Hedgehog [Hh] Signaling Pathway

• AY 9944
  Blocks cholesterol biosynthesis and esterification. Specifically blocks 7-dehydrocholesterol reductase activity.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-202965	366-93-8	C22H28Cl2N2•2HCl	5 mg

• CUR 61414
  A proline derivative used as a mediator of hedgehog signaling pathways for pharmaceutical and cosmetic uses.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-211143	334998-36-6	C31H42N4O5	1 mg

• Cyclopamine
  A teratogen natural product, inhibits smoothened protein of the hedgehog (Hh) signaling pathway, leading to improper fetus differentiation and cyclopia. Can also suppress smoothened hyperactivity and related oncogenesis.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-200929	4449-51-8	C27H41NO2	1 mg/5 mg

• GANT 58
  A GLI antagonist and an inhibitor of GLI induced transcription.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-358832	64048-12-0	C24H16N4S•xH2O	10 mg/50 mg

• GANT61
  Reported to be an inhibitor of GLI-mediated transcription and therefore a suppressor of the Hedgehog signaling pathway.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-202630	500579-04-4	C27H35N5	1 mg

• Hh Signaling Antagonist VII, JK184
  An imidazopyridine compound that blocks the Hedgehog (Hh) pathway. Described to destabilize microtubules, affecting regulation of Gil transcription factors. Inhibits Adh7 activity which may be ancillary to Hh blocking action.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-202649	315703-52-7	C19H18N4OS	5 mg

• HPI-4

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-358720	302803-72-1	C17H9Cl2N3O2	5 mg/25 mg

• Jervine
  Jervine is a naturally occuring steroidal alkaloid that causes cyclopia by blocking sonic hedgehog signaling.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-200934	469-59-0	C27H39NO3	1 mg/5 mg

• N-[4-Chloro-3-(trifluoromethyl)phenyl]-N'-[[3-(4-fluorophenyl)-3,4-dihydro-4-oxo-2-quinazolinyl]methyl]urea
  A potent modulator of Hedgehog (Hh) protein function and a nanomolar Hh antagonist.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-212054	330796-24-2	C23H15ClF4N4O2	1 mg

• Octyl Maleimide
  A sonic hedgehog inhibitor. Also a possible inhibitor of prostaglandin endoperodixide synthases.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-208128	4080-76-6	C12H19NO2	500 mg

• Oxy-16
  A cell permeable oxysterol that may be used for cholesterol transport across cell membranes. Also shown to be a Hedgehog signaling pathway activator.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-358805	596-94-1	C27H46O3	1 mg/5 mg

• Purmorphamine
  Shown to activate the Hedgehog signaling pathway and also noted to dispaly osteogenesis-inducin activity in multipotent mesenchymal progenitor cells.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-202785	483367-10-8	C31H32N6O2	1 mg/5 mg

• SAG
  A potent agonist of Hedgehog (Hh) signalling by activating the Smoothened (Smo) protein function.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-212905	912545-86-9	C28H28ClN3OS	1 mg/5 mg

• SANT-1
  A membrane permeable antagonist of the Sonic Hedgehog signaling pathway by direct binding to Smoothened.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-203253	304909-07-7	C23H27N5	5 mg

• SANT-2
  Cell permeable antagonist of the Smoothened (Smo) protein function. Inhibitor of SAG activity. Chemical tool to study the Hedgehog (Hh) signalling pathway.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-202801	329196-48-7	C26H26ClN3O4	1 mg

• Smoothened Agonist, HCl
  Highly potent activator of Smo and a Hedgehog pathway agonist.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-202814	364590-63-6	C28H28ClN3OS ·2HCl ·2H2O	1 mg/5 mg

• U 18666A
  Alters intracellular membrane protein trafficking by impairing intracellular biosynthesis and transport of LDL-derived cholesterol.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-203306	3039-71-2	C25H41NO2 ·HCl	10 mg