HDAC and Sirtuin Inhibitors

4-(dimethylamino)-N-[6-(hydroxyamino)-6-oxohexyl]-benzamide
A selective and cost-effective histone deacetylase (HDAC1) inhibitor.
Katalog # CAS Nummer Summenformel Menge
sc-223859 n.n. C₁₅H₂₃N₃O₃ 1 mg/5 mg
APHA Compound 8
An HDAC (histone deacetylase) inhibitor.
Katalog # CAS Nummer Summenformel Menge
sc-210828 676599-90-9 C₁₆H₁₆N₂O₃ 1 mg
ATRA-BA Hybrid
The differentiation-inducer all-trans-Retinoic Acid and the histone deacetylase inhibitor (HDI) Butyric Acid are incorporated chemically via a benzyl ester linkage into a single more permeant mutual prodrug (MP) to help their cellular uptake and to better synergize their cancer killing efficiency.
Katalog # CAS Nummer Summenformel Menge
sc-221275 n.n. C₃₁H₄₀O₄ 25 mg
B2
Cell permeable inhibitor of sirtuin 2 (SIRT2). Promotes inclusion formation in cellular models of both Huntington’s disease and Parkinson’s disease.
Katalog # CAS Nummer Summenformel Menge
sc-202486 115687-05-3 C₂₀H₁₇CIN₄O₃ 1 mg/5 mg
BIX01294 hydrochloride hydrate
The methylation of lysine residues on histones plays a central role in determining euchromatin structure and gene expression. The histone methyltransferase (HMTase) G9a can mono- or dimethylate lysine 9 on histone 3 (H3), contributing to early embryogenesis, genomic imprinting, and lymphocyte development. BIX01294 (hydrochloride hydrate) is a selective inhibitor of G9a HMTase (IC50 = 1.7 μM). It less effectively inhibits the HMTase G9a-like protein (GLP; IC50 = 38 μM) and has no effect on other known HMTases. BIX01294 has been used in combination with the calcium channel activator BayK8644 to facilitate the generation of induced pluripotent stem cells from somatic cells in vitro.
Katalog # CAS Nummer Summenformel Menge
sc-293525 935693-62-2 C₂₈H₃₈N₆O₂ ·3HCl ·xH₂O 1 mg/5 mg
BML-210
Shown to inhibit HDAC activity in HeLa nuclear extracts, and to exert growth inhibitory, differentiation stimulating and proapoptotic effects in several human leukemia cell lines.
Katalog # CAS Nummer Summenformel Menge
sc-221369 537034-17-6 C₂₀H₂₅N₃O₂ 1 mg/5 mg
BML-266
A structurally novel SIRT2 inhibitor (IC₅₀=56.7µM).
Katalog # CAS Nummer Summenformel Menge
sc-221371 96969-83-4 C₃₀H₂₆N₂O₄ 10 mg/50 mg
CAY10603
A potent and selective HDAC6 inhibitor that has been shown to be more active at inhibiting cell growth than other broad spectrum HDAC inhibitors like SAHA (sc-220139).
Katalog # CAS Nummer Summenformel Menge
sc-223877 1045792-66-2 C₂₂H₃₀N₄O₆ 500 µg/1 mg
CBHA
CBHA is a potent HDAC inhibitor and induces apoptosis in nine different neuroblastoma cell lines in culture. CBHA also completely suppresses neuroblastoma tumor growth in SCID mice at 200 mg/kg. Addition of retinoic acid increases efficacy of CBHA for suppressing tumor growth in mice.
Katalog # CAS Nummer Summenformel Menge
sc-205240 174664-65-4 C₁₀H₁₀N₂O₄ 5 mg/25 mg
CI 994
HDAC inhibitor that mediates arrest of the G1 phase of the cell cycle. In in vitro and in vivo studies, will inhibit proliferation as well as induce apoptosis.
Katalog # CAS Nummer Summenformel Menge
sc-205245 112522-64-2 C₁₅H₁₅N₃O₂ 10 mg/50 mg
Depudecin
Depudecin is a fungal metabolite that potently inhibits HDAC activity, , in vivo and in vitro, and has the ability to revert the morphology of transformed NIH 3T3 fibroblasts.
Katalog # CAS Nummer Summenformel Menge
sc-200651 139508-73-9 C₁₁H₁₆O₄ 100 µg
EX 527
A selective inhibitor of SIRT1 deacetylation activity. Used as a tool for probing the functions and effects of SIRT1 deacetylation in cellular regulation.
Katalog # CAS Nummer Summenformel Menge
sc-203044 49843-98-3 C₁₃H₁₃ClN₂O 5 mg
HC Toxin
HC Toxin is a potent, cell-permeable histone deacetylase inhibitor with displayable antiprotozoal, antineoplastic and antitumor activity.
Katalog # CAS Nummer Summenformel Menge
sc-200884 83209-65-8 C₂₁H₃₂N₄O₆ 1 mg
Histone (calf thymus)
Natural mixture of the histones H1, H2A, H2B, H3 and H4.
Katalog # CAS Nummer Summenformel Menge
sc-221727 37244-51-2 n.n. 10 mg
Histone Deacetylase (rat)
Liquid. In 1.4mM NaH2PO4, containing 18.6mM Na2HPO4, pH 7.9, 0.25mM EDTA, ~700mM sodium chloride, 10% (v/v) glycerol and 10mM 2-mercaptoethanol.
Katalog # CAS Nummer Summenformel Menge
sc-221728 n.n. n.n. 2 ml
Histone H1 (calf thymus)
A mixture of Histone H1 subtypes, which are components of chromatin in eukaryotic cells. It functions as a stabilizing agent between nucleosomes.
Katalog # CAS Nummer Summenformel Menge
sc-221729 n.n. n.n. 1 mg
HNHA
A cell-permeable inhibitor of histone deacetylase (HDAC) activity; induces histone hyperacetylation and p21 transcription with concomitant inhibition of cell cycle progression in human fibrosarcoma HT1080 cells.
Katalog # CAS Nummer Summenformel Menge
sc-205343 926908-04-5 C₁₇H₂₁NO₂S 5 mg/10 mg
ITSA1
ITSA1 (N-(1H-Benzotriazol-1-yl)-2,4-dichlorobenzamide) is a specific and potent TSA suppressor.
Katalog # CAS Nummer Summenformel Menge
sc-200894 200626-61-5 C₁₃H₇Cl₂N₃O 25 mg/100 mg
M 344
Potent inhibitor of histone deacetylase (HDAC) (IC₅₀≤1µM).
Katalog # CAS Nummer Summenformel Menge
sc-203124 251456-60-7 C₁₆H₂₅N₃O₃ 1 mg/5 mg
MS-275
A histone deacetylase (HDAC) inhibitor shown to preferentially block HDAC1 over HDAC3, with negligible effects on HDAC8. This compound has also been shown to induce cyclin-dependent kinase inhibitor 1A
Katalog # CAS Nummer Summenformel Menge
sc-279455 209783-80-2 C₂₁H₂₀N₄O₃ 1 mg/5 mg
N-(2-Aminophenyl)-N'-phenylheptanediamide
Histone deacetylase inhibitor IV. A cell-permeable pimeloylanilide compound that acts as a FXN (frataxin gene) specific HDAC inhibitor. Reverses the silencing of FXN transcription in FRDA (Friedreich’s ataxia) cells due to hypoacetylation of histone.
Katalog # CAS Nummer Summenformel Menge
sc-207902 537034-15-4 C₁₉H₂₃N₃O₂ 10 mg
NSC 3852
Histone deacetylase inhibitor. In MCF-7 human breast cancer cells, causes cell differentiation in vitro. In vivo, displays antitumor activity.
Katalog # CAS Nummer Summenformel Menge
sc-205773 3565-26-2 C₉H₆N₂O₂ 10 mg/50 mg
4-(1,3-Dioxo-1H,3H-benzo[de]isoquinolin-2-yl)-N-hydroxybutanamide
Katalog # CAS Nummer Summenformel Menge
sc-222083 n.n. C₁₆H₁₄N₂O₄ 1 mg/5 mg
Nullscript
Katalog # CAS Nummer Summenformel Menge
sc-222084 300816-11-9 C₁₆H₁₄N₂O₄ 1 mg/5 mg
Oxamflatin
Potent inhibitor of mammalian HDAC. Acts as a ligand for the enzyme active site metal ion. Elevates the expression of extracellular matrix proteins fibronectin and gelsolin. Induces apoptosis in P-glyoprotein (Pgp) positive and Pgp negative multidrug resistant cells. Upregulates plasminogen activator inhibitor type 2 (PAI-2) expression with concomitant inhibition of urokinase (u-PA) gene and protein expression in HT-1080 and U-937 cells.
Katalog # CAS Nummer Summenformel Menge
sc-205960 151720-43-3 C₁₇H₁₄N₂O₄S 1 mg/5 mg
Panobinostat
A histone deactylase inhibitor (HDAC) of research interest for in vitro studies of multiple myeloma.
Katalog # CAS Nummer Summenformel Menge
sc-208148 404950-80-7 C₂₁H₂₃N₃O₂ 2.5 mg
PTACH
A HDAC inhibitor that is more potent than the majority of HDAC inhibitors except for SAHA (gold standard).
Katalog # CAS Nummer Summenformel Menge
sc-253326 848354-66-5 C₂₀H₂₆N₂O₂S₂ 2 mg
S-Adenosylhomocysteine-d4
S-Adenosylhomocysteine-d4 (SAH-d4) contains four deuterium atoms at the 3, 3’, 4, and 4’ positions. It is intended for use as an internal standard for the quantification of SAH by GC- or LC-mass spectrometry (MS). S-Adenosyl-L-homocysteine (SAH) is an amino acid derivative and an intermediate, by-product, or modulator of several metabolic pathways, including the activated methyl cycle and cysteine biosynthesis. It is also a product of S-adenosyl-methionine (SAM)-dependent methylation of biological molecules, including DNA, RNA, and histones and other proteins. SAH is a risk factor for many diseases, including cancer and neurodegenerative diseases. In addition, inhibitors that block its hydrolysis are being developed as anti-viral, anti-parasitic, anti-arthritic and immunosuppressive agents.
Katalog # CAS Nummer Summenformel Menge
sc-296290 n.n. C₁₄H₁₆D₄N₆O₅S 500 µg/1 mg
(S)-HDAC-42
The dysregulation of histone acetylation contributes to the pathogenesis of some cancers. Histone deacetylases (HDACs), which participate in regulating the acetylation status of nucleosomal histones, are increasingly recognized as promising targets for cancer therapy. (S)-HDAC-42 is a potent inhibitor of HDACs (IC50 = 16 nM in vitro). It decreases the viability of prostate cancer cell lines (IC50 = 0.0 μM), increasing the expression of p21 and the acetylation of histone H3 while decreasing the phosphorylation of Akt and the expression of Bcl-XL. (S)-HDAC-42 also strongly suppresses the growth of PC-3 tumor xenografts, reducing levels of phospho-Akt and Bcl-XL protein in tumors.
Katalog # CAS Nummer Summenformel Menge
sc-296364 935881-37-1 C₁₈H₂₀N₂O₃ 1 mg/5 mg
Salermide
A reverse amide with strong inhibitory effects on Sirtuin 1 and Sirtuin 2. Found to cause acetylation of p53 and cause massive induction of cell apoptosis.
Katalog # CAS Nummer Summenformel Menge
sc-224276 1105698-15-4 C₂₆H₂₂N₂O₂ 5 mg/10 mg
Scriptaid
A histone deacetylase inhibitor (HDAC). Reported to inhibit all three class I HDACs, elevate the expression of the estrogen receptor α, reactivate the latent HIV-1 promoter, and illicit glioma cell apoptosis.
Katalog # CAS Nummer Summenformel Menge
sc-202807 287383-59-9 C₁₈H₁₈N₂O₄ 1 mg/5 mg
SIRT1 Inhibitor IV, (S)-35
SIRT 1 inhibitor IV, (S)-35 is a sirtuin protein that has high potency (IC₅₀= 38 nM). It is an entomerically pure compound that can permeate the cell and is metabolically stable.
Katalog # CAS Nummer Summenformel Menge
sc-204279 848193-72-6 C₁₄H₁₅ClN₂O 500 µg
SIRT1/2 Inhibitor IV, Cambinol
A cell-permeable β-naphthol compound that inhibits the NAD-dependent deacetylase activity of hSIRT1 and hSIRT2 (IC₅₀ = 56 µM and 59 µM, respectively) in a substrate-, but not NAD-, competitive manner.
Katalog # CAS Nummer Summenformel Menge
sc-204280 14513-15-6 C₂₁H₁₆N₂O₂S 5 mg
SIRT2 Inhibitor, AGK2
A reversible inhibitor of SIRT2. Shown to protect against α-synuclein-induced toxcity and dopaminergic cell death in Parkinson’s disease models.
Katalog # CAS Nummer Summenformel Menge
sc-202813 304896-28-4 C₂₃H₁₃Cl₂N₃O₂ 5 mg
SIRT2 Inhibitor, Inactive Control, AGK7
Cell-permeable structural isomer of SIRT2 Inhibitor, AGK2 (sc-202813) that selectively inhibits sirtuin 3 over sirtuins 1 and 2 (IC₅₀ = >5 µM, >50 µM and >50 µM for SIRT3, SIRT1 and SIRT2, respectively). Poorly affects both α-synuclein-mediated toxicity and α-Syn aggregation in α-Syn-H4 cells.
Katalog # CAS Nummer Summenformel Menge
sc-204281 304896-21-7 C₂₃H₁₃Cl₂N₃O₂ 5 mg
Sirtinol
A cell permeable specific inhibitor of sirtuin NAD-dependant deacetylases. The compound also displays senescence in cancer cells and acts as a hormone in plants.
Katalog # CAS Nummer Summenformel Menge
sc-205976 410536-97-9 C₂₆H₂₂N₂O₂ 1 mg/5 mg
Sodium Phenylbutyrate
A low molecular weight fatty acid shown to cause cellular differentiation, growth arrest, and apoptosis. Also reported to act as a chemical chaperone.
Katalog # CAS Nummer Summenformel Menge
sc-200652 1716-12-7 C₁₀H₁₁O₂··Na 1 g
Splitomicin
A cell-permeable lactone that acts as a selective inhibitor of NAD+ dependent histone deacetylase activity of Sir2 protein. It creates a conditional phenocopy of a sir2 deletion mutant in S. cerevisiae and sensitizes mammalian cells to a variety of DNA-damaging agents by abrogating Sir2p activity on p53. Acts by either altering or blocking access to the acetylated histone binding pocket.
Katalog # CAS Nummer Summenformel Menge
sc-358701 5690-03-9 C₁₃H₁₀O₂ 5 mg
Suberoyl bis-hydroxamic Acid
A histone deacetylase inhibitor that has been shown to induce apoptosis in proliferating cells via induction of P21, P53, PUMA, and Bax gene expression.
Katalog # CAS Nummer Summenformel Menge
sc-200887 38937-66-5 C₈H₁₆N₂O₄ 100 mg/500 mg
Suberoylanilide Hydroxamic Acid
A potent HDAC inhibitor that results in cell cycle arrest, downregulation of survivin and Bcl-xL, and apoptosis.
Katalog # CAS Nummer Summenformel Menge
sc-220139 149647-78-9 C₁₄H₂₀N₂O₃ 100 mg
Suberoylanilide-d5 Hydroxamic Acid
A potent, selective, cell permeable histone deacetylase inhibitor (HDAC). Displays anti-angiogenic activity by interfering with VEGF signaling in human umbilical vein endothelial cells (HUVECs). Induces differentiation in uman breast cancer cells.
Katalog # CAS Nummer Summenformel Menge
sc-220140 n.n. C₁₄H₁₅D₅N₂O₃ 1 mg
Suramin Sodium
Uncouples G proteins from receptors presumably by blocking their interaction with intracellular receptor domains. Inhibits cell surface binding of various growth factors including PDGF, EGF and TGF-β.
Katalog # CAS Nummer Summenformel Menge
sc-200833 129-46-4 C₅₁H₃₄N₆O₂₃S₆ ·Na₆ 50 mg/250 mg
Tenovin-1
A compound that belongs to the class of Tenovins, and inhibit the protein activities of SirT1 and SirT2. Shown to activate and elevate acetylated p53 levels, induce apoptosis in vitro, and acetylate histone H4.
Katalog # CAS Nummer Summenformel Menge
sc-222342 380315-80-0 C₂₀H₂₃N₃O₂S 10 mg
Tenovin-6
A water soluble analog of Tenovin-1, that acts as a potent SirT1 and SirT2 inhibitor, and p53 activator. Shown to increase p53 levels more than Tenovin-1.
Katalog # CAS Nummer Summenformel Menge
sc-224296 1011557-82-6 C₂₅H₃₄N₄O₂S 1 mg/5 mg
Trapoxin A
A cyclotetrapeptide and a histone deacetylase (HDAC) inhibitor. Trapoxin increases the level of chromatin acetylation associated with histone H3 at low nanomolar concentrations.1 Unlike the reversible HDAC inhibition induced by TCA, Trapoxin irreversibly inhibits HDAC activity in crude cell lysates and induces the accumulation of hyperacetylated core histones in a number of mammalian cell lines and tissues.2, Histone acetylation and methylation have been studied extensively for their anti-tumor activities in carcinogenesis and Trapoxin has been suggested as a potential anticancer agent for pre-clinical trials.3
Katalog # CAS Nummer Summenformel Menge
sc-253730 133155-89-2 C₃₄H₄₂N₄O₆ 1 mg
Trichostatin A
Inhibits histone deacetylation; blocks cell cycle at G₁; induces reversion of Ras transformed cells to normal morphology; inhibits IL-2 expression in Jurkat cells.
Katalog # CAS Nummer Summenformel Menge
sc-3511 58880-19-6 C₁₇H₂₂N₂O₃ 1 mg/5 mg
Valproic Acid, Sodium Salt
A branched chain, fatty acid with multiple reported effects; enhances GABAergic neurotransmission, potent inhibitor of histone deacetylases (HDACs) which leads to hyperacetylation of histones in cultured cells.
Katalog # CAS Nummer Summenformel Menge
sc-202378 1069-66-5 C₈H₁₅NaO₂ 5 g