MAPK Inhibitors and Activators

5-Iodotubercidin
Potent and competitive inhibitor of MAP Kinase ERK2. Inhibitor of Adenosine Kinase and Ser/Thr-specific kinases (casein kinase 1 and PKA).
Katalog # CAS Nummer Summenformel Menge
sc-3531 24386-93-4 C₁₁H₁₃IN₄O₄ 1 mg/5 mg
AG 126
Blocks production of tumor necrosis factor-α (TNF-α) and nitric oxide in macrophages. AG-126 prevents lipopolysaccharide-induced lethal toxicity in mice by blocking tyrosine phosphorylation of p42 MAPK protein substrate.
Katalog # CAS Nummer Summenformel Menge
sc-3528 118409-62-4 C₁₀H₅N₃O₃ 5 mg/25 mg
CAY10571
Pyridinylimidazoles, often called CSAIDs, are a class of anti-inflammatory compounds that suppress the synthesis of cytokines in human monocytes and inhibit eicosanoid productio. Because of its high specificity, one predominant pyridinylimidazole, SB203580, is frequently used to inhibit p38 MAPK, the tyrosine kinase activated by inflammatory cytokines and environmental stresses. CAY10571 is an analog of SB203580 that inhibits IL-1 production in the human monocytic cell line THP with an IC₅₀ value of 0.20 µM and binds CSAID binding protein, a serine/threonine kinase homologous to p38, inhibiting its kinase activity with an IC₅₀ value of 0.03 µM. This chemical also inhibits 5-lipoxygenase production in RBL-1 cells with an IC₅₀ value of 24 µM.
Katalog # CAS Nummer Summenformel Menge
sc-223869 152121-46-5 C₂₁H₁₆FN₃O₂S 5 mg/10 mg
CGP 57380
A selective inhibitor of mitogen-activated protein kinase-interacting kinase 1 (MNK1). Effectively inhibits eIF4E phosphorylation.
Katalog # CAS Nummer Summenformel Menge
sc-202993 522629-08-9 C₁₁H₉FN₆ 5 mg
Coumermycin A₁
Shown to be a cell permeable antibiotic that induces activation of JAKs via autophosphorylation. Also reported to cause cell proliferation.
Katalog # CAS Nummer Summenformel Menge
sc-200882 4434-05-3 C₅₅H₅₉N₅O₂₀ 5 mg/25 mg
U-0126
A selective MAPK and ERK inhibitor, displaying a preference for MEK1 and MEK2.
Katalog # CAS Nummer Summenformel Menge
sc-222395 109511-58-2 C₁₈H₁₆N₆S₂ 1 mg/5 mg
ERK Inhibitor II, FR180204
A novel ERK-selective inhibitor that can permeate the cell. The compound has been reported to inhibit ERK1 (K_i=0.31μM), ERK2 (K_i=0.14 μM), TGFβ-induced AP-1 activation and acts as a competitive inhibitor of ATP.
Katalog # CAS Nummer Summenformel Menge
sc-203945 865362-74-9 C₁₈H₁₃N₇ 1 mg
GW 5074
An Inhibitor of Raf-1 kinase, PMA-mediated activation of ERK1/2, and blocks neurodegeneration. Used in Ras/Raf-1/ERK pathway studies.
Katalog # CAS Nummer Summenformel Menge
sc-200639 220904-83-6 C₁₅H₈Br₂INO₂ 5 mg/25 mg
JX-401
JX-401 is a potent reversible inhibitor of p38alpha by reversibly binding MAPK p38alpha and has blocked differentiation of L8 myoblasts to myotubes.
Katalog # CAS Nummer Summenformel Menge
sc-200687 349087-34-9 C₂₁H₂₅NO₂S 1 mg/10 mg
MK2a Inhibitor
A p-amidophenolic compound that selectively inhibits the phosphorylation of MK2a by p38α in a non-ATP-competitive manner.
Katalog # CAS Nummer Summenformel Menge
sc-203138 41179-33-3 C₂₂H₂₀FNO₂ 10 mg
p38 MAP Kinase Inhibitor
A potent p38 MAP kinase inhibitor (IC₅₀ = 35 nM).
Katalog # CAS Nummer Summenformel Menge
sc-204157 219138-24-6 C₂₀H₁₃ClFN₃O 500 µg
p38 MAP Kinase Inhibitor III
Methylsulfanylimidazole compount that is cell-permeable and acts as a potent, selective, and ATP competitive p38 MAP kinase inhibitor. Has been shows to effectively suppress LPS-induced cytoking release in vitro and in vivo.
Katalog # CAS Nummer Summenformel Menge
sc-204158 581098-48-8 C₂₃H₂₁FN₄S 1 mg
p38 MAP Kinase Inhibitor IV
A cell permeable sulfone compound which functions as an ATP-competitive inhibitor of p38α and p38β MAP Kinases.
Katalog # CAS Nummer Summenformel Menge
sc-204159 1638-41-1 C₁₂H₄Cl₆O₄S 10 mg
p38 MAP Kinase Inhibitor V
A cell-permeable trisubstituted pyrazole compound that acts as a highly potent ATP-competitive inhibitor of CK1 and p38.
Katalog # CAS Nummer Summenformel Menge
sc-204160 271576-77-3 C₁₉H₂₀ClN₅ 1 mg
p38 MAP Kinase Inhibitor VIII
A synthetic 4-aminobenzophenone small molecule inhibitor of p38α and p38β MAP kinase. Blocks the release of TNF-α and proinflammatory interleukins.
Katalog # CAS Nummer Summenformel Menge
sc-203173 321351-00-2 C₂₀H₁₆BrClN₂O 5 mg
PD 169316
A potent, cell-permeable, and selective p38 MAP kinase inhibitor (IC₅₀ = 89 nM). Inhibition of p38 MAP kinase by PD 169316 blocks apoptosis induced by trophic factor withdrawal in non-neuronal and neuronal cell lines.
Katalog # CAS Nummer Summenformel Menge
sc-204168 152121-53-4 C₂₀H₁₃FN₄O₂ 1 mg
PD 184,352
An inhibitor of MEK, blocks MAPK activity and slows proliferation of colon tumor cells in mice.
Katalog # CAS Nummer Summenformel Menge
sc-202759 212631-79-3 C₁₇H₁₄ClF₂IN₂O₂ 1 mg/5 mg
PD 184161
A strong and selective inhibitor of MEK1/2; more effective at inhibiting phosphorylation of ERK1/2 than the selective MEK inhibitors, PD098059 and U0126.
Katalog # CAS Nummer Summenformel Menge
sc-222141 212631-67-9 C₁₇H₁₃BrClF₂IN₂O₂ 1 mg/5 mg
PD 198306
Cell-permeable amino-benzamide compound that acts as a potent and non-ATP-competitive inhibitor of MEK1/2.
Katalog # CAS Nummer Summenformel Menge
sc-203180 212631-61-3 C₁₈H₁₆F₃IN₂O₂ 5 mg
PD 98059
PD 98059 is a potent, selective and reversible cell permeable inhibitor of MEK-1, inducer of GSTA2 and enhancer of glutathione.
Katalog # CAS Nummer Summenformel Menge
sc-3532 167869-21-8 C₁₆H₁₃NO₃ 1 mg/5 mg
SB 202190
A pyridinyl imidazole that inhibits the p38 pathway. It can also induce apoptosis, and phosphorylate and activate MLK3.
Katalog # CAS Nummer Summenformel Menge
sc-202334 152121-30-7 C₂₀H₁₄FN₃O 1 mg/5 mg
SB 203580
Highly specific inhibitor of p38 MAP kinase. Blocks activation of MAPKAP Kinase-2, yet does not disrupt JNK activity. A useful tool to assess the physiological roles of p38, and for deriving and maintaining embryonic stem cells.
Katalog # CAS Nummer Summenformel Menge
sc-3533 152121-47-6 C₂₁H₁₆FN₃OS 1 mg/5 mg
SB 203580 (hydrochloride)
A pyridinyl imidazole inhibitor that can suppress proliferative activity on cytokine-activated lymphocytes. Additionally found to inhibit MAPKs.
Katalog # CAS Nummer Summenformel Menge
sc-204900 869185-85-3 C₂₁H₁₆FN₃OS ·HCl 5 mg/10 mg
SB 239063
Katalog # CAS Nummer Summenformel Menge
sc-220094 193551-21-2 C₂₀H₂₁FN₄O₂ 5 mg/25 mg
SB220025
Potent and specific inhibitor of human p38 (SAPK2a). Potent inhibitor of angiogenesis and as an inhibitor of TNF-α production.
Katalog # CAS Nummer Summenformel Menge
sc-202804 165806-53-1 C₁₈H₁₉FN₆ 500 µg
SD-169
A compound that inhibits p38α MAPK and acts as an ATP competitive inhibitor of p38 kinase. Described to decrease the expression of HSP60, insulitis, and beta cell death.
Katalog # CAS Nummer Summenformel Menge
sc-200693 1670-87-7 C₉H₈N₂O 10 mg/50 mg
SL-327
A selective inhibitor of MEK1 and MEK2. Also inhibits ERK1, MEK-3/p38, MEK-4, JNK, and PKC at higher concentrations.
Katalog # CAS Nummer Summenformel Menge
sc-200685 305350-87-2 C₁₆H₁₂F₃N₃S 1 mg/10 mg
XRP44X
Ras-Net (Elk-3) pathway inhibitor (IC₅₀ = 10-20 nM). Indirectly inhibits Net phosphorylation upstream of Erk1/2 activation. Mediates G2-M cell cycle arrest. Suppresses growth of multiple cell types (IC₅₀ ~ 2 nM). Inhibits angiogenesis and acts as a microtubule depolymerizing agent in vitro.
Katalog # CAS Nummer Summenformel Menge
sc-204404 729605-21-4 C₂₁H₂₁ClN₄O 10 mg/50 mg