EGFR Inhibitors

• AG 494
  Potent inhibitor of epidermal growth factor receptor (EGFR) kinase (IC₅₀ = 0.7 μM). Selective over ErbB2, PDGFR and insulin receptor kinase (IC₅₀s are 42, 6 and >100 μM respectively).

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-202043	133550-35-3	C16H12N2O3	10 mg/50 mg

• AG 555
  Potent epidermal growth factor receptor (EGFR) kinase inhibitor (IC₅₀ = 0.7 μM) that displays 50-fold and >140-fold selectivity over ErbB2 and insulin receptor kinase respectively. Induce G1 growth arrest selectively in transformed cells (IC₅₀ values are 6.4 and 9.4 μM in HPV16-immortalized and normal keratinocytes respectively).

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-203500	133550-34-2	C19H18N2O3	10 mg/50 mg

• AG 1478 hydrochloride

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-361101	153436-53-4	C16H14ClN3O2.HCl	10 mg/50 mg

• Tyrphostin AG 1478
  A potent and selective inhibitor of EGFR; reported to block EGF-dependent src-family kinase activation and ERK phosphorylation.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-200613	175178-82-2	C16H14ClN3O2	5 mg/25 mg

• BIBU 1361 dihydrochloride
  Selective inhibitor of EGFR-kinase. Selectivity is exhibited over a range of other related tyrosine kinases. Blocks downstream signaling. Administration orally inhibits growth of established human xenografts in athymic mice.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-203844	793726-84-8	C22H27ClFN7•2HCl	1 mg/10 mg

• BIBX 1382
  Cell-permeable pyrimidopyrimidine. Potent, reversible, ATP-competitive, and highly selective inhibitor of EGFR (ErbB-1, HER-1) both in cell-free enzymatic reactions and in culture.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-202497	196612-93-8	C18H19ClFN7 ·2HCl ·2H2O	5 mg

• DAPH
  A tyrosine kinase inhibitor, which suppresses and reverses the formation of Aβ42 fibers in neurons.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-200698	145915-58-8	C20H15N3O2	5 mg

• Erbstatin Analog
  Inhibitor of EGFR (epidermal growth factor receptor)-associated tyrosine kinase. Blocks EGFR-mediated cellular phenotypic changes and delays EGF-induced DNA synthesis.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-200511	63177-57-1	C10H10O4	5 mg/25 mg

• JNJ 28871063 hydrochloride
  Potent and selective ErbB receptor family inhibitor (IC₅₀ values are 21, 22 and 38 nM for ErbB4, EGFR and ErbB2 respectively). Displays potent growth inhibition of human cancer cell lines overexpressing ErbB2 in vitro (IC₅₀= 60 - 168 nM). Inhibits growth of human tumor xenografts in vivo. Orally active and brain penetrant.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-204025	944341-54-2	C24H27CIN6O3•HCl	10 mg/50 mg

• Lavendustin A
  Inhibitor of the EGF receptor tyrosine kinase. Binds kinase on a site distinct from the ATP and peptide substrate binding sites. Suppresses VEGF-induced angiogenesis in rats.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-200539	125697-92-9	C21H19NO6	1 mg/5 mg

• Lavendustin B
  Lavendustin B is a weak tyrosine kinase inhibitor that can be used as a negative control for lavendustin A (sc-200539).

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-200595	125697-91-8	C21H19NO5	1 mg/5 mg

• PD 153035
  An extremely potent and specific inhibitor of the tyrosine kinase activity of the epidermal growth factor receptor (EGFR).

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205909	153436-54-5 (HCl salt)	C16H14BrN3O2	1 mg

• PD 153035 Hydrochloride
  An extremely potent inhibitor of epidermal growth factor (EGF) receptor tyrosine kinase (IC₅₀ = 25 pM). Only inhibits other purified tyrosine kinases at micromolar or higher concentrations.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-205963	153436-54-5	C16H14BrN3O2 ·HCl	10 mg/50 mg

• RG-13022
  A tyrosine kinase tyrphostin. Reports indicate that it suppresses epidermal growth factor (EGF)-stimulated cancer cell proliferation in cancer cell studies.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-200591	136831-48-6	C16H14N2O2	5 mg/25 mg

• Tyrphostin RG 14620
  Non-phenolic tyrphostin analog, which is selective for the EGF receptor and long acting. Inhibits EGF-stimulated HER14 cell proliferation as well as tumor growth in vivo.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-200593	136831-49-7	C14H8Cl2N2	5 mg/25 mg

• Tyrphostin B44, (+) enantiomer
  Epidermal growth factor receptor (EGFR) kinase inhibitor. Slightly less active than the (-) enantiomer

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-203305	133550-37-5	C18H16N2O3	5 mg

• Tyrphostin B44, (-) enantiomer
  A potent inhibitor of epidermal growth factor receptor (EGFR) kinase (IC₅₀ = 0.4 μM), more active than the (+) enantiomer. Selective over ErbB2.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-203711	133550-32-0	C18H16N2O3	5 mg

• Tyrphostin 47 (RG-50864, AG-213)
  Tyrphostin 47 (RG-50864, AG-213) is a protein tyrosine kinase inhibitor particularly potent against epidermal growth factor (EGF) kinase activity.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-200543	122520-86-9	C10H8N2O2S	5 mg/25 mg

• Tyrphostin 51
  A potent inhibitor of EGF receptor kinase activity (IC₅₀=0.8 µM). Inhibition is mixed competitive with ATP and substrate.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-200545	122520-90-5	C13H8N4O3	5 mg/25 mg

• Tyrphostin AG 99
  Inhibits epidermal growth factor (EGF) receptor tyrosine kinase (IC₅₀ = 10 µM) and EGF-dependent cell proliferation. Inhibits EGFR phosphorylation and ERK1 and ERK2 activities.

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-202847	118409-59-9	C10H8N2O3	5 mg/25 mg

• Tyrphostin AG 183
  Inhibits epidermal growth factor receptor tyrosine kinase (IC₅₀ = 800 nM).

  Katalog #	CAS Nummer	Summenformel	Menge
  sc-202846	126433-07-6	C13H8N4O3	25 mg/5 mg