Insulin Receptor Inhibitors

AG 538
A potent, competitive inhibitor of IGF-1 receptor kinase (IC₅₀ = 400 nM).
Katalog # CAS Nummer Summenformel Menge
sc-203807 133550-18-2 C₁₆H₁NO₅ 5 mg
AG 1024
A specific inhibitor of insulin-like growth factor-1 (IGF-1) and insulin receptor tyrosine kinase activity. Exhibits lower IC₅₀ values for IGF-1 than for the insulin receptor. Also inhibits insulin-stimulated cellular proliferation.
Katalog # CAS Nummer Summenformel Menge
sc-205907 65678-07-1 C₁₄H₁₃BrN₂O 1 mg
AGL 2263
A cell-permeable benzoxazolone-containing bioisostere of tyrphostin AG 538 that acts as a potent, substrate-competitive, but not ATP-competitive, inhibitor of insulin receptor (IR) and insulin-like growth factor-1 receptor (IGF-1R).
Katalog # CAS Nummer Summenformel Menge
sc-221223 n.n. C₁₇H₁₀N₂O₅ 5 mg
Chromeceptin
Cell-permeable benzochromene. Blocks insulin-induced adipogenesis in 3T3-L1 cells. Suppresses IGF2-dependent growth of HepG2 cells. Binds MFP-2. Activates STAT6-mediated gene expression.
Katalog # CAS Nummer Summenformel Menge
sc-202540 331859-86-0 C₁₉H₁₆F₃N₃O 5 mg
IGF-1R Inhibitor, PPP
An insulin-like, cell-permeable compound that acts as a non-competitive, potent, and specific inhibitor of IGF-1R, without affecting IR, FGFR, PDGFR, EGFR, microtubules, or DNA topoisomerase II.
Katalog # CAS Nummer Summenformel Menge
sc-204008 477-47-4 C₂₂H₂₂O₈•xH₂O 10 mg/1 mg