Inositols and Inositolphosphates

1,2-Cyclohexylidene Tetra-O-acetyl-myo-inositol
Katalog # CAS Nummer Summenformel Menge
sc-213428 n.n. C₂₀H₂₈O₁₀ 100 mg
1,2-Dipalmitoyl-L-α-phosphatidyl-D-myo-inositol 4,5-bisphosphate
4,5-bisphosphate group on the inositol ring is critical for binding specifically to PH domains that are commonly present in signalling proteins. Also found in cytoskeleton.
Katalog # CAS Nummer Summenformel Menge
sc-221508 n.n. C₄₁H₈₁O₁₉P₃ 100 µg/1 mg
1,2-Dipalmitoylphosphatidylinositol 3,4,5-trisphosphate hexasodium salt
A signal transduction modulator.
Katalog # CAS Nummer Summenformel Menge
sc-297914 n.n. C₄₁H₇₈Na₄P₄O₂₂ 100 µg
1,2-Isopropylidene-D,L-myo-inositol
Katalog # CAS Nummer Summenformel Menge
sc-213454 n.n. C₉H₁₆O₆ 50 mg
1,2-O-Cyclohexylidene-myo-inositol
Katalog # CAS Nummer Summenformel Menge
sc-220523 6763-47-9 C₁₂H₂₀O₆ 5 g
1,2:4,5-Biscyclohexylidene-myo-inositol
Katalog # CAS Nummer Summenformel Menge
sc-220541 55123-26-7 C₁₈H₂₈O₆ 10 g
1,2:4,5-Diisopropylidene-D,L-myo-inositol
Katalog # CAS Nummer Summenformel Menge
sc-213485 98974-89-1 C₁₂H₂₀O₆ 25 mg
3-Deoxy-3-fluoro-D-myo-inositol 1,4,5-trisphosphate . hexasodium salt
Equipotent to Ins(1,4,5)P3 in releasing intracellular calcium. The 3-position is blocked by fluorine, hence it cannot be converted to Ins(1,3,4,5)P4 by the action of 3-kinases.
Katalog # CAS Nummer Summenformel Menge
sc-202416 129365-68-0 C₆H₈FO₁₄P₃ ·6Na 100 µg
3-O-(TBDPS)-6-O-(D,L-1-Ethoxyethyl)-1,2:4,5-bis-O-(1-methylethylidene)-D,L-myo-inositol
Katalog # CAS Nummer Summenformel Menge
sc-223553 n.n. C₃₂H₄₆O₇Si 10 mg
3-O-TBDPS-1,2:4,5-bis-O-(1-methylethylidene)-D,L-myo-inositol
Katalog # CAS Nummer Summenformel Menge
sc-223554 n.n. C₂₈H₃₈O₆Si 10 mg
3-PT-PtdIns (3,4,5)-P3 (1,2-dioctanoyl), sodium salt
Phosphatidylinositol (PtdIns) phosphates represent a small percentage of total membrane phospholipids. However, they play a critical role in generation and transmission of cellular signals. PtdIns(4,5)-P2 can be phosphorylated by phosphoinositide (PI)-3-kinase to make PtdIns(3,4,5)-P3 which initiates an intricate signaling cascade that has been implicated in cancer. 3-PT-PtdIns(3,4,5)-P3 is an analog of PtdIns-(3,4,5)-P3 that is resistant to hydrolysis by PTEN. It has a 5-fold reduced affinity for specific PtdIns(3,4,5)-P3-binding protein GRP1 and increases sodium transport in A6 cell monolayers.
Katalog # CAS Nummer Summenformel Menge
sc-220884 n.n. C₂₅H₄₆Na₄O₂₁P₄S 25 µg/50 µg
3,4,5,6-Tetra-O-acetyl-myo-inositol
Katalog # CAS Nummer Summenformel Menge
sc-216594 n.n. C₁₄H₂₀O₁₀ 200 mg
3,4,5,6-Tetra-O-acetyl-myo-inositol-1,2-thiocarbonate
Katalog # CAS Nummer Summenformel Menge
sc-216595 n.n. C₁₅H₁₈O₁₀S 200 mg
6-O-(D,L-1-Ethoxyethyl)-1,2:4,5-bis-O-(1-methylethylidene)-D,L-myo-inositol
Katalog # CAS Nummer Summenformel Menge
sc-217372 n.n. C₁₆H₂₈O₇ 10 mg
Adenophostin A, Hexasodium Salt
One of the most potent known agonist of type 1 inositol 1,4,5-trisphosphate receptor.
Katalog # CAS Nummer Summenformel Menge
sc-221213 n.n. C₁₆H₂₀N₅O₁₈P₃ ·6Na 50 µg
AS 1949490
Selective SHIP2 (SH2 domain-containing inositol 5’ phosphatase 2) inhibitor which is reported to exhibit a 30-fold affinity for SHIP2 as compared to SHIP1.
Katalog # CAS Nummer Summenformel Menge
sc-358828 n.n. C₂₀H₁₈ClNO₂S 10 mg/50 mg
Bt2Ins(3,4,5,6)P4/PM
Katalog # CAS Nummer Summenformel Menge
sc-221385 n.n. C₄₆H₇₆O₃₆P₄ 1 umol
Conduritol B Tetraacetate
Katalog # CAS Nummer Summenformel Menge
sc-211127 25348-63-4 C₁₄H₁₈O₈ 100 mg
D-chiro Inositol
A secondary messenger in the signal transduction of insulin. It reduces the effects of polycystic ovary syndrome (PCOS) activity in cells.
Katalog # CAS Nummer Summenformel Menge
sc-221469 643-12-9 C₆H₁₂O₆ 1 g
D-myo-Inositol 1-monophosphate dipotassium salt
Katalog # CAS Nummer Summenformel Menge
sc-211182 573-35-3 C₆H₁₁O₉P•2K 5 mg/1 mg
D-myo-Inositol-1,2,4,5-tetraphosphate, sodium salt
Katalog # CAS Nummer Summenformel Menge
sc-362076 n.n. n.n. 100 µg/500 µg
D-myo-Inositol 1,2,3-trisphosphate tripotassium salt
Katalog # CAS Nummer Summenformel Menge
sc-363274 n.n. C₆H₁₂O₁₅P₃•3K 1 mg
D-myo-Inositol 1,2,3,4,5,6-Hexakisphosphate, Dodecasodium Salt, Zea mays
Major phosphorus compound in plants that chelates with a variety of di- and trivalent cations.
Katalog # CAS Nummer Summenformel Menge
sc-203329 14306-25-3 C₆H₆O₂₄P₆ ·12Na 5 g
D-myo-Inositol 1,2,5,6-tetrakisphosphate ammonium salt
Used to study the hormonal control of Ca²⁺-dependent processes.
Katalog # CAS Nummer Summenformel Menge
sc-214815 91796-88-2 C₆H₁₆O₁₈P₄ 50 µg
D-myo-Inositol 1,4,5-tris-phosphate trisodium salt
This product has been shown to be a stimulator of intracellular calcium mobilization.
Katalog # CAS Nummer Summenformel Menge
sc-300413 n.n. C₆H₁₂O₁₅P₃Na₃ 500 µg
D-myo-Inositol 1,3,4-tris-phosphate ammonium salt
Occurs naturally in carbachol-stimulated rat parotid glands and adrenal glomerular cells.
Katalog # CAS Nummer Summenformel Menge
sc-214816 93133-76-7 C₆H₁₅O₁₅P₃•6NH₃ 100 µg
D-myo-Inositol 1,3,4-Trisphosphate, Hexapotassium Salt
Produced upon hormonal stimulation of cells. Immediate precursor is postulated to be Ins(1,3,4,5)P4
Katalog # CAS Nummer Summenformel Menge
sc-203330 140385-74-6 C₆H₉O₁₅P₃ ·6K ·11H₂O 100 µg
D-myo-Inositol 1,3,4,5,6-pentakisphosphate pentapotassium salt
Katalog # CAS Nummer Summenformel Menge
sc-221502 n.n. C₆H₁₂O₂₁P₅•5K 100 µg/1 mg
D-myo-Inositol 1,3,5-trisphosphate hexasodium salt
Katalog # CAS Nummer Summenformel Menge
sc-221503 n.n. C₆H₉Na₆O₁₅P₃ 100 µg/1 mg
D-myo-Inositol 1,3,6-trisphosphate hexasodium salt
Enantiomer of Ins(1,3,4)P3 and a viable control compound.
Katalog # CAS Nummer Summenformel Menge
sc-205939 n.n. C₆H₉O₁₅P₃•6Na 100 µg/1 mg
D-myo-Inositol 1,4,5-trisphosphate (caged) trisodium salt
Ins (1,4,5)P3 derivative with a cage on position 4, which does not show biological activity until photochemical destruction of the cage.
Katalog # CAS Nummer Summenformel Menge
sc-221504 n.n. C₁₄H₁₉NO₁₇P₃•3Na 10 µg/100 µg
D-myo-Inositol 1,4,5-trisphosphate triammonium salt
Product of phosphatidylinositol phospholipid hydrolysis. Causes release of calcium from intracellular stores.
Katalog # CAS Nummer Summenformel Menge
sc-202121 112571-69-4 C₆H₁₂O₁₅P₃ ·3NH₄ 1 mg/5 mg
D-myo-Inositol 1,4,5-trisphosphate trilithium salt
Metabolite that controls a many cellular functions such as proliferation, metabolism, and secretion. Hydrolysis of the parent phospholipid yields Ins(1,4,5)P3, a second messenger for Ca²⁺ mobilization.
Katalog # CAS Nummer Summenformel Menge
sc-202566 129828-69-9 C₆H₁₂O₁₅P₃ ·3Li 1 mg/5 mg
D-myo-Inositol 1,4,5,6-tetrakis(phosphate) potassium salt
A component of the lipid signaling pathway shown to antagonize the negative regulation of calcium-mediated chloride secretion by epidermal growth factor. It has been shown to bind to pleckstrin homology (PH) domain of p130.
Katalog # CAS Nummer Summenformel Menge
sc-214819 103497-71-8 C₆H₈O₁₈P₄K₈ 100 µg
D-myo-Inositol 1,5,6-trisphosphate tripotassium salt
Katalog # CAS Nummer Summenformel Menge
sc-221505 n.n. C₆H₁₂K₃K₃O₁₅P₃ 100 µg
D-myo-Inositol 2,4-bisphosphate ammonium salt
Katalog # CAS Nummer Summenformel Menge
sc-214821 106358-02-5 C₆H₁₄O₁₂P₂•4H₃N 100 µg
D-myo-Inositol 3,4,5,6-tetrakisphosphate octasodium salt
Uncouples chloride secretion from the Ca²⁺ signal. Reduces Cl- secretion.
Katalog # CAS Nummer Summenformel Menge
sc-221506 n.n. C₆H₈Na₈O₁₈P₄ 100 µg/1 mg
D-myo-Inositol 3,4,6-trisphosphate hexasodium salt
Katalog # CAS Nummer Summenformel Menge
sc-221507 n.n. C₆H₉Na₆O₁₅P₃ 100 µg/1 mg
D-myo-Inositol 4-monophosphate ammonium salt
Katalog # CAS Nummer Summenformel Menge
sc-214822 69256-52-6 (non-salt) C₆H₁₆NO₉P 100 µg
D-myo-Inositol 4-monophosphate bis(cyclohexylammonium) salt
Katalog # CAS Nummer Summenformel Menge
sc-214823 16006-20-5 C₁₈H₃₉N₂O₉P 100 µg
D-myo-Inositol 5-monophosphate, L-α-Phosphatidyl-(1,2-dipalmitoyl)
Katalog # CAS Nummer Summenformel Menge
sc-214825 n.n. C₄₁H₈₀O₁₆P₂ 100 µg
D-myo-Inositol-1-phosphate, sodium salt
A member of the inositol phosphate (InsP) molecular family of second messengers that play a critical role in the transmission of cellular signals. Binding of Ins(1,4,5)P3 to its receptor on the endoplasmic reticulum causes opening of the calcium channels and an increase in intracellular calcium. Ins(1)P1 can be formed by PLC hydrolysis of phosphatidylinositol or by dephosphorylation of polyphosphate inositols such as Ins(1,3)P2 by inositol polyphosphate 3-phosphatase.
Katalog # CAS Nummer Summenformel Menge
sc-223909 n.n. C₆H₁₂O₉P ·Na 500 µg/1 mg
D-myo-Inositol-1,2-diphosphate, sodium salt
Ins(1,2)P2 (sodium salt) is one of the many inositol phosphate (InsP) isomers that could act as small, soluble second messengers in the transmission of cellular signals. Binding of Ins(1,4,5)P3 to its receptor on the endoplasmic reticulum causes opening of the calcium channels and an increase in intracellular calcium. Ins(1,2)P2 is less potent than Ins(1,4,5)P3 at initiating Ca²⁺ release when injected into Xenopus oocytes.
Katalog # CAS Nummer Summenformel Menge
sc-223910 n.n. C₆H₁₂O₁₂P₂•2Na 100 µg/500 µg
D-myo-Inositol-1,2,3,4-tetraphosphate, sodium salt
One of the many inositol phosphate (InsP) isomers that could act as small, soluble second messengers in the transmission of cellular signals. Ins(1,2,3,4)-P4 displays agonist activity at the Ins(1,4,5)-P3 receptor expressed in CHO cells where it induces Ca²⁺ mobilization with an ED50 value of 18.1 µM, making it less effective than Ins(1,4,5)-P3 in the same assay.
Katalog # CAS Nummer Summenformel Menge
sc-223911 n.n. C₆H₁₂O₁₈P₄•4Na 100 µg/500 µg
D-myo-Inositol-1,2,3,5-tetraphosphate, sodium salt
One of the many inositol phosphate isomers that could act as small, soluble second messengers in the transmission of cellular signals. Ins(1,2,3,5)P4 exhibits relatively weak agonist activity at the Ins(1,4,5)P3 receptor expressed in CHO cells, where it induces Ca²⁺ mobilization with an ED50 value of 93.3 µM, making it nearly less effective than Ins(1,4,5)P3 in the same assay.
Katalog # CAS Nummer Summenformel Menge
sc-223912 n.n. C₆H₁₂O₁₈P₄•4Na 100 µg/500 µg
D-myo-Inositol-1,2,3,5,6-pentaphosphate, sodium salt
Produced from Ins(1,2,3,4,5,6)P6 via a minor enzymatic phytate degradation pathway by K. terrigena. Ins(1,2,3,5,6)-P5 (sodium salt) is minimally effective in opening calcium channels compared to Ins(1,4,5)P3.
Katalog # CAS Nummer Summenformel Menge
sc-223913 n.n. C₆H₁₂O₂₁P₅•5Na 100 µg/500 µg
D-myo-Inositol-1,2,3,6-tetraphosphate, sodium salt
One of the many inositol phosphate (InsP) isomers that act as small, soluble second messengers in the transmission of cellular signals. The most studied InsP, Ins(1,4,5)-P3 is a second messenger produced in cells by phospholipase C (PLC)-mediated hydrolysis of phosphatidylinositol-4,5-biphosphate. Binding of Ins(1,4,5)-P3 to its receptor on the endoplasmic reticulum causes opening of the calcium channels and an increase in intracellular calcium. Ins(1,2,3,6)-P3 is less potent than Ins(1,4,5)-P3 at initiating Ca²⁺ release when injected into Xenopus oocytes.
Katalog # CAS Nummer Summenformel Menge
sc-223914 n.n. C₆H₁₂O₁₈P₄•4Na 100 µg/500 µg
D-myo-Inositol-1,2,4,5,6-pentaphosphate, sodium salt
One of many different inositol oligophosphate isomers implicated in signal transduction. In human Jurkat T-lymphocytes, as well as in cytosolic extracts from fetal calf thymus, Ins(1,2,4,5,6)P5 (sodium salt) is phosphorylated by a 1/3 kinase to InsP6.
Katalog # CAS Nummer Summenformel Menge
sc-223916 n.n. C₆H₁₂Na₅O₂₁P₅ 100 µg/500 µg
D-myo-Inositol-1,2,5,6-tetraphosphate, sodium salt
One of the many inositol phosphate isomers that act as small, soluble second messengers in the transmission of cellular signals. Ins(1,2,5,6)P4 binds to the murine Grp-1 PH domain with a K_d(apparent). It binds to rat heart membranes and significantly decreases heart rate in a pithed rat model.
Katalog # CAS Nummer Summenformel Menge
sc-223917 n.n. C₆H₁₂O₁₈P₄•4Na 100 µg/500 µg
D-myo-Inositol-1,2,6-triphosphate, sodium salt
A member of the inositol phosphate (InsP) family of second messengers that play a critical role in the transmission of cellular signals. Binding of Ins(1,4,5)P3 to its receptor on the endoplasmic reticulum causes opening of the calcium channels and an increase in intracellular calcium.
Katalog # CAS Nummer Summenformel Menge
sc-223918 n.n. C₆H₁₂O₁₅P₃•3Na 100 µg/500 µg
D-myo-Inositol-1,3-diphosphate (sodium salt)
A member of the inositol phosphate (InsP) molecular family which play critical roles as small, soluble second messengers in the transmission of cellular signals.
Katalog # CAS Nummer Summenformel Menge
sc-205284 208584-52-5 C₆H₁₂Na₂O₁₂P₂ 100 µg/500 µg
D-myo-Inositol-1,3,4-triphosphate, sodium salt
One of many inositol oligophosphate isomers implicated in signal transduction. Ins(1,3,4)-P3 acts through the inhibition of Ins(3,4,5,6)-P4 kinase activity to increase the cellular level of Ins(3,4,5,6)-P4 and thus inhibit calcium-activated chloride channels.3 The levels of Ins(1,3,4)-P3 are regulated by the levels of cytosolic free calcium.4 The receptor-mediated activation of phospholipase C (PLC) can be seen as the initiating event in this cascade, since PLC generates Ins(1,4,5)-P3 which releases calcium from intracellular storage reservoirs. This leads to increase in the cytosolic concentration of free calcium.
Katalog # CAS Nummer Summenformel Menge
sc-223919 n.n. C₆H₁₂O₁₅P₃•3Na 100 µg/500 µg
D-myo-Inositol-1,3,4,5-tetrakisphosphate, octapotassium salt
Formed by phosphorylation of Ins P3. Suggested to play a second-messenger role different from that of Ins P3. A weak agonist of Ca²⁺ mobilizing receptors that is reported to mobilize intracellular Ca²⁺ stores in saponin-permeabilized SH-SY5Y neuroblastoma cells (EC₅₀ = 2.05 µM).
Katalog # CAS Nummer Summenformel Menge
sc-203559 135269-51-1 C₆H₈O₁₈P₄K₈ 10 µg
D-myo-Inositol-1,3,4,5-tetraphosphate (sodium salt)
Augments intracellular calcium levels by opening calcium channels on both the endoplasmic reticulum and on the plasma membrane.
Katalog # CAS Nummer Summenformel Menge
sc-205285 210488-61-2 C₆H₈O₁₈P₄ ·8Na 100 µg/500 µg
D-myo-Inositol-1,3,4,5,6-pentaphosphate, ammonium salt
Inositol-1,3,4,5,6-pentaphosphate (Ins(1,3,4,5,6)P5) is one of many inositol phosphate isomers that act as soluble second messengers in the transmission of cellular signals. Ins(1,3,4,5,6)P5 inhibits the phosphorylation and kinase activity of Akt/PKB, inducing apoptosis in ovarian, lung, and breast cancer cells. Exhibits antiangiogenic activity in vitro, blocking capillary tube formation of HUVEC, as well as antitumor effects against cancer xenografts in nude mice. Ins(1,3,4,5,6)P5 binds to the PH domain of Grp1 with a Kd of 590 nM.
Katalog # CAS Nummer Summenformel Menge
sc-223920 n.n. C₆H₁₇O₂₁P₅•10NH₄ 100 µg/500 µg
D-myo-Inositol-1,3,4,5,6-pentaphosphate, sodium salt
One of the many inositol phosphate isomers that act as small, soluble second messengers in the transmission of cellular signals. It can be interconverted with Ins(3,4,5,6)P4 by a 1-kinase/1-phosphatase cycle, as well as with Ins(1,4,5,6)P4 in a 3-kinase/3-phosphatase cycle.4 Ins(1,3,4,5,6)P5 inhibits the phosphorylation and kinase activity of Akt/PKB, inducing apoptosis in ovarian, lung, and breast cancer cells. It displays antiangiogenic activity in vitro, blocking capillary tube formation of HUVEC, as well as antitumor effects against cancer xenografts in nude mice. Ins(1,3,4,5,6)P5 binds to the PH domain of Grp1.
Katalog # CAS Nummer Summenformel Menge
sc-223921 n.n. C₆H₁₂Na₅O₂₁P₅ 100 µg/500 µg
D-myo-Inositol-1,3,4,6-tetraphosphate, ammonium salt
Mostly acts an intermediate, serving as substrate for inositol-1,3,4,6-tetraphosphate 5-kinase to produce inositol-1,3,4,5,6-pentaphosphate, or inositol-1,3,4,6-tetraphosphate 2-kinase to give inositol-1,2,3,4,6-pentaphosphate.1 Can be further phosphorylated to produce inositol-1,2,3,4,5,6-hexakisphosphate, or phytic acid, which serves diverse roles in eukaryotic tissues. Ins(1,3,4,6)P4 is a poor activator of the inositol 1,4,5-trisphospate receptor in vitro.2 Other functions of this IP remain to be elucidated.
Katalog # CAS Nummer Summenformel Menge
sc-223922 n.n. C₆H₁₂O₁₈P₄··4NH₄ 100 µg/500 µg
D-myo-Inositol-1,3,5-triphosphate, sodium salt
A member of the inositol phosphate (InsP) family of second messengers that play a critical role in the transmission of cellular signals. Binding of Ins(1,4,5)P3 to its receptor on the endoplasmic reticulum causes opening of the calcium channels and an increase in intracellular calcium. Less potent than Ins(1,4,5)P3 at initiating Ca²⁺ release when injected into Xenopus oocytes.
Katalog # CAS Nummer Summenformel Menge
sc-223923 n.n. C₆H₁₂O₁₅P₃•3Na 100 µg/500 µg
D-myo-Inositol-1,4-diphosphate, sodium salt
A member of the inositol phosphate (InsP) molecular family that play critical roles as small, soluble second messengers in the transmission of cellular signals. Binding of Ins(1,4,5)P3 to its receptor on the endoplasmic reticulum causes of the calcium channels and an increase in intracellular calcium.4 Ins(1,4)P2 can be dephosphorylated to Ins(4)P by inositol polyphosphate 1-phosphatase and further dephosphorylated to inositol by inositol monophosphatase.
Katalog # CAS Nummer Summenformel Menge
sc-223924 n.n. C₆H₁₂Na₂O₁₂P₂ 100 µg/500 µg
D-myo-Inositol-1,4,5-triphosphate, sodium salt
A second messenger produced in cells by phospholipase C mediated hydrolysis of phosphatidyl inositol-4,5-biphosphate. Binds to one of several Ins(1,4,5)P3 receptors, containing calcium channel domains. Binding of Ins(1,4,5)P3 to the receptor results in opening of the calcium channels and an increase in intracellular calcium.
Katalog # CAS Nummer Summenformel Menge
sc-223925 n.n. C₆H₁₂O₁₅P₃•3Na 100 µg/500 µg
D-myo-Inositol-1,4,5-triphosphate hexapotassium salt
A second messenger released by the action of phospholipase C, which stimulates the release of Ca²⁺ from intracellular stores.
Katalog # CAS Nummer Summenformel Menge
sc-201521 103476-24-0 C₆H₉O₁₅P₃ ·6K 1 mg
D-myo-Inositol-1,4,5-trisphosphate, Na6 Salt (IP3)
A secondary messenger generated through polyphosphoinositide metabolism. Binds the InsP3 receptor and stimulates the mobilization of Ca²⁺ internal stores.
Katalog # CAS Nummer Summenformel Menge
sc-201522 108340-81-4 C₆H₉O₁₅P₃ ·6Na 1 mg
D-myo-Inositol-1,4,5,6-tetraphosphate, sodium salt
One of several different inositol oligophosphate isomers implicated in signal transduction. Production of Ins(1,4,5,6)P4 by intestinal epithelial cells increases approximately 2-14 fold, following infection with Salmonella. Ins(1,4,5,6)P4 antagonizes epidermal growth factor (EGF) signalling through the phosphatidylinositol 3-kinase pathway. Ins(1,4,5,6)P3 is less potent than Ins(1,4,5)P3 at initiating Ca²⁺ release when injected into Xenopus oocytes.
Katalog # CAS Nummer Summenformel Menge
sc-223926 n.n. C₆H₁₂O₁₈P₄•4Na 100 µg/500 µg
D-myo-Inositol-1,4,6-triphosphate, sodium salt
A member of the inositol phosphate (InsP) family that acts as small, soluble second messengers in the transmission of cellular signals. The most studied InsP, Ins(1,4,5)-P3, is a second messenger produced in cells by phospholipase C (PLC)-mediated hydrolysis of phosphatidylinositol-4,5-biphosphate. Binding of Ins(1,4,5)-P3 to its receptor on the endoplasmic reticulum results in opening of the calcium channels and an increase in intracellular calcium. Ins(1,4,6)-P3 is less potent than Ins(1,4,5)-P3 at initiating Ca²⁺ release when injected into Xenopus oocytes.
Katalog # CAS Nummer Summenformel Menge
sc-223927 n.n. C₆H₁₂O₁₅P₃•3Na 100 µg/500 µg
D-myo-Inositol-1,5-diphosphate, sodium salt
A member of the inositol phosphate (InsP) molecular family that play critical roles as small, soluble second messengers in the transmission of cellular signals. Binding of Ins(1,4,5)P3 to its receptor on the endoplasmic reticulum causes opening of the calcium channels and an increase in intracellular calcium.
Katalog # CAS Nummer Summenformel Menge
sc-223928 n.n. C₆H₁₂Na₂O₁₂P₂ 100 µg/500 µg
D-myo-Inositol-1,5,6-triphosphate (sodium salt)
Part of a family of mono- to poly-phosphorylated compounds acting a messengers, cellular function regulators (i.e. cell cycling, apoptosis, differentiation, and motility).
Katalog # CAS Nummer Summenformel Menge
sc-205286 120965-76-6 C₆H₉O₁₅P₃•3Na 100 µg/1 mg
D-myo-Inositol-2,3,4,5-tetraphosphate, ammonium salt
A member of the inositol phosphate (InsP) family of molecules that play a critical role as small, soluble second messengers in the transmission of cellular signals. Binding of Ins(1,4,5)-P3 to its receptor on the endoplasmic reticulum causes opening of the calcium channels and an increase in intracellular calcium.
Katalog # CAS Nummer Summenformel Menge
sc-223929 n.n. C₆H₁₂O₁₈P₄•4NH₄ 100 µg/500 µg
D-myo-Inositol-2,3,5-triphosphate, ammonium salt
A member of the inositol phosphate (InsP) family of second messengers that play a critical role in the transmission of cellular signals. Binding Ins(1,4,5)P3 to its receptor on the endoplasmic reticulum causes opening of the calcium channels and an increase in intracellular calcium.4,5 Ins(2,3,5)P3 is less potent than Ins(1,4,5)-P3 at initiating Ca²⁺ release when injected into Xenopus oocytes.
Katalog # CAS Nummer Summenformel Menge
sc-223930 n.n. C₆H₁₂O₁₅P₃•3NH₄ 100 µg/500 µg
D-myo-Inositol-2,3,5,6-tetraphosphate, sodium salt
Produced from Ins(1,2,3,5,6)P5 via a minor enzymatic phytate degradation pathway by K. terrigena. Ins(2,3,5,6)-P4 (sodium salt) is moderately effective in opening CCa²⁺ channels relative to Ins(1,4,5)P3.
Katalog # CAS Nummer Summenformel Menge
sc-223931 n.n. C₆H₁₂O₁₈P₄•4Na 100 µg/500 µg
D-myo-Inositol-2,4-diphosphate (sodium salt)
The inositol phosphates are a family of mono- to poly-phosphorylated compounds that act as messengers, regulating cellular functions including cell cycling, apoptosis, differentiation, and motility. D-myo-Inositol-2,4-diphosphate is an intermediate compound, produced by the dephosphorylation of either inositol-2,3,4-triphosphate or inositol-2,4,5-triphosphate. The diphosphate can be further metabolized to produce inositol-2-monophosphate. The biological roles of D-myo-inositol-2,4-diphosphate remain to be determined.
Katalog # CAS Nummer Summenformel Menge
sc-221509 n.n. C₆H₁₀O₁₂P₂ ·. ·2Na 100 µg/500 µg
D-myo-Inositol-2,4,5-triphosphate (sodium salt)
The most studied InsP, D-myo-Inositol-2,4,5-triphosphate (sodium salt) (Ins(1,4,5)P3), more commonly referred to as IP3, is a second messenger produced in cells by phospholipase C (PLC)-mediated hydrolysis of phosphatidylinositol-4,5-biphosphate.Binding of Ins(1,4,5)P3 to its receptor on the endoplasmic reticulum results in opening of the calcium channels and an increase in intracellular calcium.
Katalog # CAS Nummer Summenformel Menge
sc-221510 n.n. C₆H₁₂O₁₅P₃•3Na 100 µg/500 µg
D-myo-Inositol-3-phosphate (sodium salt)
Ins(3)P1 can be formed by the dephosphorylation of polyphosphate inositols such as Ins(3,4)P2 by inositol polyphosphate 4-phosphatase.
Katalog # CAS Nummer Summenformel Menge
sc-221511 n.n. C₆H₁₂NaO₉P 100 µg/500 µg
D-myo-Inositol-3,4,5-triphosphate (sodium salt)
A structural analog of Ins(1,4,5)-P3 and a member of the inositol phosphate (InsP) cell signaling family of molecules.
Katalog # CAS Nummer Summenformel Menge
sc-221512 n.n. C₆H₁₂O₁₅P₃ ·3Na 100 µg/500 µg
D-myo-Inositol-3,4,5,6-tetraphosphate (sodium salt)
One of several different inositol oligophosphate isomers implicated in signal transduction. It almost completely inhibits calcium-activated chloride channels at a concentration of 8-10 µM.
Katalog # CAS Nummer Summenformel Menge
sc-221513 n.n. C₆H₁₂Na₄O₁₈P₄ 100 µg/500 µg
D-myo-Inositol-4-phosphate (ammonium salt)
A member of the inositol phosphate (InsP) molecular family that plays a critical roles as small, soluble second messengers in the transmission of cellular signals.
Katalog # CAS Nummer Summenformel Menge
sc-205287 142760-33-6 C₆H₁₉N₂O₉P 100 µg/500 µg
D-myo-Inositol-4,5-diphosphate (sodium salt)
A metabolite of Ins(1,4,5)P3 that lacks a phosphate at the 1' position. Ins(4,5)P2 formation has been reported as an intermediate in the metabolism Ins(1,4,5)P3 in GH3 pituitary cells.4
Katalog # CAS Nummer Summenformel Menge
sc-221514 n.n. C₆H₁₂Na₂O₁₂P₂ 100 µg/500 µg
Dioctanoyl-cAMP, Na
Cell-permeable cAMP derivative. Generally mimics the effects of exogenous cAMP but with approximately 100 times greater activity. Highly resistant to the action of phosphodiesterases. Also known to increase the level of inositol trisphosphate in acinar cells. Avoid pH extremes.
Katalog # CAS Nummer Summenformel Menge
sc-221545 n.n. C₂₆H₃₉N₅O₈P ·Na 50 mg/250 mg
DL-myo-Inositol 1,5-bisphosphate dipotassium salt
Katalog # CAS Nummer Summenformel Menge
sc-221557 n.n. C₆H₁₂K₂K₂O₁₂P₂ 100 µg
scyllo-Inositol
One of the eight naturally occurring isomers of inositol that can be detected using NMR at a peak at 3.35 ppm in the 1H-NMR spectrum, and a peak at 74.5 ppm in the 13C-NMR spectrum.
Katalog # CAS Nummer Summenformel Menge
sc-202808 488-59-5 C₆H₁₂O₆ 5 mg/25 mg
iso-Ins(1,4,5)P3/PM (caged)
Derivative of Ins (1,4,5)P3 with a cage on position 6. Light pulse to destroy cage ~360nm.
Katalog # CAS Nummer Summenformel Menge
sc-221767 n.n. C₄₂H₆₄NO₃₁P₃ 20 µg/100 µg
L-α-Phosphatidyl-D-myo-inositol-3,5-bisphosphate, Dipalmitoyl-
Phosphoinositide second messenger present in mammalian, plant, and yeast cells. When hyperosmotically stressed, yeast rapidly synthesize PI-3,5-P2 by phosphorylation of PI-3-P at the D-5 position through the action of PI-3,5-OH kinase. PI-3,5-P2 shown to be at the center of a previously uncharacterized regulatory pathway.
Katalog # CAS Nummer Summenformel Menge
sc-221816 n.n. C₄₁H₈₁O₁₉P₃ 250 µg
L-(-)-chiro-Inositol
Katalog # CAS Nummer Summenformel Menge
sc-257639 551-72-4 C₆H₁₂O₆ 1 g
L-α-Phosphatidylinositol dipalmitoyl ammonium salt
This compound is a synthetic analog of the natural phosphatidyl inositols with C16:0 saturated fatty acids and the same inositol and diacyl glycerol stereochemistry as that of the natural compound.
Katalog # CAS Nummer Summenformel Menge
sc-300874 n.n. C₄₁H₈₂NO₁₃P 500 µg
L-α-Phosphatidylinositol-3-P
Lipid product produced by the action of PI 3-kinase.
Katalog # CAS Nummer Summenformel Menge
sc-221817 n.n. C₄₁H₇₈O₁₆P₂··3NH₄ 100 µg
L-α-Phosphatidylinositol-3,4-bisphosphate•5NH3 (PtdIns-3,4-P2)
Activates Ca-insensitive PKC isotypes δ, ε and η and activates Akt/PKB by direct interaction with the Akt PH domain (2). Hygroscopic.
Katalog # CAS Nummer Summenformel Menge
sc-221818 n.n. C₄₁H₉₆O₁₉P₃N₅ 100 µg
L-α-Phosphatidylinositol-3,4,5-trisphosphate•7Na (PtdIns-3,4,5-P3)
Activates Ca²⁺-insensitive PKC isotypes δ, ε and η and binds to GRP1 via a PH domain.
Katalog # CAS Nummer Summenformel Menge
sc-221819 n.n. C₄₁H₇₅O₂₂P₄··7Na 100 µg
L-α-Phosphatidylinositol-4,5-bisphosphate•5Na (PtdIns-4,5-P2)
From bovine brain and contains mainly arachidonic and stearic acids. Substrate for phospholipase C and PI 3-kinase (2). Activates phospholipase D (3,4). Binds to pleckstrin homology (PH) domains (5,6).
Katalog # CAS Nummer Summenformel Menge
sc-221820 n.n. n.n. 1 mg
L-α-Phosphatidylinositol•Na
From soybean. Contains mainly palmitic and linoleic acids. Substrate for phospholipase C.
Katalog # CAS Nummer Summenformel Menge
sc-221821 n.n. n.n. 10 mg
L-690,488
Katalog # CAS Nummer Summenformel Menge
sc-361221 142523-14-6 C₃₂H₅₂O₁₆P₂ 5 mg
L-myo-Inositol-1,4,5-triphosphate (sodium salt)
Ins 1,4,5 P3 is an isomer of the biologically important D-myo-inositol-1,4,5-triphosphate. Unlike its isomer, Ins(1,4,5)P3 does not induce a rise in intracellular calcium when added to cells. It is not known if Ins 1,4,5 P3 can act as a competitive inhibitor of biologically-active inositol phosphates
Katalog # CAS Nummer Summenformel Menge
sc-205361 2068-89-5 C₆H₁₂O₁₅P₃•3Na 100 µg/500 µg
L-Quebrachitol
Important starting material for the synthesis of optically active inositol phosphates.
Katalog # CAS Nummer Summenformel Menge
sc-205950 642-38-6 C₇H₁₄O₆ 1 g
myo-Inositol
A growth factor for animals as well as microorganisms. The most abundant form of polyols that serves as a structural element of secondary messengers in eukaryotic cells
Katalog # CAS Nummer Summenformel Menge
sc-202714 87-89-8 C₆H₁₂O₆ 100 g
myo-Inositol 2-monophosphate bis(cyclohexylammonium) salt
Katalog # CAS Nummer Summenformel Menge
sc-215404 103529-92-6 C₆H₁₃O₉P•2C₆H₁₃N 10 mg/50 mg
myo-Inositol Hexaacetate
Katalog # CAS Nummer Summenformel Menge
sc-221963 1254-38-2 C₁₈H₂₄O₁₂ 10 g
myo-Inositol hexanicotinate
Katalog # CAS Nummer Summenformel Menge
sc-215405 6556-11-2 C₄₂H₃₀N₆O₁₂ 25 g
myo-Inositol hexasulfate hexapotassium salt
Possesses a molecular footprint and negative surface charge that is similar to that of phytic acid (InsP6), but with lower biological activity. The compound is used as a control in studies of the cellular actions of phytic acid where it is also a competitive inhibitor of Aspergillus phytase.
Katalog # CAS Nummer Summenformel Menge
sc-215406 28434-25-5 C₆H₆O₂₄S₆K₆ 25 mg/250 mg
myo-Inositol Trispyrophosphate Hexasodium Salt
Katalog # CAS Nummer Summenformel Menge
sc-362062 23103-35-7 C₆H₆Na₆O₂₁P₆ 10 mg
Phosphatidylbutanol
Phosphatidylbutanol is a useful chromatographic standard for PLD assay.
Katalog # CAS Nummer Summenformel Menge
sc-222165 n.n. C₄₁H₇₈O₈P 10 mg/50 mg
Phosphatidylethanol
In the presence of ethanol, phospholipase D converts phosphatidylcholine to phosphatidylethanol. This conversion is the basis of a selective and sensitive assay for PLD activity in intact cells. Phosphatidylethanol is a useful chromatographic standard for this assay. Protect from light. Hygroscopic.
Katalog # CAS Nummer Summenformel Menge
sc-222166 n.n. C₃₉H₇₅O₈P 10 mg/50 mg
Phosphatidylinositol
Katalog # CAS Nummer Summenformel Menge
sc-281130 383907-36-6 C₄₆H₈₀O₁₃P.Na 50mg/ml 1 ml chloroform
PI-3,4-P2, 5NH4, PIP2, Dipalmitoyl-
Activates Ca²⁺-insensitive PKC isotypes δ, ε, and η. Also activates Akt, a serine/threonine kinase (also known as PKBα or Racα) by directly interacting with the Akt plekstrin homology (PH) domain.
Katalog # CAS Nummer Summenformel Menge
sc-222173 n.n. C₄₁H₇₆O₁₉P₃•5NH₄ 100 µg
PI-3,4,5-P3, 7NH4, PIP3, Dipalmitoyl-
Activates Ca²⁺-insensitive PKC isozymes δ, ε, and η. Binds to the general receptor for phosphoinositide-1 (GRP1) protein through a plekstrin homology (PH) domain.
Katalog # CAS Nummer Summenformel Menge
sc-222174 n.n. C₄₁H₇₅O₂₂P₄•7NH₄ 100 µg
PLC Thio-PIP2 (sodium salt)
Phospholipase C (PLC) catalyzes the hydrolysis of phosphatidylinositol bisphosphate (PIP2) on the cytoplasmic side of the cell membrane to yield diacylglycerol and inositol-1,4,5-triphosphate (IP3). The reaction initiates a well-known signal transduction pathway common to most cells. PLC thio-PIP2 is an analog of naturally occurring PIP2 which contains sulfur instead of oxygen at the sn-3 position of the glycerol backbone. Hydrolysis by PLC yields a free thiol that reacts with chromogenic reagents such as DTNB (Ellman’s reagent) to allow quantitation of PLC activity.
Katalog # CAS Nummer Summenformel Menge
sc-224207 n.n. C₂₁H₃₈O₁₈P₃S•3Na 100 µg/500 µg
Propenyl-L-NIO (hydrochloride)
A potent, selective inhibitor of iNOS. The K_i values for inhibition of iNOS, nNOS, and eNOS by ENIPO are 17, 10.3 and 58.2 µM, respectively, as determined using initial rate binding kinetics. However, A time-dependent inhibitor which, with longer incubations, demonstrates reversible tight binding inhibition that is selective for iNOS over nNOS or eNOS. This selectivity results from iNOS exhibiting a 4-fold faster binding and 10-fold slower dissociation with ENIPO compared to nNOS. K_i values for ENIPO binding to iNOS and nNOS are 0.56 and 6 µM, respectively.
Katalog # CAS Nummer Summenformel Menge
sc-222191 n.n. C₁₀H₁₉N₃O₂•HCl 5 mg/10 mg
Ptd(S)Ins-(3,4)-P2 (1,2-dioctanoyl) (sodium salt)
An analog of naturally occurring PtdIns-(3,4)-P2 which contains sulfur rather than oxygen at the sn-3 position of the glycerol backbone. Potential hydrolysis by phospholipase C (PLC) would yield a free thiol which could then react with chromogenic reagents such as DTNB (Ellman’s reagent).
Katalog # CAS Nummer Summenformel Menge
sc-222204 n.n. C₂₅H₄₆Na₃O₁₈P₃S 100 µg/500 µg
PtdIns (4)-P1-fluorescein (ammonium salt)
A fluorescent derivative of phosphatidyl inositol. Shown to regulat exocytosis, endocytosis, extracellular signal transduction, and apoptosis.
Katalog # CAS Nummer Summenformel Menge
sc-358807 n.n. C₄₆H₅₈NO₂₂P₂ ·C₁₈H₄₆N₃ 10 µg/25 µg
PtdIns-(1-arachidonoyl, 2-arachidonoyl-d8) (sodium salt)
Used as an internal standard for the quantification of PtdIns-(1-arachidonoyl, 2-arachidonoyl) by stable isotope dilution MS. The accuracy of the sample weight in this vial is between 5% over and 2% under the amount shown on the vial. The phosphatidylinositols (PtdIns) represent a small percentage of total membrane phospholipids, but they play a critical role in the generation and transmission of cellular signals. PtdIns-(1-arachidonoyl, 2-arachidonoyl-d8) (sodium salt) is a synthetic analog of natural PtdIns containing deuterated C20:4 fatty acids at the sn-2 position. This synthetic standard compound features the same inositol and diacyl glycerol (DAG) stereochemistry as that of the natural compound.
Katalog # CAS Nummer Summenformel Menge
sc-224231 n.n. C₄₉H₇₀D₈O₁₃PNH₄ 25 µg/50 µg
PtdIns-(1-arachidonoyl)-d8)-(2-arachidonoyl) (sodium salt)
Contains eight deuterium atoms at the 5, 6, 8, 9, 11, 12, 14, and 15 positions and is intended for use as an internal standard for the quantification of PtdIns-(1-arachidonoyl)-(2-arachidonoyl) (sodium salt) by GC- or LC-MS.
Katalog # CAS Nummer Summenformel Menge
sc-224232 n.n. C₄₉H₇₀D₈O₁₃P•Na 25 µg/50 µg
PtdIns-(1,2-dioctanoyl) (sodium salt)
The phosphatidylinositol (PtdIns) phosphates represent a small percentage of total membrane phospholipids, but they play a crucial role in the generation and transmission of cellular signals. PtdIns-(1,2-dioctanoyl) is a synthetic analog of natural PtdIns containing saturated C8:0 fatty acids at sn-1 and sn-2 positions. The compound contains the same inositol and diacyl glycerol (DAG) stereochemistry as that of the natural compound. The short fatty acid chains of this analog, in contrast to naturally-occurring PtdIns, gives it different physical properties including high solubility in aqueous media. PtdIns are phosphorylated to mono- (PtdIns-P; PIP), di- (PtdIns-P2; PIP2), and triphosphates (PtdIns-P3; PIP3). Hydrolysis of PtdIns-(4,5)-P2 by phosphoinositide (PI)-specific phospholipase C generates inositol triphosphate (IP3) and DAG which are key second messengers in an intricate biochemical signal transduction cascade.
Katalog # CAS Nummer Summenformel Menge
sc-224233 n.n. C₂₅H₄₆O₁₃P•Na 100 µg/500 µg
PtdIns-(1,2-dipalmitoyl) (ammonium salt)
The phosphatidylinositol (PtdIns) phosphates represent a small percentage of total membrane phospholipids, but they play a crucial role in the generation and transmission of cellular signals. PtdIns-(1,2-dipalmitoyl) is a synthetic analog of natural PtdIns featuring saturated C16:0 fatty acids at sn-1 and sn-2 positions. The compound features the same inositol and diacylglycerol (DAG) stereochemistry as that of the natural compound. PtdIns are phosphorylated to mono- (PtdIns-P; PIP), di- (PtdIns-P2; PIP2), and triphosphates (PtdIns-P3; PIP3). Hydrolysis of PtdIns-(4,5)-P2 by phosphoinositide (PI)-specific phospholipase C generates inositol triphosphate (IP3) and DAG which are key second messengers in an intricate biochemical signal transduction cascade.
Katalog # CAS Nummer Summenformel Menge
sc-222205 n.n. C₄₁H₈₂NO₁₃P 100 µg/500 µg
PtdIns-(3,4,5)-P3 (1-stearoyl, 2-arachidonoyl) (sodium salt)
The phosphatidylinositol (PtdIns) phosphates represent a small percentage of total membrane phospholipids, but they play a crucial role in the generation and transmission of cellular signals. PtdIns-(3,4,5)-P3 can serve as an anchor for the binding of signal transduction proteins bearing pleckstrin homology (PH) domains. Centuarin α and Akts are examples of PtdIns-(3,4,5)-P3-binding proteins. Protein-binding to PtdIns-(3,4,5)-P3 is important for cytoskeletal rearrangements and membrane trafficking. PtdIns-(3,4,5)-P3 is resistant to cleavage by PI-specific PLC. Therefore, it is likely to function in signal transduction as a modulator in its own right, rather than as a source of inositol tetraphosphates.
Katalog # CAS Nummer Summenformel Menge
sc-222206 n.n. C₄₇H₈₂O₂₂P₄•4Na 50 µg/100 µg
PtdIns-(3,4,5)-P3 (1,2-dihexanoyl) (ammonium salt)
The phosphatidylinositol (PtdIns) phosphates represent a small percentage of total membrane phospholipids, but they play a crucial role in the generation and transmission of cellular signals. PtdIns-(3,4,5)-P3, also known as PIP3, is resistant to cleavage by PI-specific phospholipase C (PLC). Thus, it is likely to function in signal transduction as a modulator in its own right, instead of a source of inositol tetraphosphates. PIP3 can serve as an anchor for the binding of signal transduction proteins bearing pleckstrin homology (PH) domains. Protein binding to PIP3 is important for cytoskeletal rearrangement and membrane trafficking. PtdIns-(3,4,5)-P3 (1,2-dihexanoyl) is a synthetic analog of natural PIP3 with saturated C6 fatty acids at sn-1 and sn-2 positions. The compound features the same inositol and diacylglycerol (DAG) stereochemistry as the the natural compound. The short fatty acid chains of this analog give it different physical properties from naturally-occurring PIP3, including higher solubility in aqueous media.
Katalog # CAS Nummer Summenformel Menge
sc-224234 n.n. C₂₁H₅₄N₄O₂₂P₄ ·4NH₄ 100 µg/500 µg
PtdIns-(3,4,5)-P3 (1,2-dioctanoyl) (sodium salt)
The phosphatidylinositol (PtdIns) phosphates represent a small percentage of total membrane phospholipids, but they play a crucial role in the generation and transmission of cellular signals. PtdIns-(3,4,5)-P3 (1,2-dioctanoyl) is a synthetic analog of natural PtdIns featuring saturated C8:0 fatty acids at the sn-1 and sn-2 positions. The compound features the same inositol and diacylglycerol (DAG) stereochemistry as that of the natural compound. The short fatty acid chains of this analog give it different physical properties such as high solubility in aqueous media compared to naturally occurring PtdIns-(3,4,5)-P3. PtdIns are phosphorylated to mono- (PtdIns-P; PIP), di- (PtdIns-P2; PIP2), and triphosphates (PtdIns-P3; PIP3). Phosphorylation of PtdIns-(4,5)-P2 by phosphoinositide (PI)-3-kinase initiates an intricate signalling cascade at the fore front of scientific research.
Katalog # CAS Nummer Summenformel Menge
sc-222207 n.n. C₂₅H₄₆O₂₂P₄ ·4Na 100 µg/500 µg
PtdIns-(3,4,5)-P3 (1,2-dipalmitoyl) (sodium salt)
The phosphatidylinositol phosphates represent a small percentage of total membrane phospholipids, but they play a crucial role in the generation and transmission of cellular signals. PtdIns-(3,4,5)-P3 can serve as an anchor for the binding of signal transduction proteins bearing pleckstrin homology (PH) domains. Centuarin α and the Akt-family of GTPase activating proteins are examples of PtdIns-(3,4,5)-P3-binding proteins.3,4 Protein-binding to PtdIns-(3,4,5)-P3 is important for cytoskeletal rearrangements and membrane trafficking. PtdIns-(3,4,5)-P3 is resistant to cleavage by PI-specific phospholipase C (PLC). Therefore, it is likely to function in signal transduction as a modulator in its own right, rather than as a source of inositol tetraphosphates.
Katalog # CAS Nummer Summenformel Menge
sc-222208 n.n. C₄₁H₇₈O₂₂P₄ ·4Na 100 µg/500 µg
PtdIns-(3,4,5)-P3-biotinamide (sodium salt)
PtdIn phosphates play an important role in the generation and transduction of intracellular signals. PtdIns-(3,4,5)-P3-biotinamide is an affinity probe which allows the PIP3 to be detected through an interaction with the biotin ligand. The design allows PtdIns-(3,4,5)-P3-biotinamide to function as a general probe for any protein with a high affinity binding interaction with inositol-(3,4,5)-triphosphate phospholipids, such as phosphatidylinositol 3-kinase, PTEN, or PH-domain-containing proteins.
Katalog # CAS Nummer Summenformel Menge
sc-224235 n.n. C₃₅H₆₁N₃O₂₄P₄S•4Na 10 µg/25 µg
PtdIns-(3,4)-P2 (1,2-dihexanoyl) (sodium salt)
The phosphatidylinositol (PtdIns) phosphates represent a small percentage of total membrane phospholipids, but they play a crucial role in the generation and transmission of cellular signals.1,2 PtdIns-(3,4)-P2 (1,2-dihexanoyl) is a synthetic analog of natural PtdIns featuring saturated C6:0 fatty acids at sn-1 and sn-2 positions. The compound features the same inositol and diacylglycerol (DAG) stereochemistry as that of the natural compound. The natural compound is the product of phosphorylation-dephosphorylation involving PtdIns-3-kinase and 5-phosphatases. The 3D-phosphorylated PtdIns are resistant to hydrolysis by phospholipase C.3
Katalog # CAS Nummer Summenformel Menge
sc-222209 n.n. C₂₁H₃₈O₁₉P₃•3Na 100 µg/500 µg
PtdIns-(3,4)-P2 (1,2-dioctanoyl) (sodium salt)
The phosphatidylinositols (PtdIns) represent a small percentage of total membrane phospholipids, but they play a crucial role in the generation and transmission of cellular signals. PtdIns-(3,4)-P2-(1,2-dioctanoyl) is a synthetic analog of natural PtdIns featuring saturated C8:0 fatty acids at the sn-1 and sn-2 positions. The compound contains the same inositol and diacylglycerol (DAG) stereochemistry as that of the natural compound. The natural compound is the product of phosphorylation-dephosphorylation involving PtdIn 3-kinase and 5-phosphatase and the 3D-phosphorylated PtdIns are resistant to hydrolysis by phospholipase C.
Katalog # CAS Nummer Summenformel Menge
sc-224236 n.n. C₂₅H₄₉O₁₉P₃•3Na 100 µg/500 µg
PtdIns-(3,4)-P2 (1,2-dipalmitoyl) (sodium salt)
The phosphatidylinositols (PtdIns) phosphates represent a small percentage of total membrane phospholipids. but they play a crucial role in the generation and transmission of cellular signals. PtdIns is phosphorylated to mono- (PtdIns-P; PIP), di- (PtdIns-P2; PIP2) and triphosphates (PtdIns-P3; PIP3). Hydrolysis of PIP2 by PI-specific phospholipase C generates IP3 and diacylglycerol (DAG).
Katalog # CAS Nummer Summenformel Menge
sc-222210 n.n. C₄₁H₇₇Na₃O₁₉P₃ 100 µg/500 µg
PtdIns-(3,5)-P2 (1,2-dihexanoyl) (sodium salt)
PtdIns-(3,5)-P2 (1,2-dihexanoyl) (sodium salt) is a synthetic analog of natural PtdIns containing saturated C6:0 fatty acids at sn-1 and sn-2 positions. The compound has the same inositol and DAG stereochemistry as that of the natural compound. PtdIns-(3,5)-P2 is rapidly synthesized from PtdIns-(3)-P1 in yeast when a PtdIns-(3)-P5-OH kinase is activated during hyperosmotic conditions.1 PtdIns-(3,5)-P2 is also present in mammalian cells, including monkey COS-7 cells, where a similar biosynthetic route has been demonstrated.
Katalog # CAS Nummer Summenformel Menge
sc-224237 n.n. C₂₁H₃₈O₁₉P₃•3Na+ 100 µg/500 µg
PtdIns-(3,5)-P2 (1,2-dioctanoyl) (sodium salt)
The phosphatidylinositol (PtdIns) phosphates represent a small percentage of total membrane phospholipids, but they play a crucial role in the generation and transmission of cellular signals. PtdIns-(3,5)-P2 1,2-dioctanoyl) is a synthetic analog of natural PtdIns featuring saturated C8:0 fatty acids at the sn-1 and sn-2 positions. The compound features the same inositol and diacylglycerol (DAG) stereochemistry as that of the natural compound. PtdIns are phosphorylated to mono- (PtdIns-P; PIP), di- (PtdIns-P2; PIP2), and triphosphates (PtdIns-P3; PIP3). Hydrolysis of PtdIns-(4,5)-P2 by phosphoinositide (PI)-specific phospholipase C generates inositol triphosphate (IP3) and DAG which are key second messengers in an intricate biochemical signal transduction cascade. Also, PtdIns-(3,4)-P2 is resistant to hydrolysis by phospholipase C.
Katalog # CAS Nummer Summenformel Menge
sc-222211 n.n. C₂₅H₄₆O₁₉P₃•3Na 100 µg/500 µg
PtdIns-(3,5)-P2 (1,2-dipalmitoyl) (sodium salt)
The phosphatidylinositol (PtdIns) phosphates represent a small percentage of total membrane phospholipids, but they play a crucial role in the generation and transmission of cellular signals. PtdIns-(3,5)-P2 (1,2-dipalmitoyl) (sodium salt) is a synthetic analog of natural PtdIns containing saturated C16:0 fatty acids at sn-1 and sn-2 positions. The compound features the same inositol and diacylglycerol stereochemistry as that of the natural compound. PtdIns-(3,5)-P2 is rapidly synthesized from PtdIns-(3)-P1 in yeast when a PtdIns-(3)-P5-hydroxy kinase is activated during hyperosmotic conditions.3 PtdIns-(3,5)-P2 is also present in mammalian cells, including monkey COS-7 cells, where a similar biosynthetic route has been demonstrated.
Katalog # CAS Nummer Summenformel Menge
sc-224238 n.n. C₄₁H₇₆O₁₉P₃•3Na 100 µg/500 µg
PtdIns-(3)-P1 (1,2-dioctanoyl) (sodium salt)
The phosphatidylinositol (PtdIns) phosphates represent a small percentage of total membrane phospholipids, but they play a crucial role in the generation and transmission of cellular signals. PtdIns-(3)-P1 (1,2-dioctanoyl) is a synthetic analog of natural PtdIns containing saturated C8:0 fatty acids at sn-1 and sn-2 positions. The compound has the same inositol and DAG stereochemistry as that of the natural compound. PtdIns-(3)-P1 can be phosphorylated to di- (PtdIns-P2; PIP2) and triphosphates (PtdIns-P3; PIP3) by phosphatidyl inositol (PI)-specific kinases.
Katalog # CAS Nummer Summenformel Menge
sc-224239 n.n. C₂₅H₄₆Na₂O₁₆P₂ 25 µg/50 µg
PtdIns-(3)-P1 (1,2-dipalmitoyl) (ammonium salt)
The phosphatidylinositol phosphates represent a small percentage of total membrane phospholipids but they play a crucial role in the generation and transmission of cellular signals. PtdIns-(3)-P1 can be further phosphorylated to give triphosphates such as PtdIns-(3,4,5)-P3. These can also be cleaved by PI-specific phospholipase C (PLC) to give inositol triphosphates (IP3). The diacyl glycerol and IP3 generated by this PLC-cleavage are also part of a complex biochemical and signal transduction cascade which has not been entirely elucidated.
Katalog # CAS Nummer Summenformel Menge
sc-222212 n.n. C₄₁H₈₅N₂O₁₆P₂ 100 µg/500 µg
PtdIns-(3)-P1 (1,2-dipalmitoyl)-d62 (ammonium salt)
Contains 62 deuterium atoms at the 2, 2', 3, 3', 4, 4', 5, 5', 6, 6', 7, 7', 8, 8', 9, 9', 10, 10', 11, 11', 12, 12', 13, 13', 14, 14', 15, 15', 16, 16, and 16 positions and is intended for use as an internal standard for the quantification of PtdIns-(3)-P1 (1,2-dipalmitoyl) (ammonium salt) by GC- or LC-mass spectrometry. The phosphatidylinositol (PtdIns) phosphates represent a small percentage of total membrane phospholipids, but they play a critical role in the generation and transmission of cellular signals.1,2 PtdIns-(3)-P1 (1,2-dipalmitoyl)-d62 is a synthetic analog of natural PtdIns containing deuterated C16:0 fatty acids at sn-1 and sn-2 positions. It is intended for use as an internal standard for the quantification of PtdIns-(3)-P1 by GC- or LC-mass spectrometry. This synthetic standard compound features the same inositol and diacyl glycerol (DAG) stereochemistry as that of the natural compound.
Katalog # CAS Nummer Summenformel Menge
sc-224240 n.n. C₄₁H₁₈D₆₂N₂O₁₆P₂ 25 µg/50 µg
PtdIns-(4,5)-P2 (1,2-dihexanoyl) (sodium salt)
The phosphatidylinositol (PtdIns) phosphates represent a small percentage of total membrane phospholipids, but they play a crucial role in the generation and transmission of cellular signals. PtdIns-(4,5)-P2 (1,2-dihexanoyl) is a synthetic analog of natural PtdIns featuring saturated C6:0 fatty acids at sn-1 and sn-2 positions. The compound features the same inositol and diacylglycerol (DAG) stereochemistry as that of the natural compound. The natural compound is the product of PtdIns-4-phosphate 5-kinase acting on PtdIns-(4)-P1. Hydrolysis of PtdIns-(4,5)-P2 by phosphoinositide (PI)-specific phospholipase C generates inositol triphosphate (IP3) and DAG which are key second messengers in an intricate biochemical signal transduction cascade.
Katalog # CAS Nummer Summenformel Menge
sc-222213 n.n. C₂₁H₃₈O₁₉P₃•3Na 100 µg/500 µg
PtdIns-(4,5)-P2 (1,2-dioctanoyl) (sodium salt)
The phosphatidylinositol (PtdIns) represent a small percentage of total membrane phospholipids, but they play a critical role in the generation and transmission of cellular signals.PtdIns is phosphorylated to mono- (PtdIns-P; PIP), di- (PtdIns-P2; PIP2) and triphosphates (PtdIns-P3; PIP3). Hydrolysis of PIP2 by PI-specific phospholipase C generates IP3 and diacylglycerol (DAG).
Katalog # CAS Nummer Summenformel Menge
sc-222214 n.n. C₂₅H₄₉O₁₉P₃•3Na 100 µg/500 µg
PtdIns-(4,5)-P2 (1,2-dipalmitoyl) (ammonium salt)
The phosphatidylinositol phosphates represent a small percentage of total membrane phospholipids, but they play a crucial role in the generation and transmission of cellular signals. PtdIns-(4,5)-P2 incorporated into membrane lipids can bind to important proteins such as Group IV cPLA2 and PLCδ1, enhancing their adherence to the membrane and increasing the rate of substrate hydrolysis. PtdIns-(4,5)-P2 can be further phosphorylated to give triphosphates such as PtdIns-(3,4,5)-P3. It can also be cleaved by PI-specific PLC to give inositol triphosphates. The diacyl glycerol and IP3 generated by this PLC-cleavage are part of a complex biochemical and signal transduction cascade which has not been entirely elucidated.
Katalog # CAS Nummer Summenformel Menge
sc-222215 n.n. C₄₁H₇₈O₁₉P₃•3NH₄ 100 µg/500 µg
PtdIns-(4,5)-P2 (1,2-dipalmitoyl) (sodium salt)
The phosphatidylinositol (PtdIns) phosphates represent a small percentage of total membrane phospholipids, but they play a crucial role in the generation and transmission of cellular signals.1PtdIns-(4,5)-P2 (1,2-dipalmitoyl) is a synthetic analog of natural PtdIns containing saturated C16:0 fatty acids at sn-1 and sn-2 positions. The compound contains the same inositol and diacylglycerol (DAG) stereochemistry as that of the natural compound. The natural compound is the product of PtdIns-4-phosphate 5-kinase acting on PtdIns-(4)-P1. Hydrolysis of PtdIns-(4,5)-P2 by phosphoinositide (PI)-specific phospholipase C generates inositol triphosphate (IP3) and DAG which are key second messengers in an intricate biochemical signal transduction cascade.
Katalog # CAS Nummer Summenformel Menge
sc-224241 n.n. C₄₁H₇₈O₁₉P₃•3Na 100 µg/500 µg
PtdIns-(4,5)-P2 (1,2-dipamitoyl)-d62 (sodium salt)
Contains 62 deuterium atoms at the 2, 2', 3, 3', 4, 4', 5, 5', 6, 6', 7, 7', 8, 8', 9, 9', 10, 10', 11, 11', 12, 12', 13, 13', 14, 14', 15, 15', 16, 16, and 16 positions of each fatty acyl chain and is intended for use as an internal standard for the quantification of PtdIns-(4,5)-P2 (1,2-dipalmitoyl) (sodium salt) by GC- or LC-mass spectrometry. The phosphatidylinositol (PtdIns) phosphates represent a small percentage of total membrane phospholipids, but they play a critical role in the generation and transmission of cellular signals. PtdIns-4,5-P2-(1,2-dipalmitoyl)-d62 is a synthetic analog of natural PtdIns featuring deuterated C16:0 fatty acids at sn-1 and sn-2 positions. This synthetic standard contains the same inositol and diacyl glycerol (DAG) stereochemistry as that of the natural compound. The natural compound is the product of phosphatidylinositol 4-phosphate 5-kinase acting on PtdIns-(4)-P1. Hydrolysis of PtdIns-(4,5)-P2 by phosphoinositide (PI)-specific phospholipase C generates inositol triphosphate (IP3) and DAG which are key second messengers in an intricate biochemical signal transduction cascade.
Katalog # CAS Nummer Summenformel Menge
sc-224242 n.n. C₄₁H₁₆D₆₂O₁₉P₃•3Na 25 µg/50 µg
PtdIns-(4,5)-P2-biotinamide (sodium salt)
The PtdIns phosphates play an important role in the generation and transduction of intracellular signals.1 PtdIns-(4,5)-P2-biotinamide is an affinity probe which allows PIP2 to be detected through an interaction with the biotin ligand. This design allows PtdIns-(4,5)-P2 to function as a general probe for any protein with a high affinity binding interaction with inositol-(4,5)-diphosphate phospholipids, such as phosphatidylinositol 3-kinase, PTEN, or PH-domain-containing proteins.
Katalog # CAS Nummer Summenformel Menge
sc-222216 n.n. C₃₅H₅₉Na₃N₃O₂₁P₃S 10 µg/25 µg
PtdIns-(4,5)-P2-fluorescein (ammonium salt)
The phosphatidylinositol (PtdIns) phosphates represent a small percentage of total membrane phospholipids. However, they play a crucial role in the generation and transmission of cellular signals. PtdIns-(4,5)-P2-fluorescein is a fluorescent probe for any protein with a high-affinity binding interaction with inositol-(4,5)-triphosphate phospholipids, such as PI-3-kinase, PTEN, or PH-domain-containing proteins.
Katalog # CAS Nummer Summenformel Menge
sc-222217 n.n. C₄₆H₅₅NO₂₅P₃•5NH(C₂H₅)₃ 10 µg/25 µg
PtdIns-(4)-P1 (1,2-dihexanoyl) (sodium salt)
The phosphatidylinositol (PtdIns) phosphates represent a small percentage of total membrane phospholipids, but they play a crucial role in the generation and transmission of cellular signals. PtdIns-(4)-P1 (1,2-dihexanoyl) is a synthetic analog of natural PtdIns featuring saturated C6:0 fatty acids at sn-1 and sn-2 positions. The compound features the same inositol and diacylglycerol (DAG) stereochemistry as that of the natural compound. PtdIns-(4)-P1 can be phosphorylated to di- (PtdIns-P2; PIP2) and triphosphates (PtdIns-P3; PIP3) by phosphoinositol (PI)-specific kinases. Hydrolysis of PtdIns-(4,5)-P2 by PI-specific phospholipase C generates inositol triphosphate (IP3) and DAG which are key second messengers in an intricate biochemical signal transduction cascade.
Katalog # CAS Nummer Summenformel Menge
sc-222218 n.n. C₂₁H₃₈Na₂O₁₆P₂ 100 µg/500 µg
PtdIns-(4)-P1 (1,2-dioctanoyl) (ammonium salt)
The phosphatidylinositol (PtdIns) phosphates represent a small percentage of total membrane phospholipids, but they play a critical role in the generation and transmission of cellular signals. PtdIns-(4)-P1 1,2-dioctanoyl) is a synthetic analog of natural PtdIns featuring saturated C8:0 fatty acids at sn-1 and sn-2 positions. The compound contains the same inositol and diacylglycerol (DAG) stereochemistry as that of the natural compound. PtdIns-(4)-P1 can be phosphorylated to di- (PtdIns-P2; PIP2) and triphosphates (PtdIns-P3; PIP3). Hydrolysis of PtdIns-(4,5)-P2 by phosphoinositide (PI)-specific phospholipase C generates inositol triphosphate (IP3) and DAG which are key second messengers in an intricate biochemical signal transduction cascade.
Katalog # CAS Nummer Summenformel Menge
sc-222219 n.n. C₂₅H₅₄N₂O₁₆P₂ 100 µg/500 µg
PtdIns-(4)-P1 (1,2-dipalmitoyl) (ammonium salt)
The phosphatidylinositol phosphates represent a small percentage of total membrane phospholipids, but they play a crucial role in the generation and transmission of cellular signals. PtdIns-(4)-P1 can be further phosphorylated to give triphosphates such as PtdIns-(3,4,5)-P3. These can also be cleaved by PI-specific phospholipase C (PLC) to give inositol triphosphates (IP3). The diacyl glycerol and IP3 generated by this PLC-cleavage are also part of a complex biochemical and signal transduction cascade which has not been entirely elucidated.
Katalog # CAS Nummer Summenformel Menge
sc-222220 n.n. C₄₁H₈₅O₁₆P₂N₂ 100 µg/500 µg
PtdIns-(5)-P1 (1,2-dihexanoyl) (sodium salt)
The phosphatidylinositol (PtdIns) phosphates represent a small percentage of total membrane phospholipids, but they play a crucial role in the generation and transmission of cellular signals. PtdIns-(5)-P1 (1,2-dihexanoyl) is a synthetic analog of natural PtdIns containing saturated C6:0 fatty acids at sn-1 and sn-2 positions. The compound contains the same inositol and diacylglycerol (DAG) stereochemistry as that of the natural compound. PtdIns-(5)-P1 can be phosphorylated to di- (PtdIns-P2; PIP2) and triphosphates (PtdIns-P3; PIP3) by phosphoinositol (PI)-specific kinases. Hydrolysis of PtdIns-(4,5)-P2 by PI-specific phospholipase C generates inositol triphosphate (IP3) and DAG which are key second messengers in an intricate biochemical signal transduction cascade.
Katalog # CAS Nummer Summenformel Menge
sc-224243 n.n. C₂₁H₃₈O₁₆P₂•2Na 100 µg/500 µg
PtdIns-(5)-P1 (1,2-dioctanoyl) (ammonium salt)
The phosphatidylinositol (PtdIns) phosphates represent a small percentage of total membrane phospholipids, but they play a critical role in the generation and transmission of cellular signals. PtdIns-(5)-P1 (1,2-dioctanoyl) is a synthetic analog of natural PtdIns featuring saturated C8:0 fatty acids at sn-1 and sn-2 positions. The compound features the same inositol and diacylglycerol (DAG) stereochemistry as that of the natural compound. PtdIns-(5)-P1 can be phosphorylated to di- (PtdIns-P2; PIP2) and triphosphates (PtdIns-P3; PIP3) by phosphoinositol (PI)-specific kinases. Hydrolysis of PtdIns-(4,5)-P2 by PI-specific phospholipase C generates inositol triphosphate (IP3) and DAG which are key second messengers in an intricate biochemical signal transduction cascade.
Katalog # CAS Nummer Summenformel Menge
sc-222221 n.n. C₂₅H₄₆O₁₆P₂•2NH₄ 100 µg/500 µg
PtdIns-(5)-P1 (1,2-dipalmitoyl) (ammonium salt)
The phosphatidylinositol phosphates represent a small percentage of total membrane phospholipids but they play a crucial role in the generation and transmission of cellular signals. PtdIns-(5)-P1 can be further phosphorylated to give diphosphates such as PtdIns-(4,5)-P2. These can also be cleaved by PI-specific phospholipase C (PLC) to give inositol triphosphates (IP3). The diacyl glycerol and IP3 generated by this PLC-cleavage are part of a complex biochemical and signal transduction cascade which has not been entirely elucidated.
Katalog # CAS Nummer Summenformel Menge
sc-222222 n.n. C₄₁H₇₈O₁₆P₂•2NH₄ 100 µg/500 µg
Trimethylsilyl-meso-inositol
Katalog # CAS Nummer Summenformel Menge
sc-216014 2582-79-8 C₂₄H₆₀O₆Si₆ 500 mg
(+)-Xestospongin A
A marine natural product first isolated from pacific basin sponges, and noted to have vasodilatory properties. Inositol phosphates (IPs) are important signal transduction messengers acting via IP3 receptors to promote the mobilization of Ca²⁺ from intracellular storage. It antagonizes the calcium-releasing action of inositol-1,4,5-triphosphate at the receptor level in cerebral microsomes, with an IC₅₀ of 2.5 µM. It is roughly ten times less potent than Xestospongin C as an IP3 receptor antagonist.
Katalog # CAS Nummer Summenformel Menge
sc-205542 88840-02-2 C₂₈H₅₀N₂O₂ 100 µg/250 µg