Lipoxygenase Inhibitors

3-[[3-fluoro-5-(tetrahydro-4-methoxy-2H-pyran-4-yl)phenoxy]methyl]-1-[4-(methylsulfonyl)phenyl]-5-phenyl-1H-pyrazole
A dual COX-2/5-LO inhibitor; a potential therapeutic agent for prostate cancer and inflammatory disease.
Katalog # CAS Nummer Summenformel Menge
sc-205108 443919-96-8 C₂₉H₂₉FN₂O₅S 1 mg/5 mg
5(S)-HETrE
This is produced by the action of 5-LO when mead acid is the substrate. There are no literature reports of biological activity or further metabolic fate of 5(S)-HETrE.
Katalog # CAS Nummer Summenformel Menge
sc-221073 n.n. C₂₀H₃₄O₃ 25 µg/50 µg
5(S)-HpEPE
This is a monohydroperoxy polyunsaturated fatty acid produced by the action of 5-LO on EPA. It is metabolized to LTA5, a key intermediate in formation of the 5-series leukotrienes. Alternatively, 5(S)-HpEPE is reduced to 5(S)-HEPE by peroxidases.
Katalog # CAS Nummer Summenformel Menge
sc-221074 n.n. C₂₀H₃₀O₄ 25 µg/50 µg
5(S),6(R)-7-trihydroxymethyl Heptanoate
A C-7 truncated analog of LXA4 that is equiactive as LXA4 in inhibition of LTB4-induced polymorphonuclear chemotaxis.
Katalog # CAS Nummer Summenformel Menge
sc-221076 n.n. C₈H₁₆O₅ 1 mg/5 mg
AA-861
Potent, selective and orally active 5-lipoxygenase inhibitor, shown to enhance and accelerate fracture healing, increase Ca²⁺ concentration in MDCK cells, and is used to probe fatty acid metabolism and leukotriene production.
Katalog # CAS Nummer Summenformel Menge
sc-200570 80809-81-0 C₂₁H₂₆O₃ 20 mg/100 mg
Auranofin
A gold(I)-phosphine thiolate small molecule. Blocks the release of pro-inflammatory mediators from basophiles and mast cells. Inhibits mitochondrial thioredoxin reductase and 5-lipoxygenase. Quenches reactive singlet oxygen species.
Katalog # CAS Nummer Summenformel Menge
sc-202476 34031-32-8 C₂₀H₃₄AuO₉PS 25 mg/100 mg
Baicalein
A flavone that inhitbits Ca²⁺ uptake, certain types of lipoxygenase, leukotriene biosynthesis and the release of lysosomal enzymes. It is a potent anti-inflammatory agent.
Katalog # CAS Nummer Summenformel Menge
sc-200494 491-67-8 C₁₅H₁₀O₅ 10 mg/50 mg
BW A4C
Selective 5-lipoxygenase (5-LOX) inhibitor. Inhibits synthesis of LTB4.
Katalog # CAS Nummer Summenformel Menge
sc-210981 106328-57-8 C₁₇H₁₇NO₃ 5 mg/25 mg
BW B70C
A selective arachidonic acid 5-lipoxygenase inhibitor. Reported to decrease 12-HETE formation, leukotriene C4 synthesis, and decrease the formation of oligonucleosomal and high molecular weight DNA fragments.
Katalog # CAS Nummer Summenformel Menge
sc-200633 134470-38-5 C₁₇H₁₇FN₂O₃ 5 mg/25 mg
Caffeic Acid
Inhibits 5-lipoxygenase (IC₅₀=3.7 µM). At 2.2 µM, caffeic acid selectively inhibits 15-lipoxygenase. Shows moderate inhibition of human tyrosinase.
Katalog # CAS Nummer Summenformel Menge
sc-200499 331-39-5 C₉H₈O₄ 1 g/5 g
CDC
A metabolite of ciproflaxacin, CDC is a selective 12-lipoxygenase inhibitor and a 15- and 5-LO inhibiter respectively in isolated enzyme preparations.
Katalog # CAS Nummer Summenformel Menge
sc-200562 132465-11-3 C₁₉H₁₅NO₄ 10 mg/50 mg
Croton Oil
Natural source of phorbol and phorbol esters, obtained and purified from Croton tiglium L.
Katalog # CAS Nummer Summenformel Menge
sc-204698 8001-28-3 n.n. 10 g/25 g
Esculetin
A phenolic compound that acts as a 5-LO inhibitor. Reported to display anti-inflammatory and antioxidant properties, as well as induce cell cycle arrest and apoptosis.
Katalog # CAS Nummer Summenformel Menge
sc-200486 305-01-1 C₉H₆O₄ 1 g
Ethyl 3,4-dihydroxybenzylidenecyanoacetate
An inhibitor of 12- and 15-lipoxygenase.
Katalog # CAS Nummer Summenformel Menge
sc-202603 132464-92-7 C₁₂H₁₁NO₄ 25 mg
ETI
An inhibitor of lipoxygenase activity, in particle 5-lipoxygenase which affects cell proliferation. Also shown to reduce oxidative metabolism of arachidonic acid.
Katalog # CAS Nummer Summenformel Menge
sc-200762 13488-22-7 C₂₀H₂₈O₂ 1 mg/10 mg
Ferulic acid
Chemopreventive caffeic acid analogue.
Katalog # CAS Nummer Summenformel Menge
sc-204753 1135-24-6 C₁₀H₁₀O₄ 5 g/25 g
Gossypol
Male antifertility agent with antispermatogenic activity and is also shown to display anitumor, anitviral, and antioxidant properties. Reversible inhibitor of phosphotase 2B and protein kinase C.
Katalog # CAS Nummer Summenformel Menge
sc-200501 303-45-7 C₃₀H₃₀O₈ 20 mg/100 mg
(±)-Jasmonic Acid
A member of the jasmonates produced in the octadecanoid pathway. This compound is a plant growth regulator involved in the signaling mechanisms for a variety of conditions.
Katalog # CAS Nummer Summenformel Menge
sc-205355 77026-92-7 C₁₂H₁₈O₃ 100 mg/250 mg
L-655,238
Potent and selective inhibitor of 5-LO-activating protein (FLAP).
Katalog # CAS Nummer Summenformel Menge
sc-221799 n.n. C₂₂H₂₅NO₂ 10 mg/50 mg
NDGA (Nordihydroguaiaretic acid)
NDGA (Nordihydroguaiaretic acid) is an anti-oxidant lipoxeygenase inhibitor lignan found in Larrea tridentata.
Katalog # CAS Nummer Summenformel Menge
sc-200487 500-38-9 C₁₈H₂₂O₄ 1 g
MK-886 sodium salt
A potent and selective inhibitor of 5-lipoxygenase-activating protein (FLAP). Binds to FLAP with high affinity and prevents the activation of 5-lipoxygenase.
Katalog # CAS Nummer Summenformel Menge
sc-200608 118427-55-7 C₂₇H₃₃ClNO₂S•Na 5 mg/25 mg/1 mg
PD-146176
A potent and selective 15-lipoxygenase inhibitor which lacks significant nonspecific antioxidant properties. Suppresses atherogenesis and limits atherosclerotic lesion development in New Zealand White rabbits.
Katalog # CAS Nummer Summenformel Menge
sc-200678 4079-26-9 C₁₅H₁₁NS 10 mg/50 mg
Zileuton
Orally active 5-lipoxygenase (5-LOX) inhibitor that inhibits LTB4 synthesis (IC₅₀ values are 0.56, 2.3 and 2.6 μM in dog, rat and human blood respectively). Inhibits antigen-induced contraction of tracheal strips in vitro (IC₅₀ = 6 μM) and shows antiasthmatic activity in vivo. Also weakly inhibits CYP1A2 (K_i = 66 - 98 μM).
Katalog # CAS Nummer Summenformel Menge
sc-204417 111406-87-2 C₁₁H₁₂N₂O₂S 10 mg/50 mg