Immunophilin Ligands

Ascomycin
An immunosuppressant macrolide antibiotic, analog of FK506. Described to block immune response by suppressing expression of interleukins. The bound Ascomycin-FKBP12 complex inhibits the function of calcineurin.
Katalog # CAS Nummer Summenformel Menge
sc-200096 11011-38-4 C₄₃H₆₉NO₁₂ 1 mg
Cycloheximide-N-ethylethanoate
An inhibitor of FKBP12 (IC₅₀=4.4µM) with neuroregenerative properties. This compound does not inhibit protein synthesis.
Katalog # CAS Nummer Summenformel Menge
sc-221447 n.n. C₁₉H₂₉NO₆ 10 mg/50 mg
Cyclosporin B
An immunosuppressant that has revolutionized organ transplantation through its use in the prevention of graft rejection. A group of nonpolar cyclic oligopeptides with immunosupppressant activity.
Katalog # CAS Nummer Summenformel Menge
sc-204701 63775-95-1 C₆₁H₁₀₉N₁₁O₁₂ 5 mg
FK-506 monohydrate
A potent immunosuppressant, neuroprotective and neuroregenerative, as well as an in vitro T cell proliferation blocker. This compound disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
Katalog # CAS Nummer Summenformel Menge
sc-215037 109581-93-3 C₄₄H₆₉NO₁₂•H₂O 5 mg
Rapamycin
A macrolide immunosuppressant that inhibits FK506 binding protein (FKBP) proline rotamase, FRAP autophosphorylation, lymphokine induced cell proliferation and angionesis.
Katalog # CAS Nummer Summenformel Menge
sc-3504 53123-88-9 C₅₁H₇₉NO₁₃ 1 mg/5 mg