GABAergics

2-Hydroxysaclofen
Selective GABA_B antagonist, more potent than saclofen
Katalog # CAS Nummer Summenformel Menge
sc-202011 117354-64-0 C₉H₁₂CINO₄S 10 mg/50 mg
3-Methyl-GABA
Activator of GABA aminotransferase. Anticonvulsant.
Katalog # CAS Nummer Summenformel Menge
sc-203471 71424-95-8 C₅H₁₁NO₂ 10 mg/50 mg
3α,12α-Dihydroxy-5β-pregnan-20-one 3,12-diacetate
Katalog # CAS Nummer Summenformel Menge
sc-226347 15991-93-2 C₂₅H₃₈O₅ 50 mg
5α-Pregnan-3β-ol-20-one 3β-acetate
Katalog # CAS Nummer Summenformel Menge
sc-233497 906-83-2 C₂₃H₃₆O₃ 5 g
6,2'-Dihydroxyflavone
This is a partial inverse agonist at GABAA receptors with a-subunit selectivity.
Katalog # CAS Nummer Summenformel Menge
sc-300048 n.n. C₁₅H₁₀O₄ 5 mg
16-Dehydropregnenolone acetate
Katalog # CAS Nummer Summenformel Menge
sc-224976 979-02-2 C₂₃H₃₂O₃ 10 g
16,17-Epoxy-21-acetoxypregnenolone
Katalog # CAS Nummer Summenformel Menge
sc-224977 28444-97-5 C₂₃H₃₂O₅ 1 g
16α,17α-Epoxypregnenolone
Katalog # CAS Nummer Summenformel Menge
sc-223173 974-23-2 C₂₁H₃₀O₃ 5 g/10 g
16α,17α-Epoxypregnenolone acetate
Katalog # CAS Nummer Summenformel Menge
sc-224978 34209-81-9 C₂₃H₃₂O₄ 5 g
17-PA
A steroid analog that selectively antagonizes potentiation of GABA responses by 5α-reduced potentiating neurosteroids.
Katalog # CAS Nummer Summenformel Menge
sc-361075 694438-95-4 C₂₅H₃₄O 10 mg/50 mg
17α-Hydroxypregnenolone
Katalog # CAS Nummer Summenformel Menge
sc-223186 387-79-1 C₂₁H₃₂O₃ 5 g
17α-Hydroxypregnenolone 3-acetate
Katalog # CAS Nummer Summenformel Menge
sc-224980 41906-06-3 C₂₃H₃₄O₄ 5 g
Alphaxalone
A neurosteroid anesthetic that directly activates and potentiates GABA_A receptor-activated membrane current (IGABA). Efficacy but not potency is determined by the alpha subunit of the receptor (EC₅₀ values are 1.4, 1.8, 2.1, 2.4 and 2.5 μM for α1β1γ3, α1β1γ1, β1γ1, α2β1γ2L and α1β1γ2L isoforms respectively).
Katalog # CAS Nummer Summenformel Menge
sc-203814 23930-19-0 C₂₁H₃₂O₃ 10 mg/50 mg
β-CCB
Benzodiazepine inverse agonist, putative endogenous ligand
Katalog # CAS Nummer Summenformel Menge
sc-204429 84454-35-3 C₁₆H₁₆N₂O₂ 10 mg/50 mg
(±)-Baclofen
A selective agonist of the GABA_B metabotropic receptor. Produces muscle relaxant and antispastic effects. Prototypic agonist at GABA_B.
Katalog # CAS Nummer Summenformel Menge
sc-200464 1134-47-0 C₁₀H₁₂ClNO₂ 1 g/5 g
(+)-Bicuculline
An antagonist of the GABA_A receptor. Blocks the neurotransmission inhibition action of the GABA system, producing an artificial epileptic state in laboratory studies.
Katalog # CAS Nummer Summenformel Menge
sc-202498 485-49-4 C₂₀H₁₇NO₆ 50 mg/250 mg
(-)-Bicuculline methiodide
An N-methylated water-soluble derivative of the GABA_A antagonist bicuculline. Demonstrates blockade of Ca²⁺-activated K⁺ channel-mediated afterhyperpolarization, unobserved with the parent compound.
Katalog # CAS Nummer Summenformel Menge
sc-200485 40709-69-1 C₂₁H₂₀INO₆ 50 mg
(-)-Bicuculline methobromide
An N-methylated water-soluble derivative of the GABA_A antagonist bicuculline. Demonstrates blockade of Ca²⁺-activated K⁺ channel-mediated afterhyperpolarization, unobserved with the parent compound.
Katalog # CAS Nummer Summenformel Menge
sc-200436 73604-30-5 C₂₁H₂₀BrNO₆ 50 mg
(-)-Bicuculline methochloride
Methochloride salt of (+)-bicuculline. Water-soluble GABA_A antagonist. More stable than bicuculline. Non-GABA receptor-mediated actions reported.
Katalog # CAS Nummer Summenformel Menge
sc-203528 53552-05-9 C₂₁H₂₀ClNO₆ 10 mg/50 mg
CGP 7930
Positive allosteric modulator of GABA_B receptors. Increases the potency and efficacy of GABA at both native and recombinant GABA_B receptors (EC₅₀ values are 5.37 and 4.60μM respectively) and enhances the inhibitory effect of the agonist L-baclofen in cultured cortical neurons. Reduces operant self-administration of ethanol in alcohol-preferring rats following i.p. administration.
Katalog # CAS Nummer Summenformel Menge
sc-203543 57717-80-3 C₁₉H₃₂O₂ 10 mg/50 mg
CGP 13501
Positive allosteric modulator at GABA_B receptors, potentiating the effects of GABA at this receptor type.
Katalog # CAS Nummer Summenformel Menge
sc-203542 56189-68-5 C₁₉H₃₀O₂ 10 mg/50 mg
CGS 20625
Anti-anxiety drug used in research, acts as a central benzodiazepine receptor partial agonist, but is classified as a nonbenzodiazepine drug. Does not have sedative effect.
Katalog # CAS Nummer Summenformel Menge
sc-203545 111205-55-1 C₁₈H₁₉N₃O₂ 10 mg/50 mg
CGP 35348
Katalog # CAS Nummer Summenformel Menge
sc-361138 123690-79-9 C₈H₂₀NO₄P 10 mg/50 mg
CGP 36216
Katalog # CAS Nummer Summenformel Menge
sc-362724 123691-29-2 C₅H₁₄NO₂P 10 mg/50 mg
CGP 46381
Katalog # CAS Nummer Summenformel Menge
sc-361140 123691-14-5 C₁₀H₂₂NO₂P 10 mg/50 mg
CGP 52432
Katalog # CAS Nummer Summenformel Menge
sc-361141 139667-74-6 C₁₅H₂₄Cl₂NO₄P 10 mg/50 mg
CGP 54626 Hydrochloride
Katalog # CAS Nummer Summenformel Menge
sc-361142 149184-21-4 C₁₈H₂₈Cl₂NO₃P.HCl 10 mg/50 mg
CGP 55845
Katalog # CAS Nummer Summenformel Menge
sc-361143 149184-22-5 C₁₈H₂₂Cl₂NO₃P•HCl 10 mg/50 mg
Chlormethiazole hydrochloride
Potentiates GABA_A receptor function. Sedative and anticonvulsant which is neuroprotective in a number of animal models. Prevents degeneration of serotonergic nerve terminals induced by MDMA ('Ecstasy').
Katalog # CAS Nummer Summenformel Menge
sc-203548 6001-74-7 C₆H₈ClNS ·HCl 10 mg/50 mg
Chlormezanone
Skeletal muscle relaxant, acting at the benzodiazapine site of GABA_A receptors
Katalog # CAS Nummer Summenformel Menge
sc-203887 80-77-3 C₁₁H₁₂ClNO₃S 1 g
CI 966 hydrochloride
Selective inhibitor of GAT-1 that is an anticonvulsive and neuroprotective.
Katalog # CAS Nummer Summenformel Menge
sc-203891 110283-66-4 C₂₃H₂₂ClF₆NO₃ 10 mg/50 mg
CL 218872
Benzodiazepine agonist displaying selectivity for α1 subunit-containing GABA_A receptors (Ki values are 130, 1820, 1530, > 10000, 490 and > 10000 nM for α1, α2, α3, α4, α5 and α6-subunit containing receptors respectively). Orally active anxiolytic and anticonvulsant in vivo.
Katalog # CAS Nummer Summenformel Menge
sc-203552 66548-69-4 C₁₃H₉F₃N₄ 10 mg/50 mg
Cloflubicyne
Potent non-competitive GABA antagonist; convulsant; laboratory insecticide.
Katalog # CAS Nummer Summenformel Menge
sc-300382 224790-70-9 C₁₁H₆Cl₂F₆N₂ 1 mg
D-Alanine
Weak inhibitory glycine receptor agonist.
Katalog # CAS Nummer Summenformel Menge
sc-203558 338-69-2 C₃H₇NO₂ 1 g
Dansyl-gamma-Amino-n-Butyric Acid Cyclohexylammonium Salt
Katalog # CAS Nummer Summenformel Menge
sc-294267 76563-43-4 C₁₆H₂₀N₂O₄S ·C₆H₁₃N 100 mg/250 mg
DHEA
Major secretory steroidal product of the adrenal gland. DHEA and its sulfated metabolite, DHEA-S, are negative modulators of GABA_A receptors.
Katalog # CAS Nummer Summenformel Menge
sc-202573 53-43-0 C₁₉H₂₈O₂ 10 g
Dihydroergotoxine mesylate
Binds with high affinity to GABA_A receptor Cl- channel. Interacts with central dopaminergic, serotonergic and adrenergic (a1) receptors. Exhibits antirproliferative activity in vitro. Displays cognition-enhancing, anticonvulsant and sedative activity in vivo. Active orally.
Katalog # CAS Nummer Summenformel Menge
sc-203921 8067-24-1 C₃₃H₄₅N₅O₅ 100 mg
DMCM hydrochloride
Benzodiazepine inverse agonist. Exhibits strong convulsant and anxiogenic activity.
Katalog # CAS Nummer Summenformel Menge
sc-205295 82499-00-1 C₁₇H₁₈N₂O₄ ·HCl 10 mg/50 mg
Etbicyphat
A synthetic, non-competitive GABA antagonist suggested to operate by blocking GABA-gated Cl- channels. Also shown to inhibit dihydropicrotoxin and t-butylbicyclo-phosphorothionate binding.
Katalog # CAS Nummer Summenformel Menge
sc-294479 1005-93-2 C₆H₁₁O₄P 500 mg
Etomidate
General anesthetic with GABA modulatory and GABA-mimetic actions. Interacts selectively with β2- and β3-subunit containing GABA_A receptors. Short acting and potent hypnotic; low toxicity.
Katalog # CAS Nummer Summenformel Menge
sc-203577 33125-97-2 C₁₄H₁₆N₂O₂ 10 mg
FG 7142
Anxiogenic agent and Benzodiazepine inverse agonist. Shows increase in Tyr hydroxylation and exhibits upregulation of b-adrenoceptors in the cerebral cortex in mice.
Katalog # CAS Nummer Summenformel Menge
sc-203952 78538-74-6 C₁₃H₁₁N₃O 100 mg
FGIN-1-43
Potent, specific ligand for mitochondrial diazepam binding inhibitor receptor.
Katalog # CAS Nummer Summenformel Menge
sc-203953 145040-29-5 C₂₈H₃₆Cl₂N₂O 10 mg/50 mg
FrPbAII
A component of the Parawixia bistriata spider venom which has been shown to selectively inhibitf GABA and glycine uptake (IC₅₀=65 µM and 62 µM respectively) with little or no effect on monoamine or glutamate transporters. It produces neuroprotective effects in a rat retinal ischemia/reperfusion model displaying remarkable reduction in cell death1. It also abolishes convulsive tonic-clonic seizures induced by bicuculline (SCBT Catalog # sc-200485) in rats.
Katalog # CAS Nummer Summenformel Menge
sc-221630 n.n. C₆H₁₅ClN₄O₂ 5 mg
GABA
The major inhibitory neurotransmitter in mammalian central nervous system.
Katalog # CAS Nummer Summenformel Menge
sc-203053 56-12-2 C₄H₉NO₂ 10 g/25 g
gamma-Acetylenic GABA
A GABA transaminase inhibitor
Katalog # CAS Nummer Summenformel Menge
sc-295002 57659-38-8 C₆H₉NO₂ 1 mg/5 mg
Ganaxolone
A synthetic neurosteroid which functions as a stereoselective positive allosteric modulator of GABA_A receptors.
Katalog # CAS Nummer Summenformel Menge
sc-203586 38398-32-2 C₂₂H₃₆O₂ 10 mg/50 mg
GS 39783
A compound that regulates GABA_B receptors.
Katalog # CAS Nummer Summenformel Menge
sc-203589 39069-52-8 C₁₅H₂₃N₅O₂S 10 mg/50 mg
GS 39783
This product is a positive allosteric modulator of GABA_B receptors.
Katalog # CAS Nummer Summenformel Menge
sc-300773 39069-52-8 C₁₅H₂₃N₅O₂S 25 mg
Hispidulin
Potent benzodiazepine (BZD) receptor ligand. Natural sage (Salvia officinalis) flavone. Also has antioxidant, antithrombotic, antifungal, and antiproliferative properties.
Katalog # CAS Nummer Summenformel Menge
sc-203999 1447-88-7 C₁₆H₁₂O₆ 10 mg
Hypotaurine
Endogenous inhibitory amino acid.
Katalog # CAS Nummer Summenformel Menge
sc-204005 300-84-5 C₂H₇NO₂S 100 mg
Indiplon
Potent GABA_Areceptor positive allosteric modulator. Exhibits sedative, hypnotic, anxiolytic and anticonvulsant activity in vivo and is orally active.
Katalog # CAS Nummer Summenformel Menge
sc-204011 325715-02-4 C₂₀H₁₆N₄O₂S 10 mg/50 mg
Isoguvacine·HCl
Isoguvacine is an agonist of Gamma-amino butyric acid (GABA) with similar biochemical features.
Katalog # CAS Nummer Summenformel Menge
sc-200451 64603-90-3 C₅H₁₀NO₂ ·HCl 10 mg/50 mg
L-655,708
Potent and selective inverse agonist for the benzodiazepine site of α5-containing GABA_A receptors. Displays high selectivity over GABA_A receptors containing α1, α2, α3 or α6 subunits in combination with β3 and γ2.
Katalog # CAS Nummer Summenformel Menge
sc-204040 130477-52-0 C₁₈H₁₉N₃O₄ 10 mg/50 mg
Loreclezole hydrochloride
Subtype-selective GABA_A receptor agonist. Positive allosteric modulator of β2 or β3-subunit containing receptors. Also acts as a negative modulator at a novel regulatory site, enhancing GABA_A receptor sensitization. Inhibits homomeric ρ1 GABA_C receptors.
Katalog # CAS Nummer Summenformel Menge
sc-204061 117857-45-1 C₁₀H₇Cl₄N₃ 10 mg/50 mg
Mebicyphat
Shown to be a non-competitive GABA antagonist. Blocks GABA gated Cl- channels, and is shown to inhibit dihydropicrotoxin binding and t-butylbicyclophosphorothionate binding.
Katalog # CAS Nummer Summenformel Menge
sc-295376 1449-89-4 C₅H₉O₄P 500 mg
Muscimol
A structural analog of GABA and a potent, selective agonist of the GABA_A receptor.
Katalog # CAS Nummer Summenformel Menge
sc-200460 2763-96-4 C₄H₆N₂O₂ 5 mg/25 mg
NCS-382 Sodium Salt
γ-Hydroxybutyric acid antagonist, anticonvulsant.
Katalog # CAS Nummer Summenformel Menge
sc-203444 131733-92-1 C₁₃H₁₃NaO₃ 10 mg/50 mg
NCS-382 hydrate
This product is a γ-Hydroxybutyrate (GHB) receptor antagonist. It displays anti-convulsant activity.
Katalog # CAS Nummer Summenformel Menge
sc-301458 131733-92-1 C₁₃H₁₅NaO₄ 10 mg
(±)-Nipecotic acid
GABA uptake inhibitor. IC₅₀ values are 8, 38, 106 and 2370 mM for hGAT-1, rGAT-2, hGAT-3 and hBGT-1 respectively.
Katalog # CAS Nummer Summenformel Menge
sc-203645 60252-41-7 C₆H₁₁NO₂ 100 mg
NNC 05-2090 hydrochloride
GABA uptake inhibitor; displays moderate selectivity for BGT-1 (mGAT-2) transporters.
Katalog # CAS Nummer Summenformel Menge
sc-204131 184845-43-0 C₂₇H₃₀N₂O₂ ·HCl 10 mg/50 mg
NNC 711
Potent and selective inhibitor of GABA uptake by GAT-1. Anticonvulsant following systemic administration in vivo.
Katalog # CAS Nummer Summenformel Menge
sc-204132 145645-62-1 C₂₁H₂₂N₂O₃•HCl 10 mg/50 mg
Org 20599
Positive allosteric modulator. Direct agonist of GABA_Areceptors at higher concentrations. Anesthetic steroid. Shown to induce hypnosis and lost of righting reflexes in mice.
Katalog # CAS Nummer Summenformel Menge
sc-204150 187652-71-7 C₂₅H₄₀ClNO₃ 10 mg/50 mg
Phaclofen
A selective GABA_B receptor antagonist. The phosphonic acid derivative of Baclofen.
Katalog # CAS Nummer Summenformel Menge
sc-200462 114012-12-3 C₉H₁₃ClNO₃P 5 mg/25 mg
Pregnenolone sulfate sodium salt
Neurosteroid that has been demonstrated to antagonize the GABAA receptor chloride channel.
Katalog # CAS Nummer Summenformel Menge
sc-301609 1852-38-6 C₂₁H₃₁NaO₅S 25 mg
Primidone
Anticonvulsant. Potentiates GABA_A receptor function.
Katalog # CAS Nummer Summenformel Menge
sc-204861 125-33-7 C₁₂H₁₄N₂O₂ 100 mg
Propybicyphat
Demonstrated GABA-gated chloride channel blocker, non-competitive GABA antagonist in mammals.
Katalog # CAS Nummer Summenformel Menge
sc-301615 51486-74-9 C₇H₁₃O₄P 1 mg
R-(+)-Baclofen (free base)
Selective GABA_B receptor agonist. Skeletal muscle relaxant. The more active enantiomer of (±)-Baclofen (sc-200464)
Katalog # CAS Nummer Summenformel Menge
sc-203228 69308-37-8 C₁₀H₁₂ClNO₂ 10 mg/50 mg
R-(+)-Baclofen hydrochloride
Selective GABA_B receptor agonist. Skeletal muscle relaxant. The more active enantiomer of (±)-Baclofen (sc-200464)
Katalog # CAS Nummer Summenformel Menge
sc-203229 63701-55-3 C₁₀H₁₂ClNO₂•HCl 10 mg/50 mg
rac BHFF
Potent and selective GABA_B receptor positive allosteric modulator that increases the efficacy and potency of GABA ( > 149% and > 15-fold respectively). Orally active and exhibits anxiolytic activity in vivo.
Katalog # CAS Nummer Summenformel Menge
sc-204228 123557-91-5 C₁₇H₂₁F₃O₃ 10 mg/50 mg
RO 15-4513
A high affinity benzodiazepine ligand which acts as a partial inverse agonist at recombinant diazepam-sensitive (DS) benzodiazepine α1-, α2-, α3- and α5-GABA_A receptors.
Katalog # CAS Nummer Summenformel Menge
sc-203683 91917-65-6 C₁₅H₁₄N₆O₃ 10 mg
RO 19-4603
Benzodiazepine inverse agonist. Antagonizes effects of ethanol on locomotor behavior and suppresses ethanol intake in alcohol-preferring rats. Binds with high affinity to both diazepam-sensitive (DS) and diazepam-insensitive (DI) GABA_A receptors (Ki values are ~ 0.2 and ~ 2.6 nM for DS and DI receptors respectively).
Katalog # CAS Nummer Summenformel Menge
sc-203684 99632-94-7 C₁₅H₁₇N₃O₃S 10 mg/50 mg
S(+)-gamma-Vinyl-GABA
Selective GABA transaminase inhibitor. Active enantiomer. Potential usefulness in treating cocaine addiction.
Katalog # CAS Nummer Summenformel Menge
sc-222279 74046-07-4 C₆H₁₁NO₂ 5 mg
(S)-SNAP 5114
GABA uptake inhibitor, showing selectivity for GAT-3 and GAT-2 (IC₅₀ values are 5, 21 and 388 μM for hGAT-3, rGAT-2 and hGAT-1 respectively). Increases thalamic GABA levels and is an anticonvulsant following systemic administration in vivo.
Katalog # CAS Nummer Summenformel Menge
sc-204257 157604-55-2 C₃₀H₃₅NO₆ 10 mg/50 mg
Saclofen
A selective antagonist of the GABA_B receptor.
Katalog # CAS Nummer Summenformel Menge
sc-203252 125464-42-8 C₉H₁₂CINO₃S 10 mg
SB 205384
GABA_A receptor modulator; slows current decay. Displays some specificity for α3-subunit-containing receptors (in particular α3β2γ2). Has little effect on receptors containing α1 or α2 subunits.
Katalog # CAS Nummer Summenformel Menge
sc-204263 160296-13-9 C₁₇H₁₈N₂O₃S 10 mg/50 mg
SCH 50911
Katalog # CAS Nummer Summenformel Menge
sc-361352 160415-07-6 C₈H₁₅NO₃ 10 mg/50 mg
SCS
Partial inhibitor of β1-containing GABA_A receptors. May bind allosterically to a novel site on GABA_A receptor.
Katalog # CAS Nummer Summenformel Menge
sc-203375 3232-36-8 C₁₄H₁₂N₂O₃ 50 mg
SK&F 97541
SK&F 97541 is a very potent GABA_B agonist, at least ten times more active than baclofen.
Katalog # CAS Nummer Summenformel Menge
sc-200469 127729-35-5 C₄H₁₂NO₂P 5 mg/25 mg
SR 95531 Hydrobromide
Selective GABA_A receptor antagonist. Displaces [3H]-GABA from rat brain membranes with a Ki of 150 nM. Selectively antagonizes GABA-induced Cl- currents with little action on pentobarbitone-induced currents. Acts as a low affinity glycine receptor antagonist.
Katalog # CAS Nummer Summenformel Menge
sc-203701 104104-50-9 C₁₅H₁₇N₃O₃ ·HBr 10 mg/50 mg
TACA
GABA_A and GABA_C agonist. Also GABA-T substrate and GABA uptake inhibitor. Trans-isomer of CACA.
Katalog # CAS Nummer Summenformel Menge
sc-203705 38090-53-8 C₄H₇NO₂ 10 mg/50 mg
TB 21007
GABA_A receptor inverse agonist selective for the α5-subtype (Ki values are 1.6, 16, 20 and 20 nM for α5, α2, α1 and α3 subtypes respectively). Brain penetrant; enhances cognitive performance in rats in the delayed matching-to-place morris water maze test following i.p. administration.
Katalog # CAS Nummer Summenformel Menge
sc-204322 207306-50-1 C₁₅H₁₇NO₂S₃ 10 mg/50 mg
Thiocolchicoside
A potent, competitive antagonist of GABA_A receptors.
Katalog # CAS Nummer Summenformel Menge
sc-202839 602-41-5 C₂₇H₃₃NO₁₀S 1 mg/5 mg
Thiomuscimol
A structural analog of GABA_A.
Katalog # CAS Nummer Summenformel Menge
sc-213035 62020-54-6 C₄H₆N₂OS 10 mg
THIP hydrochloride
Systemically active GABA_A receptor agonist and GABAC receptor antagonist. Displays anticonvulsant, antinociceptive and sedative effects. Hypnotic agent that enhances delta activity within non-REM sleep in rats.
Katalog # CAS Nummer Summenformel Menge
sc-204342 64603-91-4 C₆H₈N₂O₂ ·HCl 50 mg
TPMPA
Competitive, selective GABA_C antagonist with minimal effects on GABA_A and GABA_B receptors (Kb values are 2.1 μM (antagonist), 320 μM (antagonist) and EC5₅₀ ~ 500 μM (weak agonist) respectively). Shows 8-fold selectivity for human recombinant ρ 1 receptors over ρ2 receptors.
Katalog # CAS Nummer Summenformel Menge
sc-204352 182485-36-5 C₆H₁₂NO₂P 10 mg/50 mg
Tracazolate hydrochloride
Subtype selective GABA_A allosteric receptor modulator. Can potentiate or inhibit recombinant GABA_A function depending on subunit combination. Enhances native GABA_A receptor function and is anxiolytic following systemic administration in vivo.
Katalog # CAS Nummer Summenformel Menge
sc-203709 41094-88-6 C₁₆H₂₄N₄O₂•HCl•xH₂O 10 mg/50 mg
trans-4-Hydroxycrotonic acid
Katalog # CAS Nummer Summenformel Menge
sc-203710 24587-49-3 C₄H₆O₃ 10 mg/50 mg
U 89843A
Positive allosteric modulator of GABA_A receptors. Enhances GABA-induced Cl- currents in the α1β2γ2, α3β2γ2 and α6β2γ2 subtypes. Causes sedation in vivo following i.v. administration without losing "righting reflex". Also displays antioxidant activity.
Katalog # CAS Nummer Summenformel Menge
sc-204361 157013-32-6 C₁₆H₂₃N₅ ·HCl 10 mg/50 mg
U 90042
GABA_A receptor ligand that binds with comparable affinities to three receptor subtypes: α1β2γ2, α3β2γ2 and α6β2γ2 (Ki values are 7.8, 9.5 and 11.0 nM respectively). Potentiates GABA-induced chloride currents in α6β2γ2 receptors. Sedative/hypnotic compound.
Katalog # CAS Nummer Summenformel Menge
sc-204362 134516-99-7 C₁₇H₁₃ClN₆O 10 mg/50 mg
U 93631
GABA_A receptor antagonist that binds picrotoxin site and stabilizes the inactive form of the channel via allosteric interaction. Accelerates decay of GABA-induced Cl- currents with little effect on peak amplitude. Also inhibits 5-HT3A receptors via similar mechanism.
Katalog # CAS Nummer Summenformel Menge
sc-204364 152273-12-6 C₁₇H₂₁N₃O₂ 10 mg/50 mg
Valerenic acid
Positive allosteric modulator of GABA_A receptors that displays preference for β2 or β3 subunit receptors. Directly activates the receptor and also blocks the channel at high concentrations. Displays a anxiolytic and sedative activity in vivo. Also acts as a partial agonist of 5-HT5A receptors.
Katalog # CAS Nummer Summenformel Menge
sc-204377 3569-10-6 C₁₅H₂₂O₂ 1 mg
Vigabatrin
Selective GABA-T inhibitor. Anticonvulsant.
Katalog # CAS Nummer Summenformel Menge
sc-204382 60643-86-9 C₆H₁₁NO₂ 10 mg/50 mg
ZAPA sulfate
A potent, selective GABA_A receptor agonist. Demonstrates higher GABA_A affinity than muscimol and GABA.
Katalog # CAS Nummer Summenformel Menge
sc-200471 92138-10-8 C₄H₆N₂O₂S ·H₂SO₄ 5 mg/25 mg
ZK 93423 hydrochloride
Potent benzodiazepine agonist. Non-selective with GABA_Areceptors containing α1-, α2-, α3- and α5-subunits. Anxiolytic post systemic administration in vivo.
Katalog # CAS Nummer Summenformel Menge
sc-204422 83910-44-5 C₂₃H₂₂N₂O₄ ·HCl 10 mg/50 mg
ZK 93426 hydrochloride
Potent, selective and competitive benzodiazepine receptor antagonist (IC₅₀ values are 0.4 and 0.7 nM for inhibition of [3H]-flunitrazepam binding to rat cerebellum and hippocampus respectively). Similar in vivo profile to flumazenil (Ro 15-1788); produces anxiogenic effects in some behavioral tests and anxiolytic effects in others. Orally active.
Katalog # CAS Nummer Summenformel Menge
sc-203727 89592-45-0 C₁₈H₂₀N₂O₃ ·HCl 10 mg/50 mg