Guanylate Cyclase Activators and Inhibitors

• A 350619 hydrochloride
  Activator of soluble guanylyl cyclase (sGC). Activates basal sGC and synergistically activates sGC in the presence of NO. Relaxes cavernosum smooth muscle in vitro and induces penile erections in rats in vivo.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-203787	538368-27-3	C21H25ClN2OS•HCl	10 mg/50 mg

• BAY 41-2272
  BAY 41-2272 is a pyrazolopyridinylpyrimidine compound with selective and potent stimulator effects on soluble guanylate cyclase (sGC).

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-202491	256376-24-6	C20F1H17N6	5 mg

• BPIPP
  Non-competitive adenylyl cyclase (AC) and guanylyl cyclase (GC) inhibitor. Downregulates cAMP and cGMP synthesis, and suppresses cGMP accumulation in a variety of cell lines (IC₅₀ = 3.4 - 11.2 μM). Inhibits GC-stimulated Cl- transport in vitro and suppresses toxin-induced intestinal fluid accumulation in vivo.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-203852	325746-94-9	C22H16BrN3O3•xH2O	10 mg/50 mg

• Guanylin (human)
  Endogenous intestinal guanylyl cyclase activator.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-203066	183200-12-6	C58H87N15O21S4	100 µg

• Guanylin (rat, mouse)
  Endogenous intestinal guanylyl cyclase activator.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-203067	144940-98-7	C60H90N16O22S4	100 µg/1 mg

• LY 83583
  Inhibits soluble guanylate cyclase and has been shown to lower levels of cGMP and cAMP, inhibit leukotriene and endothelium-derived relaxing factor release, and acts as a competitive inhibitor to NADPH.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-200314	91300-60-6	C15H10N2O2	5 mg/25 mg

• ODQ
  A selective and potent soluble guanylyl cyclase (sGC) inhibitor that increases apoptosis through fragmentation of DNA

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-200325	41443-28-1	C9H5N3O2	10 mg/50 mg

• Protoporphyrin-9
  The precursor porphyrin to metal-binding domains. Generates heme with complexation to iron, leads to chlorophyll pigment with complexation to magnesium. Activates guanylate cyclase.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-200327	553-12-8	C34H34N4O4	200 mg/1 g

• Zinc Protoporphyrin-9
  A potent, selective inhibitor of heme oxygenase and nitric oxide synthase. Blocks CO biosynthesis and thereby lowers cGMP concentrations. An extremely useful tool to elucidate the role of CO in signal transduction and as a neurotransmitter.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-200329	15442-64-5	C34H32N4O4Zn	20 mg/100 mg