Ion Pump Reagents

3-Benzidino-6-(4-chlorophenyl)pyridazine
3-Benzidino-6-(4-chlorophenyl)pyridazine is an inhibitor of delayed rectifier and transient outward potassium currents. The IC₅₀ values for the blocking action of BCP on IKDR and IKA was calculated as 7.13 µM and 0.55 µM, respectively in acutely isolated rat hippocampal pyramidal neurons by employing whole-cell patch-clamp technique.
Katalog # CAS Nummer Summenformel Menge
sc-254428 901773-91-9 C₂₂H₁₇N₄Cl 5 mg
3-formylrifamycin SV
A derivative of rifamycins found to interact with biological membranes. It causes a change in permeability to K⁺ and H⁺ in the mitochondrial membrane.
Katalog # CAS Nummer Summenformel Menge
sc-204879 13292-22-3 C₃₈H₄₇NO₁₃ 1 g/5 g
5’-Iodoresiniferatoxin
IRTX is a vanilloid receptor antagonist. IRTX binds to the VR1 receptor with high affinity (K_d = 4.3 nM) but does not induce RTX- or capsaicin-like effects in X. laevis oocytes expressing VR1.
Katalog # CAS Nummer Summenformel Menge
sc-202024 n.n. C₃₇H₃₉IO₉ 1 mg
Bromoacetylcholine bromide
Used as an affinity alkylating agent for nicotinic receptors.
Katalog # CAS Nummer Summenformel Menge
sc-252517 22004-27-9 C₇H₁₅BrNO₂•Br 500 mg
Bufalin
An inducer of U937 and HL-60 apoptosis and cell differentiation by activation of AP-1 via a MAPK pathway.
Katalog # CAS Nummer Summenformel Menge
sc-200136 465-21-4 C₂₄H₃₄O₄ 10 mg
Bumetanide (Ro 10-6338)
A specific inhibitor of Na⁺-K⁺-2Cl^- cotransporter NKCC1, which has been shown to bind with high affinity and saturate binding of the cotransporter.
Katalog # CAS Nummer Summenformel Menge
sc-200727 28395-03-1 C₁₇H₂₀N₂O₅S 1 g/5 g
CBIQ
An activator of the cystic fibrosis transmembrane conductance regulator (CFTR) and the intermediate-conductance calcium-sensitive K⁺ channel (KCNN4). May act as a novel tool for a new ion channel. First activator of F508 CFTR, the mutant form of CFTR chloride channel present in 75% of cystic fibrosis patients. Other benzoquinolines act at the normal CFTR but not at F508 CFTR. CBIQ also activates KCNN4, which hyperpolarizes airway epithelial cells to promote anion flux, a further benefit in cystic fibrosis.
Katalog # CAS Nummer Summenformel Menge
sc-252550 32081-28-0 C₁₃H₈NCl 5 mg
Cibenzoline succinate
Katalog # CAS Nummer Summenformel Menge
sc-362179 100678-32-8 C₁₈H₁₈N₂··C₄H₆O₄ 50 mg
Clopamide
Clinically useful diuretit. Clopamide selectively inhibits the chloride the sodium chloride cotransporter.
Katalog # CAS Nummer Summenformel Menge
sc-201553 636-54-4 C₁₄H₂₀ClN₃O₃S 500 mg
(-)-Cotinine
Major nicotine metabolite. Exhibits cognition-enhancing effects in vivo.Activates a subpopulation of α3/α6β2 nAChRs in monkey striatum.
Katalog # CAS Nummer Summenformel Menge
sc-205267 486-56-6 C₁₀H₁₂N₂O 50 mg
DBO-83
A novel nicotinic acetylcholine receptor agonist. Structurally related to epibatidine. Has antinociceptive properties in rodents.
Katalog # CAS Nummer Summenformel Menge
sc-252663 195211-53-1 C₁₀H₁₅Cl₃N₄ 5 mg
DK-AH 269
An HCN Channel blocker; an open channel blocker of neuronal Ih and related cardiac If channels.
Katalog # CAS Nummer Summenformel Menge
sc-252761 186097-54-1 C₂₈H₃₈N₂O₅•HCl 5 mg
(+)-Epibatidine dihydrochloride
A non-opioid analgesic alkaloid isolated from skin of Ecuadoran tree frog, Epipedobates tricolor; naturally-occurring isomer of the most potent nicotinic acetylcholine receptor agonist known. Discoveries in the nAChR field have stimulated interest in nAChR-targeted compounds as potential analgesic agents. Epibatidine has full efficacy relative to opioids in preclinical pain models. Although epibatidine is toxic, these observations demonstrated that modest efficacy is not a general limitation of nAChR agonists. Moreover, exploration of the molecular biology of nAChRs revealed evidence of receptor diversity, which suggest that nAChR subtype-selective agents are less toxic than nicotine; and early medicinal chemistry efforts have resulted in compounds with improved safety profiles.
Katalog # CAS Nummer Summenformel Menge
sc-252777 166374-43-2 C₁₁H₁₃N₂Cl•2HCl 5 mg
Esomeprazole magnesium dihydrate
A leading proton pump inhibitor.
Katalog # CAS Nummer Summenformel Menge
sc-252785 217087-10-0 C₃₄H₃₆MgN₆O₆S₂ ·2H₂O 50 mg
Fura 2 magnesium-selective analog tetrapotassium salt
A cell impermeable fluorescent probe for Mg+2
Katalog # CAS Nummer Summenformel Menge
sc-252842 132319-57-4 C₁₈H₁₀K₄N₂O₁₁ 1 mg
Glimepiride
A third generation sulfonylurea compound, which increases the release of insulin from pancreatic beta cells.
Katalog # CAS Nummer Summenformel Menge
sc-203058 93479-97-1 C₂₄H₃₄N₄O₅S 500 mg/1 g
Glycine sodium salt
An inhibitory neurotransmitter in the spinal cord which is an allosteric regulator of NMDA receptors.
Katalog # CAS Nummer Summenformel Menge
sc-257565 6000-44-8 C₂H₄NNaO₂ 100 g/500 g
Kainic acid monohydrate
Kainate class of ionotropic glutamate receptor agonist. Has been shown to induce seizures and neurodegeneration in vivo and has also been used to induce experimental epilepsy in rodents and to examine excitation-induced neuronal apoptosis mechanisms.
Katalog # CAS Nummer Summenformel Menge
sc-269283 58002-62-3 C₁₀H₁₅NO₄•H₂O 10 mg
Levosimendan
A Ca(2+) sensitizer that increases contractile force of the myocardium by enhancing the sensitivity of myofilaments to calcium without increasing intracellular calcium concentration. Shown to reduce circulating proinflammatory cytokine interleukin-6 and soluble apoptosis mediators.
Katalog # CAS Nummer Summenformel Menge
sc-204792 141505-33-1 C₁₄H₁₂N₆O 100 mg/250 mg
Lidoflazine
An antianginal calcium channel blocker that carries a significant risk of QT interval prolongation and ventricular arrhythmia. It prolongs QT interval by blocking HERG channel. IC₅₀ < 0.1 µM
Katalog # CAS Nummer Summenformel Menge
sc-255253 3416-26-0 C₃₀H₃₅F₂N₃O 5 mg
Mephetyl tetrazole
Mephetyl tetrazole is a potent and selective Kv1.5 potassium channel blocker. IC₅₀ = 330 nM; shows selective atrial prolongation (40%) of effective refractory period (ERP), and no effect on ventricular ERP Kv1.5 channel is a molecular target for the treatment of atrial fibrillation.
Katalog # CAS Nummer Summenformel Menge
sc-255261 916923-10-9 C₂₀H₂₂N₄O 5 mg
Ouabain Octhahydrate
Shown to inhibit Na⁺/K⁺-ATPase which is an important sodium pump in the eye as well as cardiac and smooth muscles of the heart.
Katalog # CAS Nummer Summenformel Menge
sc-201548 11018-89-6 C₂₉H₄₄O₁₂ ·8H₂O 1 g/5 g
Pantoprazole
A proton pump inhibitor which inhibits vesicular gastric H+/K(+)-ATPase under acid transporting conditions by accumulating in the pump generated acid space. It also inhibits acid secretion.
Katalog # CAS Nummer Summenformel Menge
sc-204830 102625-70-7 C₁₆H₁₅F₂N₃O₄S 100 mg/500 mg
Pantoprazole Sodium
A gastic proton pump inhibitor.
Katalog # CAS Nummer Summenformel Menge
sc-204831 138786-67-1 C₁₆H₁₄N₃SO₄F₂Na ·3/2H₂O 1 g/5 g
Prilocaine hydrochloride
Employed for local nerve block and for spinal anesthesia; pharmacological properties are similar to those of lidocaine.
Katalog # CAS Nummer Summenformel Menge
sc-253317 1786-81-8 C₁₃H₂₀N₂O•HCl 1 g/5 g
Quene 1-AM
A fluorescent probe for intracellular pH.
Katalog # CAS Nummer Summenformel Menge
sc-253334 86293-31-4 C₃₈H₄₁N₃O₁₇ 1 mg
R(+)-Verapamil monohydrochloride hydrate
Less active enantiomer of ±Verapamil; Inhibitor of P-glycoprotein.
Katalog # CAS Nummer Summenformel Menge
sc-253359 38176-02-2 (anhydrous) C₂₇H₃₈N₂O₄•HCl•xH₂O 25 mg
Rabeprazole
A proton pump/ATP-ase inhibitor.
Katalog # CAS Nummer Summenformel Menge
sc-204872 117976-89-3 C₁₈H₂₁N₃O₃S 10 mg/25 mg
Stevioside hydrate
A natural, noncaloric sweetener with a potency 300 times more than that of regular sucrose that is found in plants of the Stevia sp.
Katalog # CAS Nummer Summenformel Menge
sc-272502 57817-89-7 (anhydrous) C₃₈H₆₀O₁₈ ·xH₂O 10 mg
Supercinnamaldehyde
Supercinnamaldehyde is a transient receptor potential ankyrin 1 (TRPA1) activator, EC₅₀= 0.8 µM, derivative of cinnamaldehyde, covalently binds to and activates TRPA1 receptor (expressed in nociceptive neurons) by modifying its cysteine residues. Covalent modification of reactive cysteines within TRPA1 can cause channel activation, and rapid signaling potential tissue damage through the pain pathway.
Katalog # CAS Nummer Summenformel Menge
sc-253616 70351-51-8 C₁₂H₁₁NO₂ 5 mg
Tenatoprazole
A proton pump inhibitor.
Katalog # CAS Nummer Summenformel Menge
sc-204909 113712-98-4 C₁₆H₁₈N₄O₃S 100 mg/500 mg
Tetracaine
Topical ophthalmic anesthetic that is used for spinal anesthesia Blocks voltage-sensitive release of Ca²⁺ from sarcoplasmic reticulum.
Katalog # CAS Nummer Summenformel Menge
sc-255645 94-24-6 C₁₅H₂₄N₂O₂ 5 g
Tofisopam
A ligand for the GABA_A receptor benzodiazepine modulatory site.
Katalog # CAS Nummer Summenformel Menge
sc-253708 22345-47-7 C₂₂H₂₆N₂O₄ 10 mg
TRO 19622
Neuroregenerative and neuroprotective compound. Promotes nerve regeneration following sciatic nerve crush in vivo and rescues motor neurons from axotomy-induced cell death. Binds directly to two components of the mitochondrial permeability pore, the voltage-dependent anion channel (VDAC) and translocator protein.
Katalog # CAS Nummer Summenformel Menge
sc-204356 22033-87-0 C₂₇H₄₅NO 10 mg/50 mg
UK 5099
Katalog # CAS Nummer Summenformel Menge
sc-361394 56396-35-1 C₁₈H₁₂N₂O₂ 10 mg/50 mg
VU0240551
Katalog # CAS Nummer Summenformel Menge
sc-253834 893990-34-6 C₁₆H₁₄N₄OS₂ 5 mg
ZD 7288
Katalog # CAS Nummer Summenformel Menge
sc-361419 133059-99-1 C₁₅H₂₁ClN₄•xH₂O 10 mg/50 mg
Zomepirac sodium salt
An NSAID that circumvents MRP-mediated multidrug resistance. Increases the cytotoxicity of the anthracyclines (doxorubicin, daunorubicin and epirubicin), as well as teniposide, VP-16 and vincristine.
Katalog # CAS Nummer Summenformel Menge
sc-253856 64092-48-4 C₁₅H₁₃ClNO₃Na 250 mg/1 g