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Hh/Gli Antagonist, GANT58
A cell-permeable tetrapyridinylthiophene compound that acts as downstream Hedgehog (Hh) pathway blocker and targets Gli-mediated gene transactivation (IC₅₀ ~ 5 µM in SAG-stimulated Shh-L2 cells). Shown to reduce cellular mRNA levels of Hh target genes, Gli1, Hip1,& Ptch, and inhibit Gli-dependent tumor growth both in vitro and in vivo. Its action appears to be Hh pathway-selective, downstream of Smo and Sufu, but does not seem to interfere with Gli DNA binding.
Katalog # CAS Nummer Summenformel Menge
sc-221723 n.n. C₂₄H₁₆N₄S 5 mg
Cyclopamine-KAAD
A potent, cell-permeable analog of Cyclopamine that specifically inhibits the Hedgehog (Hh) signaling with similar or lower toxicity. Binds to SmoA1 and promotes its exit from the endoplasmic reticulum. Suppresses both the ShhNp-induced pathway activity and SmoA1-induced reporter activity.
Katalog # CAS Nummer Summenformel Menge
sc-221448 306387-90-6 C₄₄H₆₃N₃O₄ 100 µg
Despiro Cyclopamine
An analogue of Cyclopamine, a sonic hedgehog inhibitor.
Katalog # CAS Nummer Summenformel Menge
sc-218162 n.n. C₂₇H₄₁NO₂ 1 mg
Veratramine, HCl, V. californicum
This compound is a cell-permeable steroidal alkaloid that is structurally related to and is reported to serve as a suitable inactive control for Cyclopamine, Cyclopamine-KAAD (sc-221448), and Jervine in Shh (sonic hedgehog) signaling studies.
Katalog # CAS Nummer Summenformel Menge
sc-356191 1258005-82-1 C₂₇H₃₉NO₂•HCl 5 mg