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Home » Chemikalien » MMP Activators and Inhibitors
 

MMP Activators and Inhibitors

  • 4-epi-Chlortetracycline Hydrochloride
    A Tetracycline derivative. Acts as a metalloprotease inhibitor, used in treating tissue destructive diseases and cancer.
    Katalog #CAS NummerSummenformelMenge
    sc-206875101342-45-4C22H23ClN2O8 ·HCl1 mg/5 mg
  • ARP 100
    Selective inhibitor of MMP-2 (IC50 = 12 nM); displays selectivity over MMP-9, MMP-3, MMP-1 and MMP-7 (IC50 values are 200, 4500, > 50000 and > 50000 nM respectively). Exhibits anti-invasive properties in HT1080 fibrosarcoma cells.
    Katalog #CAS NummerSummenformelMenge
    sc-203522704888-90-4C17H20N2O5S5 mg
  • ARP 101
    Katalog #CAS NummerSummenformelMenge
    sc-203824849773-64-4C20H26N2O5S5 mg
  • Batimastat
    Potent, broad spectrum matrix metalloprotease (MMP) inhibitor that has demonstrated antiproliferative, anti-invasive and antimetastatic activity in several in vivo animal models.
    Katalog #CAS NummerSummenformelMenge
    sc-203833130370-60-4C23H31N3O4S21 mg/10 mg
  • Chlorhexidine, Dihydrochloride
    An anti-microbial agent that acts as an inhibitor of MMP-2 and MMP-9; however, MMP-2 is more sensitive to chlorhexidine than MMP-9. Inhibits the collagenase activity of MMP-8 released by PMA-triggered polymorphonuclear leukocytes (PMNs) in a dose-dependent manner. CHX may possibly act through a cation-chelating mechanism.
    Katalog #CAS NummerSummenformelMenge
    sc-2038863697-42-5C22H30Cl2N10 ·2HCl100 mg
  • cis-ACCP
    A reversible and competitive inhibitor of type IV collagen-specific MMP-2 and MMP-9 with preference towards MMP-2.
    Katalog #CAS NummerSummenformelMenge
    sc-205252777075-44-2C7H15N2O4P1 mg/5 mg
  • CL 82198 hydrochloride
    Selective inhibitor of MMP-13 (89% inhibition at 10 μg/mL) that shows no activity at MMP-1, MMP-9 or TACE. Inhibits in vitro invasion by the human pituitary adenoma cell line HP75.
    Katalog #CAS NummerSummenformelMenge
    sc-203896307002-71-7C17H22N2O3 ·HCl10 mg/50 mg
  • Fibronectin Inhibitor
    Fibronectin Inhibitor; RGDS White to off-white powder. Shown to inhibit fibronectin function by binding to platelet-binding sites and to induce apoptosis in osteoblasts.
    Katalog #CAS NummerSummenformelMenge
    sc-20215691037-65-9C15H27N7O825 mg
  • GM 1489
    A potent broad-range inhibitor of matrix metalloproteinases (MMPs). Inhibits MMPs in vitro (Ki = 0.2 nM for MMP-1; Ki = 500 nM for MMP-2; Ki = 20 µM for MMP-3; Ki = 100 nM for MMP-8; and Ki = 100 nM for MMP-9). Also reduces the inflammatory and the hyperproliferative responses that occur following topical phorbol ester application.
    Katalog #CAS NummerSummenformelMenge
    sc-203978170905-75-6C27H33N3O41 mg/5 mg
  • GM 6001
    A cell permeable hydroxamic acid isomer 6A that has been shown to potently inhibit human skin fibroblast collagenase as well as block matrix metalloproteases.
    Katalog #CAS NummerSummenformelMenge
    sc-203979142880-36-2C20H28N4O41 mg/5 mg
  • GM 6001, Negative Control
    A useful negative control for the MMP inhibitor GM 6001.
    Katalog #CAS NummerSummenformelMenge
    sc-295025n.n.C23H35N5O31 mg/5 mg
  • Marimastat
    A broad spectrum MMP inhibitor and selective TACE inhibitor. Inhibits angiogenesis in human gastric cancer cells and CD30 shedding in Karpas 299 cells.
    Katalog #CAS NummerSummenformelMenge
    sc-202223154039-60-8C15H29N3O55 mg
  • MMP Inhibitor II
    A potent, reversible, broad range inhibitor of matrix metalloproteinases. Inhibits MMP-1 (IC50 = 24 nM), MMP-3 (IC50 = 18.4 nM), MMP-7 (IC50 = 30 nM), and MMP-9 (IC50 = 2.7 nM).
    Katalog #CAS NummerSummenformelMenge
    sc-204091203915-59-7C21H27N3O8S21 mg
  • MMP Inhibitor III
    A homophenylalanine-hydroxamic acid based broad-spectrum cell-permeable, reversible inhibitor of matrix metalloproteinases.
    Katalog #CAS NummerSummenformelMenge
    sc-311427n.n.C19H29N3O41 mg
  • MMP Inhibitor V
    Non-peptidyl hydroxamate compound that acts as an effective broad-spectrum inhibitor against MMP-2/3/8/9/12/13.
    Katalog #CAS NummerSummenformelMenge
    sc-203139223472-31-9C22H28N2O62 mg
  • MMP-13 Inhibitor
    Potent inhibitor of MMP-13 activity with expected selectivity over MMP-1, -2, -3, -7, -8, -9, -10, -12, -14 and -16. Demonstrates a binding to the MMP-13 catalytic domain and acts as a non-zinc-chelating inihibitor.
    Katalog #CAS NummerSummenformelMenge
    sc-205756544678-85-5C22H20F2N4O21 mg
  • MMP-2 Inhibitor I
    An inhibitor of matrix metalloproteinase gelatinase A (MMP-2). Blocks interleukin-Iβ-stimulated migration of vascular smooth muscle cells.
    Katalog #CAS NummerSummenformelMenge
    sc-20409210335-69-0C18H35NO210 mg
  • MMP-2 Inhibitor II
    An oxirane analog of SB-3CT, pMS that is reported to be an irreversible inhibitor of MMP-2 through active-site binding. Although reported to be less potent, it has been shown to demonstrate enhanced selectivity towards MMP-2 than SB-3CT, pMS.
    Katalog #CAS NummerSummenformelMenge
    sc-354092n.n.C16H17NO6S25 mg
  • MMP-2/MMP-3 Inhibitor I
    A potent MMP-2 (gelatinase A; Ki = 17 µM) and MMP-3 (stromelysin-1; Ki = 290 nM) inhibitor.
    Katalog #CAS NummerSummenformelMenge
    sc-295483n.n.C13H14N4O3S25 mg
  • MMP-2/MMP-3 Inhibitor II
    A potent inhibitor of MMP-2 and MMP-3.
    Katalog #CAS NummerSummenformelMenge
    sc-311428n.n.C21H23N7O2S22 mg
  • MMP-2/MMP-9 Inhibitor I
    A potent inhibitor of MMP-2 and MMP-9.
    Katalog #CAS NummerSummenformelMenge
    sc-311429n.n.C21H19NO4S5 mg
  • MMP-2/MMP-9 Inhibitor II
    A potent inhibitor of MMP-2 and MMP-9.
    Katalog #CAS NummerSummenformelMenge
    sc-311430n.n.C21H20N2O4S1 mg
  • MMP-2/MMP-9 Inhibitor V
    This product is a cell-permeable SB-3CT sulfonamido analog with increased selectivity and aqueous solubility. It is an irreversible MMP-3, 7, and 1 inhibitor.
    Katalog #CAS NummerSummenformelMenge
    sc-354093n.n.C16H17NO5S3500 µg
  • MMP-3 Inhibitor
    Cell-permeable p-methoxysulfonamido D-leucinecontaining hydroxamate compound that acts as a potent inhibitor of human MMP-3.
    Katalog #CAS NummerSummenformelMenge
    sc-311431n.n.C20H26N2O5S5 mg
  • MMP-3 Inhibitor III
    A potent inhibitor of MMP-3 and inhibits MMP-2 at higher concentrations.
    Katalog #CAS NummerSummenformelMenge
    sc-311432n.n.C12H12N4O3S22 mg
  • MMP-3 Inhibitor IV
    A potent inhibitor of MMP-3 and inhibits MMP-2 only at higher concentrations.
    Katalog #CAS NummerSummenformelMenge
    sc-311433n.n.C19H25N5O2S22 mg
  • MMP-3 Inhibitor V
    A potent and competitive inhibitor of both human and rabbit MMP-3 catalytic domains.
    Katalog #CAS NummerSummenformelMenge
    sc-311434185672-77-9C16H13NO45 mg
  • MMP-3 Inhibitor VIII
    A cell permeable p-methoxysulfonamido D-leucine-containing hydroxamate compound. This compound is a potent inhibitor of human MMP-3 and murine macrophage metalloelastase MME/MMP-12.
    Katalog #CAS NummerSummenformelMenge
    sc-311435208663-26-7C20H26N2O5S5 mg
  • MMP-7 Antisense Oligonucleotide, Sodium Salt
    An antimetastatic, 15-meric phosphorothioate antisense oligonucleotide (Tm = 35°C) which suppresses MMP-7 expression at both the mRNA and protein levels. It is derived from the human MMP-7 DNA sequence in a sequence-specific manner in CaR-1, which is a human colon cancer cell line. This also effectively inhibits metastasis of colon cancer cells (WiDr) to the liver in a nude mouse model.
    Katalog #CAS NummerSummenformelMenge
    sc-221950n.n.n.n.75 nmol
  • MMP-8 Inhibitor I
    A potent and cell-permeable inhibitor of MMP-8.
    Katalog #CAS NummerSummenformelMenge
    sc-311436n.n.C17H18N2O5S1 mg
  • MMP-9 Inhibitor I
    A cell-permeable, potent, selective, and reversible MMP-9 Inhibitor.
    Katalog #CAS NummerSummenformelMenge
    sc-311437n.n.C27H33N3O5S500 µg
  • MMP-9/MMP-13 Inhibitor I
    A piperazine-based, cell-permeable, and highly potent inhibitor of MMP-9 and MMP-13.
    Katalog #CAS NummerSummenformelMenge
    sc-311438n.n.C25H25N3O6S1 mg
  • MMP-9/MMP-13 Inhibitor II
    A piperazine-based, cell-permeable, and highly potent inhibitor of MMP-9 and MMP-13.
    Katalog #CAS NummerSummenformelMenge
    sc-311439n.n.C20H23N3O7S1 mg
  • NNGH
    A potent and cell-permeable inhibitor of human MMP-3.
    Katalog #CAS NummerSummenformelMenge
    sc-222075n.n.C13H20N2O5S5 mg
  • NSC 23766
    A specific inhibitor of the binding and activation of RAC GTPase inhibitor. Has been shown to inhibit Rac1 binding and activation via Rac-specific GEF Trio or Tiam 1 without altering RhoA or CDC42 binding or activation
    Katalog #CAS NummerSummenformelMenge
    sc-204823733767-34-5C24H35N7 ·3HCl10 mg/50 mg
  • PD166793
    A cell-permeable compound that strongly inhibits MMP (matrix metalloproteinase) -2 , -3, and -13, and weakly inhibits AMP deaminase, MMP-1, -7, -9, and -14.
    Katalog #CAS NummerSummenformelMenge
    sc-202709199850-67-4C17H18BrNO4S5 mg
  • Pro-Leu-Gly hydroxamate hydrochloride
    Affinity ligand for the purification of human collagenases.
    Katalog #CAS NummerSummenformelMenge
    sc-215748120928-08-7C13H24N4O4•HCl50 mg/250 mg
  • Ro 32-3555
    A potent, collagenase-selective MMP inhibitor (Ki values are 3.0, 3.4, 4.4, 59, 154 and 527 nM for MMP-1, MMP-13, MMP-8, MMP-9, MMP-2 and MMP-3 respectively). Shown to inhibit cartilage breakdown in vitro and in vivo and displays antiarthritic activity.
    Katalog #CAS NummerSummenformelMenge
    sc-296277190648-49-8C22H35N4O5•xH2O10 mg
  • SB-3CT
    Competitive, mechanism-based inhibitor of matrix metalloproteinases 2 and 9 (MMP-2 and MMP-9)1,2. This inhibitor has also been used in vitro, in vivo, and in tissue culture1,4-7. In vivo, it is metabolized to an even more potent gelatinase inhibitor8.
    Katalog #CAS NummerSummenformelMenge
    sc-205847292605-14-2C15H14O3S21 mg/5 mg
  • TAPI-1
    A structural analog of TAPI-0 with similar in vitro efficacy for the inhibition of MMPs and TACE. TAPI-1 also blocks the shedding of several cell surface proteins such as IL-6 receptor, p60 TNF receptor, and p80 TNF receptor. Blocks constitutive and muscarinic receptor-stimulated sAAPå release in HEK 293 cells expressing M3 muscarinic receptors.
    Katalog #CAS NummerSummenformelMenge
    sc-222337n.n.C26H37N5O51 mg
  • TAPI-2
    Inhibitor of TACE1-3, other ADAMs3, ACE secretase4, and other metalloproteinases5. Blocks release of DCC7, APP8,9, TNF- α6, L-selectin9, NOTCH10, TGF- α9, IL-6R9, erbB2/HER211, and ACE12. This inhibitor has been used in tissue culture3,7-9,11,12 (typical concentration 5-100 μM).
    Katalog #CAS NummerSummenformelMenge
    sc-205851n.n.C19H37N5O51 mg
  • WAY 170523
    Katalog #CAS NummerSummenformelMenge
    sc-361402307002-73-9C33H31N3O7S1 mg/10 mg
  • UK 370106
    Highly selective MMP-3 and MMP-12 inhibitor (IC50 values are 0.023, 0.042, 1.75, 2.3, 5.8, 30.4, 34.2 amd 66.9 μM at MMP 3, 12, 8, 13, 7, 9, 2 and 14 respectively.) Has little effect on keratinocyte migration in vitro and inhibits fibronectin cleavage (IC50 = 320 nM)Substantially inhibits MMP-3 in an ex vivo model of chronic dermal ulcers.
    Katalog #CAS NummerSummenformelMenge
    sc-204375230961-21-4C35H44N2O5•xH2O10 mg