Lipid Biosynthesis Inhibitors

• 3-[4-(2-chloro-5-fluorophenoxy)-1-piperidinyl]-6-(5-methyl-1,3,4-oxadiazol-2-yl)-pyridazine
  A potent and selective inhibitor of SCD1; inhibits the conversion of saturated, long-chain fatty acyl-CoAs to monounsaturated, long-chain fatty acyl-CoAs in HepG2 cells.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205109	944808-88-2	C18H17ClFN5O2	1 mg/5 mg

• Atorvastatin

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-337542	134523-00-5	C33H35FN2O5	100 mg

• BIBB-515
  A potent and selective inhibitor of 2,3-oxidosqualene cyclase (OSC) in vivo1. Inhibits LDL production in both normolipemic and hyperlipemic hamsters1 and may represent a novel approach for the development of new lipid lowering drugs.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205602	156635-05-1	C22H21ClN2O2	10 mg/50 mg

• Cerulenin
  An antibiotic and antifungal agent that potently and specifically inhibits FAS, and has been shown to induce apoptosis in a caspase dependent manner.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-200827	17397-89-6	C12H17NO3	5 mg/25 mg

• Ciprofibrate
  Hypolipidemic compound that can induce proliferation of peroxisomes in liver cells of rats. PPARα (peroxisome proliferator-activated receptor α) agonist.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-204689	52214-84-3	C13H14Cl2O3	25 mg/100 mg

• Fenofibrate
  Hypolipidemic compound. PPARα (peroxisome proliferator-activated receptor α) agonist (EC₅₀=18µM for mouse and EC₅₀=30µM for human PPARα). Binds to PPARγ also, but with at least 10-fold less affinity and is inactive at PPARδ (up to EC₅₀=100µM).

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-204751	49562-28-9	C20H21ClO4	5 g

• HDSF
  A serine-specific, active site-directed, modifying agent that acts as an irreversible inhibitor of palmitoyl-protein thioesterase-1 (Ki = 125 µM). Inhibits lipase, but not phospholipase C activity in Pseudomonas aeruginosa culture supernatant and phospholipase A activity in E. coli.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-221708	n.n.	C16H33FO2S	25 mg/100 mg

• Terbinafine·HCl
  A potent squalene epoxidase inhibitor and, as a result, a suppressor of ergosterol biosynthesis. Also reported as a free radical scavenger as well as an anti-angiogenic agent.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-200751	78628-80-5	C21H25N ·HCl	100 mg

• TMP-153
  A potent acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor that has been shown to inhibit cholesterol esterification and reduce its influx into the plasma.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-200649	128831-46-9	C24H18ClF2N3O	20 mg/100 mg

• TOFA (5-(Tetradecyloxy)-2-furoic acid)
  An inhibitor of acetyl-CoA carboxylase, blocks fatty acid synthesis.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-200653	54857-86-2	C19H32O4	10 mg/50 mg

• Triacsin C
  A hypotensive vasodilator. Inhibitor of ACSL (long fatty acid acyl-CoA synthetase), neutrophils and β-cells.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-200574	76896-80-5	C11H17N3O	100 µg/1 mg

• URB-754
  Described inhibitor of MAG lipase. Conflicting data showed that the activity was due to a contaminant, bis(methylthio)mercurane from a different commercial source.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-200671	86672-58-4	C16H14N2O2	10 mg/50 mg