Gene Regulation Reagents

• 10074-G5
  Specifically inhibits c-Myc oncoprotein and Mac coupled folding and binding; slightly more potent than 10058-F4.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-213578	413611-93-5	C18H12N4O3	5 mg/25 mg

• 5-Aza-2′-Deoxycytidine
  Shown to inhibit methylation of newly synthesized DNA which is important in determining apoptotic susceptibility to histone deacetylase inhibitors.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-202424	2353-33-5	C8H12N4O4	25 mg

• 7-Aminoactinomycin D
  7-Aminoactinomycin D (7-AAD) is a fluorescent DNA dye which is useful for quantifying apoptosis. 7-AAD has also been used in studies on cellular necrosis, chromosome analysis and in cell cycle studies.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-221210	7240-37-1	C62H87N13O16	1 mg

• 9-cis-Retinoic acid
  A vitamin A analog that inhibits cell proliferation and induces cell differentiation.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205589	5300-03-8	C20H28O2	1 mg/5 mg

• α-Amanitin
  Major toxic bicyclic octapeptide of the Amanita phalloides mushroom. Shown to act as a specific and potent inhibitor of eukaryotic RNA pol II and a mild inhibitor of RNA pol III.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-202440	23109-05-9	C39H54N10O14S	1 mg

• Actinomycin D
  A metabolite isolated from Streptomyces parvulus that binds to the GpC steps of DNA. The compound acts as an antibiotic and is more effective against gram-positive than gram negative bacteria.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-200906	50-76-0	C62H86N12O16	5 mg

• AG-041R
  A potent gastrin/CCKB receptor antagonist that exhibits selective binding for CCKB compared to CCKA.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205202	199800-49-2	C31H36N4O5	1 mg/5 mg

• AMI-1 sodium salt hydrate
  Experimentally shown to inhibit arginine, in vitro, with no inhibitory effect on lysine. No effect has been shown against S-adenosyl methionine (AdoMet), contrary to most methyltransferase inhibitors that show active competition for the AdoMet binding site. Studies have demonstrated AMI-1 to prevent cellular arginine methylation, modulate nuclear receptor-regulated transcription from estrogen and androgen response elements, and is a HIV-1 reverse transcriptase inhibitor.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-300192	n.n.	C21H18NaN2O10S2	5 mg

• β-Amanitin
  A toxic constituent of Amanita phalloides that inhibits eukaryotic RNA polymerase II and III and bacterial RNA polymerase thus inhibtting protein synthesis.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-202860	21150-22-1	C39H53N9O15S	1 mg

• BePl
  Has been shown to electively intercalate into triple-helical DNA.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-319856	n.n.	C20H22N4O	1 mg

• CB 1954
  A prodrug used in gene therapy research and activated by NAD(P)H quinone oxidoreductase 2.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-214672	21919-05-1	C9H8N4O5	50 mg

• Chromomycin A3
  Shown to be a G-C specific DNA ligand which inhibits transcription. Reported to be a DNA stain as well as an antibiotic that prevents neuronal apoptosis induced by oxidative stress or DNA damage.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-200907	7059-24-7	C57H82O26	10 mg

• Delavirdine mesylate
  A nonnucleoside reverse transcriptase inhibitor that displays pH-dependent solubility characteristics. Also shown to not efficiently cross the blood-brain barrier.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-200919	147221-93-0	C22H28N6O3S ·CH4O3S	50 mg/250 mg

• DIF-1
  This compound supresses cell growth and promotes retinoic acid-induced cell differentiation in HL-60 cells.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-221541	n.n.	C13H16Cl2O4	100 µg/500 µg

• Dihydromyristicin
  Hydrogenated product of myristicin, a natural constituent of parsley. Inducer of glutathione S-transferases.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-202580	52811-28-6	C11H14O3	100 mg

• Hoechst-33342·3HCl (Bisbenzimide)
  An AT-specific DNA minor groove ligand that is a widely used fluorochrome for visualizing cellular DNA.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-200908	23491-52-3	C27H28N6O ·3HCl	100 mg

• Hypoxia Inducible Factor-1α Inhibitor
  A heterodimeric transcription factor composed of a HIF-1α subunit and HIF-1β subunit. Significantly suppresses transcription of the HIF-1 target genes VEGF and erythropoietin.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205346	934593-90-5	C26H29NO5	1 mg/5 mg

• Imipenem Monohydrate
  A third generation cephalosporin antibiotic. Studies show that loss of the OprD porin protein leads to Imipenen resistance in Pseudomonas aeruginosa.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205350	64221-86-9	C12H17N3O4S•H2O	25 mg/5 mg

• LED209
  A potent conserved membrane histidine sensor kinase (QseC) inhibitor that blocks both norepinephrine- and epinephrine-triggered QseC-dependent virulence gene expression.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205368	245342-14-7	C19H17N3O2S2	1 mg/5 mg

• Leptomycin B
  A potent and specific nuclear export inhibitor. Leptomycin B alkylates and inhibits CRM1/exportin, a protein required for nuclear export of proteins containing a nuclear export sequence (NES). In addition to antifungal and antibacterial activities, Leptomycin B blocks the cell cycle and is a potent anti-tumor agent. At low nM concentrations, Leptomycin B blocks the nuclear export of many proteins including HIV-1 Rev, MAPK/ERK, and NF-κB/IκB, and it stabilizes the expression of p53. Leptomycin B also inhibits the export and translation of many RNAs, including COX-2 and c-Fos mRNAs, by inhibiting export of ribonucleoproteins.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-358688	87081-35-4	C33H48O6	50 μg/500 μg

• Leptomycin B, Free Acid
  Shown to be a potent and specific nuclear export inhibitor. Also an antibacterial agent reported to block the cell cycle of rat fibroblasts at G1 and G2 phases.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-202210	87081-35-4	C33H48O6	100 µg/500 µg

• Lycorine·HCl
  Shown to be an inhibitor of viral protein synthesis and peptidyl transferase center. Additionally found to block α 1-adrenoceptors.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-200917	2188-68-3	C16H17NO4··HCl	10 mg/50 mg

• Mithramycin A
  Mithramycin A is a DNA binding transcriptional inhibitor, antibiotic, and is observed to facilitate TNF-α and Fas-ligand induced apoptosis.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-200909	18378-89-7	C52H76O24	1 mg

• Mitomycin C
  DNA crosslinking and damaging agent that inhibits DNA synthesis and induces apoptosis in a variety of cells via a p53-dependent pathway.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-3514	50-07-7	C15H18N4O5	5 mg/2 mg/10 mg

• N-(β-ketocaproyl)-L-Homoserine lactone
  Found to be apart of the Quorum sensing regulatory system; employed by numerous bacterial species in cell-to-cell communication.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205396	143537-62-6	C10H15NO4	5 mg/25 mg

• N-3-oxo-tetradec-7Z-enoyl-L-Homoserine lactone
  A bacterial quorum sensing compound that possesses antimicrobial activity, the ability to inhibit biofilm formation, and exhibits immune suppressive activity.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205401	482598-46-9	C18H29NO4	1 mg/5 mg

• N-butyryl-L-Homoserine lactone
  A small diffusible signaling molecule involved in quorum sensing, controlling gene expression, and cellular metabolism.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205402	67605-85-0	C8H13NO3	5 mg/10 mg

• N-hexanoyl-L-Homoserine lactone
  A small diffusible signaling molecule involved in quorum sensing, controlling gene expression, and affecting cellular metabolism. This molecule regulates virulence in general and in cystic fibrosis, prevents infection, reduces slime and biofilm in commercial agriculture and aquaculture industries, prevents food spoilage, and septicemia in fish.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205405	147852-83-3	C10H17NO3	5 mg/10 mg

• O6-Benzylguanine
  Effective substrate and efficient inactivator of DNA alkyltransferase.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-202747	19916-73-5	C12H11N5O	10 mg/50 mg

• RG 108
  Non-nucleoside DNA methyltransferase inhibitor that blocks the enzyme active site. In vitro inhibits DNA methylation in human cancer cell lines without detectable toxicity. Demethylates and reactivates epigenetically silences tumor suppressor genes.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-204235	48208-26-0	C19H14N2O4	10 mg/50 mg

• Rifampicin
  An antibiotic that potently inhibits RNA polymerase and blocks RNA synthesis in Escherichia coli. Shown to activate the nuclear pregnane X receptor, which affects cytochrome P450, and the activity of glucuronosyltransferases and P-glycoprotein.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-200910	13292-46-1	C43H58N4O12	1 g

• Rifampin, gamma irradiated
  Shown to specifically inhibit DNA-dependent bacterial but not mammalian RNA Polymerase.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-296271	13292-46-1	C43H58N4O12	150 mg

• RNA Polymerase III Inhibitor
  A cell-permeable indazolo-sulfonamide compound that displays broad-spectrum inhibitory activity against RNA Polymerase III. Inhibits cell growth in yeast by preventing RNA Pol III-mediated tRNA transcription.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-222257	577784-91-9	C19H15Cl2N3O2S2	10 mg

• WP900 hydrochloride
  This product is a synthetic left-handed enantiomer of (+)-daunorubicin, anti-tumor antibiotic, binds to right-handed B-form DNA under low salt conditions.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-301979	23541-50-6	C27H29NO10.HCl	100 µg