2HCl | 5 mg/25 mg |
- 2-(2-Amino-ethyl)-aniline dihydrochloride
| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-sc-202178
| 1159823-45-6 | C8H12N2•2HCl | 100 mg |
- 2-Amino-4-methylpyridine
Potent inhibitor of inducible nitric oxide synthase (iNOS; NOS II) both in vitro and in vivo. Analgesic agent.| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-202879 | 695-34-1 | C6H8N2 | 1 g |
- 2-Imino-4-methylpiperidine acetate
Specific inhibitor of inducible nitric oxide synthase (iNOS; NOS II).| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-202402 | 165383-72-2 | C6H12N2 ·C2H4O2 | 5 mg/25 mg |
- 2-Imino-4-methylpiperidine, Acetate
A strong inhibitor of human iNOS (hNOS II).| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-216215 | n.n. | C8H16N2O2 | 10 mg |
- 2-Imino-4,6-dimethylpiperidine, Acetate
A strong inhibitor of human iNOS (hNOS II).| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-216216 | 165383-79-9 | C9H18N2O2 | 10 mg |
- 2-Iminobiotin
Reversible inhibitor of mouse inducible and rat neuronal nitric oxide synthase (iNOS/NOS II; nNOS/NOS I).| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-202403 | 13395-35-2 | C10H17N3O2S | 10 mg/50 mg |
- 2-Iminopiperidine hydrochloride
An inhibitor of NO synthases with an IC50 value of 1.0 and selective for iNOS.| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-203462 | 16011-96-4 | C5H10N2•HCl | 10 mg/50 mg |
- 2-Methyl-3,4-dichloropyridine N-Oxide
| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-216247 | n.n. | C6H5Cl2NO | 250 mg |
- 2,3-Diaminonaphthalene
Inhibitor of NO formation. DAN reacts rapidly with NO-derived N-nitrosating agent(s) to yield the highly fluorescent product NAT.| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-202882 | 771-97-1 | C10H10N2 | 100 mg |
- 2,4-Diamino-6-hydroxypyrimidine
A selective inhibitor of GTP cyclohydrolase I, suppressing biopterin synthesis and inhibiting LPS-induced NO synthesis.| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-202404 | 56-06-4 | C4H6N4O | 250 mg/1g |
- 3-Bromo-7-nitroindazole
A specific inhibitor of nitric oxide synthase (NOS). Has been shown to inhibit bovine endothelial, and rat cerebellar and lung NOS enzyme activity.| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-200347 | 74209-34-0 | C7H4BrN3O2 | 5 mg/25 mg |
- 3-Bromo-7-nitroindazole sodium salt
Salt form of 3-bromo-7-nitroindazole. Strong inhibitor of rat cerebellar nitric oxide synthase (nNOS/NOS I). Stronger than 7-nitroindazole| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-220856 | n.n. | C7H3BrN3NaO2 | 5 mg |
- 4-AF DA
A cell-permeable negative control compound for the nitric oxide (NO) fluorescent indicator DAF-2 DA (sc-221526). Unlike DAF-2 DA, 4-AF DA does not react with NO to form a fluorescent product. | Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-220924 | n.n. | C24H17NO7 | 1 mg |
- 4-Amino-(6R)-5,6,7,8-tetrahydro-L-biopterin dihydrochloride
| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-362202 | n.n. | C9H17N6O3 ·2HCl | 10 mg |
- 4-Chloro-3-methylpyridine 1-Oxide
A nicotinamide analogue that acts as a neoplasm inhibitor.| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-206857 | 1073-34-3 | C6H6ClNO | 10 mg |
- 4-Methyl-1-hydrazinophthalizine Hydrochloride
| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-216923 | 29902-28-1 (non-salt) | C9H10N4•HCl | 10 mg |
- 4-Phenyl-3-furoxancarbonitrile
| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-206935 | 125520-62-9 | C9H5N3O2 | 10 mg |
- 5-Acetoxymethyl-2,3-dimethyl-4-chloropyridine N-oxide
Intermediate in the preparation of Omeprazole metabolites| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-217113 | n.n. | C10H12ClNO3 | 10 mg |
- 5-Acetoxymethyl-2,3-dimethylpyridine N-oxide
Intermediate in the preparation of Omeprazole metabolites| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-217115 | n.n. | C10H13NO3 | 25 mg |
- 7-Nitroindazole
This product is a competitive, selective, and reversible specific neuronal nitric oxide synthase (NOS) inhibitor.| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-3569 | 2942-42-9 | C7H5N3O2 | 100 mg |
- 7-Nitroindazole sodium salt
Provides a useful tool for the study of nitric oxide (NO) activity in the brain. A more soluble salt form of 7-nitroindazole. Higher solubility in artificial cerebrospinal fluid (CSF) permits its use as an inhibitor of nitric oxide synthase (NOS) in rat brain tissue. | Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-221114 | 2942-42-9 (non-salt) | C7H4N3O2 ·Na | 5 mg/25 mg |
- 7,8-Dihydro-L-biopterin
BH2 is a precursor of BH4 synthesis. It is a noncompetitive inhibitor of GTP cyclohydrolase I.| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-202895 | 6779-87-9 | C9H13N5O3 | 10 mg/50 mg |
- α-Carboline-15N2 N-Oxide
An intermediate in the preparation of labeled α-Carboline derivatives.| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-220428 | n.n. | C11H8(15N)2O | 1 mg |
- α-Guanidinoglutaric acid
Linear mixed-type inhibitor of neuronal nitric oxide synthase (nNOS/NOS I).| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-202031 | 73477-53-9 | C6H11N3O4 | 10 mg/50 mg |
- Agmatine sulfate
The decarboxylated form of L-arginine. Binds α2-adrenergic receptors and imidazoline binding sites. Blocks NMDA receptor-associated ion channels. Inhibits NOS activity.| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-202920 | 2482-00-0 | C5H14N4.H2SO4 | 100 mg/500 mg |
- Aminoguanidine bicarbonate
Inhibitor of nitric oxide synthase (NOS).
| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-202460 | 2582-30-1 | CH7N4 ·HCO3 | 100mg/500 mg |
- Aminoguanidine hemisulfate
An Inhibitor of NOS (nitric oxide synthase) and NO (nitric oxide).| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-202930 | 996-19-0 | CH6N4 ·0.5H2SO4 | 100 mg/500 mg |
- Aminoguanidine hydrochloride
Irreversible inhibitor of iNOS that displays some selectivity over eNOS and nNOS. | Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-202931 | 1937-19-5 | CH6N4•HCl | 100 mg/500 mg |
- AMT HYDROCHLORIDE
Potent, selective iNOS inhibitor| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-202052 | 21463-31-0 | C5H10N2S•HCl | 10 mg/50 mg |
- ARL 17477 dihydrochloride
| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-361108 | 180983-17-9 | C20H20ClN3S.2HCl | 10 mg/50 mg |
- Artemisinin
Powerful antimalarial agent. Inhibits angiogenesis by down-regulating HIF-1α and VEGF expression. Inhibitor of human iNOS.| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-202960 | 63968-64-9 | C15H22O5 | 100 mg/1 g |
- BAY-41-8543
Soluble guanylate cyclase (sGC) is the primary cellular receptor for nitric oxide (NO). NO binds and activates a heme group in sGC, initiating the conversion of GTP to the second messenger cyclic GMP (cGMP). BAY-41-8543 is a heme-dependent stimulator of sGC, increasing the activity of recombinant sGC dose-dependently up to 92-fold. Surprisingly, NO donors synergize with BAY-41-8543 in stimulating recombinant sGC. BAY-41-8543 relaxes vessels and inhibits platelet aggregation in vitro at nM concentrations. In vivo, BAY-41-8543 decreases blood pressure dose-dependently, prolongs bleeding time, and reduces thrombosis. Inhalation of microparticles containing BAY-41-8543 increases pulmonary vasodilation without changing mean arterial pressure suggesting that agonists of sGC may be efficacious in treating pulmonary hypertension.| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-291927 | 256498-66-5 | C21H21FN8O | 1 mg/5 mg |
- BEC, Hydrochloride
A boronic acid-based arginine analog that acts as a slow-binding, competitive transition state inhibitor of arginases I and II (K = 310 nM for human recombinant type II arginase, pH 7.5). BEC does not inhibit nitric oxide synthase (NOS), it causes significant enhancement of NO-dependent smooth muscle relaxation in human penile corpus cavernosum tissue.| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-221291 | n.n. | C5H13BClNO4S | 5 mg |
- BYK 191023 dihydrochloride
| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-361131 | 608880-48-4 | C14H14N4O ·2HCl | 10 mg/50 mg |
- Canavanine sulfate
A non-protein amino acid with structural analogy to L-arginine. Inhibits iNOS.| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-202983 | 2219-31-0 | C5H12N4O3 ·H2SO4 | 100 mg/500 mg |
- Carboxy-PTIO, potassium salt
A stable nitric oxide radical scavenger that shows in chemical and biological systems antagonistic action against the free nitric oxide radical.| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-202985 | 148819-94-7 | C14H16KN2O4 | 10 mg/50 mg |
- Carboxy-PTIO, Sodium Salt
Reacts with nitric oxide at pH 7.4, which results in the generation of NO2-/NO3--with a rate constant of 1 x 104 M-1 sec-1. It prevents SIN-1 induced endothelial cell death and has potent therapeutic value in endotoxin shock through its nitric oxide scavenging action. | Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-221395 | n.n. | C14H16NaN2O4 | 10 mg |
- D-NG-Nitroarginine Methyl Ester HCl (D-NAME)
The inactive stereoisomer of L-NAME, employed as negative control in L-NAME-induced NOS inhibition studies. | Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-200335 | 50912-92-0 | C7H15N5O4 ·HCl | 200 mg/1 g |
- DAF-FM
An important quantitative reagent for low nitric oxide concentrations in solution. Upon reaction with nitric oxide, this product exhibits fluorescence. | Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-221527 | 254109-20-1 | C21H14F2N2O5 | 1 mg |
- DAR-4M
A rhodamine-based photo-stable nitric oxide (NO) fluorescent indicator with a detection limit of ~10 nM. Reacts with NO, in the presence of oxygen, resulting in a triazolo-rhodamine analog (DAR-4M T) that exhibits about 840-fold greater fluorescence quantum efficiency. The fluorescence intensity is not dependent on pH, unlike DAF-2.| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-221529 | n.n. | C25H26N4O3 | 1 mg |
- DAR-4M AM
A cell-permeable, photo-stable nitric oxide (NO) fluorescent indicator with a detection limit of ~10 nM. Intracellularly releases DAR-4M by the action of esterases. Reacts with NO, in the presence of oxygen, resulting in a triazolo-rhodamine analog (DAR-4M T) that exhibits about 840-fold greater fluorescence quantum efficiency. The fluorescence intensity is not dependent on pH. | Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-221530 | n.n. | C28H31IN4O5 | 1 mg |
- Diethylamine NONOate/AM
An esterase-sensitive and cell permeable, O2-acetoxymethylated diazeniumdiolate that acts as an intracellular NO donor. Shown to induce apoptosis and to act as an antiproliferative agent in NO-sensitive human leukemia HL-60 and U937 cell lines. Also suppresses oxidized low-density lipoprotein-induced caspase-3 activation in bovine aortic endothelial cells. Exhibits enhanced stability in physiological buffers. May also be useful for temporal and spatial controlled NO availability.| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-221540 | n.n. | C7H15N3O4 | 1 mg/5 mg |
- Diphenyleneiodonium chloride
Binds strongly to flavoproteins. Powerful and specific inhibitor of several enzymes, including NOS, NADPH-ubiquinone oxidoreductase, NADPH oxidases and NADPH cytochrome P450 oxidoreductase.| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-202584 | 4673-26-1 | C12H8ICl | 25 mg/100 mg |
- Diphenyleneiodonium Sulfate
| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-207583 | 4510-83-2 | C12H8I•1/2SO4 | 50 mg |
- D-NG-Monomethylarginine (D-NMMA)
An endothelin-derived relaxing factor inhibitor. Cell permeable. Negative control for NG-Monomethyl-L-arginine, L-NMMA (Cat. No. sc-200739). | Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-200332 | 137694-75-8 | C7H16N4O2 ·CH3COOH | 5 mg |
- Ethylthiourea
A compound most commonly used as a corrosion inhibitor for metals but also retains bactericidal properties. Used as a precursor for the synthesis of new rhenium complexes.| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-203333 | 625-53-6 | C3H8N2S | 10 g |
- FeTPPS
A ferric porphyrin complex that catalytically isomerizes peroxynitrite to nitrate both in vivo and in vitro. Hence, serves as a decomposition catalyst and a selective peroxynitrite scavenger. Does not complex with nitric oxide and exhibits little SOD mimetic activity. Provides cytoprotection against peroxynitrite. | Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-221611 | 90384-82-0 | C44H28ClFeN4O12S4 | 25 mg |
- Gallotannin
Strongly inhibits NOS activity, endothelial constitutive NOS3 (eNOS; NOSIII), and PARG (poly (ADP-ribose) glycohydrolase). | Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-202619 | 1401-55-4 | C76H52O46 | 1 g/10 g |
- GED bicarbonate
Peroxynitrite scavenger. Potent inhibitor of mouse inducible nitric oxide synthase (iNOS; NOS II). | Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-221664 | n.n. | n.n. | 10 mg |
- Gemfibrozil
A hyperlipidemic agent that elevates plasma HDL and lowers triglycerides and LDL by stabilizing apoA-I mRNA transcripts. It was found to inhibit inducible nitric oxide synthase by inhibiting the activation of nuclear factor-kappaB, activator protein-1 and CCAAT/enhancer-binding proein beta.| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-204764 | 25812-30-0 | C15H22O3 | 5 g/25 g |
- Glyco-SNAP-1
A water-soluble nitric oxide (NO) donor. More stable (t½ = 28.5-30.2 hr) than SNAP in aqueous solution with or without EDTA and is relatively stable at high pH (pH 8 - 9). The SNAP moiety acts as an NO group donor and the sugar moiety provides hydrophilicity and specificity. Compared to SNAP, glyco-SNAP-1 decomposes at a much slower rate in the presence of thiols such as glutathione or cysteine.| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-221680 | 188849-81-2 | C13H23N3O8S | 5 mg |
- Histamine, Free Base
A potent vasodilator found in normal tissues and blood; formed by the decarboxylation of L-histidine. Activates nitric oxide synthase (NOS), resulting in the release of nitric oxide.| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-204000 | 51-45-6 | C5H9N3 | 1 g/5 g |
- Hydroxyurea-15N
Anti-neoplastic with ribonucleoside reductase and DNA replication inhibitory effects. Potential therapy for sickle cell anemia involving the nitrosylation of sickle cell hemoglobin.| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-207747 | 214331-53-0 | CH4N2O2 | 1 mg |
- Hyperforin dicyclohexylammonium salt
An inhibitor of monoamine neurotransmitter uptake. Suppresses iNOS activity. Activates the TRPC6 receptor channel. Induces cytochrome p450 3A4 monooxygenase expression through activation of the pregnane X receptor.| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-202178 | 238074-03-8 | C35H51O4•C12H24N | 500 µg/1 mg |
- Hypoestoxide, Hypoestes rosea
A naturally occurring, cell-permeable diterpene with anti-inflammatory properties. A selective and direct IκB kinase inhibitor in TNF-α stimulated HeLa cells. This prevents NF-κB activation. Also inhibits the nitric oxide production by IL-1β or IL-17 stimulated chondrocytes.| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-221735 | 88498-46-8 | C22H32O5 | 1 mg |
- Isatin
An endogenous monoamine oxidase inhibitor that is involved in stress and anxiety. This compound is an inhibitor of alkaline phosphatase, nitric oxide (NO)-
stimulated soluble guanylate cyclase, and other enzymes.| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-205721 | 91-56-5 | C8H5NO2 | 100 g/500 g |
- Isoniazid
A front-line antituberculosis agent. Generates nitric oxide when activated by KatG. Also a strong inhibitor of DPH metabolism.| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-205722 | 54-85-3 | C6H7N3O | 5 g/50 g |
- L-Biopterin
An obligate cofactor of inducible nitric oxide synthase. | Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-204781 | 22150-76-1 | C9H11N5O3 | 25 mg/100 mg |
- L-N6-(1-Iminoethyl) Lysine 5-Tetrazole Amide, Dihydrochloride
| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-280886 | n.n. | C9H22Cl2N8O | 5 mg |
- L-NG-Monomethylarginine, Acetate Salt (L-NMMA)
An inhibitor of Ca2+-dependent endothelial nitric oxide synthase. Also shown to increase leukocyte adherence and emigration and reduce venular shear rate in cat vascular endothelia.| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-200739 | 53308-83-1 | C9H20N4O4 | 25 mg |
- L-NG-Nitroarginine Methyl Ester (L-NAME)
A commonly used competitive and reversible inhibitor of NOS1, 2, and 3 which is more potent than L-NMMA (sc-200739). | Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-200333 | 51298-62-5 | C7H15N5O4 ·HCl | 1 g/5 g |
- L-NIL, Dihydrochloride
A potent inhibitor of nitric oxide synthase (NOS) that permeates the cell membrane.| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-3567 | 150403-89-7 | C8H17N3O2•2HCl | 10 mg |
- L-NIO dihydrochloride
| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-361229 | 36889-13-1 | C7H15N3O2.2HCl | 10 mg/50 mg |
- L-Sepiapterin
Key intermediate in the pterin salvage pathway of tetrahydrobiopterin biosynthesis.| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-202689 | 17094-01-8 | C9H11N5O3 | 10 mg/50 mg |
- L-Thiocitrulline
A potent inhibitor of Neuronal and Inducible Nitric Oxide Synthase.| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-221813 | 156719-37-8 | C6H13N3O2S | 10 mg/50 mg |
- L-thiocitrulline, Dihydrochloride
Potent stereospecific inhibitor of all three isoforms of rat nitric oxide synthases (NOS1,2, and 3), that demonstrates greater inhibitory activity on NOS1, compared to NOS2 or 3.| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-3572 | 212051-53-1 | C6H13N3O2S•2HCl | 10 mg |
- Lansoprazole-d4 Sulfone N-Oxide
A labeled impurity of Lansoprazole.| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-280903 | n.n. | C16H10F3N3O4S | 1 mg |
- Lipopolysaccharide, E. coli J5
Mutant of E. coli O111: B4. It stimulates the activity of inducible nitric oxide synthase. It also induces apoptosis in mouse thymus and swine lymphocytes.| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-221854 | n.n. | n.n. | 5 mg |
- Lipopolysaccharide, E. coli O55: B5
This stimulates the activity of inducible nitric oxide synthase. It induces apoptosis in mouse thymus and swine lymphocytes. | Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-221855 | n.n. | n.n. | 10 mg/25 mg |
- Lipopolysaccharide, Salmonella minnesota Re 595
This stimulates the activity of inducible nitric oxide synthase. It also induces apoptosis in mouse thymus and swine lymphocytes. | Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-221856 | n.n. | n.n. | 5 mg |
- Lipopolysaccharide, Ultra Pure, Salmonella minnesota R595 (Re)
Phenol-petroleum ether extracted lipopolysaccharide (LPS) containing 0.3% proteins. LPS 595 (Re) has been shown to stimulate Toll-like receptor-4 (TLR4), but not TLR2, signaling in human cell lines. | Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-221858 | n.n. | n.n. | 1 mg |
- MEG sodium succinate
Inhibits inducible nitric oxide synthase (iNOS; NOS II). Peroxynitrite scavenger.
| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-221879 | n.n. | C3H10N3S•C4H4O4Na | 10 mg |
- MnTBAP chloride
| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-221954 | n.n. | C48H28MnN4O8Cl | 10 mg/50 mg |
- N G-Nitro-L-arginine
A potent nitric oxide synthase inhibitor with selectivity of NOS1 and NOS3 over NOS2.| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-3570 | 2149-70-4 | C6H13N5O4 | 1 g |
- Glyco-SNAP-2
A highly soluble nitric oxide donor, which is relatively stable at a high pH (pH 8-9).| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-218911 | 188849-82-3 | C13H23N3O8S | 10 mg/50 mg |
- N-(Dithiocarbamoyl)-N-Methyl-D-Glucamine, Sodium Salt
A water soluble dithiocarbomate type chelator which is able to generate many transitional metal complexes. Useful for NO detection under physiological conditions.| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-218966 | 91840-27-6 | C8H16NNaO5S2 | 100 mg |
- N-(Indole)nitroso Naratriptan
A derivative of Naratriptan.| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-218969 | n.n. | C17H24N4O3S | 1 mg |
- N-(Methyl-d3)-N'-nitrosopiperazine
A labeled N-nitrosopiperazine derivative that displays strong nasal carcinogenicity and genotoxicity after low dose inhalation. | Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-218973 | n.n. | C5H8D3N3O | 25 mg |
- N-Benzylacetamidine Hydrobromide
Of the different types of nitric oxide synthases (NOS), the inducible (iNOS) form contributes to inflammation and immune response while the constitutively-expressed endothelial (eNOS) enzyme plays important roles in regulating vascular tone. N-Benzylacetamidine is a potent inhibitor of iNOS (IC50 = 0.0 μM), with over 1,000-fold selectivity compared to eNOS (IC50 = 350 µM).| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-295668 | 186545-76-6 | C9H12N2•HBr | 5 mg/10 mg |
- N-Methyl-L-aspartic acid
| Katalog # | CAS Nummer | Summenformel | Menge |
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| sc-212234 | 4226-18-0 | C5H9NO4 | 10 mg/50 mg |
- N-Nitroso Akardite II
| Katalog # | CAS Nummer | Summenformel | Menge |
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| sc-219204 | 1076199-26-2 | C14H13N3O2 | 250 mg |
- N, N'G-Dimethyl-L-arginine di(p-hydroxyazobenzene-p'-sulfonate)
Has been shown not to inhibit nitric oxide synthesis, both in vitro and in vivo. This salt form is more stable than the dihydrochloride.| Katalog # | CAS Nummer | Summenformel | Menge |
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| sc-202235 | 102783-24-4 | C8H18N4O2 ·2C12H10N2O4S | 5 mg/25 mg |
- N,N-Dicarboxymethyl-N,N-dinitroso-p-phenylenediamine, Disodium Salt
A caged, photolabile Nitric Oxide donor that is useful for delivering nitric oxide into intracellular compartments in microsecond time scale without any cytotoxic effects. Upon irradiation these donors produce two NO molecules per molecule of BNN.| Katalog # | CAS Nummer | Summenformel | Menge |
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| sc-219273 | 1042969-16-3 | C10H8N4Na2O6 | 1 mg/5 mg |
- N(5)-(1-Iminoethyl)-L-ornithine HCl (L-NIO)
A potent inhibitor of endothelial cell nitric oxide synthase, neutrophil, and J774 enzymes. Also shown to induce a dose-dependent increase in mean systemic arterial blood pressure.| Katalog # | CAS Nummer | Summenformel | Menge |
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| sc-200343 | 150403-88-6 | C7H15N3O2 ·HCl | 10 mg/100 mg |
- NG-Amino-L-arginine hydrochloride
Potent inhibitor of endothelial and inducible nitric oxide synthase (eNOS/NOS III and iNOS/NOS II).| Katalog # | CAS Nummer | Summenformel | Menge |
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| sc-222066 | n.n. | C6H15N5O2•HCl | 5 mg |
- NG-Monoethyl-L-arginine . monoacetate
| Katalog # | CAS Nummer | Summenformel | Menge |
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| sc-222068 | n.n. | C10H22N4O4 | 5 mg/25 mg |
- NG-Monomethyl-L-homoarginine monoacetate
| Katalog # | CAS Nummer | Summenformel | Menge |
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| sc-222069 | n.n. | C10H22N4O4 | 5 mg |
- NG, N'G-Dimethyl-L-arginine dihydrochloride
Does not inhibit nitric oxide synthesis, both in vitro and in vivo.| Katalog # | CAS Nummer | Summenformel | Menge |
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| sc-222070 | n.n. | C8H18N4O2•2HCl | 5 mg/25 mg |
- N4-tert-Butoxycarbonyl-1-[2-(2-hydroxyethoxy)ethyl]piperazine N1-Oxide
Intermediate in the preparation of Quetiapine derivatives.| Katalog # | CAS Nummer | Summenformel | Menge |
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| sc-219313 | n.n. | C13H26N2O5 | 250 mg |
- NG-Hydroxy-L-arginine, Monoacetate Salt
Cell-permeable. A key intermediate in the biosynthesis of nitric oxide by constitutive nitric oxide synthase (cNOS). Can be efficiently oxidized to nitric oxide and citrulline by cytochrome P450 system.| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-222067 | 53598-01-9 | C6H14N4O3•CH3CO2H | 25 mg/5 mg |
- NG, NG-Dimethyl-L-arginine di(p-hydroxyazobenzene-p'-sulfonate)
Inhibits nitric oxide synthesis. Also, the salt form is more stable than the dihydrochloride.| Katalog # | CAS Nummer | Summenformel | Menge |
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| sc-224167 | n.n. | C32H38N8O10S2 | 5 mg/25 mg |
- Nicotinic Acid Methyl Ester 5-N-Methylnitrone
| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-219366 | n.n. | C9H10N2O3 | 100 mg |
- Oleanolic Acid
A naturally occurring triterpenoid found in garlic and Phytolacca Americana. Exhibits strong anti-HIV activity. Mechanism of action is the induction of iNOS and of Cyclooxygenase 2.| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-205775 | 508-02-1 | C30H48O3 | 100 mg/500 mg |
- p-Nitroblue Tetrazolium Chloride
NADPH-diaphorase substrate that competitively inhibits nitric oxide synthase. Also displays activity as a scavenger of superoxide anions. Utilized as an alkaline phosphatase substrate.| Katalog # | CAS Nummer | Summenformel | Menge |
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| sc-296003 | 298-83-9 | C40H30Cl2N10O6 | 250 mg |
- Penicillamine
Exogenous NOS modulator, found to inhibit urease activity.| Katalog # | CAS Nummer | Summenformel | Menge |
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| sc-205795 | 52-67-5 | C5H11NO2S | 1 g/5 g |
- PTIO
A stable radical species. Reacts with and extinguishes NO without affecting NOS activity.| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-202782 | 18390-00-6 | C13H17N2O2 | 25 mg |
- Ropinirole N-Oxide
Reference standard.| Katalog # | CAS Nummer | Summenformel | Menge |
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| sc-219988 | 1076199-41-1 | C16H24N2O2 | 1 mg |
- ROS Probe, HPF
A cell-permeable, photo-stable hydroxyphenyl-substituted fluorescein compound that acts as a highly sensitive fluorescent probe for the detection of hydroxyl radical and peroxynitrite. It has little activity towards other reactive oxygen species (ROS), such as hypochlorite, singlet oxygen, superoxide, hydrogen peroxide, nitric oxide and alkyl peroxide. | Katalog # | CAS Nummer | Summenformel | Menge |
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| sc-222262 | 359010-69-8 | C26H16O6 | 1 mg |
- S-(2-Aminoethyl)-ITU dihydrobromide
Selective inhibitor of inducible nitric oxide synthase (iNOS/NOS II).| Katalog # | CAS Nummer | Summenformel | Menge |
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| sc-202798 | 56-10-0 | C3H9N3S. ·2HBr | 10 mg/50 mg |
- S-(3-Aminopropyl)-ITU dihydrobromide
A Nitric oxide synthase (NOS) inhibitor. Selective for inducible nitric oxide synthase (iNOS/NOS II).| Katalog # | CAS Nummer | Summenformel | Menge |
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| sc-205971 | n.n. | C4H15Br2N3S | 10 mg/50 mg |
- S-Ethyl N-[4-Triflurormethyl)phenyl]isothiourea, Hydrochloride
A selective inhibitor of nNOS (NOS I) relative to iNOS (NOS II) (115-fold) and eNOS (NOS III) (29-fold). Also binds competitively with L-Arginine.| Katalog # | CAS Nummer | Summenformel | Menge |
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| sc-208325 | 163490-78-6 | C10H12ClF3N2S | 10 mg |
- S-Ethyl N-Phenylisothiourea
A potent inhibitor of the human neuronal constitutive and inducible isoforms of nitric oxide synthetase. Demonstrates competitive binding with L-Arginine.| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-208326 | 19801-34-4 | C9H12N2S | 50 mg |
- S-Ethyl-N-[4-(trifluoromethyl)phenyl]isothiourea hydrochloride
This is a selective inhibitor of neuronal nitric oxide synthase (nNOS; NOS I) which is relative to inducible nitric oxide synthase (iNOS; NOS II) (115-fold) and endothelial nitric oxide synthase (eNOS; NOS III) (29-fold).| Katalog # | CAS Nummer | Summenformel | Menge |
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| sc-222274 | n.n. | C10H12ClF3N2S | 5 mg/25 mg |
- S-Ethylisothiourea HBr
S-Ethylisothiourea is a potent iNOS competitive inhibitor with potential use in inflammatory and autoimmune disease therapy. | Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-200351 | 1071-37-0 | C3H8N2S ·HBr | 50 mg |
- S-Isopropyl-ITU hydrobromide
This is an inhibitor of nitric oxide synthase (NOS), and is 10 times more potent than S-Methyl-ITU.| Katalog # | CAS Nummer | Summenformel | Menge |
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| sc-222276 | 4269-97-0 | C4H10N2S•HBr | 10 mg/50 mg |
- S-Isopropylisothiourea hydrobromide
Potent inhibitor of NO synthase, with selectivity for the inducible form.| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-204252 | 57200-31-4 | C4H10N2S.HBr | 10 mg/50 mg |
- S-Methyl-L thiocitrulline, Dihydrochloride
Inhibitor of NOS that exhibits about 17-fold greater selectivity for rat NOS1 compared to NOS3.| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-3571 | 156719-39-0 | C7H15N3O2S•2HCl | 10 mg |
- S-Methyl-L-thiocitrulline acetate salt
A potent inhibitor of inducible nitric oxide synthase with preference for constitutive (neuronal) over inducible (endothelial) NOS. | Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-215830 | 156719-41-4 (non-salt) | C9H19N3O4S | 10 mg/50 mg |
- S-Methylisothiourea Sulfate
A potent and selective inhibitor of inducible NOS (iNOS).| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-3566 | 867-44-7 | C4H14N4O4S3 | 100 mg |
- S-Nitroso-N-heptanoyl-D,L-penicillamine
Produced concentration-related relaxations of mouse anococcygeus, in a range similar to that already found for NO and other nitrovasodilators. A potent relaxant of non-vascular smooth muscle. Serves as an NO donor.| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-220023 | 225234-00-4 | C12H22N2O4S | 10 mg |
- S-Nitroso-N-propionyl-D,L-penicillamine
Produced concentration-related relaxations of mouse anococcygeus, in a range similar to that already found for NO and other nitrovasodilators. A potent relaxant of non-vascular smooth muscle. Serves as an NO donor.| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-220024 | n.n. | C8H14N2O4S | 10 mg |
- S-Nitroso-N-valeryl-D,L-penicillamine
Exhibits higher lipophilicity and greater stability in solution than SNAP. Its decompostion is accelerated by the presence of Cu(II) and cysteine.| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-220025 | 225233-99-8 | C10H18N2O4S | 25 mg |
- S-Nitrosocaptopril
This is an angiotensin-converting enzyme (ACE) inhibitor. It is an inhibitor of platelet aggregation. Its activity may depend on the homolytic cleavage of the S-N bond under physiological conditions, which yields nitric oxide (NO) and the parent compound, captopril.| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-222277 | 122130-63-6 | C9H14N2O4S | 10 mg/50 mg |
- Spermidine
| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-215900 | 124-20-9 | C7H19N3 | 1 g/5 g |
- tert-Butyl N-[3-(Acetimidoylaminomethyl)benzyl]carbamate, Hydrochloride
A long-acting human iNOS inhibitor possessing an IC50 value of 2.0 μM. An intermediate for a selective inducible nitric oxide synthase (iNOS) inhibitor.| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-208426 | 180001-98-3 | C15H24ClN3O2 | 10 mg |
- TRIM
An inhibitor of nitric oxide synthase nNOS and iNOS with IC50 values of 28.2 µM and 27.0 µM respectively.| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-200353 | 25371-96-4 | C10H7F3N2 | 100 mg/500 mg |
- Troleandomycin
A macrolide antibiotic that is a stronger inhibitor than Roxithromycin (sc-205845). Inhibits P450 and has been used in multiple asthma studies. | Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-200747 | 2751-09-9 | C41H67NO15 | 10 mg/50 mg |
- Vinyl-L-NIO
Very selective and potent neuronal nitric oxide synthase (nNOS/NOS I) inhibitor.| Katalog # | CAS Nummer | Summenformel | Menge |
|---|
| sc-222412 | 728944-69-2 | C9H17N3O2 ·2HCl | 5 mg/25 mg |
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